AR099856A1 - Métodos para diagnosticar y tratar la enfermedad de intestino inflamado - Google Patents
Métodos para diagnosticar y tratar la enfermedad de intestino inflamadoInfo
- Publication number
- AR099856A1 AR099856A1 ARP150100901A ARP150100901A AR099856A1 AR 099856 A1 AR099856 A1 AR 099856A1 AR P150100901 A ARP150100901 A AR P150100901A AR P150100901 A ARP150100901 A AR P150100901A AR 099856 A1 AR099856 A1 AR 099856A1
- Authority
- AR
- Argentina
- Prior art keywords
- level
- measured
- patient
- hepg
- mrna expression
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
- C07K16/2842—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta1-subunit-containing molecules, e.g. CD29, CD49
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- General Engineering & Computer Science (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Reivindicación 1: Un método para predecir la respuesta de un paciente que sufre de un trastorno inflamatorio gastrointestinal a una terapia que comprende un antagonista de integrina b7, en donde el método comprende: obtener una muestra biológica del paciente; medir el nivel de expresión de ARNm de al menos uno, al menos dos, al menos tres o al menos cuatro Genes Predictivos de Alta Expresión (HEPG) en la muestra seleccionada de GZMA, KLRB1, FOXM1, CCDC90A, CCL4, CPA2, CXCR6, DDO, ECH1, FAM125B, FASLG, FGF9, GPR15, GZMB, KCNMA1, PHF14, TIFAB, TMEM200A, TMIGD2 y SLC8A3; comparar el nivel de expresión de ARNm detectado en la muestra con un nivel de referencia para cada uno de los HEPG medidos; y predecir que el paciente responderá a la terapia cuando el nivel de expresión de ARNm de cada uno de los HEPG medidos haya sido medido como elevado en comparación con el respectivo nivel de referencia para cada uno de los HEPG medidos. Reivindicación 4: Un método para tratar a un paciente que tiene un trastorno inflamatorio gastrointestinal, en donde el método comprende: (a) medir el nivel de expresión de ARNm de al menos uno, al menos dos, al menos tres o al menos cuatro HEPG seleccionados de GZMA, KLRB1, FOXM1, CCDC90A, CCL4, CPA2, CXCR6, DDO, ECH1, FAM125B, FASLG, FGF9, GPR15, GZMB, KCNMA1, PHF14, TIFAB, TMEM200A, TMIGD2 y SLC8A3 en una muestra biológica del paciente; (b) comparar el nivel de expresión de ARNm de cada HEPG medido en (a) con un nivel de referencia para cada uno de los HEPG medidos; (c) identificar al paciente como uno que probablemente responda a la terapia que comprende un antagonista de integrina b7 cuando el nivel de expresión de ARNm de cada HEPG medido en (a) está por encima el respectivo nivel de referencia para cada uno de los HEPG medidos; y (d) administrar la terapia cuando el nivel de expresión de ARNm de cada HEPG medido en (a) está por encima del respectivo nivel de referencia para cada uno de los HEPG medidos, con lo cual se trata el trastorno inflamatorio gastrointestinal. Reivindicación 41: Un kit para estratificar a un paciente que sufre de un trastorno inflamatorio gastrointestinal, en donde el kit comprende: (a) reactivos para medir el nivel de ARNm de al menos uno, al menos dos, al menos tres o al menos cuatro marcadores seleccionados de GZMA, KLRB1, FOXM1, CCDC90A, CCL4L1.2, CPA2, CXCR6, DDO, ECH1, FAM125B, FASLG, FGF9, GPR15, GZMB, KCNMA1, PHF14, TIFAB, TMEM200A, TMIGD2 y SLC8A3 en una muestra biológica obtenida del paciente; y (b) instrucciones para (i) medir el nivel de ARNm de al menos uno, al menos dos, al menos tres o al menos cuatro marcadores, (ii) comparar el nivel del al menos uno, al menos dos, al menos tres o al menos cuatro marcadores con un nivel de referencia, y (iii) estratificar al paciente en la categoría de respondedor al antagonista de integrina b7 o no respondedor al antagonista de integrina b7 sobre la base de la comparación.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461971379P | 2014-03-27 | 2014-03-27 |
Publications (1)
Publication Number | Publication Date |
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AR099856A1 true AR099856A1 (es) | 2016-08-24 |
Family
ID=54196399
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP150100901A AR099856A1 (es) | 2014-03-27 | 2015-03-26 | Métodos para diagnosticar y tratar la enfermedad de intestino inflamado |
Country Status (15)
Country | Link |
---|---|
US (4) | US10273542B2 (es) |
EP (1) | EP3122377A4 (es) |
JP (3) | JP7054990B2 (es) |
KR (2) | KR20220065091A (es) |
CN (2) | CN113604543A (es) |
AR (1) | AR099856A1 (es) |
AU (3) | AU2015235986B2 (es) |
BR (1) | BR112016020053A2 (es) |
CA (1) | CA2939246A1 (es) |
IL (2) | IL247266B (es) |
MA (1) | MA39804A (es) |
MX (2) | MX2016012282A (es) |
RU (1) | RU2016136716A (es) |
SG (1) | SG11201607938UA (es) |
WO (1) | WO2015148809A1 (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI2279004T1 (sl) * | 2008-05-16 | 2015-05-29 | F. Hoffmann-La Roche Ag | Uporaba biomarkerjev za ocenjevanje zdravljenja gastrointestinalnih vnetnih motenj z antagonisti beta7 integrina |
CN113604543A (zh) | 2014-03-27 | 2021-11-05 | 豪夫迈·罗氏有限公司 | 用于诊断和治疗炎症性肠病的方法 |
EP3262072A1 (en) * | 2015-02-26 | 2018-01-03 | F. Hoffmann-La Roche AG | Integrin beta7 antagonists and methods of treating crohn's disease |
GB201611738D0 (en) * | 2016-07-05 | 2016-08-17 | Cambridge Entpr Ltd | Biomarkers for inflammatory bowel disease |
CN107083423B (zh) * | 2017-03-27 | 2022-01-28 | 北京极客基因科技有限公司 | 一种药物靶点预测和药物全方面评价方法 |
JP7365358B2 (ja) | 2018-04-12 | 2023-10-19 | モーフィック セラピューティック,インコーポレイテッド | ヒトインテグリンα4β7のアンタゴニスト |
WO2020104705A2 (en) * | 2018-11-23 | 2020-05-28 | Katholieke Universiteit Leuven | Predicting a treatment response in inflammatory bowel disease |
US11216742B2 (en) | 2019-03-04 | 2022-01-04 | Iocurrents, Inc. | Data compression and communication using machine learning |
KR20220102669A (ko) | 2019-10-16 | 2022-07-20 | 모픽 테라퓨틱, 인코포레이티드 | 인간 인테그린 α4β7의 억제 |
AU2021316017A1 (en) | 2020-07-31 | 2023-02-16 | F. Hoffmann-La Roche Ag | Anti-integrin beta7 antibody formulations and devices |
WO2023061502A1 (zh) * | 2021-10-15 | 2023-04-20 | 苏州生物医药转化工程中心 | 一种双特异性结合分子 |
CN114085908B (zh) * | 2021-10-30 | 2023-08-08 | 中国人民解放军陆军军医大学第一附属医院 | 用于评估胶质母细胞瘤治疗效果的基因靶点组合及其应用 |
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