JP2017505159A5 - - Google Patents

Info

Publication number

JP2017505159A5

JP2017505159A5 JP2016539077A JP2016539077A JP2017505159A5 JP 2017505159 A5 JP2017505159 A5 JP 2017505159A5 JP 2016539077 A JP2016539077 A JP 2016539077A JP 2016539077 A JP2016539077 A JP 2016539077A JP 2017505159 A5 JP2017505159 A5 JP 2017505159A5

Authority

JP

Japan

Prior art keywords

particulate composition

porous

microns

tricalcium phosphate

powder

Prior art date

2014-12-12

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 239000000203 mixture Substances 0.000 claims 80
• 239000002245 particle Substances 0.000 claims 61
• 239000000843 powder Substances 0.000 claims 46
• QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims 33
• 210000000988 bone and bone Anatomy 0.000 claims 27
• ZOMBKNNSYQHRCA-UHFFFAOYSA-J calcium sulfate hemihydrate Chemical compound O.[Ca+2].[Ca+2].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O ZOMBKNNSYQHRCA-UHFFFAOYSA-J 0.000 claims 26
• 239000004568 cement Substances 0.000 claims 15
• 230000002902 bimodal effect Effects 0.000 claims 12
• 239000001506 calcium phosphate Substances 0.000 claims 11
• 239000010419 fine particle Substances 0.000 claims 11
• 229910000391 tricalcium phosphate Inorganic materials 0.000 claims 11
• 229940078499 tricalcium phosphate Drugs 0.000 claims 11
• 239000007864 aqueous solution Substances 0.000 claims 10
• 239000008187 granular material Substances 0.000 claims 10
• 239000011859 microparticle Substances 0.000 claims 10
• PASHVRUKOFIRIK-UHFFFAOYSA-L calcium sulfate dihydrate Chemical compound O.O.[Ca+2].[O-]S([O-])(=O)=O PASHVRUKOFIRIK-UHFFFAOYSA-L 0.000 claims 5
• ZBZJARSYCHAEND-UHFFFAOYSA-L calcium;dihydrogen phosphate;hydrate Chemical compound O.[Ca+2].OP(O)([O-])=O.OP(O)([O-])=O ZBZJARSYCHAEND-UHFFFAOYSA-L 0.000 claims 5
• 239000012867 bioactive agent Substances 0.000 claims 4
• 150000001735 carboxylic acids Chemical class 0.000 claims 3
• 238000006243 chemical reaction Methods 0.000 claims 3
• 230000007547 defect Effects 0.000 claims 3
• 239000011148 porous material Substances 0.000 claims 3
• 102000002045 Endothelin Human genes 0.000 claims 2
• 108050009340 Endothelin Proteins 0.000 claims 2
• AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims 2
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
• BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 claims 2
• 239000007795 chemical reaction product Substances 0.000 claims 2
• ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 claims 2
• 239000003102 growth factor Substances 0.000 claims 2
• 238000000034 method Methods 0.000 claims 2
• 102000004169 proteins and genes Human genes 0.000 claims 2
• 108090000623 proteins and genes Proteins 0.000 claims 2
• 102100027400 A disintegrin and metalloproteinase with thrombospondin motifs 4 Human genes 0.000 claims 1
• 101710100373 A disintegrin and metalloproteinase with thrombospondin motifs 4 Proteins 0.000 claims 1
• 102100022987 Angiogenin Human genes 0.000 claims 1
• 102000007350 Bone Morphogenetic Proteins Human genes 0.000 claims 1
• 108010007726 Bone Morphogenetic Proteins Proteins 0.000 claims 1
• 108010071942 Colony-Stimulating Factors Proteins 0.000 claims 1
• 102000004127 Cytokines Human genes 0.000 claims 1
• 108090000695 Cytokines Proteins 0.000 claims 1
• 102000009024 Epidermal Growth Factor Human genes 0.000 claims 1
• 101800003838 Epidermal growth factor Proteins 0.000 claims 1
• 102000018233 Fibroblast Growth Factor Human genes 0.000 claims 1
• 108050007372 Fibroblast Growth Factor Proteins 0.000 claims 1
• 102000003972 Fibroblast growth factor 7 Human genes 0.000 claims 1
• 108090000385 Fibroblast growth factor 7 Proteins 0.000 claims 1
• 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims 1
• 102000003693 Hedgehog Proteins Human genes 0.000 claims 1
• 108090000031 Hedgehog Proteins Proteins 0.000 claims 1
• 108090000100 Hepatocyte Growth Factor Proteins 0.000 claims 1
• 102100021866 Hepatocyte growth factor Human genes 0.000 claims 1
• 102100031000 Hepatoma-derived growth factor Human genes 0.000 claims 1
• 101001083798 Homo sapiens Hepatoma-derived growth factor Proteins 0.000 claims 1
• 101000988394 Homo sapiens PDZ and LIM domain protein 5 Proteins 0.000 claims 1
• 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims 1
• 102000015696 Interleukins Human genes 0.000 claims 1
• 108010063738 Interleukins Proteins 0.000 claims 1
• 108010077077 Osteonectin Proteins 0.000 claims 1
• 102000009890 Osteonectin Human genes 0.000 claims 1
• 108010081689 Osteopontin Proteins 0.000 claims 1
• 102000004264 Osteopontin Human genes 0.000 claims 1
• 102100029181 PDZ and LIM domain protein 5 Human genes 0.000 claims 1
• 102000010780 Platelet-Derived Growth Factor Human genes 0.000 claims 1
• 108010038512 Platelet-Derived Growth Factor Proteins 0.000 claims 1
• PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims 1
• 102000013275 Somatomedins Human genes 0.000 claims 1
• CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 1
• 229930006000 Sucrose Natural products 0.000 claims 1
• 102000009618 Transforming Growth Factors Human genes 0.000 claims 1
• 108010009583 Transforming Growth Factors Proteins 0.000 claims 1
• 229940035676 analgesics Drugs 0.000 claims 1
• 108010072788 angiogenin Proteins 0.000 claims 1
• 239000000730 antalgic agent Substances 0.000 claims 1
• 239000003242 anti bacterial agent Substances 0.000 claims 1
• 239000002260 anti-inflammatory agent Substances 0.000 claims 1
• 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
• 229940088710 antibiotic agent Drugs 0.000 claims 1
• 239000002246 antineoplastic agent Substances 0.000 claims 1
• 239000003443 antiviral agent Substances 0.000 claims 1
• 210000001185 bone marrow Anatomy 0.000 claims 1
• 229940112869 bone morphogenetic protein Drugs 0.000 claims 1
• 230000002308 calcification Effects 0.000 claims 1
• XAAHAAMILDNBPS-UHFFFAOYSA-L calcium hydrogenphosphate dihydrate Chemical compound O.O.[Ca+2].OP([O-])([O-])=O XAAHAAMILDNBPS-UHFFFAOYSA-L 0.000 claims 1
• 229940127089 cytotoxic agent Drugs 0.000 claims 1
• 230000004069 differentiation Effects 0.000 claims 1
• 229940116977 epidermal growth factor Drugs 0.000 claims 1
• 229940126864 fibroblast growth factor Drugs 0.000 claims 1
• 239000012530 fluid Substances 0.000 claims 1
• 239000012634 fragment Substances 0.000 claims 1
• 230000006698 induction Effects 0.000 claims 1
• 239000002917 insecticide Substances 0.000 claims 1
• 230000000921 morphogenic effect Effects 0.000 claims 1
• 239000008188 pellet Substances 0.000 claims 1
• OTYBMLCTZGSZBG-UHFFFAOYSA-L potassium sulfate Chemical compound [K+].[K+].[O-]S([O-])(=O)=O OTYBMLCTZGSZBG-UHFFFAOYSA-L 0.000 claims 1
• 229910052939 potassium sulfate Inorganic materials 0.000 claims 1
• 235000011151 potassium sulphates Nutrition 0.000 claims 1
• 239000011780 sodium chloride Substances 0.000 claims 1
• 229910052938 sodium sulfate Inorganic materials 0.000 claims 1
• 235000011152 sodium sulphate Nutrition 0.000 claims 1
• 239000005720 sucrose Substances 0.000 claims 1
• VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 claims 1