JP2018537410A5 - - Google Patents

Info

Publication number

JP2018537410A5

JP2018537410A5 JP2018516820A JP2018516820A JP2018537410A5 JP 2018537410 A5 JP2018537410 A5 JP 2018537410A5 JP 2018516820 A JP2018516820 A JP 2018516820A JP 2018516820 A JP2018516820 A JP 2018516820A JP 2018537410 A5 JP2018537410 A5 JP 2018537410A5

Authority

JP

Japan

Prior art keywords

antibody

chain

modified

antigen

binding

Prior art date

2016-09-30

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 101000840258 Homo sapiens Immunoglobulin J chain Proteins 0.000 claims 15
• 102100029571 Immunoglobulin J chain Human genes 0.000 claims 15
• 239000000427 antigen Substances 0.000 claims 10
• 102000036639 antigens Human genes 0.000 claims 10
• 108091007433 antigens Proteins 0.000 claims 10
• 239000000178 monomer Substances 0.000 claims 7
• 108010052285 Membrane Proteins Proteins 0.000 claims 4
• 102000018697 Membrane Proteins Human genes 0.000 claims 4
• 102000004190 Enzymes Human genes 0.000 claims 3
• 108090000790 Enzymes Proteins 0.000 claims 3
• 210000004027 cell Anatomy 0.000 claims 3
• 239000012634 fragment Substances 0.000 claims 3
• 108090000765 processed proteins & peptides Proteins 0.000 claims 3
• JWDFQMWEFLOOED-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 3-(pyridin-2-yldisulfanyl)propanoate Chemical group O=C1CCC(=O)N1OC(=O)CCSSC1=CC=CC=N1 JWDFQMWEFLOOED-UHFFFAOYSA-N 0.000 claims 2
• 102100023990 60S ribosomal protein L17 Human genes 0.000 claims 2
• 108010074708 B7-H1 Antigen Proteins 0.000 claims 2
• 201000009030 Carcinoma Diseases 0.000 claims 2
• 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 claims 2
• 101001068133 Homo sapiens Hepatitis A virus cellular receptor 2 Proteins 0.000 claims 2
• 101001137987 Homo sapiens Lymphocyte activation gene 3 protein Proteins 0.000 claims 2
• 102000017578 LAG3 Human genes 0.000 claims 2
• 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims 2
• 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 2
• 239000000126 substance Substances 0.000 claims 2
• JJAHTWIKCUJRDK-UHFFFAOYSA-N succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate Chemical compound C1CC(CN2C(C=CC2=O)=O)CCC1C(=O)ON1C(=O)CCC1=O JJAHTWIKCUJRDK-UHFFFAOYSA-N 0.000 claims 2
• 102100031585 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Human genes 0.000 claims 1
• 102100029822 B- and T-lymphocyte attenuator Human genes 0.000 claims 1
• 102100038080 B-cell receptor CD22 Human genes 0.000 claims 1
• 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims 1
• 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims 1
• 102100024217 CAMPATH-1 antigen Human genes 0.000 claims 1
• 102100027207 CD27 antigen Human genes 0.000 claims 1
• 101150013553 CD40 gene Proteins 0.000 claims 1
• 108010065524 CD52 Antigen Proteins 0.000 claims 1
• 102100025221 CD70 antigen Human genes 0.000 claims 1
• 102100025570 Cancer/testis antigen 1 Human genes 0.000 claims 1
• 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 claims 1
• 102000018651 Epithelial Cell Adhesion Molecule Human genes 0.000 claims 1
• 108010066687 Epithelial Cell Adhesion Molecule Proteins 0.000 claims 1
• 101000777636 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Proteins 0.000 claims 1
• 101000864344 Homo sapiens B- and T-lymphocyte attenuator Proteins 0.000 claims 1
• 101000884305 Homo sapiens B-cell receptor CD22 Proteins 0.000 claims 1
• 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 1
• 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims 1
• 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims 1
• 101000934356 Homo sapiens CD70 antigen Proteins 0.000 claims 1
• 101000945318 Homo sapiens Calponin-1 Proteins 0.000 claims 1
• 101000856237 Homo sapiens Cancer/testis antigen 1 Proteins 0.000 claims 1
• 101000889276 Homo sapiens Cytotoxic T-lymphocyte protein 4 Proteins 0.000 claims 1
• 101001005728 Homo sapiens Melanoma-associated antigen 1 Proteins 0.000 claims 1
• 101001057131 Homo sapiens Melanoma-associated antigen D4 Proteins 0.000 claims 1
• 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 claims 1
• 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 1
• 101000831007 Homo sapiens T-cell immunoreceptor with Ig and ITIM domains Proteins 0.000 claims 1
• 101000652736 Homo sapiens Transgelin Proteins 0.000 claims 1
• 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 claims 1
• 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 claims 1
• 101000666896 Homo sapiens V-type immunoglobulin domain-containing suppressor of T-cell activation Proteins 0.000 claims 1
• 102100025050 Melanoma-associated antigen 1 Human genes 0.000 claims 1
• 108010061593 Member 14 Tumor Necrosis Factor Receptors Proteins 0.000 claims 1
• 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 claims 1
• 206010028980 Neoplasm Diseases 0.000 claims 1
• RMINQIRDFIBNLE-NNRWGFCXSA-N O-[N-acetyl-alpha-neuraminyl-(2->6)-N-acetyl-alpha-D-galactosaminyl]-L-serine Chemical compound O1[C@H](OC[C@H](N)C(O)=O)[C@H](NC(=O)C)[C@@H](O)[C@@H](O)[C@H]1CO[C@@]1(C(O)=O)O[C@@H]([C@H](O)[C@H](O)CO)[C@H](NC(C)=O)[C@@H](O)C1 RMINQIRDFIBNLE-NNRWGFCXSA-N 0.000 claims 1
• 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 1
• 102100029986 Receptor tyrosine-protein kinase erbB-3 Human genes 0.000 claims 1
• 101710100969 Receptor tyrosine-protein kinase erbB-3 Proteins 0.000 claims 1
• 108010003723 Single-Domain Antibodies Proteins 0.000 claims 1
• 102100024834 T-cell immunoreceptor with Ig and ITIM domains Human genes 0.000 claims 1
• 210000001744 T-lymphocyte Anatomy 0.000 claims 1
• 102100031013 Transgelin Human genes 0.000 claims 1
• 102100028785 Tumor necrosis factor receptor superfamily member 14 Human genes 0.000 claims 1
• 102100033728 Tumor necrosis factor receptor superfamily member 18 Human genes 0.000 claims 1
• 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims 1
• 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 1
• 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims 1
• 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 claims 1
• 102100038282 V-type immunoglobulin domain-containing suppressor of T-cell activation Human genes 0.000 claims 1
• 150000001299 aldehydes Chemical class 0.000 claims 1
• NIGUVXFURDGQKZ-KRAHZTDDSA-N alpha-Neup5Ac-(2->3)-beta-D-Galp-(1->4)-[alpha-L-Fucp-(1->3)]-D-GlcpNAc Chemical compound O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](O[C@H]2[C@@H]([C@@H](O[C@]3(O[C@H]([C@H](NC(C)=O)[C@@H](O)C3)[C@H](O)[C@H](O)CO)C(O)=O)[C@@H](O)[C@@H](CO)O2)O)[C@@H](CO)OC(O)[C@@H]1NC(C)=O NIGUVXFURDGQKZ-KRAHZTDDSA-N 0.000 claims 1
• 125000000539 amino acid group Chemical group 0.000 claims 1
• 239000000611 antibody drug conjugate Substances 0.000 claims 1
• 229940049595 antibody-drug conjugate Drugs 0.000 claims 1
• 230000001588 bifunctional effect Effects 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 1
• 238000001212 derivatisation Methods 0.000 claims 1
• 125000005442 diisocyanate group Chemical group 0.000 claims 1
• 239000000539 dimer Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 1
• 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 1
• 150000002148 esters Chemical class 0.000 claims 1
• 229910052731 fluorine Inorganic materials 0.000 claims 1
• 150000002222 fluorine compounds Chemical class 0.000 claims 1
• IJJVMEJXYNJXOJ-UHFFFAOYSA-N fluquinconazole Chemical compound C=1C=C(Cl)C=C(Cl)C=1N1C(=O)C2=CC(F)=CC=C2N=C1N1C=NC=N1 IJJVMEJXYNJXOJ-UHFFFAOYSA-N 0.000 claims 1
• 230000013595 glycosylation Effects 0.000 claims 1
• 238000006206 glycosylation reaction Methods 0.000 claims 1
• 201000005787 hematologic cancer Diseases 0.000 claims 1
• 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims 1
• -1 imide esters Chemical class 0.000 claims 1
• 230000002401 inhibitory effect Effects 0.000 claims 1
• 230000037431 insertion Effects 0.000 claims 1
• 238000003780 insertion Methods 0.000 claims 1
• 239000003446 ligand Substances 0.000 claims 1
• YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 108020003175 receptors Proteins 0.000 claims 1
• 102000005962 receptors Human genes 0.000 claims 1
• 230000019491 signal transduction Effects 0.000 claims 1
• CNHYKKNIIGEXAY-UHFFFAOYSA-N thiolan-2-imine Chemical compound N=C1CCCS1 CNHYKKNIIGEXAY-UHFFFAOYSA-N 0.000 claims 1