ES2062519T5 - Vacunacion y metodos contra enfermedades originadas a partir de respuestas patogenicas mediante poblaciones especificas de linfocitos t. - Google Patents

Vacunacion y metodos contra enfermedades originadas a partir de respuestas patogenicas mediante poblaciones especificas de linfocitos t.

Info

Publication number
ES2062519T5
ES2062519T5 ES90905821T ES90905821T ES2062519T5 ES 2062519 T5 ES2062519 T5 ES 2062519T5 ES 90905821 T ES90905821 T ES 90905821T ES 90905821 T ES90905821 T ES 90905821T ES 2062519 T5 ES2062519 T5 ES 2062519T5
Authority
ES
Spain
Prior art keywords
cells
mediate
pathology
tcr
vaccination
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90905821T
Other languages
English (en)
Other versions
ES2062519T3 (es
Inventor
Mark D Howell
Steven W Brostoff
Dennis J Carlo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Immune Response Corp
Original Assignee
Immune Response Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27406453&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2062519(T5) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Immune Response Corp filed Critical Immune Response Corp
Application granted granted Critical
Publication of ES2062519T3 publication Critical patent/ES2062519T3/es
Publication of ES2062519T5 publication Critical patent/ES2062519T5/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
    • G01N2800/102—Arthritis; Rheumatoid arthritis, i.e. inflammation of peripheral joints

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

LA PRESENTE INVENCION PROPORCIONA VACUNAS Y UN ELEMENTO DE VACUNACION DE UN MAMIFERO PARA EVITAR O CONTROLAR LAS PATOLOGIAS MEDIADAS POR CELULA T ESPECIFICA O PARA TRATAR LA REPRODUCCION INCONTROLADA DE CELULAS T. LA VACUNA ESTA COMPUESTA DE UN RECEPTOR DE CELULA T (TCR) O UN FRAGMENTO SUYO CORRESPONDIENTE A UN TCR PRESENTE EN LA SUPERFICIE DE CELULAS T QUE MEDIAN LA PATOLOGIA. EL FRAGMENTO DE VACUNA PUEDE SER UN PEPTIDO CORRESPONDIENTE A LAS SECUENCIAS DE TCRS CARACTERISTICA DE LAS CELULAS T QUE MEDIAN ESTA PATOLOGIA. TAMBIEN SE PRESENTAN MEDIOS DE DETERMINACION DE SECUENCIAS DE AMINO-ACIDOS APROPIADAS PARA ESTAS VACUNAS. LA VACUNA SE SE ADMINISTRA AL MAMIFERO DE UNA FORMA QUE INDUCE UNA RESPUESTA INMUNOLOGICA DIRIGIDA CONTRA EL TCR DE CELULAS T QUE MEDIAN LA PATOLOGIA . ESTA RESPUESTA INMUNOLOGICA REGULA HACIA ABAJO O RETRASA LAS CELULAS T PATOGENAS, SOMETIENDO ASI A ABLACION LA PATOGENESIS DE LA ENFERMEDAD. LA INVENCION PROPORCIONA ADICIONALMENTE UNA REGION VARIABLE ESPEFIFICA DE CADENA(BETA) DEL RECEPTOR DE CELULA T, LLAMADO V(BETA)17, QUE ES CENTRAL A LA PATOGENESIS DE ARTRITIS REUMATICA (RA). TAMBIEN SE PRESENTAN MEDIOS PARA DETECTAR, PREVENIR Y TRATAR RA
ES90905821T 1989-03-21 1990-03-21 Vacunacion y metodos contra enfermedades originadas a partir de respuestas patogenicas mediante poblaciones especificas de linfocitos t. Expired - Lifetime ES2062519T5 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32631489A 1989-03-21 1989-03-21
US38208589A 1989-07-18 1989-07-18
US38208689A 1989-07-18 1989-07-18

Publications (2)

Publication Number Publication Date
ES2062519T3 ES2062519T3 (es) 1994-12-16
ES2062519T5 true ES2062519T5 (es) 2003-07-16

Family

ID=27406453

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90905821T Expired - Lifetime ES2062519T5 (es) 1989-03-21 1990-03-21 Vacunacion y metodos contra enfermedades originadas a partir de respuestas patogenicas mediante poblaciones especificas de linfocitos t.

Country Status (14)

Country Link
EP (1) EP0463101B2 (es)
JP (1) JP3472297B2 (es)
KR (1) KR920700674A (es)
AU (5) AU6892994A (es)
BG (1) BG61164B1 (es)
CA (1) CA2046909A1 (es)
DE (1) DE69006018T3 (es)
DK (1) DK0463101T3 (es)
ES (1) ES2062519T5 (es)
FI (1) FI914432A0 (es)
NO (2) NO309164B1 (es)
RO (1) RO110397B1 (es)
RU (1) RU2138512C1 (es)
WO (1) WO1990011294A1 (es)

Families Citing this family (105)

* Cited by examiner, † Cited by third party
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AU7650096A (en) 1997-02-13
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NO20002425L (no) 1991-09-20
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ES2062519T3 (es) 1994-12-16
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AU6892694A (en) 1994-10-27
DE69006018T3 (de) 2004-01-15
AU6892894A (en) 1994-11-03
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NO913722D0 (no) 1991-09-20
EP0463101B2 (en) 2003-03-19
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EP0463101A1 (en) 1992-01-02
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AU672313B2 (en) 1996-09-26
CA2046909A1 (en) 1990-09-22
DE69006018T2 (de) 1994-05-11
RO110397B1 (ro) 1996-01-30
AU5356790A (en) 1990-10-22
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