HRP20240088T1 - Mutageneza usmjerena na mjesto protutijela trem-1 za smanjenje viskoziteta - Google Patents
Mutageneza usmjerena na mjesto protutijela trem-1 za smanjenje viskoziteta Download PDFInfo
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- HRP20240088T1 HRP20240088T1 HRP20240088TT HRP20240088T HRP20240088T1 HR P20240088 T1 HRP20240088 T1 HR P20240088T1 HR P20240088T T HRP20240088T T HR P20240088TT HR P20240088 T HRP20240088 T HR P20240088T HR P20240088 T1 HRP20240088 T1 HR P20240088T1
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- Prior art keywords
- seq
- heavy chain
- variable region
- antibody
- light chain
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- 230000003247 decreasing effect Effects 0.000 title 1
- 238000002741 site-directed mutagenesis Methods 0.000 title 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 9
- 239000000825 pharmaceutical preparation Substances 0.000 claims 8
- 208000023275 Autoimmune disease Diseases 0.000 claims 3
- 210000003527 eukaryotic cell Anatomy 0.000 claims 2
- 208000027866 inflammatory disease Diseases 0.000 claims 2
- 210000001236 prokaryotic cell Anatomy 0.000 claims 2
- 206010064539 Autoimmune myocarditis Diseases 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 208000030939 Chronic inflammatory demyelinating polyneuropathy Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 206010012438 Dermatitis atopic Diseases 0.000 claims 1
- 208000024869 Goodpasture syndrome Diseases 0.000 claims 1
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 1
- 208000003807 Graves Disease Diseases 0.000 claims 1
- 208000015023 Graves' disease Diseases 0.000 claims 1
- 208000030836 Hashimoto thyroiditis Diseases 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 208000029523 Interstitial Lung disease Diseases 0.000 claims 1
- 208000011200 Kawasaki disease Diseases 0.000 claims 1
- 208000005777 Lupus Nephritis Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims 1
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims 1
- 206010039710 Scleroderma Diseases 0.000 claims 1
- 208000021386 Sjogren Syndrome Diseases 0.000 claims 1
- 201000009594 Systemic Scleroderma Diseases 0.000 claims 1
- 206010042953 Systemic sclerosis Diseases 0.000 claims 1
- 102000018368 Triggering Receptor Expressed on Myeloid Cells-1 Human genes 0.000 claims 1
- 108010066451 Triggering Receptor Expressed on Myeloid Cells-1 Proteins 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 206010047642 Vitiligo Diseases 0.000 claims 1
- 208000038016 acute inflammation Diseases 0.000 claims 1
- 230000006022 acute inflammation Effects 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 230000007815 allergy Effects 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 201000008937 atopic dermatitis Diseases 0.000 claims 1
- 230000001363 autoimmune Effects 0.000 claims 1
- 230000000903 blocking effect Effects 0.000 claims 1
- 208000037976 chronic inflammation Diseases 0.000 claims 1
- 230000006020 chronic inflammation Effects 0.000 claims 1
- 201000005795 chronic inflammatory demyelinating polyneuritis Diseases 0.000 claims 1
- 208000029078 coronary artery disease Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000024908 graft versus host disease Diseases 0.000 claims 1
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 208000001725 mucocutaneous lymph node syndrome Diseases 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 201000008383 nephritis Diseases 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000003259 recombinant expression Methods 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Claims (11)
1. Protutijelo koje je sposobno za vezanje na TREM-1 i za njegovo blokiranje, naznačeno time, da obuhvaća:
(i) teški lanac koji sadržava varijabilnu regiju teškog lanca od SEQ ID NO: 2 i laki lanac koji sadržava SEQ ID NO: 4;
(ii) teški lanac koji sadržava varijabilnu regiju teškog lanca od SEQ ID NO: 2 i laki lanac koji sadržava SEQ ID NO: 5;
(iii) teški lanac koji sadržava varijabilnu regiju teškog lanca od SEQ ID NO: 2 i laki lanac koji sadržava SEQ ID NO: 6;
(iv) teški lanac koji sadržava varijabilnu regiju teškog lanca od SEQ ID NO: 2 i laki lanac koji sadržava SEQ ID NO: 7;
(v) teški lanac koji sadržava varijabilnu regiju teškog lanca od SEQ ID NO: 2 i laki lanac koji sadržava SEQ ID NO: 8;
(vi) teški lanac koji sadržava varijabilnu regiju teškog lanca od SEQ ID NO: 2 i laki lanac koji sadržava SEQ ID NO: 9;
(vii) teški lanac koji sadržava varijabilnu regiju teškog lanca od SEQ ID NO: 2 i laki lanac koji sadržava SEQ ID NO: 10;
(viii) teški lanac koji sadržava varijabilnu regiju teškog lanca od SEQ ID NO: 2 i laki lanac koji sadržava SEQ ID NO: 14;
(ix) teški lanac koji sadržava varijabilnu regiju teškog lanca od SEQ ID NO: 11 i laki lanac koji sadržava SEQ ID NO: 3;
(x) teški lanac koji sadržava varijabilnu regiju teškog lanca od SEQ ID NO: 12 i laki lanac koji sadržava SEQ ID NO: 3;
(xi) teški lanac koji sadržava varijabilnu regiju teškog lanca od SEQ ID NO: 13 i laki lanac koji sadržava SEQ ID NO: 3;
(xii) teški lanac koji sadržava varijabilnu regiju teškog lanca od SEQ ID NO: 15 i laki lanac koji sadržava SEQ ID NO: 5; ili
(xiii) teški lanac koji sadržava varijabilnu regiju teškog lanca od SEQ ID NO: 16 i laki lanac koji sadržava SEQ ID NO: 14;
pri čemu teški lanac sadrži IgG4 konstantnu regiju.
2. Protutijelo prema patentnom zahtjevu 1, naznačeno time, da teški lanac sadržava varijabilnu regiju teškog lanca od SEQ ID NO: 2 i pritom laki lanac sadržava SEQ ID NO: 5.
3. Farmaceutski pripravak, naznačen time, da sadrži protutijelo prema patentnom zahtjevu 1 ili patentnom zahtjevu 2 i farmaceutski prihvatljiv nosač.
4. Prokariotska ili eukariotska stanica, naznačena time, da rekombinantno eksprimira protutijelo u skladu s patentnim zahtjevom 1 ili patentnim zahtjevom 2.
5. Postupak za proizvodnju protutijela prema patentnom zahtjevu 1 ili patentnom zahtjevu 2, naznačen time, da obuhvaća rekombinantnu ekspresiju protutijela u prokariotskoj ili eukariotskoj stanici.
6. Protutijelo prema patentnom zahtjevu 1 ili patentnom zahtjevu 2, ili farmaceutski pripravak prema patentnom zahtjevu 3, naznačeni time, da su za uporabu kao lijek za pojedinca kojemu je on potreban.
7. Protutijelo prema patentnom zahtjevu 1 ili patentnom zahtjevu 2, ili farmaceutski pripravak prema patentnom zahtjevu 3, naznačeni time, da su za uporabu u liječenju upalne bolesti ili autoimune bolesti kod pojedinca kojemu je to potrebno.
8. Protutijelo ili farmaceutski pripravak za uporabu prema patentnom zahtjevu 7, naznačeni time, da se upalna bolest ili autoimuna bolest bira iz skupine koju čine:
upalna bolest crijeva, Crohnova bolest, ulcerativni kolitis, sindrom iritabilnih crijeva, reumatoidni artritis, psorijaza, psorijatički artritis, sistemski eritematozni lupus, lupus nefritis, dijabetes tipa I, Graveova bolest, multipla skleroza, autoimuni miokarditis, Kawasaki bolest, bolest koronarnih arterija, kronična opstrukcijska plućna bolest, intersticijska plućna bolest, autoimuni tiroiditis, skleroderma, sistemska skleroza, osteoartritis, atopijski dermatitis, vitiligo, bolest usadak protiv domaćina, Sjögrensov sindrom, autoimuni nefritis, Goodpastureov sindrom, kronična upalna demijelinizacijska polineuropatija, alergija, astma i ostale autoimune bolesti koje su rezultat akutne ili kronične upale.
9. Protutijelo ili farmaceutski pripravak za uporabu prema bilo kojem od patentnih zahtjeva 6 do 8, naznačeni time, da se protutijelo ili farmaceutski pripravak primjenjuju parenteralno.
10. Protutijelo ili farmaceutski pripravak za uporabu prema bilo kojem od patentnih zahtjeva 6 do 8, naznačeni time, da se protutijelo ili farmaceutski pripravak primjenjuju profilaktički.
11. Protutijelo ili farmaceutski pripravak za uporabu prema bilo kojem od patentnih zahtjeva 6 do 10, naznačeni time, da pojedinac je čovjek.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14177547.8A EP2975056A1 (en) | 2014-07-17 | 2014-07-17 | Site directed mutagenesis of TREM-1 antibodies for decreasing viscosity |
| EP14194893.5A EP3026061A1 (en) | 2014-11-26 | 2014-11-26 | Site directed mutagenesis of trem-1 antibodies for decreasing viscosity. |
| EP15738925.5A EP3172232B1 (en) | 2014-07-17 | 2015-07-17 | Site directed mutagenesis of trem-1 antibodies for decreasing viscosity. |
| PCT/EP2015/066501 WO2016009086A1 (en) | 2014-07-17 | 2015-07-17 | Site directed mutagenesis of trem-1 antibodies for decreasing viscosity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20240088T1 true HRP20240088T1 (hr) | 2024-04-12 |
Family
ID=53673951
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20240088TT HRP20240088T1 (hr) | 2014-07-17 | 2015-07-17 | Mutageneza usmjerena na mjesto protutijela trem-1 za smanjenje viskoziteta |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US10179814B2 (hr) |
| EP (2) | EP3172232B1 (hr) |
| JP (2) | JP6738316B2 (hr) |
| KR (3) | KR102641268B1 (hr) |
| CN (2) | CN113214397A (hr) |
| AU (1) | AU2015289054B2 (hr) |
| BR (1) | BR112016030947A2 (hr) |
| CA (1) | CA2955253C (hr) |
| CL (1) | CL2017000113A1 (hr) |
| CO (1) | CO2017001397A2 (hr) |
| DK (1) | DK3172232T3 (hr) |
| EA (1) | EA037844B1 (hr) |
| FI (1) | FI3172232T3 (hr) |
| HK (1) | HK1232231A1 (hr) |
| HR (1) | HRP20240088T1 (hr) |
| IL (1) | IL250082B (hr) |
| LT (1) | LT3172232T (hr) |
| MX (2) | MX2017000484A (hr) |
| MY (1) | MY178347A (hr) |
| PE (1) | PE20170192A1 (hr) |
| PH (1) | PH12017500054A1 (hr) |
| RS (1) | RS65136B1 (hr) |
| SG (2) | SG11201700250WA (hr) |
| TN (1) | TN2017000008A1 (hr) |
| WO (1) | WO2016009086A1 (hr) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9550830B2 (en) | 2012-02-15 | 2017-01-24 | Novo Nordisk A/S | Antibodies that bind and block triggering receptor expressed on myeloid cells-1 (TREM-1) |
| CN105431548A (zh) | 2013-03-15 | 2016-03-23 | 生物医学研究机构基金会 | 用于癌转移的诊断、预后和治疗的方法 |
| LT3172232T (lt) | 2014-07-17 | 2024-02-12 | Novo Nordisk A/S | Į vietą nukreipta trem-1 antikūnų mutagenezė, skirta klampumui sumažinti |
| WO2017152102A2 (en) | 2016-03-04 | 2017-09-08 | Alector Llc | Anti-trem1 antibodies and methods of use thereof |
| JOP20190248A1 (ar) | 2017-04-21 | 2019-10-20 | Amgen Inc | بروتينات ربط مولد ضد trem2 واستخداماته |
| JP7267280B2 (ja) * | 2017-08-08 | 2023-05-01 | パイオニア イミュノセラピューティクス インコーポレイテッド | Ｔｒｅｍ１を発現する骨髄細胞を無能化させるための組成物および方法 |
| JP2021519594A (ja) | 2018-04-02 | 2021-08-12 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | 抗ｔｒｅｍ−１抗体およびその使用 |
| US10836828B2 (en) | 2019-02-06 | 2020-11-17 | Pionyr Immunotherapeutics, Inc. | Anti-TREM1 antibodies and related methods |
| WO2021011678A1 (en) | 2019-07-15 | 2021-01-21 | Bristol-Myers Squibb Company | Anti-trem-1 antibodies and uses thereof |
| JP2022540904A (ja) | 2019-07-15 | 2022-09-20 | ブリストル－マイヤーズ スクイブ カンパニー | ヒトｔｒｅｍ－１に対する抗体およびその使用 |
| EP4141093A1 (en) | 2020-04-20 | 2023-03-01 | Suntory Holdings Limited | Alcoholic beverage containing steviol glycosides |
| CN115586338A (zh) * | 2022-09-20 | 2023-01-10 | 杭州赛基生物科技有限公司 | 用于检测可溶性细胞因子受体的试剂盒及其制备方法 |
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- 2015-07-17 EA EA201790104A patent/EA037844B1/ru not_active IP Right Cessation
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2017
- 2017-01-09 PH PH12017500054A patent/PH12017500054A1/en unknown
- 2017-01-11 MX MX2020013920A patent/MX2020013920A/es unknown
- 2017-01-12 IL IL250082A patent/IL250082B/en unknown
- 2017-01-16 CL CL2017000113A patent/CL2017000113A1/es unknown
- 2017-02-13 CO CONC2017/0001397A patent/CO2017001397A2/es unknown
- 2017-06-05 HK HK17105554.8A patent/HK1232231A1/zh unknown
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2018
- 2018-11-28 US US16/203,327 patent/US11072654B2/en active Active
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2020
- 2020-07-17 JP JP2020122759A patent/JP6995170B2/ja active Active
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2021
- 2021-07-20 US US17/380,404 patent/US20220010012A1/en active Pending
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