MA40761A - Utilisation de panels de gènes mutants du fgfr dans l'identification de patients atteints de cancer qui seront sensibles à un traitement avec un inhibiteur du fgfr - Google Patents
Utilisation de panels de gènes mutants du fgfr dans l'identification de patients atteints de cancer qui seront sensibles à un traitement avec un inhibiteur du fgfrInfo
- Publication number
- MA40761A MA40761A MA040761A MA40761A MA40761A MA 40761 A MA40761 A MA 40761A MA 040761 A MA040761 A MA 040761A MA 40761 A MA40761 A MA 40761A MA 40761 A MA40761 A MA 40761A
- Authority
- MA
- Morocco
- Prior art keywords
- fgfr
- cancer
- sensitive
- treatment
- mutant gene
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Wood Science & Technology (AREA)
- Pathology (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Oncology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462056159P | 2014-09-26 | 2014-09-26 | |
| PCT/US2015/050996 WO2016048833A2 (fr) | 2014-09-26 | 2015-09-18 | Utilisation de panels de gènes mutants du fgfr dans l'identification de patients atteints de cancer qui seront sensibles à un traitement avec un inhibiteur du fgfr |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA40761A true MA40761A (fr) | 2017-08-01 |
| MA40761B1 MA40761B1 (fr) | 2022-04-29 |
Family
ID=54337343
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA40761A MA40761B1 (fr) | 2014-09-26 | 2015-09-18 | Utilisation de panels de gènes mutants du fgfr dans l'identification de patients atteints de cancer qui seront sensibles à un traitement avec un inhibiteur du fgfr |
Country Status (37)
| Country | Link |
|---|---|
| US (3) | US20160090633A1 (fr) |
| EP (2) | EP3198033B1 (fr) |
| JP (3) | JP6766037B2 (fr) |
| KR (2) | KR102470456B1 (fr) |
| CN (2) | CN107002141B (fr) |
| AR (1) | AR102345A1 (fr) |
| AU (2) | AU2015321626B2 (fr) |
| BR (1) | BR112017006088A2 (fr) |
| CA (1) | CA2962075A1 (fr) |
| CO (1) | CO2017003528A2 (fr) |
| CR (1) | CR20170104A (fr) |
| DK (1) | DK3198033T3 (fr) |
| EA (1) | EA037920B1 (fr) |
| EC (1) | ECSP17025787A (fr) |
| ES (1) | ES2912567T3 (fr) |
| GT (1) | GT201700059A (fr) |
| HR (1) | HRP20220496T1 (fr) |
| HU (1) | HUE058219T2 (fr) |
| IL (2) | IL251264B (fr) |
| JO (1) | JO3681B1 (fr) |
| LT (1) | LT3198033T (fr) |
| MA (1) | MA40761B1 (fr) |
| MX (2) | MX2017003954A (fr) |
| MY (1) | MY194567A (fr) |
| NI (1) | NI201700035A (fr) |
| PH (1) | PH12017500556A1 (fr) |
| PL (1) | PL3198033T3 (fr) |
| PT (1) | PT3198033T (fr) |
| RS (1) | RS63178B1 (fr) |
| SG (1) | SG11201702381QA (fr) |
| SI (1) | SI3198033T1 (fr) |
| SV (1) | SV2017005415A (fr) |
| TW (1) | TWI706136B (fr) |
| UA (1) | UA122564C2 (fr) |
| UY (1) | UY36325A (fr) |
| WO (1) | WO2016048833A2 (fr) |
| ZA (1) | ZA201702899B (fr) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2673943C2 (ru) | 2012-09-27 | 2018-12-03 | Чугаи Сейяку Кабусики Кайся | Fgfr3 гибридный ген и лекарственный препарат, нацеленный на него |
| US10048277B2 (en) | 2014-01-24 | 2018-08-14 | Japanese Foundation For Cancer Research | Method for detecting an FGFR3/TACC3 fusion protein, or encoding gene thereof |
| PL3122358T3 (pl) | 2014-03-26 | 2021-06-14 | Astex Therapeutics Ltd. | Połączenia inhibitorów fgfr i cmet w leczeniu nowotworu |
| LT3198033T (lt) | 2014-09-26 | 2022-05-10 | Janssen Pharmaceutica Nv | Fgfr mutantinių genų rinkinių panaudojimas identifikuojant vėžiu sergančius pacientus, kurie reaguos į gydymą fgfr inhibitoriumi |
| JOP20200201A1 (ar) | 2015-02-10 | 2017-06-16 | Astex Therapeutics Ltd | تركيبات صيدلانية تشتمل على n-(3.5- ثنائي ميثوكسي فينيل)-n'-(1-ميثيل إيثيل)-n-[3-(ميثيل-1h-بيرازول-4-يل) كينوكسالين-6-يل]إيثان-1.2-ثنائي الأمين |
| US10478494B2 (en) * | 2015-04-03 | 2019-11-19 | Astex Therapeutics Ltd | FGFR/PD-1 combination therapy for the treatment of cancer |
| EP3424505A4 (fr) * | 2016-03-04 | 2019-10-16 | Taiho Pharmaceutical Co., Ltd. | Préparation et composition de traitement de tumeurs malignes |
| US11883404B2 (en) | 2016-03-04 | 2024-01-30 | Taiho Pharmaceuticals Co., Ltd. | Preparation and composition for treatment of malignant tumors |
| JOP20190280A1 (ar) | 2017-06-02 | 2019-12-02 | Janssen Pharmaceutica Nv | مثبطات fgfr2 لعلاج سرطان الأوعية الصفراوية |
| JOP20210052A1 (ar) * | 2018-09-21 | 2021-03-18 | Janssen Pharmaceutica Nv | علاج سرطان الأوعية الصفراوية |
| JOP20210260A1 (ar) | 2019-03-29 | 2023-01-30 | Janssen Pharmaceutica Nv | مثبطات كيناز تيروسين مستقبل عامل نمو الأرومة الليفية لمعالجة كارسينوما الظهارة البولية |
| CN113645974A (zh) | 2019-03-29 | 2021-11-12 | 詹森药业有限公司 | 用于治疗尿路上皮癌的fgfr酪氨酸激酶抑制剂 |
| WO2020243442A1 (fr) * | 2019-05-31 | 2020-12-03 | Qed Therapeutics, Inc. | Procédés de traitement de cancers du système urinaire |
| CN110241183B (zh) * | 2019-06-13 | 2022-10-28 | 南京世和基因生物技术股份有限公司 | 一种fgfr融合基因的检测方法、试剂盒以及探针库 |
| CN115335701A (zh) * | 2019-09-09 | 2022-11-11 | 泽普托生命技术有限责任公司 | 用于检测核酸中基因变异的系统和方法 |
| AU2020352668A1 (en) | 2019-09-26 | 2022-03-31 | Janssen Pharmaceutica Nv | Use of FGFR inhibitors in FGFR-genetically altered cancers to enhance patient response to immune checkpoint inhibitors in sequential treatment settings |
| TW202140012A (zh) | 2020-02-12 | 2021-11-01 | 比利時商健生藥品公司 | 用於治療尿路上皮癌的ｆｇｆｒ酪胺酸激酶抑制劑和抗ｐｄ１藥劑 |
| WO2021160764A1 (fr) | 2020-02-12 | 2021-08-19 | Janssen Pharmaceutica Nv | Inhibiteurs de la tyrosine kinase fgfr pour le traitement du cancer de la vessie invasif non musculaire à haut risque |
| CN115916241A (zh) * | 2020-04-15 | 2023-04-04 | 奥克梅斯制药爱尔兰有限公司 | 与血管生成抑制剂组合的免疫刺激剂 |
| CN111440790A (zh) * | 2020-05-08 | 2020-07-24 | 公安部物证鉴定中心 | 唾液斑迹dna和rna同时提取的方法 |
| CA3191538A1 (fr) | 2020-09-14 | 2022-03-17 | Ademi Elena SANTIAGO-WALKER | Therapies combinees d'inhibiteurs de fgfr |
| CN112143815B (zh) * | 2020-11-25 | 2021-02-26 | 江苏申基生物科技有限公司 | 一种用于检测人fgfr2基因融合突变的核酸组合物、试剂盒及检测方法 |
| EP4340840A1 (fr) | 2021-05-19 | 2024-03-27 | JANSSEN Pharmaceutica NV | Inhibiteurs de tyrosine kinase fgfr destinés au traitement des tumeurs solides avancées |
| CA3235311A1 (fr) | 2021-10-12 | 2023-04-20 | Taris Biomedical Llc | Formulations d'erdafitinib et systemes d'administration intravesicale |
| WO2023159216A1 (fr) | 2022-02-18 | 2023-08-24 | Taris Biomedical Llc | Formulations d'erdafitinib et systèmes osmotiques pour administration intravésicale |
| WO2024170495A1 (fr) | 2023-02-13 | 2024-08-22 | Janssen Pharmaceutica Nv | Inhibiteurs de la tyrosine kinase fgfr pour le traitement du cancer de la vessie invasif non musculaire à haut risque |
| WO2024173377A1 (fr) | 2023-02-13 | 2024-08-22 | Taris Biomedical Llc | Erdafitinib pour administration intravésicale destiné à être utilisé dans le traitement du cancer de la vessie |
| WO2024173716A1 (fr) | 2023-02-17 | 2024-08-22 | Taris Biomedical Llc | Erdafitinib pour administration intravésicale destiné à être utilisé dans le traitement du cancer de la vessie |
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| US7135311B1 (en) | 1999-05-05 | 2006-11-14 | Institut Curie | Means for detecting and treating pathologies linked to FGFR3 |
| ES2280218T5 (es) | 1999-05-05 | 2010-05-14 | Institut Curie | Medios de deteccion y tratamiento de patologias asociadas a fgfr3. |
| JP4649331B2 (ja) | 2002-10-01 | 2011-03-09 | エピゲノミクス アーゲー | 乳房細胞増殖障害の改良治療方法および核酸 |
| DE602004022266D1 (de) * | 2003-03-26 | 2009-09-10 | Progenika Biopharma Sa | Lkarzinoms der blase |
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| KR20080080525A (ko) * | 2005-12-08 | 2008-09-04 | 노파르티스 아게 | 유전자 전사에 대한 ｆｇｆｒ３의 억제제의 효과 |
| EP1918376A1 (fr) * | 2006-11-03 | 2008-05-07 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | FGFR4 favorise la résistance des cellules cancéreuses en réponse aux agents chimiothérapeutiques |
| AU2008220821B2 (en) | 2007-02-27 | 2012-09-13 | Novartis Ag | A method of identification of cells that show sensitivity to modulation of signaling mediated by a Fibroblast Growth Factor Receptor or a variant thereof |
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| US8163923B2 (en) | 2007-03-14 | 2012-04-24 | Advenchen Laboratories, Llc | Spiro substituted compounds as angiogenesis inhibitors |
| CN101970111B (zh) | 2007-06-21 | 2013-09-11 | 简·探针公司 | 用于执行处理的仪器和容器 |
| US8071338B2 (en) | 2007-08-08 | 2011-12-06 | Roche Molecular Systems, Inc. | Suppression of amplification using an oligonucleotide and a polymerase significantly lacking 5′-3′ nuclease activity |
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| AR073770A1 (es) | 2008-10-20 | 2010-12-01 | Imclone Llc | Anticuerpo aislado que se enlaza especificamente con, e induce la degradacion del receptor-3 del factor de crecimiento del fibroblasto humano (fgfr-3), fragmento de enlace fgfr-3 humano del mismo, composicion farmaceutica y producto que lo comprenden |
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| JP6382194B2 (ja) * | 2012-07-24 | 2018-08-29 | ザ トラスティーズ オブ コロンビア ユニバーシティ イン ザ シティ オブ ニューヨーク | 融合タンパク質およびその方法 |
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| RU2673943C2 (ru) * | 2012-09-27 | 2018-12-03 | Чугаи Сейяку Кабусики Кайся | Fgfr3 гибридный ген и лекарственный препарат, нацеленный на него |
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| US9783853B2 (en) | 2013-07-12 | 2017-10-10 | The Regents Of The University Of Michigan | Recurrent gene fusions in cancer |
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| LT3198033T (lt) | 2014-09-26 | 2022-05-10 | Janssen Pharmaceutica Nv | Fgfr mutantinių genų rinkinių panaudojimas identifikuojant vėžiu sergančius pacientus, kurie reaguos į gydymą fgfr inhibitoriumi |
| JOP20190190A1 (ar) | 2017-02-06 | 2019-08-04 | Janssen Pharmaceutica Nv | معالجة سرطان |
-
2015
- 2015-09-18 LT LTEPPCT/US2015/050996T patent/LT3198033T/lt unknown
- 2015-09-18 KR KR1020177010946A patent/KR102470456B1/ko active IP Right Grant
- 2015-09-18 HR HRP20220496TT patent/HRP20220496T1/hr unknown
- 2015-09-18 CN CN201580064601.1A patent/CN107002141B/zh active Active
- 2015-09-18 PT PT157821091T patent/PT3198033T/pt unknown
- 2015-09-18 ES ES15782109T patent/ES2912567T3/es active Active
- 2015-09-18 US US14/858,627 patent/US20160090633A1/en not_active Abandoned
- 2015-09-18 CN CN202111247854.6A patent/CN113957146A/zh active Pending
- 2015-09-18 RS RS20220400A patent/RS63178B1/sr unknown
- 2015-09-18 CR CR20170104A patent/CR20170104A/es unknown
- 2015-09-18 MX MX2017003954A patent/MX2017003954A/es unknown
- 2015-09-18 WO PCT/US2015/050996 patent/WO2016048833A2/fr active Application Filing
- 2015-09-18 AU AU2015321626A patent/AU2015321626B2/en active Active
- 2015-09-18 KR KR1020227040649A patent/KR20220162823A/ko active Search and Examination
- 2015-09-18 EP EP15782109.1A patent/EP3198033B1/fr active Active
- 2015-09-18 BR BR112017006088A patent/BR112017006088A2/pt active Search and Examination
- 2015-09-18 HU HUE15782109A patent/HUE058219T2/hu unknown
- 2015-09-18 PL PL15782109.1T patent/PL3198033T3/pl unknown
- 2015-09-18 SI SI201531836T patent/SI3198033T1/sl unknown
- 2015-09-18 UA UAA201704090A patent/UA122564C2/uk unknown
- 2015-09-18 EA EA201790716A patent/EA037920B1/ru unknown
- 2015-09-18 JP JP2017516458A patent/JP6766037B2/ja active Active
- 2015-09-18 MY MYPI2017700955A patent/MY194567A/en unknown
- 2015-09-18 MA MA40761A patent/MA40761B1/fr unknown
- 2015-09-18 SG SG11201702381QA patent/SG11201702381QA/en unknown
- 2015-09-18 EP EP22156319.0A patent/EP4063516A1/fr active Pending
- 2015-09-18 DK DK15782109.1T patent/DK3198033T3/da active
- 2015-09-18 CA CA2962075A patent/CA2962075A1/fr active Pending
- 2015-09-22 JO JOP/2015/0238A patent/JO3681B1/ar active
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