JP2017511131A5 - - Google Patents
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- JP2017511131A5 JP2017511131A5 JP2016559188A JP2016559188A JP2017511131A5 JP 2017511131 A5 JP2017511131 A5 JP 2017511131A5 JP 2016559188 A JP2016559188 A JP 2016559188A JP 2016559188 A JP2016559188 A JP 2016559188A JP 2017511131 A5 JP2017511131 A5 JP 2017511131A5
- Authority
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- Japan
- Prior art keywords
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- mrna expression
- seq
- hepg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108020004999 messenger RNA Proteins 0.000 claims 70
- 238000000034 method Methods 0.000 claims 48
- 102100033016 Integrin beta-7 Human genes 0.000 claims 31
- 108091006255 SLC8A3 Proteins 0.000 claims 31
- 102100032576 Sodium/calcium exchanger 3 Human genes 0.000 claims 31
- 239000005557 antagonist Substances 0.000 claims 31
- 108010021315 integrin beta7 Proteins 0.000 claims 31
- 150000001413 amino acids Chemical class 0.000 claims 25
- -1 CCL4 Proteins 0.000 claims 21
- 208000017189 Gastrointestinal inflammatory disease Diseases 0.000 claims 19
- 239000012472 biological sample Substances 0.000 claims 19
- 101000830596 Homo sapiens Tumor necrosis factor ligand superfamily member 15 Proteins 0.000 claims 16
- 102100024587 Tumor necrosis factor ligand superfamily member 15 Human genes 0.000 claims 16
- 102100028170 Bestrophin-2 Human genes 0.000 claims 15
- 108010008599 Forkhead Box Protein M1 Proteins 0.000 claims 15
- 102000007237 Forkhead Box Protein M1 Human genes 0.000 claims 15
- 102100030386 Granzyme A Human genes 0.000 claims 15
- 101000697368 Homo sapiens Bestrophin-2 Proteins 0.000 claims 15
- 101001009599 Homo sapiens Granzyme A Proteins 0.000 claims 15
- 101001049181 Homo sapiens Killer cell lectin-like receptor subfamily B member 1 Proteins 0.000 claims 15
- 102100023678 Killer cell lectin-like receptor subfamily B member 1 Human genes 0.000 claims 15
- 102100021943 C-C motif chemokine 2 Human genes 0.000 claims 14
- 102100040515 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial Human genes 0.000 claims 14
- 101000897480 Homo sapiens C-C motif chemokine 2 Proteins 0.000 claims 14
- 101000966982 Homo sapiens Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial Proteins 0.000 claims 14
- 101000854774 Homo sapiens Pantetheine hydrolase VNN2 Proteins 0.000 claims 13
- 102100020748 Pantetheine hydrolase VNN2 Human genes 0.000 claims 13
- 101150009379 AS1 gene Proteins 0.000 claims 11
- 102100034673 C-C motif chemokine 3-like 1 Human genes 0.000 claims 11
- 102100025618 C-X-C chemokine receptor type 6 Human genes 0.000 claims 11
- 102100023073 Calcium-activated potassium channel subunit alpha-1 Human genes 0.000 claims 11
- 102100030614 Carboxypeptidase A2 Human genes 0.000 claims 11
- 102100030621 Carboxypeptidase A4 Human genes 0.000 claims 11
- 101100324551 Chlamydomonas reinhardtii ARSA1 gene Proteins 0.000 claims 11
- 108010070357 D-Aspartate Oxidase Proteins 0.000 claims 11
- 102100039462 D-aspartate oxidase Human genes 0.000 claims 11
- 102100028071 Fibroblast growth factor 7 Human genes 0.000 claims 11
- 102100037665 Fibroblast growth factor 9 Human genes 0.000 claims 11
- 102100023416 G-protein coupled receptor 15 Human genes 0.000 claims 11
- 102100027362 GTP-binding protein REM 2 Human genes 0.000 claims 11
- 102100030385 Granzyme B Human genes 0.000 claims 11
- 102100036284 Hepcidin Human genes 0.000 claims 11
- 101000946370 Homo sapiens C-C motif chemokine 3-like 1 Proteins 0.000 claims 11
- 101000856683 Homo sapiens C-X-C chemokine receptor type 6 Proteins 0.000 claims 11
- 101001049859 Homo sapiens Calcium-activated potassium channel subunit alpha-1 Proteins 0.000 claims 11
- 101001060261 Homo sapiens Fibroblast growth factor 7 Proteins 0.000 claims 11
- 101001027380 Homo sapiens Fibroblast growth factor 9 Proteins 0.000 claims 11
- 101000829794 Homo sapiens G-protein coupled receptor 15 Proteins 0.000 claims 11
- 101000581787 Homo sapiens GTP-binding protein REM 2 Proteins 0.000 claims 11
- 101001009603 Homo sapiens Granzyme B Proteins 0.000 claims 11
- 101001021253 Homo sapiens Hepcidin Proteins 0.000 claims 11
- 101001128393 Homo sapiens Interferon-induced GTP-binding protein Mx1 Proteins 0.000 claims 11
- 101001002634 Homo sapiens Interleukin-1 alpha Proteins 0.000 claims 11
- 101001135094 Homo sapiens LIM domain transcription factor LMO4 Proteins 0.000 claims 11
- 101001017833 Homo sapiens Leucine-rich repeat-containing protein 4 Proteins 0.000 claims 11
- 101001013796 Homo sapiens Metallothionein-1M Proteins 0.000 claims 11
- 101000961382 Homo sapiens Mitochondrial calcium uniporter regulator 1 Proteins 0.000 claims 11
- 101001018157 Homo sapiens Mitogen-activated protein kinase kinase kinase 20 Proteins 0.000 claims 11
- 101001030625 Homo sapiens Mucin-like protein 1 Proteins 0.000 claims 11
- 101000957340 Homo sapiens Multivesicular body subunit 12B Proteins 0.000 claims 11
- 101001071238 Homo sapiens PHD finger protein 14 Proteins 0.000 claims 11
- 101001018494 Homo sapiens Pro-MCH Proteins 0.000 claims 11
- 101000829127 Homo sapiens Somatostatin receptor type 2 Proteins 0.000 claims 11
- 101000651291 Homo sapiens TRAF-interacting protein with FHA domain-containing protein B Proteins 0.000 claims 11
- 101000658581 Homo sapiens Transmembrane 4 L6 family member 4 Proteins 0.000 claims 11
- 101000764622 Homo sapiens Transmembrane and immunoglobulin domain-containing protein 2 Proteins 0.000 claims 11
- 101000655149 Homo sapiens Transmembrane protein 154 Proteins 0.000 claims 11
- 101000787917 Homo sapiens Transmembrane protein 200A Proteins 0.000 claims 11
- 101000638161 Homo sapiens Tumor necrosis factor ligand superfamily member 6 Proteins 0.000 claims 11
- 102100027004 Inhibin beta A chain Human genes 0.000 claims 11
- 102100031802 Interferon-induced GTP-binding protein Mx1 Human genes 0.000 claims 11
- 102100020881 Interleukin-1 alpha Human genes 0.000 claims 11
- 102100033494 LIM domain transcription factor LMO4 Human genes 0.000 claims 11
- 102100033304 Leucine-rich repeat-containing protein 4 Human genes 0.000 claims 11
- 102100032352 Leukemia inhibitory factor Human genes 0.000 claims 11
- 108090000581 Leukemia inhibitory factor Proteins 0.000 claims 11
- 102100031783 Metallothionein-1M Human genes 0.000 claims 11
- 102100039374 Mitochondrial calcium uniporter regulator 1 Human genes 0.000 claims 11
- 102100033116 Mitogen-activated protein kinase kinase kinase 20 Human genes 0.000 claims 11
- 108091006675 Monovalent cation:proton antiporter-2 Proteins 0.000 claims 11
- 108091006676 Monovalent cation:proton antiporter-3 Proteins 0.000 claims 11
- 102100038565 Mucin-like protein 1 Human genes 0.000 claims 11
- 102100038748 Multivesicular body subunit 12B Human genes 0.000 claims 11
- 101100372838 Mus musculus Vnn3 gene Proteins 0.000 claims 11
- 102100036866 PHD finger protein 14 Human genes 0.000 claims 11
- 101100146539 Podospora anserina RPS15 gene Proteins 0.000 claims 11
- 102100033721 Pro-MCH Human genes 0.000 claims 11
- 102100023802 Somatostatin receptor type 2 Human genes 0.000 claims 11
- 102100027653 TRAF-interacting protein with FHA domain-containing protein B Human genes 0.000 claims 11
- 102100034897 Transmembrane 4 L6 family member 4 Human genes 0.000 claims 11
- 102100026224 Transmembrane and immunoglobulin domain-containing protein 2 Human genes 0.000 claims 11
- 102100033042 Transmembrane protein 154 Human genes 0.000 claims 11
- 102100025940 Transmembrane protein 200A Human genes 0.000 claims 11
- 102100031988 Tumor necrosis factor ligand superfamily member 6 Human genes 0.000 claims 11
- 102100034397 Uroporphyrinogen-III synthase Human genes 0.000 claims 11
- 108020000963 Uroporphyrinogen-III synthase Proteins 0.000 claims 11
- 108010019691 inhibin beta A subunit Proteins 0.000 claims 11
- 229910052717 sulfur Inorganic materials 0.000 claims 11
- 101001019615 Homo sapiens Interleukin-18 receptor accessory protein Proteins 0.000 claims 10
- 102100035010 Interleukin-18 receptor accessory protein Human genes 0.000 claims 10
- 239000000523 sample Substances 0.000 claims 10
- 125000003275 alpha amino acid group Chemical group 0.000 claims 9
- 101001046687 Homo sapiens Integrin alpha-E Proteins 0.000 claims 8
- 102100022341 Integrin alpha-E Human genes 0.000 claims 8
- 229910052740 iodine Inorganic materials 0.000 claims 7
- 239000003153 chemical reaction reagent Substances 0.000 claims 6
- 229910052698 phosphorus Inorganic materials 0.000 claims 6
- 229910052757 nitrogen Inorganic materials 0.000 claims 5
- 230000004044 response Effects 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 229910052700 potassium Inorganic materials 0.000 claims 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 3
- 230000004043 responsiveness Effects 0.000 claims 3
- LRDIEHDJWYRVPT-UHFFFAOYSA-N 4-amino-5-hydroxynaphthalene-1-sulfonic acid Chemical compound C1=CC(O)=C2C(N)=CC=C(S(O)(=O)=O)C2=C1 LRDIEHDJWYRVPT-UHFFFAOYSA-N 0.000 claims 2
- UBDHSURDYAETAL-UHFFFAOYSA-N 8-aminonaphthalene-1,3,6-trisulfonic acid Chemical compound OS(=O)(=O)C1=CC(S(O)(=O)=O)=C2C(N)=CC(S(O)(=O)=O)=CC2=C1 UBDHSURDYAETAL-UHFFFAOYSA-N 0.000 claims 2
- 206010009900 Colitis ulcerative Diseases 0.000 claims 2
- 108091007491 NSP3 Papain-like protease domains Proteins 0.000 claims 2
- 206010038063 Rectal haemorrhage Diseases 0.000 claims 2
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 2
- 238000005259 measurement Methods 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- USWINTIHFQKJTR-UHFFFAOYSA-N 3-hydroxynaphthalene-2,7-disulfonic acid Chemical compound C1=C(S(O)(=O)=O)C=C2C=C(S(O)(=O)=O)C(O)=CC2=C1 USWINTIHFQKJTR-UHFFFAOYSA-N 0.000 claims 1
- 101100315554 Arabidopsis thaliana ECH gene Proteins 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 238000003559 RNA-seq method Methods 0.000 claims 1
- 238000011529 RT qPCR Methods 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 229910052805 deuterium Inorganic materials 0.000 claims 1
- 238000001839 endoscopy Methods 0.000 claims 1
- 230000035876 healing Effects 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 230000000968 intestinal effect Effects 0.000 claims 1
- 238000002493 microarray Methods 0.000 claims 1
- 230000002093 peripheral effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461971379P | 2014-03-27 | 2014-03-27 | |
| US61/971,379 | 2014-03-27 | ||
| PCT/US2015/022762 WO2015148809A1 (en) | 2014-03-27 | 2015-03-26 | Methods for diagnosing and treating inflammatory bowel disease |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019210883A Division JP2020062013A (ja) | 2014-03-27 | 2019-11-21 | 炎症性腸疾患の診断及び治療のための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017511131A JP2017511131A (ja) | 2017-04-20 |
| JP2017511131A5 true JP2017511131A5 (enExample) | 2018-05-10 |
| JP7054990B2 JP7054990B2 (ja) | 2022-04-15 |
Family
ID=54196399
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016559188A Active JP7054990B2 (ja) | 2014-03-27 | 2015-03-26 | 炎症性腸疾患の診断及び治療のための方法 |
| JP2019210883A Withdrawn JP2020062013A (ja) | 2014-03-27 | 2019-11-21 | 炎症性腸疾患の診断及び治療のための方法 |
| JP2021185176A Pending JP2022043033A (ja) | 2014-03-27 | 2021-11-12 | 炎症性腸疾患の診断及び治療のための方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019210883A Withdrawn JP2020062013A (ja) | 2014-03-27 | 2019-11-21 | 炎症性腸疾患の診断及び治療のための方法 |
| JP2021185176A Pending JP2022043033A (ja) | 2014-03-27 | 2021-11-12 | 炎症性腸疾患の診断及び治療のための方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US10273542B2 (enExample) |
| EP (1) | EP3122377A4 (enExample) |
| JP (3) | JP7054990B2 (enExample) |
| KR (2) | KR20220065091A (enExample) |
| CN (2) | CN106102767B (enExample) |
| AR (1) | AR099856A1 (enExample) |
| AU (3) | AU2015235986B2 (enExample) |
| BR (1) | BR112016020053A2 (enExample) |
| CA (1) | CA2939246A1 (enExample) |
| IL (2) | IL247266B (enExample) |
| MA (1) | MA39804A (enExample) |
| MX (2) | MX2016012282A (enExample) |
| RU (1) | RU2016136716A (enExample) |
| SG (1) | SG11201607938UA (enExample) |
| WO (1) | WO2015148809A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100255508A1 (en) * | 2008-05-16 | 2010-10-07 | Thomas Richard Gelzleichter | Use of biomarkers for assessing treatment of gastrointestinal inflammatory disorders with beta7 integrin antagonists |
| MA39804A (fr) | 2014-03-27 | 2017-02-01 | Hoffmann La Roche | Méthodes permettant le diagnostic et le traitement d'une maladie inflammatoire de l'intestin |
| JP2018507868A (ja) * | 2015-02-26 | 2018-03-22 | ジェネンテック， インコーポレイテッド | インテグリンベータ７アンタゴニスト及びクローン病の治療方法 |
| GB201611738D0 (en) * | 2016-07-05 | 2016-08-17 | Cambridge Entpr Ltd | Biomarkers for inflammatory bowel disease |
| CN107083423B (zh) * | 2017-03-27 | 2022-01-28 | 北京极客基因科技有限公司 | 一种药物靶点预测和药物全方面评价方法 |
| EP3773573A4 (en) | 2018-04-12 | 2022-04-06 | Morphic Therapeutic, Inc. | ANTAGONISTS OF HUMAN INTEGRIN (ALPHA4) (BETA7) |
| EP3884276A2 (en) * | 2018-11-23 | 2021-09-29 | Katholieke Universiteit Leuven | Predicting a treatment response in inflammatory bowel disease |
| EP3935581A4 (en) | 2019-03-04 | 2022-11-30 | Iocurrents, Inc. | DATA COMPRESSION AND COMMUNICATION USING MACHINE LEARNING |
| WO2020232125A1 (en) | 2019-05-14 | 2020-11-19 | Prometheus Biosciences, Inc. | Tl1a patient selection methods, systems, and devices |
| RS66976B1 (sr) | 2019-10-16 | 2025-07-31 | Morphic Therapeutic Inc | Inhibiranje ljudskog integrina alfa4beta7 |
| US12394524B2 (en) * | 2020-07-22 | 2025-08-19 | Iterative Scopes, Inc. | Systems and methods for analysis of medical images for scoring of inflammatory bowel disease |
| EP4188958A1 (en) | 2020-07-31 | 2023-06-07 | Genentech, Inc. | Anti-integrin beta7 antibody formulations and devices |
| GB2616129A (en) * | 2020-09-01 | 2023-08-30 | Scipher Medicine Corp | Methods and systems for predicting response to anti-TNF therapies |
| EP4467573A4 (en) * | 2021-10-15 | 2025-08-06 | Yichen Therapeutics Ltd | BISPECIFIC BINDING MOLECULE |
| CN114085908B (zh) * | 2021-10-30 | 2023-08-08 | 中国人民解放军陆军军医大学第一附属医院 | 用于评估胶质母细胞瘤治疗效果的基因靶点组合及其应用 |
| AU2024282654A1 (en) | 2023-05-30 | 2025-12-04 | Paragon Therapeutics, Inc. | Alpha4beta7 integrin antibody compositions and methods of use |
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- 2015-03-26 JP JP2016559188A patent/JP7054990B2/ja active Active
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