JP2017505794A5 - - Google Patents
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- Publication number
- JP2017505794A5 JP2017505794A5 JP2016551294A JP2016551294A JP2017505794A5 JP 2017505794 A5 JP2017505794 A5 JP 2017505794A5 JP 2016551294 A JP2016551294 A JP 2016551294A JP 2016551294 A JP2016551294 A JP 2016551294A JP 2017505794 A5 JP2017505794 A5 JP 2017505794A5
- Authority
- JP
- Japan
- Prior art keywords
- tert
- butyl
- pyrazol
- naphthalen
- pyridin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019162164A JP6952085B2 (ja) | 2014-02-14 | 2019-09-05 | キナーゼ阻害剤としてのピラゾリル尿素 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461940282P | 2014-02-14 | 2014-02-14 | |
| US61/940,282 | 2014-02-14 | ||
| US201461941064P | 2014-02-18 | 2014-02-18 | |
| US61/941,064 | 2014-02-18 | ||
| PCT/GB2015/050401 WO2015121660A1 (en) | 2014-02-14 | 2015-02-13 | Pyrazolyl-ureas as kinase inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019162164A Division JP6952085B2 (ja) | 2014-02-14 | 2019-09-05 | キナーゼ阻害剤としてのピラゾリル尿素 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017505794A JP2017505794A (ja) | 2017-02-23 |
| JP2017505794A5 true JP2017505794A5 (OSRAM) | 2019-04-04 |
| JP6586098B2 JP6586098B2 (ja) | 2019-10-02 |
Family
ID=52573661
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016551294A Active JP6586098B2 (ja) | 2014-02-14 | 2015-02-13 | キナーゼ阻害剤としてのピラゾリル尿素 |
| JP2016550815A Active JP6630280B2 (ja) | 2014-02-14 | 2015-02-13 | 抗炎症化合物としての芳香族複素環化合物 |
| JP2019162164A Active JP6952085B2 (ja) | 2014-02-14 | 2019-09-05 | キナーゼ阻害剤としてのピラゾリル尿素 |
| JP2019220267A Active JP6841891B2 (ja) | 2014-02-14 | 2019-12-05 | 抗炎症化合物としての芳香族複素環化合物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016550815A Active JP6630280B2 (ja) | 2014-02-14 | 2015-02-13 | 抗炎症化合物としての芳香族複素環化合物 |
| JP2019162164A Active JP6952085B2 (ja) | 2014-02-14 | 2019-09-05 | キナーゼ阻害剤としてのピラゾリル尿素 |
| JP2019220267A Active JP6841891B2 (ja) | 2014-02-14 | 2019-12-05 | 抗炎症化合物としての芳香族複素環化合物 |
Country Status (20)
| Country | Link |
|---|---|
| US (8) | US9884845B2 (OSRAM) |
| EP (4) | EP3418279B1 (OSRAM) |
| JP (4) | JP6586098B2 (OSRAM) |
| KR (1) | KR102413704B1 (OSRAM) |
| CN (4) | CN106573914B (OSRAM) |
| AU (3) | AU2015216705B2 (OSRAM) |
| BR (1) | BR112016015838B1 (OSRAM) |
| CA (1) | CA2938924C (OSRAM) |
| DK (2) | DK3357919T3 (OSRAM) |
| EA (1) | EA034927B1 (OSRAM) |
| ES (2) | ES2677595T3 (OSRAM) |
| JO (1) | JO3392B1 (OSRAM) |
| MX (2) | MX371312B (OSRAM) |
| PL (2) | PL3105222T3 (OSRAM) |
| PT (2) | PT3105222T (OSRAM) |
| SG (1) | SG11201607058PA (OSRAM) |
| TR (1) | TR201809072T4 (OSRAM) |
| TW (2) | TWI664967B (OSRAM) |
| UY (1) | UY35998A (OSRAM) |
| WO (2) | WO2015121660A1 (OSRAM) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5511680B2 (ja) | 2007-12-19 | 2014-06-04 | キャンサー・リサーチ・テクノロジー・リミテッド | ピリド［２，３−ｂ］ピラジン−８−置換化合物及びその使用 |
| NZ601085A (en) | 2010-02-01 | 2015-04-24 | Cancer Rec Tech Ltd | 1-(5-tert-butyl-2-phenyl-2h-pyrazol-3-yl)-3-[2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1h-imidazo[4,5-b]pyridin-7-yloxy)-phenyl]-urea and related compounds and their use in therapy |
| EP2763984B1 (en) | 2011-10-03 | 2016-04-20 | Respivert Limited | 1-pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl)oxy)napththalen-1-yl)ureas as p38 map kinase inhibitors |
| EP2578582A1 (en) | 2011-10-03 | 2013-04-10 | Respivert Limited | 1-Pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl)oxy)napththalen-1-yl)ureas as p38 MAP kinase inhibitors |
| GB201214750D0 (en) | 2012-08-17 | 2012-10-03 | Respivert Ltd | Compounds |
| WO2014033447A2 (en) | 2012-08-29 | 2014-03-06 | Respivert Limited | Kinase inhibitors |
| US20150210722A1 (en) | 2012-08-29 | 2015-07-30 | Respivert Limited | Kinase inhibitors |
| EP2890701B1 (en) | 2012-08-29 | 2017-03-29 | Respivert Limited | Kinase inhibitors |
| WO2014076484A1 (en) | 2012-11-16 | 2014-05-22 | Respivert Limited | Kinase inhibitors |
| US20160016934A1 (en) | 2013-03-14 | 2016-01-21 | Respivert Limited | Kinase inhibitors |
| BR112015024678B1 (pt) | 2013-04-02 | 2023-02-23 | Oxular Acquisitions Limited | Composto inibidor da cinase, formulação farmacêutica que compreende o mesmo, seus usos, processo para sua preparação e intermediários |
| US9771353B2 (en) | 2013-04-02 | 2017-09-26 | Topivert Pharma Limited | Kinase inhibitors based upon N-alkyl pyrazoles |
| GB201320729D0 (en) | 2013-11-25 | 2014-01-08 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| GB201320732D0 (en) | 2013-11-25 | 2014-01-08 | Cancer Rec Tech Ltd | Methods of chemical synthesis |
| JP6514703B2 (ja) | 2013-12-20 | 2019-05-15 | トピバート ファーマ リミテッド | キナーゼインヒビターとして有用な尿素誘導体 |
| TWI664967B (zh) | 2014-02-14 | 2019-07-11 | 英商瑞斯比維特有限公司 | 新穎化合物（一） |
| MA40775A (fr) | 2014-10-01 | 2017-08-08 | Respivert Ltd | Dérivé d'acide 4-(4-(4-phényluréido-naphtalén -1-yl) oxy-pyridin-2-yl) amino-benzoïque utilisé en tant qu'inhibiteur de la kinase p38 |
| CN105801486A (zh) * | 2016-03-31 | 2016-07-27 | 常州大学 | 一种1-（2,4二溴苯基）-3-吡唑醇的合成方法 |
| CA3015978A1 (en) | 2016-04-06 | 2017-10-12 | Topivert Pharma Limited | Kinase inhibitors |
| AU2017281222B2 (en) * | 2016-06-23 | 2022-06-16 | The Usa As Represented By The Department Of Veterans Affairs; Dept. Of Veterans Affairs Office Of General Counsel - Pag Iv (024) | Non-catalytic substrate-selective P38α-specific MAPK inhibitors with endothelial-stabilizing and anti-inflammatory activity, and methods of use thereof |
| EP3558363A1 (en) | 2016-12-21 | 2019-10-30 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
| PT3691620T (pt) | 2017-10-05 | 2022-10-06 | Fulcrum Therapeutics Inc | Os inibidores da quinase p38 reduzem a expressão de dux4 e genes a jusante para o tratamento de fshd |
| ES3025468T3 (en) | 2018-12-07 | 2025-06-09 | Univ Maryland | Non-atp/catalytic site p38 mitogen activated protein kinase inhibitors |
| EP3914348A1 (en) * | 2019-01-23 | 2021-12-01 | Theravance Biopharma R&D IP, LLC | Imidazo[1,5-a]pyridine, 1,2,4-triazolo[4,3-a]pyridine and imidazo[1,5-a]pyrazine as jak inhibitors |
| EP4153303A1 (en) | 2020-05-18 | 2023-03-29 | GEN1E Lifesciences Inc. | P38alpha mitogen-activated protein kinase inhibitors |
| CN111889025B (zh) * | 2020-09-01 | 2022-01-11 | 山东大学 | 一种耐酸碱耐盐超两亲分子乳化剂及其制备方法和乳液 |
| EP4237415A1 (en) | 2020-10-29 | 2023-09-06 | GEN1E Lifesciences Inc. | Crystalline 5-(dimethylamino)-n-(4-(morpholinomethyl)phenyl) naphthalene-1-sulfonamide di-hydrochloride di-hydrate |
| CA3205921A1 (en) * | 2021-02-03 | 2022-08-11 | Sheng CUI | Formulation of furin inhibitor for inhalation |
| WO2022204046A1 (en) | 2021-03-23 | 2022-09-29 | Gen1E Lifesciences Inc. | Substituted naphthyl p38alpha mitogen-activated protein kinase inhibitors |
| CN116655608B (zh) * | 2023-05-30 | 2025-08-19 | 成都瑞芬思德丹生物科技有限公司 | 一种具有抗炎活性的吡咯烷酮类化合物及其制备方法和应用 |
Family Cites Families (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1043995T3 (da) | 1997-12-22 | 2007-03-05 | Bayer Pharmaceuticals Corp | Inhibering af p38 kinaseaktivitet ved anvendelse af aryl- og heteroaryl-substituerede, heterocykliske urinstoffer |
| RU2265597C2 (ru) | 1997-12-22 | 2005-12-10 | Байер Копэрейшн | Арил- и гетероарилзамещенные гетероциклические производные мочевины, способ ингибирования киназы raf и фармацевтическая композиция |
| US7329670B1 (en) | 1997-12-22 | 2008-02-12 | Bayer Pharmaceuticals Corporation | Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas |
| US20080300281A1 (en) | 1997-12-22 | 2008-12-04 | Jacques Dumas | Inhibition of p38 Kinase Activity Using Aryl and Heteroaryl Substituted Heterocyclic Ureas |
| UA73492C2 (en) * | 1999-01-19 | 2005-08-15 | Aromatic heterocyclic compounds as antiinflammatory agents | |
| EP1200411B1 (en) | 1999-07-09 | 2005-12-14 | Boehringer Ingelheim Pharmaceuticals Inc. | Process for synthesis of heteroaryl-substituted urea compounds |
| CA2389360C (en) | 1999-11-16 | 2008-06-03 | Steffen Breitfelder | Urea derivatives as anti-inflammatory agents |
| US6525046B1 (en) | 2000-01-18 | 2003-02-25 | Boehringer Ingelheim Pharmaceuticals, Inc. | Aromatic heterocyclic compounds as antiinflammatory agents |
| US6492529B1 (en) | 2000-01-18 | 2002-12-10 | Boehringer Ingelheim Pharmaceuticals, Inc. | Bis pyrazole-1H-pyrazole intermediates and their synthesis |
| ATE311366T1 (de) | 2000-02-29 | 2005-12-15 | Millennium Pharm Inc | Benzamide und ähnliche inhibitoren vom faktor xa |
| JP2004530690A (ja) | 2001-05-16 | 2004-10-07 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | 抗炎症性薬剤として有用なジアリールウレア誘導体 |
| ATE360417T1 (de) | 2001-07-11 | 2007-05-15 | Boehringer Ingelheim Pharma | Methode zur behandlung von zytokinvermittelten erkrankungen |
| US20030216396A1 (en) | 2002-02-11 | 2003-11-20 | Bayer Corporation | Pyridine, quinoline, and isoquinoline N-oxides as kinase inhibitors |
| SI1478358T1 (sl) | 2002-02-11 | 2013-09-30 | Bayer Healthcare Llc | Sorafenib tozilat za zdravljenje bolezni, značilnih po abnormalni angiogenezi |
| WO2003072569A1 (en) | 2002-02-25 | 2003-09-04 | Boehringer Ingelheim Pharmaceuticals, Inc. | 1,4-disubstituted benzofused cycloalkyl urea compounds useful in treating cytokine mediated diseases |
| EP1531815B1 (en) | 2002-06-27 | 2014-09-24 | Novo Nordisk A/S | Glucokinase activators |
| AU2003252478A1 (en) | 2002-07-10 | 2004-02-02 | Ono Pharmaceutical Co., Ltd. | Ccr4 antagonist and medicinal use thereof |
| US7557129B2 (en) | 2003-02-28 | 2009-07-07 | Bayer Healthcare Llc | Cyanopyridine derivatives useful in the treatment of cancer and other disorders |
| WO2004078746A2 (en) | 2003-02-28 | 2004-09-16 | Bayer Pharmaceuticals Corporation | 2-oxo-1,3,5-perhydrotriazapine derivatives useful in the treatment of hyper-proliferative, angiogenesis, and inflammatrory disorders |
| WO2005110994A2 (en) | 2004-04-30 | 2005-11-24 | Bayer Pharmaceuticals Corporation | Substituted pyrazolyl urea derivatives useful in the treatment of cancer |
| GB0500435D0 (en) | 2005-01-10 | 2005-02-16 | Novartis Ag | Organic compounds |
| US7700620B2 (en) | 2005-06-27 | 2010-04-20 | Bristol-Myers Squibb Company | C-linked cyclic antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions |
| EA200900571A1 (ru) | 2006-10-20 | 2009-12-30 | Айкос Корпорейшн | Композиции chk1 ингибиторов |
| PT2947072T (pt) | 2008-03-17 | 2016-12-06 | Ambit Biosciences Corp | 1-(3-(6,7-dimetoxiquinazolin-4-iloxi)fenil)-3-(5-(1,1,1-trifluoro-2-metilpropan-2-il)isoxazol-3-il)ureia como modulador da cinase raf no tratamento de doenças oncológicas |
| PE20110598A1 (es) | 2008-10-02 | 2011-08-31 | Respivert Ltd | Inhibidores de las enzimas de proteina cinasa activadas por mitogeno p38 |
| GB0818033D0 (en) | 2008-10-02 | 2008-11-05 | Respivert Ltd | Novel compound |
| MX2011006220A (es) | 2008-12-11 | 2011-06-28 | Respivert Ltd | Inhibidores de la proteina cinasa activada por el mitogeno p38. |
| GB0905955D0 (en) | 2009-04-06 | 2009-05-20 | Respivert Ltd | Novel compounds |
| GB0921730D0 (en) | 2009-12-11 | 2010-01-27 | Respivert Ltd | Method of treatment |
| GB0921731D0 (en) | 2009-12-11 | 2010-01-27 | Respivert Ltd | Theraputic uses |
| EP2738162B1 (en) | 2010-03-15 | 2018-01-03 | Ube Industries, Ltd. | Method for producing amide compound |
| GB201005589D0 (en) | 2010-04-01 | 2010-05-19 | Respivert Ltd | Novel compounds |
| US9260410B2 (en) | 2010-04-08 | 2016-02-16 | Respivert Ltd. | P38 MAP kinase inhibitors |
| JP5787977B2 (ja) | 2010-04-08 | 2015-09-30 | レスピバート・リミテツド | Ｐ３８ｍａｐキナーゼ阻害剤 |
| WO2011158044A2 (en) | 2010-06-17 | 2011-12-22 | Respivert Limited | Respiratory formulations and compounds for use therein |
| GB201010193D0 (en) | 2010-06-17 | 2010-07-21 | Respivert Ltd | Medicinal use |
| GB201010196D0 (en) | 2010-06-17 | 2010-07-21 | Respivert Ltd | Methods |
| EP2763984B1 (en) | 2011-10-03 | 2016-04-20 | Respivert Limited | 1-pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl)oxy)napththalen-1-yl)ureas as p38 map kinase inhibitors |
| EP2578582A1 (en) | 2011-10-03 | 2013-04-10 | Respivert Limited | 1-Pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl)oxy)napththalen-1-yl)ureas as p38 MAP kinase inhibitors |
| WO2013083604A1 (en) | 2011-12-09 | 2013-06-13 | Chiesi Farmaceutici S.P.A. | Kinase inhibitors |
| GB201214750D0 (en) | 2012-08-17 | 2012-10-03 | Respivert Ltd | Compounds |
| GB201215357D0 (en) | 2012-08-29 | 2012-10-10 | Respivert Ltd | Compounds |
| WO2014033447A2 (en) | 2012-08-29 | 2014-03-06 | Respivert Limited | Kinase inhibitors |
| US20150210722A1 (en) | 2012-08-29 | 2015-07-30 | Respivert Limited | Kinase inhibitors |
| EP2890701B1 (en) | 2012-08-29 | 2017-03-29 | Respivert Limited | Kinase inhibitors |
| WO2014076484A1 (en) | 2012-11-16 | 2014-05-22 | Respivert Limited | Kinase inhibitors |
| US20160016934A1 (en) | 2013-03-14 | 2016-01-21 | Respivert Limited | Kinase inhibitors |
| BR112015024678B1 (pt) | 2013-04-02 | 2023-02-23 | Oxular Acquisitions Limited | Composto inibidor da cinase, formulação farmacêutica que compreende o mesmo, seus usos, processo para sua preparação e intermediários |
| US9771353B2 (en) | 2013-04-02 | 2017-09-26 | Topivert Pharma Limited | Kinase inhibitors based upon N-alkyl pyrazoles |
| JP6514703B2 (ja) | 2013-12-20 | 2019-05-15 | トピバート ファーマ リミテッド | キナーゼインヒビターとして有用な尿素誘導体 |
| TWI664967B (zh) * | 2014-02-14 | 2019-07-11 | 英商瑞斯比維特有限公司 | 新穎化合物（一） |
| MA40775A (fr) | 2014-10-01 | 2017-08-08 | Respivert Ltd | Dérivé d'acide 4-(4-(4-phényluréido-naphtalén -1-yl) oxy-pyridin-2-yl) amino-benzoïque utilisé en tant qu'inhibiteur de la kinase p38 |
| EP3201189A1 (en) | 2014-10-01 | 2017-08-09 | Respivert Limited | N-phenyl-3-quinazolin-6-yl-benzamide derivatives as p38 kinase inhibitors |
-
2015
- 2015-02-13 TW TW104104905A patent/TWI664967B/zh active
- 2015-02-13 US US15/118,708 patent/US9884845B2/en active Active
- 2015-02-13 EP EP18186182.4A patent/EP3418279B1/en active Active
- 2015-02-13 MX MX2016010571A patent/MX371312B/es active IP Right Grant
- 2015-02-13 KR KR1020167023275A patent/KR102413704B1/ko active Active
- 2015-02-13 PL PL15705797T patent/PL3105222T3/pl unknown
- 2015-02-13 UY UY0001035998A patent/UY35998A/es active IP Right Grant
- 2015-02-13 WO PCT/GB2015/050401 patent/WO2015121660A1/en not_active Ceased
- 2015-02-13 PL PL18161869T patent/PL3357919T3/pl unknown
- 2015-02-13 CN CN201580019810.4A patent/CN106573914B/zh active Active
- 2015-02-13 EP EP15705797.7A patent/EP3105222B1/en active Active
- 2015-02-13 JP JP2016551294A patent/JP6586098B2/ja active Active
- 2015-02-13 CA CA2938924A patent/CA2938924C/en active Active
- 2015-02-13 MX MX2016010572A patent/MX371353B/es active IP Right Grant
- 2015-02-13 JP JP2016550815A patent/JP6630280B2/ja active Active
- 2015-02-13 CN CN202110516085.9A patent/CN113264921B/zh active Active
- 2015-02-13 PT PT157057977T patent/PT3105222T/pt unknown
- 2015-02-13 SG SG11201607058PA patent/SG11201607058PA/en unknown
- 2015-02-13 CN CN201910753454.9A patent/CN110522731B/zh active Active
- 2015-02-13 EP EP18161869.5A patent/EP3357919B1/en active Active
- 2015-02-13 EA EA201691625A patent/EA034927B1/ru unknown
- 2015-02-13 PT PT181618695T patent/PT3357919T/pt unknown
- 2015-02-13 CN CN201580008529.0A patent/CN106164067B/zh active Active
- 2015-02-13 DK DK18161869.5T patent/DK3357919T3/da active
- 2015-02-13 WO PCT/EP2015/053151 patent/WO2015121444A1/en not_active Ceased
- 2015-02-13 AU AU2015216705A patent/AU2015216705B2/en active Active
- 2015-02-13 US US14/622,368 patent/US9447076B2/en active Active
- 2015-02-13 AU AU2015216957A patent/AU2015216957B2/en active Active
- 2015-02-13 ES ES15705797.7T patent/ES2677595T3/es active Active
- 2015-02-13 DK DK15705797.7T patent/DK3105222T3/en active
- 2015-02-13 BR BR112016015838-5A patent/BR112016015838B1/pt active IP Right Grant
- 2015-02-13 TR TR2018/09072T patent/TR201809072T4/tr unknown
- 2015-02-13 ES ES18161869T patent/ES2774249T3/es active Active
- 2015-02-13 EP EP15706511.1A patent/EP3105223B1/en active Active
- 2015-02-13 TW TW104104906A patent/TWI751099B/zh active
- 2015-02-15 JO JOP/2015/0032A patent/JO3392B1/ar active
-
2016
- 2016-08-31 US US15/253,141 patent/US9624196B2/en active Active
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2017
- 2017-03-13 US US15/457,810 patent/US10045980B2/en active Active
- 2017-12-21 US US15/849,987 patent/US10294216B2/en active Active
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2018
- 2018-07-11 US US16/032,858 patent/US10815217B2/en active Active
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2019
- 2019-03-27 US US16/366,103 patent/US11142515B2/en active Active
- 2019-06-26 AU AU2019204525A patent/AU2019204525B2/en active Active
- 2019-09-05 JP JP2019162164A patent/JP6952085B2/ja active Active
- 2019-12-05 JP JP2019220267A patent/JP6841891B2/ja active Active
-
2020
- 2020-09-24 US US17/031,190 patent/US11634406B2/en active Active
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