JP2017512815A5 - - Google Patents
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- JP2017512815A5 JP2017512815A5 JP2016560487A JP2016560487A JP2017512815A5 JP 2017512815 A5 JP2017512815 A5 JP 2017512815A5 JP 2016560487 A JP2016560487 A JP 2016560487A JP 2016560487 A JP2016560487 A JP 2016560487A JP 2017512815 A5 JP2017512815 A5 JP 2017512815A5
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- Prior art keywords
- igg
- igm
- iga
- antibody
- antigen
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- 101000840258 Homo sapiens Immunoglobulin J chain Proteins 0.000 claims description 74
- 102100029571 Immunoglobulin J chain Human genes 0.000 claims description 74
- 239000000427 antigen Substances 0.000 claims description 45
- 108091007433 antigens Proteins 0.000 claims description 45
- 102000036639 antigens Human genes 0.000 claims description 45
- 239000012634 fragment Substances 0.000 claims description 41
- 210000004027 cell Anatomy 0.000 claims description 23
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 18
- 239000012636 effector Substances 0.000 claims description 16
- 206010028980 Neoplasm Diseases 0.000 claims description 15
- 108090000790 Enzymes Proteins 0.000 claims description 12
- 102000004190 Enzymes Human genes 0.000 claims description 12
- 210000004881 tumor cell Anatomy 0.000 claims description 10
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 9
- 230000004927 fusion Effects 0.000 claims description 9
- 230000003612 virological effect Effects 0.000 claims description 9
- 201000011510 cancer Diseases 0.000 claims description 8
- 235000001014 amino acid Nutrition 0.000 claims description 7
- 150000001413 amino acids Chemical class 0.000 claims description 7
- 210000002540 macrophage Anatomy 0.000 claims description 7
- 210000000440 neutrophil Anatomy 0.000 claims description 7
- JWDFQMWEFLOOED-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 3-(pyridin-2-yldisulfanyl)propanoate Chemical compound O=C1CCC(=O)N1OC(=O)CCSSC1=CC=CC=N1 JWDFQMWEFLOOED-UHFFFAOYSA-N 0.000 claims description 6
- 101000946860 Homo sapiens T-cell surface glycoprotein CD3 epsilon chain Proteins 0.000 claims description 6
- 102100035794 T-cell surface glycoprotein CD3 epsilon chain Human genes 0.000 claims description 6
- 210000000822 natural killer cell Anatomy 0.000 claims description 6
- 239000000126 substance Substances 0.000 claims description 6
- JJAHTWIKCUJRDK-UHFFFAOYSA-N succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate Chemical compound C1CC(CN2C(C=CC2=O)=O)CCC1C(=O)ON1C(=O)CCC1=O JJAHTWIKCUJRDK-UHFFFAOYSA-N 0.000 claims description 6
- 101000917839 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-B Proteins 0.000 claims description 5
- 102100029185 Low affinity immunoglobulin gamma Fc region receptor III-B Human genes 0.000 claims description 5
- 201000010099 disease Diseases 0.000 claims description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- 235000018102 proteins Nutrition 0.000 claims description 5
- 108090000623 proteins and genes Proteins 0.000 claims description 5
- 102000004169 proteins and genes Human genes 0.000 claims description 5
- 238000001212 derivatisation Methods 0.000 claims description 4
- 102000005962 receptors Human genes 0.000 claims description 4
- 108020003175 receptors Proteins 0.000 claims description 4
- 108010067306 Fibronectins Proteins 0.000 claims description 3
- 102100026122 High affinity immunoglobulin gamma Fc receptor I Human genes 0.000 claims description 3
- 101000913074 Homo sapiens High affinity immunoglobulin gamma Fc receptor I Proteins 0.000 claims description 3
- 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 claims description 3
- 101001109501 Homo sapiens NKG2-D type II integral membrane protein Proteins 0.000 claims description 3
- 102100022680 NKG2-D type II integral membrane protein Human genes 0.000 claims description 3
- 150000001299 aldehydes Chemical class 0.000 claims description 3
- 239000000611 antibody drug conjugate Substances 0.000 claims description 3
- 229940049595 antibody-drug conjugate Drugs 0.000 claims description 3
- 210000004899 c-terminal region Anatomy 0.000 claims description 3
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims description 3
- 125000005442 diisocyanate group Chemical group 0.000 claims description 3
- 150000002148 esters Chemical class 0.000 claims description 3
- 150000002222 fluorine compounds Chemical class 0.000 claims description 3
- 230000013595 glycosylation Effects 0.000 claims description 3
- 238000006206 glycosylation reaction Methods 0.000 claims description 3
- -1 imide ester Chemical class 0.000 claims description 3
- 238000003780 insertion Methods 0.000 claims description 3
- 230000037431 insertion Effects 0.000 claims description 3
- 239000003446 ligand Substances 0.000 claims description 3
- 239000002245 particle Substances 0.000 claims description 3
- 231100000654 protein toxin Toxicity 0.000 claims description 3
- CNHYKKNIIGEXAY-UHFFFAOYSA-N thiolan-2-imine Chemical compound N=C1CCCS1 CNHYKKNIIGEXAY-UHFFFAOYSA-N 0.000 claims description 3
- 108700012359 toxins Proteins 0.000 claims description 3
- 125000000539 amino acid group Chemical group 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 108010025905 Cystine-Knot Miniproteins Proteins 0.000 claims 1
- 108700022150 Designed Ankyrin Repeat Proteins Proteins 0.000 claims 1
- 102000016359 Fibronectins Human genes 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 230000002489 hematologic effect Effects 0.000 description 3
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 description 2
- 201000009030 Carcinoma Diseases 0.000 description 2
- 102100037362 Fibronectin Human genes 0.000 description 2
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 description 2
- 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 description 2
- 206010025323 Lymphomas Diseases 0.000 description 2
- 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 description 2
- 108010003723 Single-Domain Antibodies Proteins 0.000 description 2
- 230000001588 bifunctional effect Effects 0.000 description 2
- 229910052731 fluorine Inorganic materials 0.000 description 2
- 208000032839 leukemia Diseases 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 230000001323 posttranslational effect Effects 0.000 description 2
- NHKZQYJGWDGXMY-UHFFFAOYSA-N pyridin-2-ylsulfanyl pentanoate Chemical compound CCCCC(=O)OSC1=CC=CC=N1 NHKZQYJGWDGXMY-UHFFFAOYSA-N 0.000 description 2
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 description 1
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 description 1
- 208000031261 Acute myeloid leukaemia Diseases 0.000 description 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 description 1
- 102100038080 B-cell receptor CD22 Human genes 0.000 description 1
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 description 1
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 description 1
- 206010005003 Bladder cancer Diseases 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 102100025221 CD70 antigen Human genes 0.000 description 1
- 108010078791 Carrier Proteins Proteins 0.000 description 1
- 108010001857 Cell Surface Receptors Proteins 0.000 description 1
- 206010008342 Cervix carcinoma Diseases 0.000 description 1
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 description 1
- 206010009944 Colon cancer Diseases 0.000 description 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 description 1
- 206010014733 Endometrial cancer Diseases 0.000 description 1
- 206010014759 Endometrial neoplasm Diseases 0.000 description 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 description 1
- 208000022072 Gallbladder Neoplasms Diseases 0.000 description 1
- 208000032612 Glial tumor Diseases 0.000 description 1
- 206010018338 Glioma Diseases 0.000 description 1
- 108060003393 Granulin Proteins 0.000 description 1
- 208000017604 Hodgkin disease Diseases 0.000 description 1
- 208000021519 Hodgkin lymphoma Diseases 0.000 description 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 description 1
- 101000884305 Homo sapiens B-cell receptor CD22 Proteins 0.000 description 1
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 description 1
- 101000934356 Homo sapiens CD70 antigen Proteins 0.000 description 1
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 description 1
- 101000581981 Homo sapiens Neural cell adhesion molecule 1 Proteins 0.000 description 1
- 101000874179 Homo sapiens Syndecan-1 Proteins 0.000 description 1
- 208000008839 Kidney Neoplasms Diseases 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 description 1
- 208000009018 Medullary thyroid cancer Diseases 0.000 description 1
- 201000003793 Myelodysplastic syndrome Diseases 0.000 description 1
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 description 1
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 description 1
- 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 description 1
- 102100027347 Neural cell adhesion molecule 1 Human genes 0.000 description 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 description 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 description 1
- 206010033128 Ovarian cancer Diseases 0.000 description 1
- 206010061535 Ovarian neoplasm Diseases 0.000 description 1
- 206010035226 Plasma cell myeloma Diseases 0.000 description 1
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 description 1
- 206010060862 Prostate cancer Diseases 0.000 description 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
- 206010038389 Renal cancer Diseases 0.000 description 1
- 208000005718 Stomach Neoplasms Diseases 0.000 description 1
- 102100035721 Syndecan-1 Human genes 0.000 description 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 description 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 201000010881 cervical cancer Diseases 0.000 description 1
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 201000004101 esophageal cancer Diseases 0.000 description 1
- 201000010175 gallbladder cancer Diseases 0.000 description 1
- 206010017758 gastric cancer Diseases 0.000 description 1
- 201000010536 head and neck cancer Diseases 0.000 description 1
- 208000014829 head and neck neoplasm Diseases 0.000 description 1
- 201000010982 kidney cancer Diseases 0.000 description 1
- 201000007270 liver cancer Diseases 0.000 description 1
- 208000014018 liver neoplasm Diseases 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 208000023356 medullary thyroid gland carcinoma Diseases 0.000 description 1
- 201000001441 melanoma Diseases 0.000 description 1
- 102000006240 membrane receptors Human genes 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 201000000050 myeloid neoplasm Diseases 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 201000011549 stomach cancer Diseases 0.000 description 1
- 201000005112 urinary bladder cancer Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461974738P | 2014-04-03 | 2014-04-03 | |
| US61/974,738 | 2014-04-03 | ||
| PCT/US2015/024149 WO2015153912A1 (en) | 2014-04-03 | 2015-04-02 | Modified j-chain |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020041558A Division JP7062025B2 (ja) | 2014-04-03 | 2020-03-11 | 修飾ｊ鎖 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017512815A JP2017512815A (ja) | 2017-05-25 |
| JP2017512815A5 true JP2017512815A5 (enExample) | 2018-05-17 |
| JP6744822B2 JP6744822B2 (ja) | 2020-08-19 |
Family
ID=52998235
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016560487A Active JP6744822B2 (ja) | 2014-04-03 | 2015-04-02 | 修飾ｊ鎖 |
| JP2020041558A Active JP7062025B2 (ja) | 2014-04-03 | 2020-03-11 | 修飾ｊ鎖 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020041558A Active JP7062025B2 (ja) | 2014-04-03 | 2020-03-11 | 修飾ｊ鎖 |
Country Status (21)
| Country | Link |
|---|---|
| US (5) | US10400038B2 (enExample) |
| EP (3) | EP3126383B8 (enExample) |
| JP (2) | JP6744822B2 (enExample) |
| KR (3) | KR102380402B1 (enExample) |
| CN (2) | CN106459213B (enExample) |
| AU (3) | AU2015240595B2 (enExample) |
| BR (1) | BR112016022841B1 (enExample) |
| CA (1) | CA2944647C (enExample) |
| DK (2) | DK3126383T3 (enExample) |
| ES (2) | ES2717704T3 (enExample) |
| HU (2) | HUE055693T2 (enExample) |
| IL (3) | IL292311A (enExample) |
| MX (2) | MX366588B (enExample) |
| NZ (1) | NZ725568A (enExample) |
| PL (2) | PL3560954T3 (enExample) |
| PT (2) | PT3560954T (enExample) |
| RU (2) | RU2761118C2 (enExample) |
| SG (2) | SG10201909716RA (enExample) |
| SI (2) | SI3126383T1 (enExample) |
| WO (1) | WO2015153912A1 (enExample) |
| ZA (1) | ZA201606906B (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112516179A (zh) | 2013-06-14 | 2021-03-19 | 普赛奥克苏斯治疗公司 | 用于b型腺病毒的给药方案及制剂 |
| DK3041862T3 (da) | 2013-09-05 | 2020-07-27 | Igm Biosciences Inc | Modificerede bispecifikke, penta- og hexavalente ig-m-antistoffer med konstant kæde |
| SG11201602887QA (en) | 2013-10-25 | 2016-05-30 | Psioxus Therapeutics Ltd | Oncolytic adenoviruses armed with heterologous genes |
| DK3105250T3 (da) | 2014-02-10 | 2020-09-28 | Igm Biosciences Inc | Multispecifikke iga-bindingsmolekyler |
| IL292311A (en) | 2014-04-03 | 2022-06-01 | Igm Biosciences Inc | J-chain qualified |
| JP7179464B2 (ja) | 2015-01-20 | 2022-11-29 | アイジーエム バイオサイエンシズ インコーポレイテッド | 腫瘍壊死因子 （ｔｎｆ） スーパーファミリー受容体結合分子およびその使用 |
| SG11201707144VA (en) * | 2015-03-04 | 2017-09-28 | Igm Biosciences Inc | Cd20 binding molecules and uses thereof |
| AU2016238246B2 (en) | 2015-03-25 | 2021-05-13 | Igm Biosciences, Inc. | Multi-valent hepatitis B virus antigen binding molecules and uses thereof |
| JP6811723B2 (ja) | 2015-04-17 | 2021-01-13 | アイジーエム バイオサイエンシズ インコーポレイテッド | 多価ヒト免疫不全ウイルス抗原結合分子およびその使用方法 |
| US11639389B2 (en) | 2015-09-30 | 2023-05-02 | Igm Biosciences, Inc. | Binding molecules with modified J-chain |
| CA2999284C (en) | 2015-09-30 | 2023-06-13 | Igm Biosciences A/S | Binding molecules with modified j-chain |
| EA201891022A1 (ru) | 2015-12-17 | 2019-01-31 | Псайоксус Терапьютикс Лимитед | Вирус, кодирующий антитело к комплексу tcr или фрагмент указанного антитела |
| DK3455257T3 (da) * | 2016-05-09 | 2021-11-01 | Igm Biosciences Inc | Anti-pd-l1-antistoffer |
| GB201713765D0 (en) | 2017-08-28 | 2017-10-11 | Psioxus Therapeutics Ltd | Modified adenovirus |
| MY197324A (en) | 2016-08-29 | 2023-06-13 | Akamis Bio Ltd | Adenovirus armed with bispecific t cell activator |
| DK3579848T3 (da) | 2017-02-08 | 2025-01-20 | Dragonfly Therapeutics Inc | Multispecifikke bindende proteiner til aktivering af naturlige dræberceller og terapeutiske anvendelser heraf til behandling af kræft |
| KR20240060739A (ko) | 2017-02-20 | 2024-05-08 | 드래곤플라이 쎄라퓨틱스, 인크. | Her2, nkg2d 및 cd16에 결합하는 단백질 |
| KR102696143B1 (ko) | 2017-04-07 | 2024-08-21 | 아이쥐엠 바이오사이언스 인코포레이티드 | 보체-의존성 세포용해 효과기 기능의 조정을 위한 변형된 인간 IgM 불변 영역 |
| GB201801614D0 (en) | 2018-01-31 | 2018-03-14 | Psioxus Therapeutics Ltd | Formulation |
| SG11202007482WA (en) | 2018-02-08 | 2020-09-29 | Dragonfly Therapeutics Inc | Antibody variable domains targeting the nkg2d receptor |
| SG11202007579TA (en) | 2018-02-08 | 2020-09-29 | Dragonfly Therapeutics Inc | Combination therapy of cancer involving multi-specific binding proteins that activate natural killer cells |
| JP7353576B2 (ja) | 2018-02-20 | 2023-10-02 | ドラゴンフライ セラピューティクス， インコーポレイテッド | Ｃｄ３３、ｎｋｇ２ｄ、及びｃｄ１６に結合する多重特異性結合タンパク質、ならびにその使用方法 |
| EP3758752A4 (en) | 2018-03-01 | 2021-12-15 | IGM Biosciences Inc. | IGM-FC AND J-CHAIN MUTATIONS AFFECTING IGM SERUM HALF-LIFE |
| EA202091888A1 (ru) | 2018-08-08 | 2020-10-23 | Драгонфлай Терапьютикс, Инк. | Вариабельные домены антител, нацеленные на рецептор nkg2d |
| EP3833385A4 (en) | 2018-08-08 | 2021-12-22 | Dragonfly Therapeutics, Inc. | PROTEINS THAT BINDING NKG2D, CD16 AND A TUMOR-ASSOCIATED ANTIGEN |
| EP3833392A4 (en) | 2018-08-08 | 2022-05-18 | Dragonfly Therapeutics, Inc. | MULTISPECIFIC BINDING PROTEINS FOR BINDING CD33, NKG2D AND CD16 AND METHODS OF USE |
| WO2020156405A1 (en) * | 2019-01-28 | 2020-08-06 | Wuxi Biologics (Shanghai) Co. Ltd. | Novel bispecific cd3/cd20 polypeptide complexes |
| AU2020322031A1 (en) * | 2019-07-31 | 2022-03-10 | The Wistar Institute Of Anatomy And Biology | Multivalent DNA antibody constructs and use thereof |
| AU2020329301A1 (en) * | 2019-08-15 | 2022-02-17 | Igm Biosciences, Inc. | Immunostimulatory multimeric binding molecules |
| EP4013796A4 (en) * | 2019-08-17 | 2023-08-02 | IGM Biosciences Inc. | MULTIMERIC BISPECIFIC ANTI-CD123 BINDING MOLECULES AND THEIR USES |
| US20220306760A1 (en) * | 2019-08-23 | 2022-09-29 | Igm Biosciences, Inc. | Igm glycovariants |
| CN114616031A (zh) * | 2019-09-19 | 2022-06-10 | Igm生物科学股份有限公司 | 对靶标密度高的细胞的选择性增强的多聚体抗体 |
| CN115052884B (zh) * | 2019-09-27 | 2026-03-17 | 北京烁星生物医药科技有限公司 | 单特异性和多特异性抗体 |
| BR112022021392A2 (pt) | 2020-04-22 | 2022-12-06 | Igm Biosciences Inc | Moléculas de ligação multiméricas de agonista de pd-1 |
| CN115836088A (zh) | 2020-05-06 | 2023-03-21 | 蜻蜓疗法股份有限公司 | 结合nkg2d、cd16和clec12a的蛋白质 |
| JP2024500847A (ja) | 2020-12-18 | 2024-01-10 | センチュリー セラピューティクス，インコーポレイテッド | 適合可能な受容体特異性を有するキメラ抗原受容体システム |
| WO2022187539A1 (en) | 2021-03-03 | 2022-09-09 | Dragonfly Therapeutics, Inc. | Methods of treating cancer using multi-specific binding proteins that bind nkg2d, cd16 and a tumor-associated antigen |
| WO2022256740A1 (en) | 2021-06-04 | 2022-12-08 | Curia Ip Holdings, Llc | Polymeric fusion proteins and compositions for inducing an immune response against infection |
| US20250326844A1 (en) | 2022-04-07 | 2025-10-23 | Repertoire Immune Medicines, Inc. | T cell receptor multimers and uses thereof |
| US12600801B2 (en) | 2022-07-11 | 2026-04-14 | Fred Hutchinson Cancer Center | Single-domain antibodies that bind ROR1 |
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