JP2018035192A5 - - Google Patents

Info

Publication number

JP2018035192A5

JP2018035192A5 JP2017217408A JP2017217408A JP2018035192A5 JP 2018035192 A5 JP2018035192 A5 JP 2018035192A5 JP 2017217408 A JP2017217408 A JP 2017217408A JP 2017217408 A JP2017217408 A JP 2017217408A JP 2018035192 A5 JP2018035192 A5 JP 2018035192A5

Authority

JP

Japan

Prior art keywords

protein

blood clotting

blood

modified

factor

Prior art date

2017-11-10

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 230000023555 blood coagulation Effects 0.000 claims 71
• 101000882917 Penaeus paulensis Hemolymph clottable protein Proteins 0.000 claims 41
• 102000004169 proteins and genes Human genes 0.000 claims 34
• 108090000623 proteins and genes Proteins 0.000 claims 34
• 239000003114 blood coagulation factor Substances 0.000 claims 18
• 230000000694 effects Effects 0.000 claims 14
• LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical group OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 8
• 108010054218 Factor VIII Proteins 0.000 claims 8
• 102000001690 Factor VIII Human genes 0.000 claims 8
• 230000004071 biological effect Effects 0.000 claims 8
• 229960000301 factor viii Drugs 0.000 claims 8
• JQWHASGSAFIOCM-UHFFFAOYSA-M sodium periodate Chemical group [Na+].[O-]I(=O)(=O)=O JQWHASGSAFIOCM-UHFFFAOYSA-M 0.000 claims 8
• 229920003169 water-soluble polymer Polymers 0.000 claims 8
• 102100022641 Coagulation factor IX Human genes 0.000 claims 6
• 108010076282 Factor IX Proteins 0.000 claims 6
• 239000000427 antigen Substances 0.000 claims 6
• 102000036639 antigens Human genes 0.000 claims 6
• 108091007433 antigens Proteins 0.000 claims 6
• 150000001720 carbohydrates Chemical group 0.000 claims 6
• 229960004222 factor ix Drugs 0.000 claims 6
• 241000872931 Myoporum sandwicense Species 0.000 claims 4
• 239000008280 blood Substances 0.000 claims 4
• 210000004369 blood Anatomy 0.000 claims 4
• 239000007800 oxidant agent Substances 0.000 claims 4
• 125000005629 sialic acid group Chemical group 0.000 claims 4
• 101800001401 Activation peptide Proteins 0.000 claims 2
• 102400000069 Activation peptide Human genes 0.000 claims 2
• 102000015081 Blood Coagulation Factors Human genes 0.000 claims 2
• 108010039209 Blood Coagulation Factors Proteins 0.000 claims 2
• 108010054265 Factor VIIa Proteins 0.000 claims 2
• 108010014173 Factor X Proteins 0.000 claims 2
• 108010074864 Factor XI Proteins 0.000 claims 2
• 108010080865 Factor XII Proteins 0.000 claims 2
• 102000000429 Factor XII Human genes 0.000 claims 2
• 108010000499 Thromboplastin Proteins 0.000 claims 2
• 102000002262 Thromboplastin Human genes 0.000 claims 2
• 239000002253 acid Substances 0.000 claims 2
• 229940019700 blood coagulation factors Drugs 0.000 claims 2
• 235000014633 carbohydrates Nutrition 0.000 claims 2
• 229940012414 factor viia Drugs 0.000 claims 2
• 150000002923 oximes Chemical class 0.000 claims 2
• 230000037081 physical activity Effects 0.000 claims 2
• 108010047303 von Willebrand Factor Proteins 0.000 claims 2
• 102100036537 von Willebrand factor Human genes 0.000 claims 2
• 229960001134 von willebrand factor Drugs 0.000 claims 2
• KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 1
• SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims 1
• 102000043853 ADAMTS13 Human genes 0.000 claims 1
• 108091005670 ADAMTS13 Proteins 0.000 claims 1
• 229920001661 Chitosan Polymers 0.000 claims 1
• 229920001287 Chondroitin sulfate Polymers 0.000 claims 1
• 229920000045 Dermatan sulfate Polymers 0.000 claims 1
• 108010022233 Plasminogen Activator Inhibitor 1 Proteins 0.000 claims 1
• 102000012335 Plasminogen Activator Inhibitor 1 Human genes 0.000 claims 1
• 101800004937 Protein C Proteins 0.000 claims 1
• 102000017975 Protein C Human genes 0.000 claims 1
• 229940096437 Protein S Drugs 0.000 claims 1
• 102000029301 Protein S Human genes 0.000 claims 1
• 108010066124 Protein S Proteins 0.000 claims 1
• 229920001218 Pullulan Polymers 0.000 claims 1
• 239000004373 Pullulan Substances 0.000 claims 1
• 101800001700 Saposin-D Proteins 0.000 claims 1
• 229920002472 Starch Polymers 0.000 claims 1
• 108090000190 Thrombin Proteins 0.000 claims 1
• 229940045110 chitosan Drugs 0.000 claims 1
• 229940059329 chondroitin sulfate Drugs 0.000 claims 1
• AVJBPWGFOQAPRH-FWMKGIEWSA-L dermatan sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](C([O-])=O)O1 AVJBPWGFOQAPRH-FWMKGIEWSA-L 0.000 claims 1
• 229940051593 dermatan sulfate Drugs 0.000 claims 1
• 239000012634 fragment Substances 0.000 claims 1
• 150000004676 glycans Chemical class 0.000 claims 1
• 229920002674 hyaluronan Polymers 0.000 claims 1
• 229960003160 hyaluronic acid Drugs 0.000 claims 1
• 229920000765 poly(2-oxazolines) Polymers 0.000 claims 1
• 229920002627 poly(phosphazenes) Polymers 0.000 claims 1
• 229920001282 polysaccharide Polymers 0.000 claims 1
• 239000005017 polysaccharide Substances 0.000 claims 1
• 229960000856 protein c Drugs 0.000 claims 1
• 235000019423 pullulan Nutrition 0.000 claims 1
• 235000019698 starch Nutrition 0.000 claims 1
• 239000008107 starch Substances 0.000 claims 1
• 229940032147 starch Drugs 0.000 claims 1
• -1 tPA Proteins 0.000 claims 1
• 229960004072 thrombin Drugs 0.000 claims 1