JP2017534256A5 - - Google Patents

Info

Publication number

JP2017534256A5

JP2017534256A5 JP2017513781A JP2017513781A JP2017534256A5 JP 2017534256 A5 JP2017534256 A5 JP 2017534256A5 JP 2017513781 A JP2017513781 A JP 2017513781A JP 2017513781 A JP2017513781 A JP 2017513781A JP 2017534256 A5 JP2017534256 A5 JP 2017534256A5

Authority

JP

Japan

Prior art keywords

seq

antibody

amino acid

cll

hvr

Prior art date

2015-09-11

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 108090001123 antibodies Proteins 0.000 claims 51
• 102000004965 antibodies Human genes 0.000 claims 51
• 125000003275 alpha amino acid group Chemical group 0.000 claims 29
• 102100013153 CLEC12A Human genes 0.000 claims 25
• 101710010518 CLEC12A Proteins 0.000 claims 25
• 108010047814 Antigen-Antibody Complex Proteins 0.000 claims 19
• 210000004027 cells Anatomy 0.000 claims 12
• 239000003814 drug Substances 0.000 claims 10
• 201000011510 cancer Diseases 0.000 claims 7
• 239000008194 pharmaceutical composition Substances 0.000 claims 7
• 235000018417 cysteine Nutrition 0.000 claims 5
• NFGXHKASABOEEW-UHFFFAOYSA-N (+)-methoprene Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 4
• 206010000880 Acute myeloid leukaemia Diseases 0.000 claims 4
• 125000005843 halogen group Chemical group 0.000 claims 4
• 230000002401 inhibitory effect Effects 0.000 claims 4
• 108010027440 Immunoconjugates Proteins 0.000 claims 3
• 102000018748 Immunoconjugates Human genes 0.000 claims 3
• 241000282567 Macaca fascicularis Species 0.000 claims 3
• 210000003819 Peripheral blood mononuclear cell Anatomy 0.000 claims 3
• NMUSYJAQQFHJEW-KVTDHHQDSA-N U-18,496 Chemical group O=C1N=C(N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 NMUSYJAQQFHJEW-KVTDHHQDSA-N 0.000 claims 3
• 235000001014 amino acid Nutrition 0.000 claims 3
• 150000001413 amino acids Chemical class 0.000 claims 3
• 238000010276 construction Methods 0.000 claims 3
• 229960002756 Azacitidine Drugs 0.000 claims 2
• 102100013894 BCL2 Human genes 0.000 claims 2
• 108060000885 BCL2 Proteins 0.000 claims 2
• XAUDJQYHKZQPEU-KVQBGUIXSA-N Decitabine Chemical compound O=C1N=C(N)N=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 XAUDJQYHKZQPEU-KVQBGUIXSA-N 0.000 claims 2
• 125000003118 aryl group Chemical group 0.000 claims 2
• 239000012472 biological sample Substances 0.000 claims 2
• 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 2
• 239000002254 cytotoxic agent Substances 0.000 claims 2
• 229960003603 decitabine Drugs 0.000 claims 2
• 238000000338 in vitro Methods 0.000 claims 2
• 239000003112 inhibitor Substances 0.000 claims 2
• CTMCWCONSULRHO-UHQPFXKFSA-N nemorubicin Chemical class C1CO[C@H](OC)CN1[C@@H]1[C@H](O)[C@H](C)O[C@@H](O[C@@H]2C3=C(O)C=4C(=O)C5=C(OC)C=CC=C5C(=O)C=4C(O)=C3C[C@](O)(C2)C(=O)CO)C1 CTMCWCONSULRHO-UHQPFXKFSA-N 0.000 claims 2
• 150000007523 nucleic acids Chemical class 0.000 claims 2
• 108020004707 nucleic acids Proteins 0.000 claims 2
• 239000000523 sample Substances 0.000 claims 2
• 125000001963 4 membered heterocyclic group Chemical group 0.000 claims 1
• 125000002373 5 membered heterocyclic group Chemical group 0.000 claims 1
• 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 1
• 125000003341 7 membered heterocyclic group Chemical group 0.000 claims 1
• HXCHCVDVKSCDHU-LULTVBGHSA-N Calicheamicin Chemical compound C1[C@H](OC)[C@@H](NCC)CO[C@H]1O[C@H]1[C@H](O[C@@H]2C\3=C(NC(=O)OC)C(=O)C[C@](C/3=C/CSSSC)(O)C#C\C=C/C#C2)O[C@H](C)[C@@H](NO[C@@H]2O[C@H](C)[C@@H](SC(=O)C=3C(=C(OC)C(O[C@H]4[C@@H]([C@H](OC)[C@@H](O)[C@H](C)O4)O)=C(I)C=3C)OC)[C@@H](O)C2)[C@@H]1O HXCHCVDVKSCDHU-LULTVBGHSA-N 0.000 claims 1
• 241000283080 Proboscidea <mammal> Species 0.000 claims 1
• 125000000217 alkyl group Chemical group 0.000 claims 1
• 125000002947 alkylene group Chemical group 0.000 claims 1
• 150000001768 cations Chemical class 0.000 claims 1
• 230000004663 cell proliferation Effects 0.000 claims 1
• 239000003795 chemical substances by application Substances 0.000 claims 1
• 108091006028 chimera Proteins 0.000 claims 1
• 238000004581 coalescence Methods 0.000 claims 1
• 230000001472 cytotoxic Effects 0.000 claims 1
• 231100000433 cytotoxic Toxicity 0.000 claims 1
• 231100000599 cytotoxic agent Toxicity 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 229940079593 drugs Drugs 0.000 claims 1
• 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 1
• 125000005842 heteroatoms Chemical group 0.000 claims 1
• 125000000623 heterocyclic group Chemical group 0.000 claims 1
• TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl radical Chemical compound [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 claims 1
• 230000036039 immunity Effects 0.000 claims 1
• 125000005647 linker group Chemical group 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 239000002184 metal Substances 0.000 claims 1
• 108010045030 monoclonal antibodies Proteins 0.000 claims 1
• 102000005614 monoclonal antibodies Human genes 0.000 claims 1
• 230000035772 mutation Effects 0.000 claims 1
• 229910052757 nitrogen Inorganic materials 0.000 claims 1
• 125000004433 nitrogen atoms Chemical group N* 0.000 claims 1
• 230000035755 proliferation Effects 0.000 claims 1
• YUOCYTRGANSSRY-UHFFFAOYSA-N pyrrolo[2,3-i][1,2]benzodiazepine Chemical class C1=CN=NC2=C3C=CN=C3C=CC2=C1 YUOCYTRGANSSRY-UHFFFAOYSA-N 0.000 claims 1