JP2017533710A5 - - Google Patents
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- JP2017533710A5 JP2017533710A5 JP2017524429A JP2017524429A JP2017533710A5 JP 2017533710 A5 JP2017533710 A5 JP 2017533710A5 JP 2017524429 A JP2017524429 A JP 2017524429A JP 2017524429 A JP2017524429 A JP 2017524429A JP 2017533710 A5 JP2017533710 A5 JP 2017533710A5
- Authority
- JP
- Japan
- Prior art keywords
- capture
- primer
- well
- layer
- primer pair
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108091033319 polynucleotide Proteins 0.000 claims 36
- 102000040430 polynucleotide Human genes 0.000 claims 36
- 239000002157 polynucleotide Substances 0.000 claims 36
- 239000000758 substrate Substances 0.000 claims 25
- 239000002773 nucleotide Substances 0.000 claims 20
- 125000003729 nucleotide group Chemical group 0.000 claims 20
- 238000000034 method Methods 0.000 claims 19
- 238000002493 microarray Methods 0.000 claims 13
- 102000039446 nucleic acids Human genes 0.000 claims 12
- 108020004707 nucleic acids Proteins 0.000 claims 12
- 150000007523 nucleic acids Chemical class 0.000 claims 12
- 230000000295 complement effect Effects 0.000 claims 11
- 108091093088 Amplicon Proteins 0.000 claims 10
- 239000011248 coating agent Substances 0.000 claims 9
- 238000000576 coating method Methods 0.000 claims 9
- 238000000151 deposition Methods 0.000 claims 9
- 229920000642 polymer Polymers 0.000 claims 9
- 230000003321 amplification Effects 0.000 claims 3
- 238000003199 nucleic acid amplification method Methods 0.000 claims 3
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 claims 3
- -1 5-azidoacetamidylpentyl Chemical group 0.000 claims 2
- 238000009396 hybridization Methods 0.000 claims 2
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims 1
- 108091000080 Phosphotransferase Proteins 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 230000003190 augmentative effect Effects 0.000 claims 1
- 230000007717 exclusion Effects 0.000 claims 1
- 102000020233 phosphotransferase Human genes 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021213441A JP7323598B2 (ja) | 2014-11-11 | 2021-12-27 | 核酸のモノクローナルクラスターの生成および配列決定のための方法およびアレイ |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462078346P | 2014-11-11 | 2014-11-11 | |
| US62/078,346 | 2014-11-11 | ||
| US201462096464P | 2014-12-23 | 2014-12-23 | |
| US62/096,464 | 2014-12-23 | ||
| PCT/EP2015/076353 WO2016075204A1 (en) | 2014-11-11 | 2015-11-11 | Methods and arrays for producing and sequencing monoclonal clusters of nucleic acid |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021213441A Division JP7323598B2 (ja) | 2014-11-11 | 2021-12-27 | 核酸のモノクローナルクラスターの生成および配列決定のための方法およびアレイ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017533710A JP2017533710A (ja) | 2017-11-16 |
| JP2017533710A5 true JP2017533710A5 (enExample) | 2018-12-20 |
| JP7032930B2 JP7032930B2 (ja) | 2022-03-09 |
Family
ID=54540094
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017524429A Active JP7032930B2 (ja) | 2014-11-11 | 2015-11-11 | 核酸のモノクローナルクラスターの生成および配列決定のための方法およびアレイ |
| JP2021213441A Active JP7323598B2 (ja) | 2014-11-11 | 2021-12-27 | 核酸のモノクローナルクラスターの生成および配列決定のための方法およびアレイ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021213441A Active JP7323598B2 (ja) | 2014-11-11 | 2021-12-27 | 核酸のモノクローナルクラスターの生成および配列決定のための方法およびアレイ |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US10619204B2 (enExample) |
| EP (1) | EP3218511B1 (enExample) |
| JP (2) | JP7032930B2 (enExample) |
| KR (1) | KR102590448B1 (enExample) |
| CN (1) | CN107208019B (enExample) |
| AU (1) | AU2015345125B2 (enExample) |
| DK (1) | DK3218511T3 (enExample) |
| ES (1) | ES2802405T3 (enExample) |
| MY (1) | MY182476A (enExample) |
| PL (1) | PL3218511T3 (enExample) |
| PT (1) | PT3218511T (enExample) |
| SG (2) | SG10202004350TA (enExample) |
| WO (1) | WO2016075204A1 (enExample) |
Families Citing this family (58)
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| KR20160039229A (ko) | 2013-07-30 | 2016-04-08 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 정량적 dna-기반 영상화 및 초해상도 영상화 |
| US10415083B2 (en) | 2013-10-28 | 2019-09-17 | The Translational Genomics Research Institute | Long insert-based whole genome sequencing |
| DK3218511T3 (da) | 2014-11-11 | 2020-07-20 | Illumina Cambridge Ltd | Fremgangsmåder og arrays til frembringelse og sekventering af monoklonale klynger af nukleinsyre |
| EP3283656A4 (en) * | 2015-04-17 | 2018-12-05 | Centrillion Technology Holdings Corporation | Methods for performing spatial profiling of biological molecules |
| WO2017027370A1 (en) * | 2015-08-07 | 2017-02-16 | President And Fellows Of Harvard College | Super resolution imaging of protein-protein interactions |
| WO2017027653A1 (en) | 2015-08-11 | 2017-02-16 | The Johns Hopkins University | Assaying ovarian cyst fluid |
| JP2017209051A (ja) * | 2016-05-25 | 2017-11-30 | 株式会社ニコン | 標的生体分子の検出方法、標的生体分子検出用基板、及び標的生体分子検出装置 |
| JP7126501B2 (ja) * | 2016-12-22 | 2022-08-26 | イラミーナ インコーポレーテッド | 品質管理トレーサー付きアレイ |
| GB201704754D0 (en) | 2017-01-05 | 2017-05-10 | Illumina Inc | Kinetic exclusion amplification of nucleic acid libraries |
| NL2019044B1 (en) | 2017-05-11 | 2018-11-15 | Illumina Inc | Protective surface coatings for flow cells |
| WO2018218136A1 (en) * | 2017-05-25 | 2018-11-29 | Integrated Dna Technologies, Inc. | Reverse complement adapters for the mitigation of umi hopping |
| US11001885B2 (en) | 2017-06-13 | 2021-05-11 | Personal Genomics Taiwan, Inc. | Apparatus for single molecular sequencing and method of sequencing nucleic acid molecules |
| CN120400338A (zh) | 2017-08-07 | 2025-08-01 | 约翰斯霍普金斯大学 | 用于评估和治疗癌症的方法和材料 |
| CN107523640A (zh) * | 2017-10-12 | 2017-12-29 | 厦门燕旭安生物科技有限公司 | 一种ctDNA精准测序的扩增子文库构建方法 |
| MY203405A (en) * | 2017-12-21 | 2024-06-26 | Illumina Inc | Flow cells with hydrogel coating |
| CN112204154B (zh) * | 2018-05-28 | 2024-06-25 | 豪夫迈·罗氏有限公司 | Dna-孔隙-聚合酶复合物的酶促富集 |
| KR102406439B1 (ko) | 2018-06-29 | 2022-06-08 | 일루미나, 인코포레이티드 | 플로우 셀 |
| TWI730352B (zh) | 2018-08-06 | 2021-06-11 | 英商伊路米納劍橋有限公司 | 流體槽與定序系統及製備用於其之基板的方法 |
| US20200149095A1 (en) * | 2018-11-14 | 2020-05-14 | Element Biosciences, Inc. | Low binding supports for improved solid-phase dna hybridization and amplification |
| EP3891305A1 (en) | 2018-12-05 | 2021-10-13 | Illumina Cambridge Limited | Methods and compositions for cluster generation by bridge amplification |
| SG11202012807YA (en) | 2018-12-18 | 2021-01-28 | Illumina Cambridge Ltd | Methods and compositions for paired end sequencing using a single surface primer |
| PT3899037T (pt) * | 2018-12-19 | 2023-12-22 | Illumina Inc | Métodos para melhorar a prioridade de clonalidade de agrupamento polinucleotídico |
| TWI873119B (zh) | 2019-01-29 | 2025-02-21 | 美商伊路米納有限公司 | 流通槽及製備其之方法 |
| TWI857000B (zh) | 2019-01-29 | 2024-10-01 | 美商伊路米納有限公司 | 流體槽以及將複合物引入至流體槽之方法 |
| TWI857001B (zh) | 2019-01-29 | 2024-10-01 | 美商伊路米納有限公司 | 定序套組 |
| EP3976826A4 (en) * | 2019-05-31 | 2023-08-23 | Illumina, Inc. | SYSTEMS AND METHODS FOR STORAGE AND RETRIEVAL OF INFORMATION USING CELL STREAM |
| EP3979252A4 (en) | 2019-05-31 | 2022-08-17 | NEC Corporation | INFORMATION PROCESSING DEVICE, INFORMATION PROCESSING METHOD AND INFORMATION PROCESSING PROGRAM |
| TW202120693A (zh) * | 2019-08-21 | 2021-06-01 | 美商伊路米納有限公司 | 偵測核苷酸之聚合酶併入的方法 |
| KR20220115857A (ko) * | 2019-12-16 | 2022-08-19 | 일루미나, 인코포레이티드 | 키트 및 플로우 셀 |
| EP3969178A2 (en) * | 2019-12-20 | 2022-03-23 | Illumina, Inc. | Flow cells |
| EP4081662A1 (en) * | 2019-12-23 | 2022-11-02 | Illumina, Inc. | Nanoparticle with single site for template polynucleotide attachment |
| IL295297A (en) | 2020-02-14 | 2022-10-01 | Univ Johns Hopkins | Methods and materials for assessing nucleic acids |
| WO2021168097A1 (en) * | 2020-02-19 | 2021-08-26 | Genapsys, Inc. | Methods and systems for nucleic acid processing |
| DK3969613T3 (da) * | 2020-02-26 | 2024-01-08 | Illumina Inc | Kits til genotypebestemmelse |
| EP4114966B1 (en) * | 2020-03-03 | 2025-02-26 | Pacific Biosciences Of California, Inc. | Methods and compositions for sequencing double stranded nucleic acids |
| US20220251626A1 (en) * | 2020-03-09 | 2022-08-11 | Illumina, Inc. | Improvements in nucleic acid sequencing |
| WO2021231477A2 (en) | 2020-05-12 | 2021-11-18 | Illumina, Inc. | Generating nucleic acids with modified bases using recombinant terminal deoxynucleotidyl transferase |
| IL299327A (en) * | 2020-09-14 | 2023-02-01 | Illumina Cambridge Ltd | Compositions and methods for amplifying polynucleotides |
| CN115803112A (zh) * | 2020-09-29 | 2023-03-14 | 伊鲁米纳公司 | 用于制造流通池的方法 |
| WO2022072275A1 (en) * | 2020-09-29 | 2022-04-07 | Illumina, Inc. | Flow cells and methods for making the same |
| EP4260373A4 (en) * | 2020-12-10 | 2024-11-20 | Illumina, Inc. | Image sensor structures and related methods |
| US20220195516A1 (en) * | 2020-12-17 | 2022-06-23 | Illumina Cambridge Limited | Methods, systems and compositions for nucleic acid sequencing |
| US11884977B2 (en) | 2021-03-12 | 2024-01-30 | Singular Genomics Systems, Inc. | Nanoarrays and methods of use thereof |
| WO2022192671A1 (en) * | 2021-03-12 | 2022-09-15 | Singular Genomics Systems, Inc. | Nanoarrays and methods of use thereof |
| CA3214697A1 (en) * | 2021-04-30 | 2022-11-03 | Wayne N. GEORGE | Flow cell and methods |
| WO2022240764A1 (en) * | 2021-05-10 | 2022-11-17 | Pacific Biosciences Of California, Inc. | Single-molecule seeding and amplification on a surface |
| US20250388951A1 (en) * | 2022-06-27 | 2025-12-25 | Somalogic Operating Co., Inc. | Monoclonal polony generation using nucleic acid supramolecular structures |
| WO2024006816A1 (en) * | 2022-06-29 | 2024-01-04 | 10X Genomics, Inc. | Compositions and methods for oligonucleotide inversion on arrays |
| CN116024320A (zh) * | 2022-07-13 | 2023-04-28 | 上海翔琼生物技术有限公司 | 一种用于检测核酸的荧光定量pcr方法 |
| EP4584391A1 (en) * | 2022-09-09 | 2025-07-16 | TODX Ltd. | Device for parallel detection and quantification of nucleic acid based markers |
| KR20250069478A (ko) * | 2022-09-16 | 2025-05-19 | 일루미나, 인코포레이티드 | 폴리뉴클레오티드 결합부위를 갖는 나노입자 및 이의 제조방법 |
| WO2024256580A1 (en) * | 2023-06-14 | 2024-12-19 | Illumina, Inc. | Concurrent sequencing with spatially separated rings |
| WO2025062001A1 (en) * | 2023-09-20 | 2025-03-27 | Illumina, Inc. | Optimised nucleic acid sequencing |
| US20250188529A1 (en) | 2023-12-12 | 2025-06-12 | Illumina, Inc. | Capturing and amplifying polynucleotides using molecules and particles |
| WO2025137479A1 (en) * | 2023-12-22 | 2025-06-26 | Illumina, Inc. | Reusable flow cells and methods of using them for nucleic acid sequencing |
| CN117778578B (zh) * | 2023-12-29 | 2024-10-15 | 深圳海普洛斯医学检验实验室 | 一种基于高通量测序检测目标基因甲基化程度的引物组合物及其应用 |
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-
2015
- 2015-11-11 DK DK15793823.4T patent/DK3218511T3/da active
- 2015-11-11 JP JP2017524429A patent/JP7032930B2/ja active Active
- 2015-11-11 SG SG10202004350TA patent/SG10202004350TA/en unknown
- 2015-11-11 PL PL15793823T patent/PL3218511T3/pl unknown
- 2015-11-11 PT PT157938234T patent/PT3218511T/pt unknown
- 2015-11-11 CN CN201580072860.9A patent/CN107208019B/zh active Active
- 2015-11-11 EP EP15793823.4A patent/EP3218511B1/en active Active
- 2015-11-11 ES ES15793823T patent/ES2802405T3/es active Active
- 2015-11-11 KR KR1020177015817A patent/KR102590448B1/ko active Active
- 2015-11-11 WO PCT/EP2015/076353 patent/WO2016075204A1/en not_active Ceased
- 2015-11-11 AU AU2015345125A patent/AU2015345125B2/en active Active
- 2015-11-11 MY MYPI2017000708A patent/MY182476A/en unknown
- 2015-11-11 US US15/525,892 patent/US10619204B2/en active Active
- 2015-11-11 SG SG11201703693UA patent/SG11201703693UA/en unknown
-
2020
- 2020-04-10 US US16/846,028 patent/US11692223B2/en active Active
-
2021
- 2021-12-27 JP JP2021213441A patent/JP7323598B2/ja active Active
-
2023
- 2023-05-18 US US18/320,122 patent/US12385092B2/en active Active
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