US2977315A - Water soluble iodine-phosphoric-acidsynthetic detergent composition - Google Patents

Water soluble iodine-phosphoric-acidsynthetic detergent composition Download PDF

Info

Publication number
US2977315A
US2977315A US61208256A US2977315A US 2977315 A US2977315 A US 2977315A US 61208256 A US61208256 A US 61208256A US 2977315 A US2977315 A US 2977315A
Authority
US
Grant status
Grant
Patent type
Prior art keywords
iodine
composition
detergent
phosphoric acid
water soluble
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
Inventor
Bernard J Scheib
Nathan E Lazarus
Michael T Sullivan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LAZARUS LAB Inc
LAZARUS LABORATORIES Inc
Original Assignee
LAZARUS LAB Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Grant date

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C11ANIMAL AND VEGETABLE OILS, FATS, FATTY SUBSTANCES AND WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/48Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
    • C11D3/485Halophors, e.g. iodophors

Description

I WATER SOLUBLE United States Patent IODINE-PHOSPHORIC-ACID- SYNTHETIC DETERGENT COMPOSITION Bernard J. Scheib, Kenmore, and Nathan E. Lazarus and Michael T. Sullivan, Buffalo, N .Y., assignors to Lazarus Laboratories, Inc., Buffalo, N.Y., a\ corporation of New York No Drawing. Filed Sept. 12, 1956, Ser. No. 612,082

. Claims. (Cl. 252-106) (Filed under Rule 47(a) and 35 U.S.C. 116) This invention relates tov water soluble compositions of phosphoric acid and iodine-synthetic detergent complex having detergent-germicidal and sanitizing properties wherein the components exhibit synergistic action, and the method of preparing such compositions. The invention is more particularly directed to compositions adapted for rapid dilution in the field for use in the cleaning and sanitizing in one operation, of apparatus such as food handling equipment, where the use dilution must have highly efficient cleaning properties as well as highly eflicient germicidal and sanitizing properties in reducing the micro-organism count of the treated surface. The compositions of the present invention can be marketed either in powder or liquid form for dilution in water by the user.

Essentially the present invention is directed to dispersing iodine and phosphoric acid, together with a synthetic surface active agent or agents having detergent properties in water, so as to render the iodine efiective as a germicide and/or as a fungicide for treating food handling equipment. In such use it is desirable that the iodine and phosphoric acid be associated with an amount of synthetic detergent which will be effective in the removal of the organic and inorganic soil from the apparatus. It is also essential that the user receive the composition as a concentrate so that a measured amount can be added to the available water in providing an adequate quantity of use solution. It is also essential that there be no substantial loss of strength, particularly of the iodine, for normal periods of shelf life, and it is equally important that the composition rapidly disperses in the wash and/or rinse water used to provide the use dilution, and that the hardness ingredients of this water, as well as the organic soil of the apparatus being cleaned, do not materially reduce the effective strength of the iodine as a germicide or fungicide.

In the compositions of the present invention the iodine is loosely bound or carried by the synthetic detergent in what will hereinafter be referred to as an iodine-synthetic detergent complex. This complex together with phosphoric acid as hereinafter described is mixed with water or a solid water soluble diluent to provide a liquid or solid composition in concentrate form adapted for addition to water in providing use solutions thereof. The synthetic detergent can comprise one or more nonionic and/or anionic synthetic surface active agents having strong detergent and wetting properties.

In general any nonionic and/or anionic synthetic detergent which is itself an effective iodine carrier can be employed in our improved compositions whereinthe car rier-iodine complex is stabilized and made more effective, as a source 'of iodine by the presence of phosphoric acid. As' preferred synthetic detergents, however, we employ one or more of the following:

Nonionics which are alkyl aryl polethylene glycols and which are sold by General Aniline and Film Corporation under the trademark Antarox. An example of such nonionic is Antarox A-400, which is a nonyl phenol ethylene oxide condensate containing 8 to 9 mols of ethylene oxide per mol of phenol.

Nonionics which are distributed by Wyandotte Chem- ICC icals Corporation under the trademark Pluronics, and which are disclosed and claimed in US. Patent No. 2,674,- 619 dated April 6, 1954, issued to Wyandotte Chemicals Corporation, as compounds according to the formula HO(C H O) (C H O) (C H O) '-H where y equals at least 15, and (C H O) equals to 90% of the total weight of the compound. Examples of such nonionics are Pluronics L-62, liquid condensate of polypropylene oxide and ethylene oxide wherein the polyoxypropylene group has a molecular weight within the range of 1501 to 1800 and the condensate contains 20 to 30% by weight of ethylene oxide; and Pluronics F-68, a condensate of polypropylene oxide and ethylene oxide in the form of flakes wherein the polypropylene oxide group has a molecular Weight within the range of 1501 to 1800 and the condensate contains from to 9.0% by weight of ethylene oxide.

Anionics which are alkyl aryl sulfonates and which are sold by National Aniline Division, Allied Chemical and Dye Corporation under the trademark Nacconol. Examples of such anionics are Nacconol 60, Nacco- 1101 Z and Nacconol NRSF. In these products the active component or anionic is alkyl benzene sulfonate wherein the alkyl substituent contains 12 to 18 carbon atoms. They differ in concentration or amount of water associated with the active component. NacconoF 60 is a 60% concentration. Nacconol Z is an concentration, and Nacconol NRSF is a 92%.% concentration of the active component with water.

The compositions include phosphoric acid, preferably orthophosphoric acid. Pyro, meta and hypophosphoric acids can be used instead of orthophosphoric acid, but orthophosphoric acid is preferred because of its inherent stability and its acceptability in food processing. The phosphoric acid has numerable functions. It functions not only to counter-act the salts or hard water minerals present in the waters used to dilute the composition, but also to counter-act the organic and inorganic soil on the apparatus being cleaned and/ or sanitized by the use solution. It has been found to greatly increase the effect of a given amount of iodine in so acting as a buffer against water impurities and soil on the apparatus which would normally interfere with the action of the iodine. the acid has the further effect of adjusting the pH to that low value of about 2.0 to 4.0, and suitably about pH 3.0, needed to maintain the stability of the iodine in the compos tions and in the use dilutions thereof.

The phosphoric acid in the compositions also has the further effect of acting as a synergistic agent upon the iodine by extending the activity of the iodine to higher values than that which would be obtained by using the detergent-iodine complex without this acid. While any acid, organic or inorganic could be employed to adjust the pH of the concentrate to that value which stabilizes the iodine content, phosphoric acid has been found to exhibit novel synergistic activity. In addition, the phosphoric acid provides a physically stable or homogeneous composition both as concentrate and in use solutions,

which cannot be attained with other'mineral acids such as hydrochloric and sulfuric acids.

Where the water soluble phosphoric acid iodine-syn thetic detergent composition is produced in liquid form, we have found the following to be the range of amounts by weight of the ingredients: e

Where the water soluble phosphoric acid iodine-synthetic detergent composition is produced as a powder, urea is an essential ingredient. The urea acts a car- Also tier of the acid in the powdered composition and also exhibits synergistic activity by increasing the detergency of the surface active agent or agents. In preparing the. phosphoric acid iodine-synthetic detergent compositions in powder form, it is also desirable to effect an initial solution of the iodine and a part of the carrier in ethyl alcohol. Ethyl alcohol is preferred for this purpose because it acts as a common solvent for both the iodine and the synthetic detergents.

Where the water soluble phosphoric acid iodine-synthetic detergent composition is produced in powder form, we have found the following to be the range of amounts by weight of the ingredients:

Percent [odine 0.5-7.0 Phosphoric acid (85%) 4.0- Synthetic surface active detergent 1.5-10 Urea Balance The following examples will serve to show how typical compositions of phosphoric acid and iodine-synthetic detergent complex in accordance with the present invention can be prepared. It is to be understood however, that these examples are given by way of illustration and not of limitation.

Example 1 As an example of producing in liquid form a water soluble phosphoric acid iodine-synthetic detergent composition in accordance with the present invention and using both a nonionic and an anionic synthetic surface active agent, the nonionic agent or carrier was Antarox A-400 a product of General Aniline & Film Corporation as above defined and the anionic synthetic surface active agent or carrier was Nacconol Z. a product of National Aniline Division, Allied Chemical & Dye Corporation as above defined.

In preparing this composition, 21 parts of elemental iodine were mixed with 66 parts of the Antarox A-400. To this mixture were added 81 parts of the Nacconol Z, 175 parts of phosphoric acid (85%), and 607 parts of water. In providing the use solution one fluid ounce of this composition was diluted in five gallons of water, the use solution having 25-30 p.p.m. active iodine, a pH of 3.1, and being highly effective as a germicide, a sanitizer and as a detergent in treating dairy equipment. The parts indicated are by weight.

Example 2 As an example of producing in liquid form a Water soluble phosphoric acid iodine-synthetic detergent composition in accordance with the present invention and using an anionic synthetic surface active agent or carrier for the iodine, the anionic agent or carrier was Nacconol 60, a product of National Aniline Division, Allied Chemical and Dye Corporation as defined above.

In preparing this composition, 21 parts of elemental iodine were mixed with 230 parts of the Nacconol 60. To this mixture were added 175 parts of phosphoric acid (85%) and 524 parts of water. In providing the use solution one fluid ounce of this composition was diluted in five gallons of water, the use solution having 25-30 p.p.m. active iodine, a pH of 3.1, and being highlyeifective as a germicide, a sanitizer and as a detergent in treating dairy equipment. The parts indicated are by weight.

Example 3 As an example of producing in liquid form a water soluble phosphoric acid iodine-synthetic detergent composition in accordance with the present invention and using a nonionic synthetic surface active agent or carrier for the iodine, the nonionic agent or carrier was Antarox A-400, as described in Example 1.

In preparing this composition, 35 parts of elemental iodine were mixed with 111 parts of Antarox A-400. To this mixture were added 175 parts of phosphoric acid 4 and 629 parts of water. In providing the use solution, one fluid ounce of this composition was diluted in five gallons of water, the use solution having 47-50 ppm. active iodine, a pH of 3.1, and being highly effective as a germicide, a sanitizer and as a detergent in treating dairy equipment. The parts indicated are by weight.

Example 4 As an example of producing a powdered or substantially dry, water soluble phosphoric acid iodine-synthetic detergent composition in accordance with the present invention and using both a nonionic and anionic synthetic surface active agent or carrier for the iodine, the nonionic agent or carrier was Pluronic F-68, a product of Wyandotte Chemicals Corporation as above defined, and the anionic agent or carrier was Nacconol NRSF, a product of National Aniline Division, Allied Chemical & Dye Corporation as above defined.

The various ingredients were used in the following percentages, it being noted that the ethyl alcohol evaporated out so that the remaining ingredients total The percentages are by weight:

In compounding the above 2 /2 parts by weight of the Pluronic F-68 and 2 /2 parts by weight of the iodine were dissolved in 12.4 parts by weight of ethyl alcohol. This solution was then deposited on a mixture of 1.8 parts by weight of the Pluronic F-68, 4.6 parts by weight of the Nacconol NRSF, 10 parts by weight of the phosphoric acid, and the 78.6 parts by weight of urea. Upon evaporation of the alcohol the composition was in the form of a cake which was readily reduced to a fine powder highly soluble in water.

In preparing an aqueous solution of the above composition, the ratio by weight, of the composition to the water was 1 to 320. This provided a use dilution having a pH of 3.0 and 49 ppm. of titratable iodine by weight. The use dilution was highly effective as a germicide, a sanitizer and as a detergent in treating dairy equipment.

Example 5 Percent Elemental iodine 2.5 Pluronic F-68 8.5 Phosphoric acid (85 10.0 Urea 79.0 Ethyl alcohol 12.4

In compounding the above 2% parts by weight of the Pluronic F-68 and 2 /2 parts by weight of the iodine were dissolved in 12.4 parts by weight of ethyl alcohol. This solution was then deposited on a mixture of the remaining ingredients, namely 6 parts by weight of the Pluronic F-68, 10 parts by weight of phosphoric acid and 79 parts by weight of urea. Upon evaporation of the alcohol the composition was in the form of a cake which was readily reduced to a fine powder highly soluble in water.

In preparing an aqueous use solution of the above composition, the ratio, by weight, of the composition to the water was 1 to 320. This provided a solution having a pH of 3.05 and 47 p.p.m. of titratable iodine by weight. The use dilution was highly effective as a germicide, a sanitizer and as a detergent in treating dairy equipment.

Example 6 As an example of producing in liquid form a water soluble phosphoric acid iodine-synthetic detergent composition in accordance with the present invention using a Pluronic type of nonionic surface active agent or carrier for the iodine, the nonionic agent or carrier was Pluronic L62 as defined above.

In preparing this composition 33 parts of elemental iodine were mixed with 111 parts of Pluronic L-62. To this mixture were added 175 parts of phosphoric acid (85%) and 629 parts of water. In providing the use solution, one fluid ounce of this composition was diluted in 5 gallons of water, the use solution having about 47-50 p.p.m. of active iodine, a pH of 3.1, and being highly efiective as a germicide, a sanitizer and as a detergent in treating dairy equipment. The parts indicated are by weight.

Various changes and modifications in the phosphoric acid iodine-synthetic detergent compositions herein disclosed will occur to those skilled in the art, and to the extent that such changes and modifications are embraced by the appended claims, it is to be understood that they constitute part of our invention.

This application is a continuation-in-part of our prior application Serial No. 298,828, filed July 14, 1952 (now abandoned).

We claim:

1. A water soluble iodine-synthetic detergent-phosphoric acid composition having detergent, germicidal and sanitizing properties, said composition consisting essentially of an iodine-synthetic detergent complex with phosphoric acid, the amount of iodine present being such as to provide a germicidally efiective amount of iodine in the intended use dilution of said composition, the amount of phosphoric acid in said composition being in excess of four times the amount of iodine present and being suflicient to provide a pH within the range of about 2.0 to 4.0 in said use dilution, and the synthetic detergent in said composition being selected from the group consisting of acid stable, organic nonionic and anionic surface active agents having detergent properties and which are themselves efiective iodine carriers.

2. A water soluble iodine composition as defined in claim 1 wherein the nonionic synthetic detergent is an alkyl aryl polyethylene glycol.

3. A water soluble iodine composition as defined in claim 1 wherein the nonionic synthetic detergent is a compound according to the formula where y equals at least 15, and (C H O), equals 20 to 90% of the total weight of the compound.

4. A water soluble iodine composition as defined in claim 1 wherein the anionic synthetic detergent is an alkyl aryl sulfonate.

5. A water soluble iodine composition as defined in claim 1 in the form of a liquid concentrate consisting of 0.5 to 6.0% iodine, 4.0 to 30% phosphoric acid of 85% concentration, 1.5 to 25% of acid synthetic detergent, and water to 100%.

6. A water soluble iodine composition as defined in claim 1 wherein the detergent cons1sts of a mixture of said nonionic and anionic synthetic detergents.

7. A water soluble iodine composition as defined in claim 2 wherein the nonionic synthetic detergent is a nonyl phenol ethylene oxide condensate containing 8 to 9 mols V oxide wherein the polyoxypropylene group has a molecular weight within the range of 1501 to 1800 and the condensate contains 20 to 30% by weight of ethylene oxide.

9. A water soluble iodine composition as defined in claim 3 wherein the nonionic synthetic detergent is a condensate of polypropylene oxide and ethylene oxide in the form of flakes wherein the polypropylene oxide group has a molecular weight within the range of 1501 to 1800 and the condensate contains to by weight of ethylene oxide.

10. A water soluble iodine composition as defined in claim 4 wherein the anionic synthetic detergent is alkyl benzene sulfonate wherein the alkyl substituent contains 12 to 18 carbon atoms.

11. A water soluble iodine composition as defined in claim 6 wherein the nonionic synthetic detergent is in alkyl aryl polyethylene glycol and the anionic synthetic detergent is an alkyl aryl sulfonate.

12. A water soluble iodine composition as defined in claim 6 wherein the nonionic synthetic detergent is a compound according to the formula where y equals at least 15, and (C H O) equals 20 to 90% of the total weight of the compound and the anionic synthetic detergent is an alkyl aryl sulfonate.

13. A water soluble iodine composition as defined in claim 11 wherein the nonionic synthetic detergent is a nonyl phenol ethylene oxide condensate containing 8 to 9 mols of ethylene oxide per mol of phenol and the anionic synthetic detergent component is alkyl benzene sulfonate wherein the alkyl substituent contains 12 to 18 carbon atoms.

14. A water soluble iodine composition as defined'in claim 12 wherein the nonionic synthetic detergent is a condensate of polypropylene oxide and ethylene oxide in the form of flakes wherein the polypropylene oxide group has a molecular weight within the range of 1501 to 1800 and i the condensate contains 80 to 90% by weight of ethylene oxide and the anionicsynthetic detergent is alkyl benzene sulfonate wherein the alkyl substituent contains 12110 18 carbon atoms.

15. A water soluble iodine-synthetic detergent-phosphoric acid composition having detergent, germicidal and sanitizing properties, said composition consisting essentially of an iodine-synthetic detergent complex with phosphoric acid, the amount of iodine present being such as to provide a germicidally effective amount of iodine in the intended use dilution of said composition, the amount. I of phosphoric acid in said composition being in excess of.

four times the amount of iodine present and being sulficient to provide a pH of about 3.0 in said use dilution,

and the synthetic detergent in said composition being selected from the group consisting of acid stable, organic nonionic and anionic surface active agents having detergent properties and which are themselves efiective iodine carriers.

References Cited in the file of this patent OTHER REFERENCES Chemical Week, Dec. 22, 1951, pages 19 and 20, 7 i

Claims (1)

1. A WATER SOLUBLE IODINE-SYNTHETIC DETERGENT-PHOSPHORIC ACID COMPOSITION HAVING DETERGENT, GERMICIDAL AND SANITIZING PROPERTIES, SAID COMPOSITION CONSISTING ESSENTIALLY OF AN IODINE-SYNTHETIC DETERGENT COMPLEX WITH PHOSPHORIC ACID, THE AMOUNT OF IODINE PRESENT BEING SUCH AS TO PROVIDE A GERMICIDALLY EFFECTIVE AMOUNT OF IODINE IN THE INTENDED USE DILUTION OF SAID COMPOSITION, THE AMOUNT OF PHOSPHORIC ACID IN SAID COMPOSITION BEING IN EXCESS OF FOUR TIMES THE AMOUNT OF IODINE PRESENT AND BEING SUFFICIENT TO PROVIDE A PH WITHIN THE RANGE OF ABOUT 2.0 TO 4.0 IN SAID USE DILUTION, AND THE SYNTHETIC DETERGENT IN SAID COMPOSITION BEING SELECTED FROM THE GROUP CONSISTING OF ACID STABLE, ORGANIC NONIONIC AND ANIONIC SURFACE ACTIVE AGENTS HAVING DETERGENT PROPERTIES AND WHICH ARE THEMSELVES EFFECTIVE IODINE CARRIERS.
US2977315A 1956-09-12 1956-09-12 Water soluble iodine-phosphoric-acidsynthetic detergent composition Expired - Lifetime US2977315A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US2977315A US2977315A (en) 1956-09-12 1956-09-12 Water soluble iodine-phosphoric-acidsynthetic detergent composition

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2977315A US2977315A (en) 1956-09-12 1956-09-12 Water soluble iodine-phosphoric-acidsynthetic detergent composition

Publications (1)

Publication Number Publication Date
US2977315A true US2977315A (en) 1961-03-28

Family

ID=24451646

Family Applications (1)

Application Number Title Priority Date Filing Date
US2977315A Expired - Lifetime US2977315A (en) 1956-09-12 1956-09-12 Water soluble iodine-phosphoric-acidsynthetic detergent composition

Country Status (1)

Country Link
US (1) US2977315A (en)

Cited By (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3119726A (en) * 1962-10-22 1964-01-28 Virginia Carolina Chem Corp Process and composition for brightening aluminum
US3150096A (en) * 1961-03-27 1964-09-22 West Laboratories Inc Cleansing and sanitizing compositions for food handling equipment
US3167517A (en) * 1960-08-11 1965-01-26 American Cyanamid Co Dyeing assistant and leveling compositions
US3218260A (en) * 1960-06-15 1965-11-16 Bonewitz Chemicals Inc Cleaner
US3220951A (en) * 1962-03-30 1965-11-30 West Laboratories Inc Liquid acidic detergent iodine concentrates
US3235446A (en) * 1961-07-12 1966-02-15 Ind Biology Lab Inc Iodinated polyurethane foams and films
US3274116A (en) * 1963-08-05 1966-09-20 Dow Chemical Co Iodine detergent solution
US3377130A (en) * 1960-08-11 1968-04-09 American Cyanamid Co Dyed nitrogenous fibers and anionic dye composition therefor
US3438905A (en) * 1965-07-26 1969-04-15 Wyandotte Chemicals Corp Iodine-containing nonionic surfactant compositions
US3438906A (en) * 1965-07-26 1969-04-15 Wyandotte Chemicals Corp Iodine-containing nonionic surfactant compositions
US3525696A (en) * 1966-04-25 1970-08-25 West Laboratories Inc Low-foaming germicidal surfactantiodine compositions for cleaned-inplace equipment
US3538520A (en) * 1967-12-26 1970-11-10 Madison Chem Corp Lavatory sanitation bodies
US3620773A (en) * 1969-04-03 1971-11-16 Robert P Gabriel Method for treating harvested nonchlorophylleous produce
USB530303I5 (en) * 1973-12-17 1976-03-23
US3965025A (en) * 1973-02-07 1976-06-22 Instytut Chemii Przemyslowej Method for manufacturing alkaline detergents and desinfectants
US4077898A (en) * 1976-11-02 1978-03-07 Economics Laboratory, Inc. Iodine/phosphate ester compositions and methods of using them
US4088597A (en) * 1977-06-13 1978-05-09 Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler Iodophor solution
EP0079782A1 (en) * 1981-11-16 1983-05-25 Euroceltique S.A. Stabilized iodine-containing germicidal preparation
US4444756A (en) * 1981-09-19 1984-04-24 Henkel Kgaa Iodine containing disinfectants
US4597975A (en) * 1981-11-06 1986-07-01 Woodward Fred E Iodine surface active compositions
WO1986006404A1 (en) * 1985-04-26 1986-11-06 A.E. Staley Manufacturing Company Stability and compatibility of glycosides in acid systems
WO1986006417A1 (en) * 1985-04-26 1986-11-06 A. E. Staley Manufacturing Company Method for inhibiting oxidation or acid attack of ferrous metals utilizing glycosides and cleaning compositions for ferrous metals
EP0259982A2 (en) * 1986-09-12 1988-03-16 Euroceltique S.A. Solid iodophor composition
US4822513A (en) * 1984-11-12 1989-04-18 Diversey Corporation Cleaning/disinfecting process and composition
US4851149A (en) * 1985-11-13 1989-07-25 Henkel Corporation Non-toxic acid cleaner corrosion inhibitors
US4994280A (en) * 1988-06-28 1991-02-19 Kochinsky Lyle J Iodophor composition for aquaculture
US20040230309A1 (en) * 2003-02-14 2004-11-18 Depuy Spine, Inc. In-situ formed intervertebral fusion device and method
WO2012003326A1 (en) 2010-07-02 2012-01-05 Wright Medical Technology, Inc. Composition comprising calcium phosphate and sulfate powders and tri - calcium phosphate particles used in the treatment of degenerative bone conditions
WO2015089373A1 (en) 2013-12-13 2015-06-18 Wright Medical Technology, Inc. Multiphasic bone graft substitute material
US9320614B2 (en) 2006-07-31 2016-04-26 DePuy Synthes Products, Inc. Spinal fusion implant
US9801725B2 (en) 2009-12-09 2017-10-31 DePuy Synthes Products, Inc. Aspirating implants and method of bony regeneration

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2070487A (en) * 1934-12-24 1937-02-09 Du Pont Metal cleaning
US2413495A (en) * 1946-12-31 Phosphoric acid detergent
US2516685A (en) * 1944-04-19 1950-07-25 American Chem Paint Co Process of preparing iron and aluminum surfaces to receive organic coatings and solution therefor
US2517651A (en) * 1944-10-16 1950-08-08 Burnham Soluble Iodine Company Treatment of waters for human consumption and iodine-diglycine hydriodide composition useful in such treatment
US2599140A (en) * 1949-03-30 1952-06-03 Benjamin Clayton Iodine detergent
US2759869A (en) * 1952-01-05 1956-08-21 West Laboratories Inc Germicidal iodine preparations

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2413495A (en) * 1946-12-31 Phosphoric acid detergent
US2070487A (en) * 1934-12-24 1937-02-09 Du Pont Metal cleaning
US2516685A (en) * 1944-04-19 1950-07-25 American Chem Paint Co Process of preparing iron and aluminum surfaces to receive organic coatings and solution therefor
US2517651A (en) * 1944-10-16 1950-08-08 Burnham Soluble Iodine Company Treatment of waters for human consumption and iodine-diglycine hydriodide composition useful in such treatment
US2599140A (en) * 1949-03-30 1952-06-03 Benjamin Clayton Iodine detergent
US2759869A (en) * 1952-01-05 1956-08-21 West Laboratories Inc Germicidal iodine preparations

Cited By (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3218260A (en) * 1960-06-15 1965-11-16 Bonewitz Chemicals Inc Cleaner
US3377130A (en) * 1960-08-11 1968-04-09 American Cyanamid Co Dyed nitrogenous fibers and anionic dye composition therefor
US3167517A (en) * 1960-08-11 1965-01-26 American Cyanamid Co Dyeing assistant and leveling compositions
US3150096A (en) * 1961-03-27 1964-09-22 West Laboratories Inc Cleansing and sanitizing compositions for food handling equipment
US3235446A (en) * 1961-07-12 1966-02-15 Ind Biology Lab Inc Iodinated polyurethane foams and films
US3220951A (en) * 1962-03-30 1965-11-30 West Laboratories Inc Liquid acidic detergent iodine concentrates
US3119726A (en) * 1962-10-22 1964-01-28 Virginia Carolina Chem Corp Process and composition for brightening aluminum
US3274116A (en) * 1963-08-05 1966-09-20 Dow Chemical Co Iodine detergent solution
US3438905A (en) * 1965-07-26 1969-04-15 Wyandotte Chemicals Corp Iodine-containing nonionic surfactant compositions
US3438906A (en) * 1965-07-26 1969-04-15 Wyandotte Chemicals Corp Iodine-containing nonionic surfactant compositions
US3438907A (en) * 1965-07-26 1969-04-15 Wyandotte Chemicals Corp Iodine-containing nonionic surfactant compositions
US3525696A (en) * 1966-04-25 1970-08-25 West Laboratories Inc Low-foaming germicidal surfactantiodine compositions for cleaned-inplace equipment
US3538520A (en) * 1967-12-26 1970-11-10 Madison Chem Corp Lavatory sanitation bodies
US3620773A (en) * 1969-04-03 1971-11-16 Robert P Gabriel Method for treating harvested nonchlorophylleous produce
US3965025A (en) * 1973-02-07 1976-06-22 Instytut Chemii Przemyslowej Method for manufacturing alkaline detergents and desinfectants
USB530303I5 (en) * 1973-12-17 1976-03-23
US4006093A (en) * 1973-12-17 1977-02-01 Basf Aktiengesellschaft Surfactants containing iodine
US4077898A (en) * 1976-11-02 1978-03-07 Economics Laboratory, Inc. Iodine/phosphate ester compositions and methods of using them
US4088597A (en) * 1977-06-13 1978-05-09 Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler Iodophor solution
US4444756A (en) * 1981-09-19 1984-04-24 Henkel Kgaa Iodine containing disinfectants
US4597975A (en) * 1981-11-06 1986-07-01 Woodward Fred E Iodine surface active compositions
EP0079782A1 (en) * 1981-11-16 1983-05-25 Euroceltique S.A. Stabilized iodine-containing germicidal preparation
US4822513A (en) * 1984-11-12 1989-04-18 Diversey Corporation Cleaning/disinfecting process and composition
WO1986006417A1 (en) * 1985-04-26 1986-11-06 A. E. Staley Manufacturing Company Method for inhibiting oxidation or acid attack of ferrous metals utilizing glycosides and cleaning compositions for ferrous metals
US4683074A (en) * 1985-04-26 1987-07-28 A. E. Staley Manufacturing Company Stability and compatibility of glycosides in acid systems
US4705665A (en) * 1985-04-26 1987-11-10 A. E. Staley Manufacturing Company Method for inhibiting oxidation of ferrous metals with alkyl glycosides and composition for cleaning ferrous metals
WO1986006404A1 (en) * 1985-04-26 1986-11-06 A.E. Staley Manufacturing Company Stability and compatibility of glycosides in acid systems
US4851149A (en) * 1985-11-13 1989-07-25 Henkel Corporation Non-toxic acid cleaner corrosion inhibitors
EP0259982A2 (en) * 1986-09-12 1988-03-16 Euroceltique S.A. Solid iodophor composition
EP0259982A3 (en) * 1986-09-12 1990-12-19 Euroceltique Sa Solid iodophor composition
US4994280A (en) * 1988-06-28 1991-02-19 Kochinsky Lyle J Iodophor composition for aquaculture
US9730803B2 (en) 2003-02-14 2017-08-15 DePuy Synthes Products, Inc. Method of in-situ formation of an intervertebral fusion device
US9925060B2 (en) 2003-02-14 2018-03-27 DePuy Synthes Products, Inc. In-situ formed intervertebral fusion device and method
US9814590B2 (en) 2003-02-14 2017-11-14 DePuy Synthes Products, Inc. In-situ formed intervertebral fusion device and method
US9814589B2 (en) 2003-02-14 2017-11-14 DePuy Synthes Products, Inc. In-situ formed intervertebral fusion device and method
US9808351B2 (en) 2003-02-14 2017-11-07 DePuy Synthes Products, Inc. In-situ formed intervertebral fusion device and method
US9333091B2 (en) 2003-02-14 2016-05-10 DePuy Synthes Products, Inc. In-situ formed intervertebral fusion device and method
US9801729B2 (en) 2003-02-14 2017-10-31 DePuy Synthes Products, Inc. In-situ formed intervertebral fusion device and method
US20040230309A1 (en) * 2003-02-14 2004-11-18 Depuy Spine, Inc. In-situ formed intervertebral fusion device and method
US9439776B2 (en) 2003-02-14 2016-09-13 DePuy Synthes Products, Inc. In-situ formed intervertebral fusion device and method
US9788963B2 (en) 2003-02-14 2017-10-17 DePuy Synthes Products, Inc. In-situ formed intervertebral fusion device and method
US9724207B2 (en) 2003-02-14 2017-08-08 DePuy Synthes Products, Inc. In-situ formed intervertebral fusion device and method
US9439777B2 (en) 2003-02-14 2016-09-13 DePuy Synthes Products, Inc. In-situ formed intervertebral fusion device and method
US10085843B2 (en) 2003-02-14 2018-10-02 DePuy Synthes Products, Inc. In-situ formed intervertebral fusion device and method
US9737413B2 (en) 2006-07-31 2017-08-22 DePuy Synthes Products, Inc. Spinal fusion implant
US9713538B2 (en) 2006-07-31 2017-07-25 DePuy Synthes Products, Inc. Spinal fusion implant
US9387091B2 (en) 2006-07-31 2016-07-12 DePuy Synthes Products, Inc. Spinal fusion implant
US10010428B2 (en) 2006-07-31 2018-07-03 DePuy Synthes Products, Inc. Spinal fusion implant
US9320614B2 (en) 2006-07-31 2016-04-26 DePuy Synthes Products, Inc. Spinal fusion implant
US9801725B2 (en) 2009-12-09 2017-10-31 DePuy Synthes Products, Inc. Aspirating implants and method of bony regeneration
EP2987507A1 (en) 2010-07-02 2016-02-24 Agnovos Healthcare, LLC Methods of treating degenerative bone conditions
WO2012003326A1 (en) 2010-07-02 2012-01-05 Wright Medical Technology, Inc. Composition comprising calcium phosphate and sulfate powders and tri - calcium phosphate particles used in the treatment of degenerative bone conditions
WO2015089373A1 (en) 2013-12-13 2015-06-18 Wright Medical Technology, Inc. Multiphasic bone graft substitute material
EP3269399A1 (en) 2013-12-13 2018-01-17 Agnovos Healthcare, LLC Multiphasic bone graft substitute material

Similar Documents

Publication Publication Date Title
US3650964A (en) Low foam anionic acid sanitizer compositions
US3554915A (en) Cleansing and sanitizing compositions
US5578134A (en) Method of sanitizing and destaining tableware
US4240921A (en) Liquid cleaning concentrate
US4919837A (en) Antiseptic cleansing composition comprising a water-soluble salt of chlorhexidine
US3539520A (en) Compositions comprising quaternary ammonium germicides and nonionic surfactants
US5280042A (en) Disinfecting and sanitizing compositions
US3728449A (en) Germicidal iodine compositions for application to skin tissue including teats of milk animals
US5503778A (en) Cleaning compositions based on N-alkyl pyrrolidones having about 8 to about 12 carbon atoms in the alkyl group and corresponding methods of use
US4051058A (en) Stable peroxy-containing microbicides
US4597887A (en) Germicidal hard surface cleaning composition
US4867898A (en) Broad spectrum antimicrobial system for hard surface cleaners
US5489434A (en) Peroxyacid antimicrobail composition
US6211237B1 (en) Aqueous disinfecting agent containing performic acid and peracetic acid process for production and process for use thereof
US5718910A (en) Peroxyacid antimicrobial composition
US5336500A (en) Sanitizing composition comprising a blend of aromatic and polyunsaturated carboxylic acid
US5436008A (en) Sanitizing compositions
US6346279B1 (en) Hydrogen peroxide disinfectant with increased activity
US4695453A (en) Thickened alcoholic antimicrobial compositions
US3666668A (en) Cleanser, disinfectant, combinations thereof and aerosol systems containing same
US6479454B1 (en) Antimicrobial compositions and methods containing hydrogen peroxide and octyl amine oxide
US3223643A (en) Liquid acid-detergent-sanitizer composition
US4946672A (en) Deodorizing compositions
US5403587A (en) Disinfectant and sanitizing compositions based on essential oils
US4917815A (en) Stable aqueous aromatic percarboxylic acid solution