HRP20191884T1 - St2l antagonisti i postupci upotrebe - Google Patents
St2l antagonisti i postupci upotrebe Download PDFInfo
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- HRP20191884T1 HRP20191884T1 HRP20191884TT HRP20191884T HRP20191884T1 HR P20191884 T1 HRP20191884 T1 HR P20191884T1 HR P20191884T T HRP20191884T T HR P20191884TT HR P20191884 T HRP20191884 T HR P20191884T HR P20191884 T1 HRP20191884 T1 HR P20191884T1
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- Prior art keywords
- antibody antagonist
- isolated antibody
- pharmaceutical composition
- optionally
- preventing
- Prior art date
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- 239000005557 antagonist Substances 0.000 title claims 12
- 238000000034 method Methods 0.000 title claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 210000003630 histaminocyte Anatomy 0.000 claims 4
- 208000019693 Lung disease Diseases 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 230000036755 cellular response Effects 0.000 claims 3
- 238000006467 substitution reaction Methods 0.000 claims 3
- 101000852968 Homo sapiens Interleukin-1 receptor-like 1 Proteins 0.000 claims 2
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 208000036971 interstitial lung disease 2 Diseases 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 201000003883 Cystic fibrosis Diseases 0.000 claims 1
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 1
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims 1
- 101000680096 Homo sapiens Transmembrane emp24 domain-containing protein 1 Proteins 0.000 claims 1
- 108090000174 Interleukin-10 Proteins 0.000 claims 1
- 108090000176 Interleukin-13 Proteins 0.000 claims 1
- 108010002616 Interleukin-5 Proteins 0.000 claims 1
- 108090001007 Interleukin-8 Proteins 0.000 claims 1
- 206010039085 Rhinitis allergic Diseases 0.000 claims 1
- 206010039710 Scleroderma Diseases 0.000 claims 1
- 102100022243 Transmembrane emp24 domain-containing protein 1 Human genes 0.000 claims 1
- 230000036428 airway hyperreactivity Effects 0.000 claims 1
- 201000010105 allergic rhinitis Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000004700 fetal blood Anatomy 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 210000002175 goblet cell Anatomy 0.000 claims 1
- 102000055002 human IL1RL1 Human genes 0.000 claims 1
- 206010020718 hyperplasia Diseases 0.000 claims 1
- 210000004969 inflammatory cell Anatomy 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 210000003097 mucus Anatomy 0.000 claims 1
- 201000000306 sarcoidosis Diseases 0.000 claims 1
- 230000028327 secretion Effects 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/01—Hydrolysed proteins; Derivatives thereof
- A61K38/012—Hydrolysed proteins; Derivatives thereof from animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
- Y10S530/809—Fused cells, e.g. hybridoma
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Endocrinology (AREA)
- General Chemical & Material Sciences (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Catching Or Destruction (AREA)
Claims (11)
1. Izolirani antagonist antitijela ili njegov fragment koji se specifično veže za domenu I (SEQ ID NO: 9) humanog ST2L, koji sadrži varijabilnu regiju teškog lanca (VH) i varijabilnu regiju lakog lanca (VL), gdje:
(a) VH sadrži SEQ ID NO: 191; i
(b) VL sadrži SEQ ID NO: 209.
2. Izolirani antagonist antitijela prema patentnom zahtjevu 1, pri čemu je antagonist antitijela tipa IgG1, IgG2, IgG3, ili IgG4, opcionalno ima supstituciju u regiji Fc, i opcionalno gdje supstitucija uključuje supstituciju M252Y/S254T/T256E, V234A/G237A/P238S/H268A/V309L/A330S/P331S, ili S228P/L234A/L235A, gdje je numeriranje ostataka prema EU numeraciji.
3. Izolirani polinukleotid koji kodira izoliranog antagonista antitijela prema bilo kojem od patentnih zahtjeva 1-2.
4. Vektor koji sadrži izolirani polinukleotid patentnog zahtjeva 3.
5. Stanica domaćina koja sadrži vektor patentnog zahtjeva 4.
6. Postupak za proizvodnju antagonista antitijela, koji obuhvaća uzgoj stanica domaćina patentnog zahtjeva 5 i izolaciju antagonista antitijela iz stanice domaćina.
7. Farmaceutski sastav koji sadrži izoliranog antagonista antitijela prema bilo kojem od patentnih zahtjeva 1-2 i farmaceutski prihvaćeni nosač.
8. Izolirani antagonist antitijela prema bilo kojem od patentnih zahtjeva 1-2 ili farmaceutski sastav patentnog zahtjeva 7 za upotrebu u terapiji.
9. Izolirani antagonist antitijela ili farmaceutski sastav za upotrebu prema patentnom zahtjevu 8, gdje je terapija liječenje ili sprječavanje plućne bolesti, opcionalno gdje liječenje ili prevencija obuhvaća:
a) Sprječavanje odgovora mastocita kod pacijenata, opcionalno gdje sprječavanje odgovora mastocita obuhvaća sprječavanje razine GM-CSF, IL-5, IL-8, IL-10, ili IL-13 oslobođenih iz mastocita koji potječu najmanje 50% iz krvi pupčane vrpce sa 50 μg/ml antitijela; i/ili
b) Sprječavanje interakcije IL-33 i ST2L kod subjekta.
10. Izolirani antagonist antitijela ili farmaceutski sastav za upotrebu u skladu s patentnim zahtjevom 9, gdje je plućna bolest astma, hiperreaktivnost dišnih puteva, sarkoidoza, kronična opstruktivna bolest pluća (COPD), idiopatska plućna fibroza (IPF), cistična fibroza, sklerodermija, alergijski rinitis, ili je povezan s pronalaženjem inflamatornih stanica u plućima, hiperplazijom vrčastih stanica, ili povećanom sluzavom izlučevinom ili odgovorom mastocita.
11. Izolirani antagonist antitijela ili farmaceutski sastav za upotrebu u skladu s patentnim zahtjevom 10, gdje je plućna bolest astma.
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261640407P | 2012-04-30 | 2012-04-30 | |
| US201261640238P | 2012-04-30 | 2012-04-30 | |
| US13/798,204 US9090694B2 (en) | 2012-04-30 | 2013-03-13 | ST2L antibody antagonists |
| US13/798,226 US9212227B2 (en) | 2012-04-30 | 2013-03-13 | ST2L antibody antagonists for the treatment of ST2L-mediated inflammatory pulmonary conditions |
| PCT/US2013/038637 WO2013165894A2 (en) | 2012-04-30 | 2013-04-29 | St2l antagonists and methods of use |
| EP13785158.0A EP2844292B1 (en) | 2012-04-30 | 2013-04-29 | St2l antagonists and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20191884T1 true HRP20191884T1 (hr) | 2020-02-07 |
Family
ID=49477497
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20191884TT HRP20191884T1 (hr) | 2012-04-30 | 2019-10-16 | St2l antagonisti i postupci upotrebe |
Country Status (37)
| Country | Link |
|---|---|
| US (4) | US9212227B2 (hr) |
| EP (2) | EP3597219A1 (hr) |
| JP (3) | JP6283354B2 (hr) |
| KR (2) | KR20150008152A (hr) |
| CN (2) | CN107098973A (hr) |
| AR (1) | AR090909A1 (hr) |
| AU (2) | AU2013256645B2 (hr) |
| BR (1) | BR112014027165A2 (hr) |
| CA (1) | CA2871948C (hr) |
| CL (1) | CL2014002955A1 (hr) |
| CO (1) | CO7240389A2 (hr) |
| CR (1) | CR20140488A (hr) |
| CY (1) | CY1122308T1 (hr) |
| DK (1) | DK2844292T3 (hr) |
| EA (2) | EA031047B1 (hr) |
| EC (1) | ECSP14025178A (hr) |
| ES (1) | ES2755094T3 (hr) |
| HK (1) | HK1208182A1 (hr) |
| HR (1) | HRP20191884T1 (hr) |
| HU (1) | HUE045864T2 (hr) |
| IL (2) | IL235401B (hr) |
| LT (1) | LT2844292T (hr) |
| MX (2) | MX358134B (hr) |
| MY (1) | MY166062A (hr) |
| NI (1) | NI201400125A (hr) |
| NZ (3) | NZ729913A (hr) |
| PE (1) | PE20150641A1 (hr) |
| PH (2) | PH12014502435A1 (hr) |
| PL (1) | PL2844292T3 (hr) |
| PT (1) | PT2844292T (hr) |
| RS (1) | RS59511B1 (hr) |
| SG (2) | SG10201608525SA (hr) |
| SI (1) | SI2844292T1 (hr) |
| TW (3) | TWI700299B (hr) |
| UA (1) | UA118336C2 (hr) |
| UY (1) | UY34774A (hr) |
| WO (1) | WO2013165894A2 (hr) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10053513B2 (en) | 2009-11-30 | 2018-08-21 | Janssen Biotech, Inc. | Antibody Fc mutants with ablated effector functions |
| CN102711810B (zh) | 2009-11-30 | 2015-04-22 | 詹森生物科技公司 | 效应子功能已消除的抗体Fc区突变体 |
| US9212227B2 (en) * | 2012-04-30 | 2015-12-15 | Janssen Biotech, Inc. | ST2L antibody antagonists for the treatment of ST2L-mediated inflammatory pulmonary conditions |
| AR091069A1 (es) * | 2012-05-18 | 2014-12-30 | Amgen Inc | Proteinas de union a antigeno dirigidas contra el receptor st2 |
| JO3532B1 (ar) | 2013-03-13 | 2020-07-05 | Regeneron Pharma | الأجسام المضادة لمضاد انترلوكين-33 واستعمالاتها |
| CA2904377C (en) | 2013-03-15 | 2021-07-13 | Regeneron Pharmaceuticals, Inc. | Il-33 antagonists and uses thereof |
| EP3092253B1 (en) | 2014-01-10 | 2021-03-17 | AnaptysBio, Inc. | Antibodies directed against interleukin-33 (il-33) |
| CA2946511C (en) | 2014-04-21 | 2023-08-22 | The Childen's Hospital Of Philadelphia | Compositions and methods for treating cytokine-related disorders |
| EP3157634B1 (en) | 2014-06-23 | 2018-12-12 | Bionomics, Inc. | Antibodies that bind lgr4 |
| EA201791029A1 (ru) | 2014-11-10 | 2017-12-29 | Дженентек, Инк. | Антитела против интерлейкина-33 и их применение |
| JP7231326B2 (ja) | 2014-11-10 | 2023-03-01 | ジェネンテック， インコーポレイテッド | Ｉｌ－３３媒介性障害のための治療及び診断方法 |
| EP3265107B1 (en) | 2015-03-02 | 2024-10-02 | 180 Therapeutics LP | Method of treating a localized fibrotic disorder using a tnf receptor 2 antagonist |
| EP3313887A2 (en) * | 2015-06-26 | 2018-05-02 | MAB Discovery GmbH | Monoclonal anti-il-1racp antibodies |
| CN109475622A (zh) * | 2016-01-14 | 2019-03-15 | 安奈普泰斯生物有限公司 | 使用il-33抑制剂抑制过敏反应 |
| EP3241845A1 (en) | 2016-05-06 | 2017-11-08 | MAB Discovery GmbH | Humanized anti-il-1r3 antibodies |
| US20190202907A1 (en) * | 2016-09-02 | 2019-07-04 | 180 Therapeutics Lp | Method of treating systemic fibrotic disorders using an il-33/tnf bispecific antibody |
| US20190225682A1 (en) * | 2016-09-02 | 2019-07-25 | 180 Therapeutics Lp | Method of treating localized fibrotic disorders using an il-33/tnf bispecific antibody |
| JOP20190093A1 (ar) | 2016-10-28 | 2019-04-25 | Lilly Co Eli | أجسام مضادة لـ il-33 واستخداماتها |
| TWI784988B (zh) | 2016-12-01 | 2022-12-01 | 美商再生元醫藥公司 | 治療發炎症狀的方法 |
| JP6995127B2 (ja) | 2017-02-10 | 2022-02-04 | ジェネンテック， インコーポレイテッド | 抗トリプターゼ抗体、その組成物、及びその使用 |
| EP3610041A1 (en) | 2017-04-13 | 2020-02-19 | Regeneron Pharmaceuticals, Inc. | Treatment and inhibition of inflammatory lung diseases in patients having risk alleles in the genes encoding il33 and il1rl1 |
| EP3401332A1 (en) | 2017-05-08 | 2018-11-14 | MAB Discovery GmbH | Anti-il-1r3 antibodies for use in inflammatory conditions |
| MX2020006119A (es) | 2017-12-21 | 2020-08-24 | Hoffmann La Roche | Anticuerpos de union a hla-a2/wt1. |
| JP7418337B2 (ja) | 2018-02-09 | 2024-01-19 | ジェネンテック， インコーポレイテッド | マスト細胞媒介性炎症性疾患の治療法及び診断法 |
| IL277890B2 (en) | 2018-04-11 | 2024-03-01 | Regeneron Pharma | Methods for quantification of IL-33 |
| JP2022513406A (ja) * | 2018-10-31 | 2022-02-07 | デリニア インコーポレイテッド | 多価制御性ｔ細胞調節因子 |
| KR102353568B1 (ko) * | 2018-11-14 | 2022-01-20 | 주식회사 헬릭스미스 | 안정성이 향상된 항 c-Met 항체 또는 그의 항원 결합 단편 |
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