LT3172232T - Į vietą nukreipta trem-1 antikūnų mutagenezė, skirta klampumui sumažinti - Google Patents

Į vietą nukreipta trem-1 antikūnų mutagenezė, skirta klampumui sumažinti

Info

Publication number
LT3172232T
LT3172232T LTEPPCT/EP2015/066501T LTEP2015066501T LT3172232T LT 3172232 T LT3172232 T LT 3172232T LT EP2015066501 T LTEP2015066501 T LT EP2015066501T LT 3172232 T LT3172232 T LT 3172232T
Authority
LT
Lithuania
Prior art keywords
trem
antibodies
directed mutagenesis
site directed
decreasing viscosity
Prior art date
Application number
LTEPPCT/EP2015/066501T
Other languages
English (en)
Inventor
Anette HENRIKSEN
Kristian Kjaergaard
Vibeke WESTPHAL STENNICKE
Charlotte WIBERG
Original Assignee
Novo Nordisk A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53673951&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LT3172232(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from EP14177547.8A external-priority patent/EP2975056A1/en
Priority claimed from EP14194893.5A external-priority patent/EP3026061A1/en
Application filed by Novo Nordisk A/S filed Critical Novo Nordisk A/S
Publication of LT3172232T publication Critical patent/LT3172232T/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
LTEPPCT/EP2015/066501T 2014-07-17 2015-07-17 Į vietą nukreipta trem-1 antikūnų mutagenezė, skirta klampumui sumažinti LT3172232T (lt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14177547.8A EP2975056A1 (en) 2014-07-17 2014-07-17 Site directed mutagenesis of TREM-1 antibodies for decreasing viscosity
EP14194893.5A EP3026061A1 (en) 2014-11-26 2014-11-26 Site directed mutagenesis of trem-1 antibodies for decreasing viscosity.
PCT/EP2015/066501 WO2016009086A1 (en) 2014-07-17 2015-07-17 Site directed mutagenesis of trem-1 antibodies for decreasing viscosity

Publications (1)

Publication Number Publication Date
LT3172232T true LT3172232T (lt) 2024-02-12

Family

ID=53673951

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEPPCT/EP2015/066501T LT3172232T (lt) 2014-07-17 2015-07-17 Į vietą nukreipta trem-1 antikūnų mutagenezė, skirta klampumui sumažinti

Country Status (25)

Country Link
US (3) US10179814B2 (lt)
EP (2) EP4332119A2 (lt)
JP (2) JP6738316B2 (lt)
KR (3) KR102641268B1 (lt)
CN (2) CN106536559B (lt)
AU (1) AU2015289054B2 (lt)
BR (1) BR112016030947A2 (lt)
CA (1) CA2955253C (lt)
CL (1) CL2017000113A1 (lt)
CO (1) CO2017001397A2 (lt)
DK (1) DK3172232T3 (lt)
EA (1) EA037844B1 (lt)
FI (1) FI3172232T3 (lt)
HK (1) HK1232231A1 (lt)
HR (1) HRP20240088T1 (lt)
IL (1) IL250082B (lt)
LT (1) LT3172232T (lt)
MX (2) MX2017000484A (lt)
MY (1) MY178347A (lt)
PE (1) PE20170192A1 (lt)
PH (1) PH12017500054A1 (lt)
RS (1) RS65136B1 (lt)
SG (2) SG10201913702WA (lt)
TN (1) TN2017000008A1 (lt)
WO (1) WO2016009086A1 (lt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9550830B2 (en) 2012-02-15 2017-01-24 Novo Nordisk A/S Antibodies that bind and block triggering receptor expressed on myeloid cells-1 (TREM-1)
JP2016518815A (ja) 2013-03-15 2016-06-30 フンダシオ、インスティトゥト、デ、レセルカ、ビオメディカ（イエレベ、バルセロナ）Ｆｕｎｄａｃｉｏ Ｉｎｓｔｉｔｕｔ Ｄｅ Ｒｅｃｅｒｃａ Ｂｉｏｍｅｄｉｃａ （Ｉｒｂ Ｂａｒｃｅｌｏｎａ） 転移性がんの診断、予後、および処置の方法
JP6738316B2 (ja) 2014-07-17 2020-08-12 ノヴォ ノルディスク アクティーゼルスカブ 粘度を低下させるためのｔｒｅｍ−１抗体の部位特異的変異誘発
JP7023853B2 (ja) 2016-03-04 2022-02-22 アレクトル エルエルシー 抗ｔｒｅｍ１抗体及びその使用方法
JOP20190248A1 (ar) 2017-04-21 2019-10-20 Amgen Inc بروتينات ربط مولد ضد trem2 واستخداماته
JP7267280B2 (ja) * 2017-08-08 2023-05-01 パイオニア イミュノセラピューティクス インコーポレイテッド Ｔｒｅｍ１を発現する骨髄細胞を無能化させるための組成物および方法
US11155618B2 (en) * 2018-04-02 2021-10-26 Bristol-Myers Squibb Company Anti-TREM-1 antibodies and uses thereof
US10836828B2 (en) 2019-02-06 2020-11-17 Pionyr Immunotherapeutics, Inc. Anti-TREM1 antibodies and related methods
WO2021011678A1 (en) 2019-07-15 2021-01-21 Bristol-Myers Squibb Company Anti-trem-1 antibodies and uses thereof
EP3999541A1 (en) 2019-07-15 2022-05-25 Bristol-Myers Squibb Company Antibodies against human trem-1 and uses thereof
CN115461439A (zh) 2020-04-20 2022-12-09 三得利控股株式会社 含甜菊醇糖苷的酒精饮料

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