JP2015522246A5 - - Google Patents
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- JP2015522246A5 JP2015522246A5 JP2015503288A JP2015503288A JP2015522246A5 JP 2015522246 A5 JP2015522246 A5 JP 2015522246A5 JP 2015503288 A JP2015503288 A JP 2015503288A JP 2015503288 A JP2015503288 A JP 2015503288A JP 2015522246 A5 JP2015522246 A5 JP 2015522246A5
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- JP
- Japan
- Prior art keywords
- seq
- amino acid
- acid sequence
- antibody
- cdr
- Prior art date
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261616394P | 2012-03-27 | 2012-03-27 | |
| US61/616,394 | 2012-03-27 | ||
| US201261707411P | 2012-09-28 | 2012-09-28 | |
| US61/707,411 | 2012-09-28 | ||
| PCT/US2013/031178 WO2013148232A1 (en) | 2012-03-27 | 2013-03-14 | Methods of prognosing, diagnosing and treating idiopathic pulmonary fibrosis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015522246A JP2015522246A (ja) | 2015-08-06 |
| JP2015522246A5 true JP2015522246A5 (enExample) | 2016-05-12 |
| JP6404208B2 JP6404208B2 (ja) | 2018-10-10 |
Family
ID=49261043
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015503288A Active JP6404208B2 (ja) | 2012-03-27 | 2013-03-14 | 特発性肺線維症の予後予測、診断および処置の方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US20160230226A1 (enExample) |
| EP (2) | EP3725892A1 (enExample) |
| JP (1) | JP6404208B2 (enExample) |
| KR (1) | KR102197524B1 (enExample) |
| CN (2) | CN104334744A (enExample) |
| AR (1) | AR090339A1 (enExample) |
| AU (2) | AU2013240344A1 (enExample) |
| BR (1) | BR112014023348A2 (enExample) |
| CA (1) | CA2864884A1 (enExample) |
| HK (1) | HK1206796A1 (enExample) |
| IL (1) | IL256396A (enExample) |
| MX (2) | MX370486B (enExample) |
| NZ (1) | NZ628458A (enExample) |
| RU (1) | RU2014139546A (enExample) |
| SG (2) | SG10201702842SA (enExample) |
| WO (1) | WO2013148232A1 (enExample) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10236078B2 (en) | 2008-11-17 | 2019-03-19 | Veracyte, Inc. | Methods for processing or analyzing a sample of thyroid tissue |
| EP3360978A3 (en) | 2009-05-07 | 2018-09-26 | Veracyte, Inc. | Methods for diagnosis of thyroid conditions |
| EP2754672B1 (en) | 2011-09-06 | 2019-02-27 | Shino-Test Corporation | Antibody capable of binding to specific region of periostin, and method of measuring periostin using the same |
| US11976329B2 (en) | 2013-03-15 | 2024-05-07 | Veracyte, Inc. | Methods and systems for detecting usual interstitial pneumonia |
| CA2919498C (en) | 2013-07-31 | 2023-07-25 | Windward Pharma, Inc. | Aerosol nintedanib compounds and uses thereof |
| BR112016008694A2 (pt) * | 2013-10-23 | 2017-10-03 | Genentech Inc | Métodos de previsão da reação de pacientes com asma, de previsão da capacidade de reação de pacientes com asma, de identificação de pacientes com asma, de tratamento de pacientes portadores de asma e de tratamento de asma, uso de um kit e kit |
| JP6312054B2 (ja) * | 2013-11-06 | 2018-04-18 | 学校法人日本大学 | 間質性肺炎のバイオマーカー |
| MX2016006252A (es) * | 2013-11-14 | 2017-02-02 | Proterris Inc | Tratamiento o prevencion de afecciones pulmonares con monoxido de carbono. |
| AU2014386209B2 (en) * | 2013-12-20 | 2021-03-11 | President And Fellows Of Harvard College | Low shear microfluidic devices and methods of use and manufacturing thereof |
| US9970935B2 (en) | 2014-02-06 | 2018-05-15 | The Brigham And Women's Hospital, Inc. | Uses of GLI1 in detecting tissue fibrosis |
| TW201618795A (zh) | 2014-04-15 | 2016-06-01 | 波泰里斯股份有限公司 | 用以改良器官功能及延長器官移植物壽命之系統及方法 |
| WO2015164716A1 (en) * | 2014-04-25 | 2015-10-29 | Brown University | Methods for the diagnosis and treatment of pulmonary fibrosis in subjects with hermansky pudlak syndrome |
| US9913819B2 (en) | 2014-06-12 | 2018-03-13 | Yale University | Methods of treating or preventing fibrotic lung diseases |
| EP2957634A1 (en) | 2014-06-20 | 2015-12-23 | Consejo Superior De Investigaciones Científicas | Compounds for prevention and/or treatment of fibrotic diseases |
| US12297505B2 (en) | 2014-07-14 | 2025-05-13 | Veracyte, Inc. | Algorithms for disease diagnostics |
| US20170335396A1 (en) | 2014-11-05 | 2017-11-23 | Veracyte, Inc. | Systems and methods of diagnosing idiopathic pulmonary fibrosis on transbronchial biopsies using machine learning and high dimensional transcriptional data |
| CN104792998B (zh) * | 2015-03-09 | 2016-06-08 | 中国人民解放军第四军医大学 | Loxl2抗原用于制备甲状腺癌预示、侵袭、转移试剂盒的应用 |
| CN111718413A (zh) * | 2015-06-26 | 2020-09-29 | 上海市肿瘤研究所 | Cthrc1在肝硬化诊断和治疗中的应用 |
| WO2017044752A1 (en) * | 2015-09-10 | 2017-03-16 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Anti-fibrotic effect of cd70 |
| PL3368512T3 (pl) | 2015-10-27 | 2024-05-27 | Taipei Medical University | Pochodne indoliny do leczenia i/albo zapobiegania chorobie zwłóknieniowej |
| CN105400870B (zh) * | 2015-11-11 | 2018-09-25 | 南方医科大学 | CD1c在菌阴肺结核诊断中的应用 |
| AU2016360661B2 (en) * | 2015-11-23 | 2023-12-14 | Merck Patent Gmbh | Anti-alpha-v integrin antibody for the treatment of fibrosis and/or fibrotic disorders |
| US20190144547A1 (en) | 2015-11-23 | 2019-05-16 | Merck Patent Gmbh | Anti-alpha-v integrin antibody for the treatment of fibrosis and/or fibrotic disorders |
| EP3464240A1 (en) * | 2016-05-27 | 2019-04-10 | Boehringer Ingelheim International GmbH | Use of ecm biomarkers for the determining the treatment onset with nintedanib and pirfenidone |
| CN106319058B (zh) * | 2016-08-31 | 2019-09-10 | 汪道文 | 一种检测特发性肺纤维化致病基因的dna文库及其应用 |
| CA3033241A1 (en) * | 2016-09-07 | 2018-03-15 | Veracyte, Inc. | Methods and systems for detecting usual interstitial pneumonia |
| WO2018081236A1 (en) * | 2016-10-28 | 2018-05-03 | Cedars-Sinai Medical Center | Method of predicting progression of idiopathic pulmonary fibrosis and monitoring of therapeutic efficacy |
| US20200017913A1 (en) * | 2017-03-02 | 2020-01-16 | President And Fellows Of Harvard College | Methods and systems for predicting treatment responses in subjects |
| IT201700026858A1 (it) * | 2017-03-10 | 2018-09-10 | Univ Degli Studi Padova | Uso di inibitori delle serin proteasi, in particolare di serpinb3 |
| US20190127456A1 (en) * | 2017-10-31 | 2019-05-02 | Fibrogen, Inc. | Methods of treating idiopathic pulmonary fibrosis |
| CN108931645A (zh) * | 2018-07-26 | 2018-12-04 | 北京大学第医院 | 一种hcv清除后肝纤维化评估系统及评估方法 |
| KR20210084453A (ko) | 2018-09-10 | 2021-07-07 | 렁 세라퓨틱스, 인크. | Cav-1 단백질의 변형된 펩타이드 단편 및 섬유증의 치료에 있어서 이의 용도 |
| WO2020090683A1 (ja) * | 2018-10-29 | 2020-05-07 | 国立大学法人東京医科歯科大学 | 間質性肺炎患者の呼吸機能の低下リスクに関する情報を取得する方法及びその利用 |
| US12480960B2 (en) | 2019-01-11 | 2025-11-25 | University Of Virginia Patent Foundation | Compositions and methods for predicting lung function decline in idiopathic pulmonary fibrosis |
| CN116157688A (zh) * | 2020-07-31 | 2023-05-23 | 基因泰克公司 | 用于治疗炎症性呼吸系统疾病的恶化的方法 |
| CA3209638A1 (en) | 2021-02-25 | 2022-09-01 | Lung Therapeutics, Inc. | Biomarkers for the treatment of interstitial lung disease |
| JP2024523034A (ja) * | 2021-06-18 | 2024-06-25 | エフ． ホフマン－ラ ロシュ アーゲー | 二重特異性抗ｃｃｌ２抗体 |
| ES2957479B2 (es) * | 2022-06-07 | 2025-07-28 | Baigene S L | Metodo de obtencion de datos utiles para la prediccion del riesgo de un sujeto de sufrir fibrosis |
| JP2025522482A (ja) | 2022-06-17 | 2025-07-15 | アポジー バイオロジクス， インコーポレイテッド | インターロイキン１３に結合する抗体及び使用方法 |
| CN115925920B (zh) * | 2022-08-04 | 2023-07-25 | 瑞因细胞工程科技(广州)有限公司 | 一种基因增强型免疫细胞治疗肝硬化的方法 |
| EP4619762A1 (en) * | 2022-11-14 | 2025-09-24 | Alentis Therapeutics AG | Biomarkers for fibrosis treatment using anti-claudin-1 antibodies |
| CN117747093B (zh) * | 2024-02-20 | 2024-06-07 | 神州医疗科技股份有限公司 | 一种特发性肺纤维化诊断模型的构建方法及诊断系统 |
| CN119162300A (zh) * | 2024-09-12 | 2024-12-20 | 中国人民解放军陆军军医大学第一附属医院 | 用于预测肺纤维化程度及预后情况的标志物、模型及应用 |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4018653A (en) | 1971-10-29 | 1977-04-19 | U.S. Packaging Corporation | Instrument for the detection of Neisseria gonorrhoeae without culture |
| US4016043A (en) | 1975-09-04 | 1977-04-05 | Akzona Incorporated | Enzymatic immunological method for the determination of antigens and antibodies |
| US4424279A (en) | 1982-08-12 | 1984-01-03 | Quidel | Rapid plunger immunoassay method and apparatus |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5175384A (en) | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
| US5413923A (en) | 1989-07-25 | 1995-05-09 | Cell Genesys, Inc. | Homologous recombination for universal donor cells and chimeric mammalian hosts |
| ES2087997T3 (es) | 1990-01-12 | 1996-08-01 | Cell Genesys Inc | Generacion de anticuerpos xenogenicos. |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
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| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| ES2108048T3 (es) | 1990-08-29 | 1997-12-16 | Genpharm Int | Produccion y utilizacion de animales inferiores transgenicos capaces de producir anticuerpos heterologos. |
| US5814318A (en) | 1990-08-29 | 1998-09-29 | Genpharm International Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| ATE463573T1 (de) | 1991-12-02 | 2010-04-15 | Medimmune Ltd | Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken |
| ES2136664T3 (es) | 1992-06-09 | 1999-12-01 | Hoppe Ag | Sistema de cierre y conjunto de cerradura. |
| EP0822830B1 (en) | 1995-04-27 | 2008-04-02 | Amgen Fremont Inc. | Human anti-IL-8 antibodies, derived from immunized xenomice |
| CA2219486A1 (en) | 1995-04-28 | 1996-10-31 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| DE19544393A1 (de) | 1995-11-15 | 1997-05-22 | Hoechst Schering Agrevo Gmbh | Synergistische herbizide Mischungen |
| US5916771A (en) | 1996-10-11 | 1999-06-29 | Abgenix, Inc. | Production of a multimeric protein by cell fusion method |
| EP2305027B1 (en) | 1996-12-03 | 2014-07-02 | Amgen Fremont Inc. | Transgenic mammals having human Ig loci including plural VH and Vkappa regions and antibodies produced therefrom |
| AR045614A1 (es) * | 2003-09-10 | 2005-11-02 | Hoffmann La Roche | Anticuerpos contra el recepctor de la interleuquina- 1 y los usos de los mismos |
| DK2805728T3 (da) * | 2003-12-23 | 2020-04-20 | Genentech Inc | Hidtil ukendte anti-IL13-antistoffer og anvendelser deraf |
| WO2006124451A2 (en) | 2005-05-11 | 2006-11-23 | Centocor, Inc. | Anti-il-13 antibodies, compositions, methods and uses |
| WO2007036745A2 (en) | 2005-09-30 | 2007-04-05 | Medimmune Limited | Interleukin-13 antibody composition |
| MY144906A (en) | 2005-10-21 | 2011-11-30 | Novartis Ag | Human antibodies against il13 and therapeutic uses |
| CA2965211C (en) * | 2006-01-13 | 2020-06-30 | Indiana University Research & Technology Corporation | Type v collagen-related molecules for the treatment of lung disease involving autoimmunity to type v collagen _________________________________________ |
| TWI395754B (zh) * | 2006-04-24 | 2013-05-11 | Amgen Inc | 人類化之ｃ-ｋｉｔ抗體 |
| CA2665808A1 (en) * | 2006-10-05 | 2008-05-22 | Centocor Ortho Biotech Inc. | Ccr2 antagonists for treatment of fibrosis |
| WO2008083695A1 (de) | 2006-12-20 | 2008-07-17 | Patent-Treuhand-Gesellschaft für elektrische Glühlampen mbH | Vorrichtung und verfahren zur messung der intensität des lichtes einer ersten gruppe von lichtquellen einer beleuchtungseinheit |
| JP2010527916A (ja) * | 2007-04-23 | 2010-08-19 | ワイス・エルエルシー | Ｉｌ−１３関連障害を治療する方法および組成物ならびにその治療をモニターする方法 |
| EP2050764A1 (en) * | 2007-10-15 | 2009-04-22 | sanofi-aventis | Novel polyvalent bispecific antibody format and uses thereof |
| JP5580205B2 (ja) * | 2007-11-19 | 2014-08-27 | セレラ コーポレーション | 肺癌マーカーとその使用 |
| RU2607569C2 (ru) * | 2008-03-31 | 2017-01-10 | Дженентек, Инк. | Композиции и способы для лечения и диагностики астмы |
| WO2010028274A1 (en) * | 2008-09-05 | 2010-03-11 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Marker panels for idiopathic pulmonary fibrosis diagnosis and evaluation |
| EA201100653A1 (ru) * | 2008-11-26 | 2011-12-30 | Глаксо Груп Лимитед | Лиганды, связывающиеся с интерлейкином-13 (il-13) |
| WO2010141469A2 (en) * | 2009-06-01 | 2010-12-09 | Case Western Reserve University | Protein biomarkers and therapeutic targets for autoimmune and alloimmune diseases |
| JP6005657B2 (ja) * | 2010-12-16 | 2016-10-12 | ジェネンテック， インコーポレイテッド | Ｔｈ２阻害に関連する診断及び治療 |
-
2013
- 2013-03-14 CN CN201380027564.8A patent/CN104334744A/zh active Pending
- 2013-03-14 KR KR1020147029554A patent/KR102197524B1/ko not_active Expired - Fee Related
- 2013-03-14 SG SG10201702842SA patent/SG10201702842SA/en unknown
- 2013-03-14 EP EP20153153.0A patent/EP3725892A1/en not_active Withdrawn
- 2013-03-14 WO PCT/US2013/031178 patent/WO2013148232A1/en not_active Ceased
- 2013-03-14 CA CA2864884A patent/CA2864884A1/en not_active Abandoned
- 2013-03-14 BR BR112014023348-9A patent/BR112014023348A2/pt not_active IP Right Cessation
- 2013-03-14 SG SG11201405830VA patent/SG11201405830VA/en unknown
- 2013-03-14 NZ NZ628458A patent/NZ628458A/en not_active IP Right Cessation
- 2013-03-14 EP EP13768451.0A patent/EP2831280B1/en active Active
- 2013-03-14 HK HK15107420.8A patent/HK1206796A1/xx unknown
- 2013-03-14 MX MX2014011503A patent/MX370486B/es active IP Right Grant
- 2013-03-14 AU AU2013240344A patent/AU2013240344A1/en not_active Abandoned
- 2013-03-14 AR ARP130100827A patent/AR090339A1/es unknown
- 2013-03-14 CN CN201611178102.8A patent/CN107099581B/zh active Active
- 2013-03-14 JP JP2015503288A patent/JP6404208B2/ja active Active
- 2013-03-14 RU RU2014139546A patent/RU2014139546A/ru not_active Application Discontinuation
-
2014
- 2014-09-23 US US14/493,649 patent/US20160230226A1/en not_active Abandoned
- 2014-09-25 MX MX2019015159A patent/MX2019015159A/es unknown
-
2017
- 2017-12-18 IL IL256396A patent/IL256396A/en unknown
-
2018
- 2018-03-16 US US15/924,114 patent/US20190062836A1/en not_active Abandoned
- 2018-10-16 AU AU2018250393A patent/AU2018250393A1/en not_active Abandoned
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