JP2017535284A - 免疫エフェクター細胞の拡大のための遺伝子改変免疫エフェクター細胞及び遺伝子操作細胞 - Google Patents

免疫エフェクター細胞の拡大のための遺伝子改変免疫エフェクター細胞及び遺伝子操作細胞 Download PDF

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JP2017535284A
JP2017535284A JP2017543315A JP2017543315A JP2017535284A JP 2017535284 A JP2017535284 A JP 2017535284A JP 2017543315 A JP2017543315 A JP 2017543315A JP 2017543315 A JP2017543315 A JP 2017543315A JP 2017535284 A JP2017535284 A JP 2017535284A
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cells
car
cell
antigen
domain
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JP2017535284A5 (OSRAM
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ローレンス ジェイ．エヌ． クーパー，
ローレンス ジェイ．エヌ． クーパー，
ハルジート シング，
ハルジート シング，
ヘレン ハルズ，
ヘレン ハルズ，
サイモン オリバレス，
サイモン オリバレス，
ビプレンデュ ジェナ，
ビプレンデュ ジェナ，
クリーナ パテル，
クリーナ パテル，
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University of Texas System
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University of Texas System
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
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    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
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    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/00—Fusion polypeptide
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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2017543315A 2014-11-05 2015-11-05 免疫エフェクター細胞の拡大のための遺伝子改変免疫エフェクター細胞及び遺伝子操作細胞 Withdrawn JP2017535284A (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201462075667P 2014-11-05 2014-11-05
US201462075642P 2014-11-05 2014-11-05
US201462075561P 2014-11-05 2014-11-05
US62/075,561 2014-11-05
US62/075,667 2014-11-05
US62/075,642 2014-11-05
US201562169979P 2015-06-02 2015-06-02
US62/169,979 2015-06-02
PCT/US2015/059293 WO2016073755A2 (en) 2014-11-05 2015-11-05 Gene modified immune effector cells and engineered cells for expansion of immune effector cells

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JP2017535284A5 JP2017535284A5 (OSRAM) 2018-12-13

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JP2019203260A Pending JP2020022504A (ja) 2014-11-05 2019-11-08 免疫エフェクター細胞の拡大のための遺伝子改変免疫エフェクター細胞及び遺伝子操作細胞

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EP (2) EP3215535A2 (OSRAM)
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KR (1) KR20170075785A (OSRAM)
CN (1) CN107207615A (OSRAM)
AU (2) AU2015343013B2 (OSRAM)
CA (1) CA2964785A1 (OSRAM)
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Cited By (7)

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WO2020013315A1 (ja) * 2018-07-13 2020-01-16 国立大学法人京都大学 γδＴ細胞の製造方法
JPWO2020004622A1 (ja) * 2018-06-29 2020-07-16 大鵬薬品工業株式会社 抗腫瘍剤及びその評価方法
WO2021020526A1 (ja) * 2019-07-31 2021-02-04 国立大学法人信州大学 Ｃａｒ発現免疫細胞を含む細胞集団の製造方法
WO2021100585A1 (ja) * 2019-11-20 2021-05-27 国立大学法人東海国立大学機構 キメラ抗原受容体遺伝子改変リンパ球の調製方法
JPWO2020085480A1 (ja) * 2018-10-26 2021-09-16 国立大学法人信州大学 高効率な遺伝子改変細胞の作製方法
JP2021528048A (ja) * 2019-03-05 2021-10-21 ンカルタ・インコーポレイテッドＮｋａｒｔａ， Ｉｎｃ． Ｃｄ１９指向性キメラ抗原受容体および免疫療法におけるその使用
WO2024058234A1 (ja) * 2022-09-13 2024-03-21 株式会社サイト－ファクト 移植用ｔ細胞およびその製造方法

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KR102833088B1 (ko) * 2016-11-07 2025-07-10 제노비에 에이비 T-세포 수용체 및 t-세포 항원의 식별 및 특징규명을 위한 조작된 다성분 시스템
CN108276493B (zh) * 2016-12-30 2023-11-14 南京传奇生物科技有限公司 一种嵌合抗原受体及其应用
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