KR102197524B1 - 특발성 폐 섬유증의 예후, 진단 및 치료 방법 - Google Patents

특발성 폐 섬유증의 예후, 진단 및 치료 방법 Download PDF

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KR102197524B1
KR102197524B1 KR1020147029554A KR20147029554A KR102197524B1 KR 102197524 B1 KR102197524 B1 KR 102197524B1 KR 1020147029554 A KR1020147029554 A KR 1020147029554A KR 20147029554 A KR20147029554 A KR 20147029554A KR 102197524 B1 KR102197524 B1 KR 102197524B1
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antibody
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KR20140143196A (ko
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알렉산더 알. 압바스
조셉 알. 아론
산제이 찬드리아니
구이콴 지아
니콜라스 제이.아이. 르윈-코
대릴 데피안토
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제넨테크, 인크.
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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • G01N2333/914Hydrolases (3)
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    • G01N2333/964Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96486Metalloendopeptidases (3.4.24)
    • G01N2333/96491Metalloendopeptidases (3.4.24) with definite EC number
    • G01N2333/96494Matrix metalloproteases, e. g. 3.4.24.7
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    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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KR1020147029554A 2012-03-27 2013-03-14 특발성 폐 섬유증의 예후, 진단 및 치료 방법 Expired - Fee Related KR102197524B1 (ko)

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Application Number Priority Date Filing Date Title
US201261616394P 2012-03-27 2012-03-27
US61/616,394 2012-03-27
US201261707411P 2012-09-28 2012-09-28
US61/707,411 2012-09-28
PCT/US2013/031178 WO2013148232A1 (en) 2012-03-27 2013-03-14 Methods of prognosing, diagnosing and treating idiopathic pulmonary fibrosis

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KR20140143196A KR20140143196A (ko) 2014-12-15
KR102197524B1 true KR102197524B1 (ko) 2020-12-31

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US (2) US20160230226A1 (enExample)
EP (2) EP2831280B1 (enExample)
JP (1) JP6404208B2 (enExample)
KR (1) KR102197524B1 (enExample)
CN (2) CN107099581B (enExample)
AR (1) AR090339A1 (enExample)
AU (2) AU2013240344A1 (enExample)
BR (1) BR112014023348A2 (enExample)
CA (1) CA2864884A1 (enExample)
HK (1) HK1206796A1 (enExample)
IL (1) IL256396A (enExample)
MX (2) MX370486B (enExample)
NZ (1) NZ628458A (enExample)
RU (1) RU2014139546A (enExample)
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Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10236078B2 (en) 2008-11-17 2019-03-19 Veracyte, Inc. Methods for processing or analyzing a sample of thyroid tissue
JP6078339B2 (ja) 2009-05-07 2017-02-08 ベラサイト インコーポレイテッド 甲状腺状態の診断のための方法および組成物
US9347954B2 (en) 2011-09-06 2016-05-24 Shino-Test Corporation Antibody capable of binding to specific region of periostin, and method of measuring periostin using the same
US11976329B2 (en) 2013-03-15 2024-05-07 Veracyte, Inc. Methods and systems for detecting usual interstitial pneumonia
US20150044288A1 (en) 2013-07-31 2015-02-12 Windward Pharma, Inc. Aerosol tyrosine kinase inhibitor compounds and uses thereof
AR098155A1 (es) * 2013-10-23 2016-05-04 Genentech Inc Métodos para diagnosticar y tratar trastornos eosinofílicos
JP6312054B2 (ja) * 2013-11-06 2018-04-18 学校法人日本大学 間質性肺炎のバイオマーカー
EP3068409A4 (en) * 2013-11-14 2017-08-23 Proterris, Inc. Treatment or prevention of pulmonary conditions with carbon monoxide
CA2934662C (en) 2013-12-20 2024-02-20 President And Fellows Of Harvard College Low shear microfluidic devices and methods of use and manufacturing thereof
WO2015120257A2 (en) * 2014-02-06 2015-08-13 The Brigham And Women's Hospital, Inc. Uses of gli1 in detecting tissue fibrosis
TW201618795A (zh) 2014-04-15 2016-06-01 波泰里斯股份有限公司 用以改良器官功能及延長器官移植物壽命之系統及方法
US9994905B2 (en) 2014-04-25 2018-06-12 Brown University Methods for the diagnosis and treatment of pulmonary fibrosis in subjects with hermansky pudlak syndrome
WO2015191841A1 (en) * 2014-06-12 2015-12-17 Yale University Novel methods of treating or preventing fibrotic lung diseases
EP2957634A1 (en) 2014-06-20 2015-12-23 Consejo Superior De Investigaciones Científicas Compounds for prevention and/or treatment of fibrotic diseases
US12297505B2 (en) 2014-07-14 2025-05-13 Veracyte, Inc. Algorithms for disease diagnostics
EP3770274A1 (en) 2014-11-05 2021-01-27 Veracyte, Inc. Systems and methods of diagnosing idiopathic pulmonary fibrosis on transbronchial biopsies using machine learning and high dimensional transcriptional data
CN104792998B (zh) * 2015-03-09 2016-06-08 中国人民解放军第四军医大学 Loxl2抗原用于制备甲状腺癌预示、侵袭、转移试剂盒的应用
CN106290892A (zh) * 2015-06-26 2017-01-04 上海市肿瘤研究所 Cthrc1在肝硬化诊断和治疗中的应用
WO2017044752A1 (en) * 2015-09-10 2017-03-16 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Anti-fibrotic effect of cd70
ES2965877T3 (es) * 2015-10-27 2024-04-17 Univ Taipei Medical Derivados de indolina para el tratamiento y/o la prevención de enfermedades fibróticas
CN105400870B (zh) * 2015-11-11 2018-09-25 南方医科大学 CD1c在菌阴肺结核诊断中的应用
US20190144547A1 (en) * 2015-11-23 2019-05-16 Merck Patent Gmbh Anti-alpha-v integrin antibody for the treatment of fibrosis and/or fibrotic disorders
TW201720843A (zh) * 2015-11-23 2017-06-16 馬克專利公司 用於治療纖維化及/或纖維化病症之抗-αV整合素抗體
WO2017203027A1 (en) * 2016-05-27 2017-11-30 Boehringer Ingelheim International Gmbh Use of ecm biomarkers for the determining the treatment onset with nintedanib and pirfenidone
CN106319058B (zh) * 2016-08-31 2019-09-10 汪道文 一种检测特发性肺纤维化致病基因的dna文库及其应用
AU2017324949B2 (en) * 2016-09-07 2024-05-23 Veracyte, Inc. Methods and systems for detecting usual interstitial pneumonia
WO2018081236A1 (en) * 2016-10-28 2018-05-03 Cedars-Sinai Medical Center Method of predicting progression of idiopathic pulmonary fibrosis and monitoring of therapeutic efficacy
WO2018160925A1 (en) * 2017-03-02 2018-09-07 President And Fellows Of Harvard College Methods and systems for predicting treatment responses in subjects
IT201700026858A1 (it) * 2017-03-10 2018-09-10 Univ Degli Studi Padova Uso di inibitori delle serin proteasi, in particolare di serpinb3
US20190127456A1 (en) * 2017-10-31 2019-05-02 Fibrogen, Inc. Methods of treating idiopathic pulmonary fibrosis
CN108931645A (zh) * 2018-07-26 2018-12-04 北京大学第医院 一种hcv清除后肝纤维化评估系统及评估方法
AU2019339260B2 (en) 2018-09-10 2025-06-26 Rein Therapeutics, Inc. Modified peptide fragments of Cav-1 protein and the use thereof in the treatment of fibrosis
WO2020090683A1 (ja) * 2018-10-29 2020-05-07 国立大学法人東京医科歯科大学 間質性肺炎患者の呼吸機能の低下リスクに関する情報を取得する方法及びその利用
EP3908668A4 (en) * 2019-01-11 2022-11-09 University of Virginia Patent Foundation COMPOSITIONS AND METHODS FOR PREDICTING LUNG FUNCTION DECLINE RELATED TO IDIOPATHIC PULMONARY FIBROSIS
JP2023536159A (ja) * 2020-07-31 2023-08-23 ジェネンテック, インコーポレイテッド 炎症性呼吸器疾患の増悪を治療するための方法
AU2022226999A1 (en) 2021-02-25 2023-10-05 Rein Therapeutics, Inc. Biomarkers for the treatment of interstitial lung disease
ES2957479B2 (es) * 2022-06-07 2025-07-28 Baigene S L Metodo de obtencion de datos utiles para la prediccion del riesgo de un sujeto de sufrir fibrosis
EP4540284A2 (en) 2022-06-17 2025-04-23 Apogee Therapeutics, Inc. Antibodies that bind interleukin 13 and methods of use
CN115925920B (zh) * 2022-08-04 2023-07-25 瑞因细胞工程科技(广州)有限公司 一种基因增强型免疫细胞治疗肝硬化的方法
EP4619762A1 (en) * 2022-11-14 2025-09-24 Alentis Therapeutics AG Biomarkers for fibrosis treatment using anti-claudin-1 antibodies
CN117747093B (zh) * 2024-02-20 2024-06-07 神州医疗科技股份有限公司 一种特发性肺纤维化诊断模型的构建方法及诊断系统
CN119162300A (zh) * 2024-09-12 2024-12-20 中国人民解放军陆军军医大学第一附属医院 用于预测肺纤维化程度及预后情况的标志物、模型及应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090214523A1 (en) * 2003-12-23 2009-08-27 Genentech, Inc. Novel anti-IL13 antibodies and uses thereof
US20120035067A1 (en) * 2008-09-05 2012-02-09 Naftali Kaminski Marker Panels For Idiopathic Pulmonary Fibrosis Diagnosis And Evaluation

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4018653A (en) 1971-10-29 1977-04-19 U.S. Packaging Corporation Instrument for the detection of Neisseria gonorrhoeae without culture
US4016043A (en) 1975-09-04 1977-04-05 Akzona Incorporated Enzymatic immunological method for the determination of antigens and antibodies
US4424279A (en) 1982-08-12 1984-01-03 Quidel Rapid plunger immunoassay method and apparatus
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5175384A (en) 1988-12-05 1992-12-29 Genpharm International Transgenic mice depleted in mature t-cells and methods for making transgenic mice
US5413923A (en) 1989-07-25 1995-05-09 Cell Genesys, Inc. Homologous recombination for universal donor cells and chimeric mammalian hosts
DE69133566T2 (de) 1990-01-12 2007-12-06 Amgen Fremont Inc. Bildung von xenogenen Antikörpern
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5814318A (en) 1990-08-29 1998-09-29 Genpharm International Inc. Transgenic non-human animals for producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
KR100272077B1 (ko) 1990-08-29 2000-11-15 젠팜인터내셔날,인코포레이티드 이종 항체를 생산할 수 있는 전이유전자를 가진 인간이외의 동물
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
ATE408012T1 (de) 1991-12-02 2008-09-15 Medical Res Council Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken
ATE182651T1 (de) 1992-06-09 1999-08-15 Hoppe Ag Riegel und türschloss
JP4312259B2 (ja) 1995-04-27 2009-08-12 アムジェン フレモント インク. 免疫したゼノマウス(XenoMouse)に由来するヒト抗体
EP0823941A4 (en) 1995-04-28 2001-09-19 Abgenix Inc HUMAN ANTIBODIES DERIVED FROM IMMUNIZED XENO MOUSES
DE19544393A1 (de) 1995-11-15 1997-05-22 Hoechst Schering Agrevo Gmbh Synergistische herbizide Mischungen
US5916771A (en) 1996-10-11 1999-06-29 Abgenix, Inc. Production of a multimeric protein by cell fusion method
DE69738539T2 (de) 1996-12-03 2009-03-26 Amgen Fremont Inc. Vollkommen humane Antikörper die EGFR binden
AR045614A1 (es) * 2003-09-10 2005-11-02 Hoffmann La Roche Anticuerpos contra el recepctor de la interleuquina- 1 y los usos de los mismos
WO2006124451A2 (en) 2005-05-11 2006-11-23 Centocor, Inc. Anti-il-13 antibodies, compositions, methods and uses
JP2009510046A (ja) 2005-09-30 2009-03-12 メドイミューン・リミテッド インターロイキン−13抗体組成物
MY144906A (en) 2005-10-21 2011-11-30 Novartis Ag Human antibodies against il13 and therapeutic uses
BRPI0706575B8 (pt) * 2006-01-13 2021-05-25 Univ Indiana Res & Tech Corp uso colágeno de tipo v ou um componente antigênico do mesmo, e, método para identificar um paciente em espera de transplante de pulmão para um risco aumentado de rejeição de tecido de órgão transplantado.
TWI395754B (zh) * 2006-04-24 2013-05-11 Amgen Inc 人類化之c-kit抗體
AU2007319660A1 (en) * 2006-10-05 2008-05-22 Centocor Ortho Biotech Inc. CCR2 antagonists for treatment of fibrosis
WO2008083695A1 (de) 2006-12-20 2008-07-17 Patent-Treuhand-Gesellschaft für elektrische Glühlampen mbH Vorrichtung und verfahren zur messung der intensität des lichtes einer ersten gruppe von lichtquellen einer beleuchtungseinheit
RU2009140134A (ru) * 2007-04-23 2011-05-27 Вайет (Us) Способы и композиции для лечения и мониторинга лечения связанных с ил-13 нарушений
EP2050764A1 (en) * 2007-10-15 2009-04-22 sanofi-aventis Novel polyvalent bispecific antibody format and uses thereof
EP2227556B1 (en) * 2007-11-19 2014-08-27 Celera Corporation Lung cancer markers and uses thereof
RU2607569C2 (ru) * 2008-03-31 2017-01-10 Дженентек, Инк. Композиции и способы для лечения и диагностики астмы
EP2358754A1 (en) * 2008-11-26 2011-08-24 Glaxo Group Limited Ligands that bind il-13
WO2010141469A2 (en) * 2009-06-01 2010-12-09 Case Western Reserve University Protein biomarkers and therapeutic targets for autoimmune and alloimmune diseases
KR101615474B1 (ko) * 2010-12-16 2016-04-25 제넨테크, 인크. Th2 억제에 관한 진단 및 치료

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090214523A1 (en) * 2003-12-23 2009-08-27 Genentech, Inc. Novel anti-IL13 antibodies and uses thereof
US20120035067A1 (en) * 2008-09-05 2012-02-09 Naftali Kaminski Marker Panels For Idiopathic Pulmonary Fibrosis Diagnosis And Evaluation

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
A. Belperio et al., The Journal of Immunology, Vol. 173, 2004, pp. 4692-4698.*
Korthagen et al., Respiratory Medicine, Vol. 105, 2011, pp. 106-113.*
M. Korthagen et al., Respiratory Medicine, Vol. 105, 2011, pp. 106-113.*
M. Okamoto et al., European Respiratory Journal, Vol. 37, No. 5, 2011, pp. 1119-1127.*
Pardo et al., PLOS Medicine, Vol. 2, Iss. 9, 2005, pp. 891-903.*
Prasse et al., ARTHRITIS & RHEUMATISM, Vol. 56, No. 5, 2007, pp. 1685-1693.*
S. Bridges et al., The American Journal of Pathology, Vol. 175, No. 6, 2009, pp. 2351-2361.*

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