ECSP17025787A - Uso de paneles de genes mutantes de fgfr en la identificación de pacientes con cáncer que responderán al tratamiento con un inhibidor de fgfr - Google Patents

Uso de paneles de genes mutantes de fgfr en la identificación de pacientes con cáncer que responderán al tratamiento con un inhibidor de fgfr

Info

Publication number
ECSP17025787A
ECSP17025787A ECIEPI201725787A ECPI201725787A ECSP17025787A EC SP17025787 A ECSP17025787 A EC SP17025787A EC IEPI201725787 A ECIEPI201725787 A EC IEPI201725787A EC PI201725787 A ECPI201725787 A EC PI201725787A EC SP17025787 A ECSP17025787 A EC SP17025787A
Authority
EC
Ecuador
Prior art keywords
fgfr
respond
treatment
cancer patients
mutant gene
Prior art date
Application number
ECIEPI201725787A
Other languages
English (en)
Inventor
Bimbo S A B De C V Grupo
S A R L Abbvie
Original Assignee
Janssen Pharmaceutica Nv
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Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of ECSP17025787A publication Critical patent/ECSP17025787A/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2531/00—Reactions of nucleic acids characterised by
    • C12Q2531/10—Reactions of nucleic acids characterised by the purpose being amplify/increase the copy number of target nucleic acid
    • C12Q2531/113—PCR
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

En la presente descripción, se describen métodos para identificar un paciente con cáncer que responderá al tratamiento con un inhibidor del receptor del factor de crecimiento de fibroblastos (FGFR) y métodos para tratar pacientes con cáncer. Los métodos implican evaluar una muestra biológica del paciente para detectar la presencia de uno o más mutantes de FGFR a partir de un panel de genes mutantes de FGFR. En la presente descripción se describen, además, estuches e iniciadores para identificar la presencia de uno o más genes mutantes de FGFR en una muestra biológica.
ECIEPI201725787A 2014-09-26 2017-04-26 Uso de paneles de genes mutantes de fgfr en la identificación de pacientes con cáncer que responderán al tratamiento con un inhibidor de fgfr ECSP17025787A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462056159P 2014-09-26 2014-09-26

Publications (1)

Publication Number Publication Date
ECSP17025787A true ECSP17025787A (es) 2018-07-31

Family

ID=54337343

Family Applications (1)

Application Number Title Priority Date Filing Date
ECIEPI201725787A ECSP17025787A (es) 2014-09-26 2017-04-26 Uso de paneles de genes mutantes de fgfr en la identificación de pacientes con cáncer que responderán al tratamiento con un inhibidor de fgfr

Country Status (38)

Country Link
US (3) US20160090633A1 (es)
EP (2) EP3198033B1 (es)
JP (4) JP6766037B2 (es)
KR (3) KR102839867B1 (es)
CN (2) CN113957146A (es)
AR (1) AR102345A1 (es)
AU (3) AU2015321626B2 (es)
CA (1) CA2962075C (es)
CO (1) CO2017003528A2 (es)
CR (1) CR20170104A (es)
CY (1) CY1125190T1 (es)
DK (1) DK3198033T3 (es)
EA (1) EA037920B1 (es)
EC (1) ECSP17025787A (es)
ES (1) ES2912567T3 (es)
GT (1) GT201700059A (es)
HR (1) HRP20220496T1 (es)
HU (1) HUE058219T2 (es)
IL (3) IL324511A (es)
JO (1) JO3681B1 (es)
LT (1) LT3198033T (es)
MA (1) MA40761B1 (es)
MX (2) MX392774B (es)
MY (1) MY194567A (es)
NI (1) NI201700035A (es)
PH (1) PH12017500556A1 (es)
PL (1) PL3198033T3 (es)
PT (1) PT3198033T (es)
RS (1) RS63178B1 (es)
SG (1) SG11201702381QA (es)
SI (1) SI3198033T1 (es)
SM (1) SMT202200177T1 (es)
SV (1) SV2017005415A (es)
TW (1) TWI706136B (es)
UA (1) UA122564C2 (es)
UY (1) UY36325A (es)
WO (1) WO2016048833A2 (es)
ZA (1) ZA201702899B (es)

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WO2016048833A2 (en) 2016-03-31
UY36325A (es) 2016-04-01
CO2017003528A2 (es) 2017-07-11
SV2017005415A (es) 2017-07-03
MX2017003954A (es) 2017-12-14
HRP20220496T1 (hr) 2022-05-27
KR20220162823A (ko) 2022-12-08
US20190078166A1 (en) 2019-03-14
IL291633A (en) 2022-05-01
IL251264B (en) 2022-04-01
DK3198033T3 (da) 2022-04-11
JP2022109910A (ja) 2022-07-28
EP4063516A1 (en) 2022-09-28
AU2021277633A1 (en) 2021-12-23
KR20170062495A (ko) 2017-06-07
RS63178B1 (sr) 2022-06-30
WO2016048833A3 (en) 2016-05-19
UA122564C2 (uk) 2020-12-10
NZ730886A (en) 2024-08-30
BR112017006088A2 (pt) 2017-12-19
MX392774B (es) 2025-03-24
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