JP2017537061A5 - - Google Patents

Info

Publication number

JP2017537061A5

JP2017537061A5 JP2017519487A JP2017519487A JP2017537061A5 JP 2017537061 A5 JP2017537061 A5 JP 2017537061A5 JP 2017519487 A JP2017519487 A JP 2017519487A JP 2017519487 A JP2017519487 A JP 2017519487A JP 2017537061 A5 JP2017537061 A5 JP 2017537061A5

Authority

JP

Japan

Prior art keywords

crystalline

liver

dihydrate

anhydride

erobixibat

Prior art date

2015-10-23

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 150000004683 dihydrates Chemical class 0.000 claims 12
• 150000008064 anhydrides Chemical class 0.000 claims 10
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
• 238000000634 powder X-ray diffraction Methods 0.000 claims 6
• 206010008635 Cholestasis Diseases 0.000 claims 5
• 206010010774 Constipation Diseases 0.000 claims 5
• 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims 5
• 206010019708 Hepatic steatosis Diseases 0.000 claims 4
• 230000007870 cholestasis Effects 0.000 claims 4
• 231100000359 cholestasis Toxicity 0.000 claims 4
• 201000010099 disease Diseases 0.000 claims 4
• 208000019423 liver disease Diseases 0.000 claims 4
• 206010023126 Jaundice Diseases 0.000 claims 3
• 230000001684 chronic effect Effects 0.000 claims 3
• 208000019425 cirrhosis of liver Diseases 0.000 claims 3
• 210000004185 liver Anatomy 0.000 claims 3
• 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims 3
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
• HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 claims 2
• 208000008439 Biliary Liver Cirrhosis Diseases 0.000 claims 2
• 208000033222 Biliary cirrhosis primary Diseases 0.000 claims 2
• 208000004930 Fatty Liver Diseases 0.000 claims 2
• 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
• 208000012654 Primary biliary cholangitis Diseases 0.000 claims 2
• 201000002150 Progressive familial intrahepatic cholestasis Diseases 0.000 claims 2
• 208000003251 Pruritus Diseases 0.000 claims 2
• 239000003613 bile acid Substances 0.000 claims 2
• 230000007547 defect Effects 0.000 claims 2
• 208000035475 disorder Diseases 0.000 claims 2
• 208000010706 fatty liver disease Diseases 0.000 claims 2
• 230000001771 impaired effect Effects 0.000 claims 2
• 208000002551 irritable bowel syndrome Diseases 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 230000035935 pregnancy Effects 0.000 claims 2
• 230000002265 prevention Effects 0.000 claims 2
• 231100000240 steatosis hepatitis Toxicity 0.000 claims 2
• 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 2
• 201000011374 Alagille syndrome Diseases 0.000 claims 1
• 206010003827 Autoimmune hepatitis Diseases 0.000 claims 1
• 206010004637 Bile duct stone Diseases 0.000 claims 1
• 206010053684 Cerebrohepatorenal syndrome Diseases 0.000 claims 1
• 208000008964 Chemical and Drug Induced Liver Injury Diseases 0.000 claims 1
• 201000009331 Choledocholithiasis Diseases 0.000 claims 1
• 201000003883 Cystic fibrosis Diseases 0.000 claims 1
• 206010012735 Diarrhoea Diseases 0.000 claims 1
• 206010072268 Drug-induced liver injury Diseases 0.000 claims 1
• 208000032928 Dyslipidaemia Diseases 0.000 claims 1
• 206010016654 Fibrosis Diseases 0.000 claims 1
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
• 208000027761 Hepatic autoimmune disease Diseases 0.000 claims 1
• 206010019728 Hepatitis alcoholic Diseases 0.000 claims 1
• 206010019799 Hepatitis viral Diseases 0.000 claims 1
• 208000035150 Hypercholesterolemia Diseases 0.000 claims 1
• 229940125922 IBAT inhibitor Drugs 0.000 claims 1
• 206010022489 Insulin Resistance Diseases 0.000 claims 1
• 206010065973 Iron Overload Diseases 0.000 claims 1
• 208000017170 Lipid metabolism disease Diseases 0.000 claims 1
• 208000001145 Metabolic Syndrome Diseases 0.000 claims 1
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 208000008589 Obesity Diseases 0.000 claims 1
• 206010033645 Pancreatitis Diseases 0.000 claims 1
• 208000017855 Progressive familial intrahepatic cholestasis type 1 Diseases 0.000 claims 1
• 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
• 201000004525 Zellweger Syndrome Diseases 0.000 claims 1
• 208000036813 Zellweger spectrum disease Diseases 0.000 claims 1
• 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 1
• 238000005299 abrasion Methods 0.000 claims 1
• 208000002353 alcoholic hepatitis Diseases 0.000 claims 1
• 210000003445 biliary tract Anatomy 0.000 claims 1
• 230000015572 biosynthetic process Effects 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 230000002490 cerebral effect Effects 0.000 claims 1
• 201000001883 cholelithiasis Diseases 0.000 claims 1
• 230000007882 cirrhosis Effects 0.000 claims 1
• 150000001875 compounds Chemical class 0.000 claims 1
• 239000013078 crystal Substances 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• 230000006806 disease prevention Effects 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 201000008865 drug-induced hepatitis Diseases 0.000 claims 1
• 208000009866 extrahepatic cholestasis Diseases 0.000 claims 1
• 230000004129 fatty acid metabolism Effects 0.000 claims 1
• 208000001130 gallstones Diseases 0.000 claims 1
• 239000008103 glucose Substances 0.000 claims 1
• 230000010224 hepatic metabolism Effects 0.000 claims 1
• 208000006454 hepatitis Diseases 0.000 claims 1
• 231100000283 hepatitis Toxicity 0.000 claims 1
• 208000001024 intrahepatic cholestasis Diseases 0.000 claims 1
• 230000007872 intrahepatic cholestasis Effects 0.000 claims 1
• 201000007270 liver cancer Diseases 0.000 claims 1
• 208000014018 liver neoplasm Diseases 0.000 claims 1
• 235000020824 obesity Nutrition 0.000 claims 1
• 201000002528 pancreatic cancer Diseases 0.000 claims 1
• 208000007232 portal hypertension Diseases 0.000 claims 1
• 230000000750 progressive effect Effects 0.000 claims 1
• 201000002162 progressive familial intrahepatic cholestasis 1 Diseases 0.000 claims 1
• 208000010157 sclerosing cholangitis Diseases 0.000 claims 1
• 239000002002 slurry Substances 0.000 claims 1
• 239000000126 substance Substances 0.000 claims 1
• 208000024891 symptom Diseases 0.000 claims 1
• 208000011580 syndromic disease Diseases 0.000 claims 1
• 238000003786 synthesis reaction Methods 0.000 claims 1
• 210000002435 tendon Anatomy 0.000 claims 1
• 201000001862 viral hepatitis Diseases 0.000 claims 1
• 239000011800 void material Substances 0.000 claims 1