JP2017095457A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017095457A5 JP2017095457A5 JP2016222861A JP2016222861A JP2017095457A5 JP 2017095457 A5 JP2017095457 A5 JP 2017095457A5 JP 2016222861 A JP2016222861 A JP 2016222861A JP 2016222861 A JP2016222861 A JP 2016222861A JP 2017095457 A5 JP2017095457 A5 JP 2017095457A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- antibody
- drug
- drug conjugate
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000611 antibody drug conjugate Substances 0.000 claims 8
- 229940049595 antibody-drug conjugate Drugs 0.000 claims 8
- 206010009944 Colon cancer Diseases 0.000 claims 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 239000002246 antineoplastic agent Substances 0.000 claims 4
- 229940041181 antineoplastic drug Drugs 0.000 claims 4
- 208000029742 colonic neoplasm Diseases 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 206010005003 Bladder cancer Diseases 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 206010008342 Cervix carcinoma Diseases 0.000 claims 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 2
- 206010014733 Endometrial cancer Diseases 0.000 claims 2
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 2
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 2
- 206010051066 Gastrointestinal stromal tumour Diseases 0.000 claims 2
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 206010025323 Lymphomas Diseases 0.000 claims 2
- 208000032271 Malignant tumor of penis Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
- 208000002471 Penile Neoplasms Diseases 0.000 claims 2
- 206010034299 Penile cancer Diseases 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 208000007452 Plasmacytoma Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 2
- 206010038389 Renal cancer Diseases 0.000 claims 2
- 208000004337 Salivary Gland Neoplasms Diseases 0.000 claims 2
- 206010061934 Salivary gland cancer Diseases 0.000 claims 2
- 206010039491 Sarcoma Diseases 0.000 claims 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 2
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 2
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 2
- 206010047741 Vulval cancer Diseases 0.000 claims 2
- 208000004354 Vulvar Neoplasms Diseases 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 201000010881 cervical cancer Diseases 0.000 claims 2
- 201000004101 esophageal cancer Diseases 0.000 claims 2
- 206010017758 gastric cancer Diseases 0.000 claims 2
- 201000011243 gastrointestinal stromal tumor Diseases 0.000 claims 2
- 210000003494 hepatocyte Anatomy 0.000 claims 2
- 201000010982 kidney cancer Diseases 0.000 claims 2
- 208000032839 leukemia Diseases 0.000 claims 2
- 125000005647 linker group Chemical group 0.000 claims 2
- 201000007270 liver cancer Diseases 0.000 claims 2
- 208000014018 liver neoplasm Diseases 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
- 201000000050 myeloid neoplasm Diseases 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 201000002528 pancreatic cancer Diseases 0.000 claims 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
- 201000002628 peritoneum cancer Diseases 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 206010038038 rectal cancer Diseases 0.000 claims 2
- 201000001275 rectum cancer Diseases 0.000 claims 2
- 206010041823 squamous cell carcinoma Diseases 0.000 claims 2
- 201000011549 stomach cancer Diseases 0.000 claims 2
- 201000002510 thyroid cancer Diseases 0.000 claims 2
- 206010044412 transitional cell carcinoma Diseases 0.000 claims 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims 2
- 206010046766 uterine cancer Diseases 0.000 claims 2
- 201000005102 vulva cancer Diseases 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 150000004677 hydrates Chemical class 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014017777 | 2014-01-31 | ||
| JP2014017777 | 2014-01-31 | ||
| JP2014168944 | 2014-08-22 | ||
| JP2014168944 | 2014-08-22 | ||
| JP2014227886 | 2014-11-10 | ||
| JP2014227886 | 2014-11-10 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016166850A Division JP6046301B1 (ja) | 2014-01-31 | 2016-08-29 | 抗ｈｅｒ２抗体−薬物コンジュゲート |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017003826A Division JP6105183B1 (ja) | 2014-01-31 | 2017-01-13 | 抗ｈｅｒ２抗体−薬物コンジュゲート |
| JP2019002311A Division JP6665325B2 (ja) | 2014-01-31 | 2019-01-10 | 抗ｈｅｒ２抗体−薬物コンジュゲート |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017095457A JP2017095457A (ja) | 2017-06-01 |
| JP2017095457A5 true JP2017095457A5 (enExample) | 2018-03-01 |
| JP6466895B2 JP6466895B2 (ja) | 2019-02-06 |
Family
ID=53756672
Family Applications (10)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015542503A Active JP5998289B2 (ja) | 2014-01-31 | 2015-01-28 | 抗ｈｅｒ２抗体−薬物コンジュゲート |
| JP2016166850A Active JP6046301B1 (ja) | 2014-01-31 | 2016-08-29 | 抗ｈｅｒ２抗体−薬物コンジュゲート |
| JP2016222861A Active JP6466895B2 (ja) | 2014-01-31 | 2016-11-16 | 抗ｈｅｒ２抗体−薬物コンジュゲート |
| JP2017003826A Active JP6105183B1 (ja) | 2014-01-31 | 2017-01-13 | 抗ｈｅｒ２抗体−薬物コンジュゲート |
| JP2019002311A Active JP6665325B2 (ja) | 2014-01-31 | 2019-01-10 | 抗ｈｅｒ２抗体−薬物コンジュゲート |
| JP2020025886A Active JP6914380B2 (ja) | 2014-01-31 | 2020-02-19 | 抗ｈｅｒ２抗体−薬物コンジュゲート |
| JP2021115436A Active JP7146031B2 (ja) | 2014-01-31 | 2021-07-13 | 抗ｈｅｒ２抗体－薬物コンジュゲート |
| JP2022149242A Active JP7467557B2 (ja) | 2014-01-31 | 2022-09-20 | 抗ｈｅｒ２抗体－薬物コンジュゲート |
| JP2024059913A Active JP7703727B2 (ja) | 2014-01-31 | 2024-04-03 | 抗ｈｅｒ２抗体－薬物コンジュゲート |
| JP2025107304A Pending JP2025138756A (ja) | 2014-01-31 | 2025-06-25 | 抗ｈｅｒ２抗体－薬物コンジュゲート |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015542503A Active JP5998289B2 (ja) | 2014-01-31 | 2015-01-28 | 抗ｈｅｒ２抗体−薬物コンジュゲート |
| JP2016166850A Active JP6046301B1 (ja) | 2014-01-31 | 2016-08-29 | 抗ｈｅｒ２抗体−薬物コンジュゲート |
Family Applications After (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017003826A Active JP6105183B1 (ja) | 2014-01-31 | 2017-01-13 | 抗ｈｅｒ２抗体−薬物コンジュゲート |
| JP2019002311A Active JP6665325B2 (ja) | 2014-01-31 | 2019-01-10 | 抗ｈｅｒ２抗体−薬物コンジュゲート |
| JP2020025886A Active JP6914380B2 (ja) | 2014-01-31 | 2020-02-19 | 抗ｈｅｒ２抗体−薬物コンジュゲート |
| JP2021115436A Active JP7146031B2 (ja) | 2014-01-31 | 2021-07-13 | 抗ｈｅｒ２抗体－薬物コンジュゲート |
| JP2022149242A Active JP7467557B2 (ja) | 2014-01-31 | 2022-09-20 | 抗ｈｅｒ２抗体－薬物コンジュゲート |
| JP2024059913A Active JP7703727B2 (ja) | 2014-01-31 | 2024-04-03 | 抗ｈｅｒ２抗体－薬物コンジュゲート |
| JP2025107304A Pending JP2025138756A (ja) | 2014-01-31 | 2025-06-25 | 抗ｈｅｒ２抗体－薬物コンジュゲート |
Country Status (31)
| Country | Link |
|---|---|
| US (4) | US10155821B2 (enExample) |
| EP (5) | EP4212552B1 (enExample) |
| JP (10) | JP5998289B2 (enExample) |
| KR (13) | KR102314913B1 (enExample) |
| CN (2) | CN110464847B (enExample) |
| AU (3) | AU2015212265B2 (enExample) |
| BR (1) | BR112016013482B1 (enExample) |
| CA (1) | CA2928794C (enExample) |
| CY (3) | CY1121573T1 (enExample) |
| DK (3) | DK4212552T3 (enExample) |
| ES (3) | ES2895254T3 (enExample) |
| FI (1) | FI4212552T3 (enExample) |
| FR (1) | FR21C1030I2 (enExample) |
| HR (3) | HRP20241783T1 (enExample) |
| HU (4) | HUE044389T2 (enExample) |
| IL (5) | IL310627B1 (enExample) |
| LT (4) | LT3101032T (enExample) |
| MX (2) | MX375930B (enExample) |
| NL (1) | NL301117I2 (enExample) |
| NO (1) | NO2021027I1 (enExample) |
| NZ (1) | NZ719202A (enExample) |
| PH (2) | PH12020552271A1 (enExample) |
| PL (3) | PL3101032T3 (enExample) |
| PT (3) | PT3101032T (enExample) |
| RS (3) | RS58415B1 (enExample) |
| SG (2) | SG10201800210TA (enExample) |
| SI (3) | SI3466976T1 (enExample) |
| SM (3) | SMT202100659T1 (enExample) |
| TW (11) | TWI796243B (enExample) |
| WO (1) | WO2015115091A1 (enExample) |
| ZA (1) | ZA201602802B (enExample) |
Families Citing this family (116)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL294622B2 (en) | 2012-10-11 | 2023-10-01 | Daiichi Sankyo Co Ltd | Antibody-drug conjugates and methods for their preparation |
| DK3424955T3 (da) * | 2013-12-25 | 2025-06-16 | Daiichi Sankyo Co Ltd | Fremgangsmåde til fremstilling af anti-trop2 antistof-lægemiddelkonjugat |
| EP4212552B1 (en) * | 2014-01-31 | 2024-11-13 | Daiichi Sankyo Company, Limited | Anti-her2 antibody-drug conjugate |
| US11185594B2 (en) * | 2014-04-10 | 2021-11-30 | Daiichi Sankyo Company, Limited | (Anti-HER2 antibody)-drug conjugate |
| US9808528B2 (en) | 2014-06-18 | 2017-11-07 | Mersana Therapeutics, Inc. | Protein-polymer-drug conjugates and methods of using same |
| TWI695011B (zh) | 2014-06-18 | 2020-06-01 | 美商梅爾莎納醫療公司 | 抗ｈｅｒ２表位之單株抗體及其使用之方法 |
| AU2016286898B2 (en) | 2015-06-29 | 2022-12-08 | Daiichi Sankyo Company, Limited | Method for selectively manufacturing antibody-drug conjugate |
| CN109789211A (zh) * | 2016-10-07 | 2019-05-21 | 第一三共株式会社 | 基于抗her2抗体-药物偶联物施予的耐性癌的治疗 |
| JPWO2018110515A1 (ja) * | 2016-12-12 | 2019-10-24 | 第一三共株式会社 | 抗体−薬物コンジュゲートと免疫チェックポイント阻害剤の組み合わせ |
| BR112019015915A2 (pt) * | 2017-02-28 | 2020-04-07 | Daiichi Sankyo Co Ltd | método para o tratamento de câncer de pulmão de células não pequenas resistentes a egfr-tki através da administração do conjugado de anticorpo anti-her3-fármaco |
| CN108653746B (zh) * | 2017-03-29 | 2021-04-27 | 北京键凯科技股份有限公司 | 一种多载药点、高载药配基药物偶联物 |
| BR112020003474A2 (pt) | 2017-08-23 | 2020-10-20 | Daiichi Sankyo Company, Limited | composição farmacêutica, e, método para produzir uma composição farmacêutica |
| AU2018327171B2 (en) * | 2017-08-31 | 2023-03-09 | Daiichi Sankyo Company, Limited | Improved method for producing antibody-drug conjugate |
| JP7248578B2 (ja) | 2017-08-31 | 2023-03-29 | 第一三共株式会社 | 抗体－薬物コンジュゲートの新規製造方法 |
| HUE067382T2 (hu) | 2018-05-18 | 2024-10-28 | Daiichi Sankyo Co Ltd | Anti-MUC1-exatecan antitest-hatóanyag konjugátum |
| CN112153989B (zh) * | 2018-05-28 | 2025-07-29 | 第一三共株式会社 | 通过施用抗her2抗体-药物缀合物治疗her2突变的癌 |
| WO2019232449A1 (en) | 2018-06-01 | 2019-12-05 | Eisai R&D Management Co., Ltd. | Splicing modulator antibody-drug conjugates and methods of use |
| KR20210038904A (ko) | 2018-07-25 | 2021-04-08 | 다이이찌 산쿄 가부시키가이샤 | 항체-약물 콘쥬게이트의 효과적인 제조 방법 |
| EP3831853A4 (en) * | 2018-07-27 | 2022-06-01 | Daiichi Sankyo Company, Limited | ANTIBODY-DRUG CONJUGATE PROTEIN-RECOGNIZING DRUG UNIT |
| KR20250172902A (ko) * | 2018-07-31 | 2025-12-09 | 다이이찌 산쿄 가부시키가이샤 | 항체-약물 콘주게이트 투여에 의한 전이성 뇌종양의 치료 |
| CN110790840A (zh) * | 2018-08-01 | 2020-02-14 | 三生国健药业（上海）股份有限公司 | 结合人her2的抗体、其制备方法和用途 |
| EP3834843A4 (en) | 2018-08-06 | 2022-05-11 | Daiichi Sankyo Company, Limited | COMBINATION OF ANTIBODY-DRUG CONJUGATE AND TUBULIN INHIBITOR |
| EP3842546A4 (en) | 2018-08-23 | 2022-06-29 | Daiichi Sankyo Company, Limited | Sensitivity marker for antibody-drug conjugate |
| AU2019349207B2 (en) | 2018-09-26 | 2026-01-08 | Jiangsu Hengrui Medicine Co., Ltd. | Ligand-drug conjugate of exatecan analogue, preparation method therefor and application thereof |
| JP7408646B2 (ja) | 2018-09-30 | 2024-01-05 | ジエンス ハンソー ファーマスーティカル グループ カンパニー リミテッド | 抗－ｂ７ｈ３抗体－エキサテカンアナログコンジュゲート及びその医薬用途 |
| BR112021011119A2 (pt) * | 2018-12-11 | 2022-01-25 | Daiichi Sankyo Co Ltd | Composição farmacêutica |
| US20220040324A1 (en) * | 2018-12-21 | 2022-02-10 | Daiichi Sankyo Company, Limited | Combination of antibody-drug conjugate and kinase inhibitor |
| CN109824759A (zh) * | 2019-03-08 | 2019-05-31 | 联宁（苏州）生物制药有限公司 | 一种用于抗体药物偶联物的药物-连接子mc-mmaf的制备方法及其中间体 |
| CN118221763A (zh) | 2019-03-29 | 2024-06-21 | 免疫医疗有限公司 | 化合物及其缀合物 |
| CN111686259B (zh) * | 2019-05-26 | 2023-08-08 | 成都百利多特生物药业有限责任公司 | 一种含sn38的抗体药物偶联物 |
| CN113766933B (zh) * | 2019-06-28 | 2024-09-06 | 上海复旦张江生物医药股份有限公司 | 一种抗体偶联药物、其中间体、制备方法及应用 |
| JP7467610B2 (ja) * | 2019-09-18 | 2024-04-15 | バイリ－バイオ（チェンドゥ）ファーマスーティカル シーオー．，エルティーディー． | カンプトテシン誘導体及びその複合体 |
| AU2020381495A1 (en) | 2019-11-15 | 2022-05-19 | Seagen Inc. | Methods of treating HER2 positive breast cancer with tucatinib in combination with an anti-HER2 antibody-drug conjugate |
| TW202128227A (zh) | 2019-12-12 | 2021-08-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 抗密蛋白抗體藥物偶聯物及其醫藥用途 |
| UA129521C2 (uk) | 2019-12-16 | 2025-05-21 | Джянгсу Хенгруй Медісін Ко., Лтд. | Аналог кон'югата анти-сеа антитілo-ексатекан та його фармацевтичне застосування |
| US20230101735A1 (en) | 2020-01-22 | 2023-03-30 | Jiangsu Hengrui Medicine Co., Ltd. | Anti-trop-2 antidody-exatecan analog conjugate and medical use thereof |
| TWI888517B (zh) | 2020-03-25 | 2025-07-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 抗ｐｓｍａ抗體-依喜替康類似物偶聯物及其醫藥用途 |
| EP4130045A4 (en) * | 2020-03-25 | 2023-12-27 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | METHOD FOR PREPARING AN ANTIBODY-DRUG CONJUGATE |
| TWI885105B (zh) * | 2020-03-25 | 2025-06-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 一種含抗體藥物偶聯物的醫藥組成物及其用途 |
| US12466784B2 (en) | 2020-06-12 | 2025-11-11 | Apical Molecular Biotech Co., Ltd. | Analogs of pterostilbene amino acid bearing carbonates for treating a non-alcoholic fatty liver disease and nonalcoholic steatohepatitis |
| WO2021260579A1 (en) * | 2020-06-24 | 2021-12-30 | Astrazeneca Uk Limited | Combination of antibody-drug conjugate and atr inhibitor |
| EP4171651A1 (en) * | 2020-06-24 | 2023-05-03 | AstraZeneca UK Limited | Combination of antibody-drug conjugate and atm inhibitor |
| WO2021260582A1 (en) | 2020-06-24 | 2021-12-30 | Astrazeneca Uk Limited | Combination of antibody-drug conjugate and aurora b inhibitor |
| WO2021260583A1 (en) | 2020-06-24 | 2021-12-30 | Astrazeneca Uk Limited | Combination of antibody-drug conjugate and dna-pk inhibitor |
| US20230233540A1 (en) * | 2020-06-24 | 2023-07-27 | Astrazeneca Uk Limited | Combination of antibody-drug conjugate and cdk9 inhibitor |
| WO2022001864A1 (zh) * | 2020-06-28 | 2022-01-06 | 昆山新蕴达生物科技有限公司 | 一种抗体-药物偶联物，其制备方法及应用 |
| KR20240038138A (ko) * | 2020-07-13 | 2024-03-22 | 리제너론 파마슈티칼스 인코포레이티드 | 단백질에서 글루타민 잔기에 접합된 캄토테신 유사체 및 그의 용도 |
| KR102349925B1 (ko) * | 2020-07-16 | 2022-01-12 | 주식회사 피노바이오 | Fl118 약물을 포함하는 화합물 및 이를 이용한 면역접합체 |
| US20230293714A1 (en) * | 2020-07-20 | 2023-09-21 | Daiichi Sankyo Company, Limited | Combination of anti-her2 antibody-drug conjugate with her dimerization inhibitor |
| CN119792564A (zh) * | 2020-08-13 | 2025-04-11 | 正大天晴药业集团股份有限公司 | 抗体药物偶联物 |
| CA3195062A1 (en) * | 2020-09-12 | 2022-03-17 | Astrazeneca Uk Limited | A scoring method for an anti-her2 antibody-drug conjugate therapy |
| EP3995496A4 (en) * | 2020-09-15 | 2022-11-30 | Baili-Bio (Chengdu) Pharmaceutical Co., Ltd. | COMMUNICATION METHOD AND DEVICE |
| IL301793A (en) | 2020-09-30 | 2023-05-01 | Duality Biologics Suzhou Co Ltd | Anticancer compound and method for its preparation and use |
| AU2021356762A1 (en) | 2020-10-09 | 2023-05-25 | Astrazeneca Uk Limited | Combination of antibody-drug conjugate and parp1 selective inhibitor |
| EP4227310A4 (en) * | 2020-10-12 | 2024-11-06 | Sichuan Baili Pharmaceutical Co. Ltd. | CAMPTOTHECIN DERIVATIVE AND LIGAND-DRUG CONJUGATE THEREOF |
| CN113943310A (zh) * | 2020-10-12 | 2022-01-18 | 四川百利药业有限责任公司 | 一种氘代的喜树碱衍生物及其抗体药物偶联物 |
| KR20230106645A (ko) | 2020-11-11 | 2023-07-13 | 다이이찌 산쿄 가부시키가이샤 | 항체-약물 콘주게이트와 항 SIRPα 항체의 조합 |
| EP4245322A4 (en) | 2020-11-12 | 2025-09-10 | Daiichi Sankyo Co Ltd | TREATMENT OF MESOTHELIOMA BY ADMINISTRATION OF AN ANTI-B7-H3 ANTIBODY-DRUG CONJUGATE |
| CN112535738B (zh) * | 2020-12-04 | 2022-09-09 | 中国科学技术大学 | 奥沙利铂偶联物及其制备方法和应用 |
| EP4265620A4 (en) * | 2020-12-11 | 2025-01-08 | Wigen Biomedicine Technology (Shanghai) Co., Ltd. | Novel camptothecin derivative, composition containing same, and use thereof |
| CA3204731A1 (en) * | 2021-01-13 | 2022-07-21 | John T. POIRIER | Anti-dll3 antibody-drug conjugate |
| CN116888123B (zh) * | 2021-02-09 | 2026-02-24 | 微境生物医药科技(上海)有限公司 | 用于adc制备的喜树碱衍生物 |
| TW202300148A (zh) * | 2021-03-17 | 2023-01-01 | 大陸商江蘇恒瑞醫藥股份有限公司 | 喜樹鹼衍生物的製備方法 |
| KR20230158005A (ko) | 2021-03-18 | 2023-11-17 | 씨젠 인크. | 생물학적 활성 화합물의 내재화된 접합체로부터의 선택적 약물 방출 |
| CN116867789B (zh) * | 2021-03-31 | 2025-06-24 | 上海复旦张江生物医药股份有限公司 | 一种伊喜替康衍生物的制备方法及其中间体 |
| US12037346B2 (en) | 2021-04-13 | 2024-07-16 | Nuvalent, Inc. | Amino-substituted heteroaryls for treating cancers with EGFR mutations |
| CA3219236A1 (en) * | 2021-05-07 | 2022-11-10 | ALX Oncology Inc. | Exatecan derivatives and antibody-drug conjugates thereof |
| CN113402584A (zh) * | 2021-07-06 | 2021-09-17 | 联宁（苏州）生物制药有限公司 | 一种抗体偶联药物连接子的中间体lnd1067-l1的合成方法 |
| US11806405B1 (en) | 2021-07-19 | 2023-11-07 | Zeno Management, Inc. | Immunoconjugates and methods |
| AU2022315277A1 (en) | 2021-07-19 | 2024-01-18 | Immunome, Inc. | Immunoconjugates and methods |
| KR20240101682A9 (ko) | 2021-11-15 | 2025-12-10 | 시스트이뮨, 인코포레이티드 | 이중특이 항체-캄프토테신 약물 접합체 및 이의 약학적 용도 |
| US11814394B2 (en) | 2021-11-16 | 2023-11-14 | Genequantum Healthcare (Suzhou) Co., Ltd. | Exatecan derivatives, linker-payloads, and conjugates and thereof |
| CN118414173A (zh) | 2021-11-18 | 2024-07-30 | 阿斯利康(英国)有限公司 | 抗体-药物缀合物和parp1选择性抑制剂的组合 |
| AU2022408887A1 (en) | 2021-12-16 | 2024-07-18 | Jiangsu Mabwell Health Pharmaceutical R&D Co., Ltd. | Camptothecin compound and conjugate thereof |
| US20250064967A1 (en) | 2021-12-28 | 2025-02-27 | Astrazeneca Uk Limited | Combination of antibody-drug conjugate and atr inhibitor |
| EP4456899A1 (en) * | 2021-12-28 | 2024-11-06 | AstraZeneca UK Limited | Combination of antibody-drug conjugate and rasg12c inhibitor |
| CA3255700A1 (en) | 2022-03-16 | 2023-09-21 | Astrazeneca Uk Limited | A scoring method for an anti-trop2 antibody‑drug conjugate therapy |
| JP2025513620A (ja) | 2022-04-27 | 2025-04-24 | 第一三共株式会社 | 抗体－薬物コンジュゲートとｅｚｈ１阻害剤および／またはｅｚｈ２阻害剤との組合せ |
| EP4522658A1 (en) | 2022-05-11 | 2025-03-19 | Daiichi Sankyo Company, Limited | Combination of an antibody specific for a tumor antigen and a cd47 inhibitor |
| CN119630428A (zh) | 2022-07-12 | 2025-03-14 | 西托姆克斯治疗公司 | Epcam免疫缀合物及其用途 |
| IL318296A (en) | 2022-07-15 | 2025-03-01 | Genequantum Healthcare Suzhou Co Ltd | Anti-TROP2 antibody and its conjugate |
| TW202412859A (zh) | 2022-07-28 | 2024-04-01 | 英商阿斯特捷利康英國股份有限公司 | 抗體-藥物結合物及雙特異性檢查點抑制劑之組合 |
| CN117024438A (zh) * | 2022-07-29 | 2023-11-10 | 杭州爱科瑞思生物医药有限公司 | 依沙替康衍生物及其应用 |
| JP2025527263A (ja) | 2022-08-02 | 2025-08-20 | ノナ・バイオサイエンシズ（スーチョウ）カンパニー，リミテッド | Ｍｓｌｎ抗体－薬物コンジュゲート |
| GEAP202516720A (en) * | 2022-09-02 | 2025-07-10 | Merck Sharp & Dohme Llc | Exatecan-derived topoisomerase-1 inhibitors pharmaceutical compositions, and uses thereof |
| IL320396A (en) * | 2022-10-25 | 2025-06-01 | Merck Sharp & Dohme Llc | Charge-linkers of anti-drug conjugates derived from extacan, pharmaceutical compositions, and uses thereof |
| CN116712561A (zh) * | 2022-12-29 | 2023-09-08 | 杭州爱科瑞思生物医药有限公司 | 含n-亚甲基酰胺连接子的抗体-药物偶联物 |
| WO2024153149A1 (zh) | 2023-01-18 | 2024-07-25 | 苏州宜联生物医药有限公司 | 一种抗体药物偶联物、制备方法及其应用 |
| WO2024158996A2 (en) | 2023-01-25 | 2024-08-02 | Zeno Management, Inc. | Immunoconjugates and methods |
| WO2024175069A1 (zh) * | 2023-02-23 | 2024-08-29 | 一线医药（杭州）有限公司 | 喜树碱衍生物及其偶联物以及其制备方法和医药用途 |
| WO2024190815A1 (ja) | 2023-03-14 | 2024-09-19 | 第一三共株式会社 | 抗ｃｄｈ６抗体－薬物コンジュゲートとｖｅｇｆ阻害剤の組み合わせ |
| CN118666946A (zh) * | 2023-03-15 | 2024-09-20 | 上海亲合力生物医药科技股份有限公司 | 连接子及使用其的偶联药物、抗体偶联药物及其应用 |
| EP4692351A1 (en) | 2023-03-29 | 2026-02-11 | Daiichi Sankyo Company, Limited | Anti-cd25 antibody and anti-cd25 antibody-drug conjugate |
| KR20250173601A (ko) | 2023-03-31 | 2025-12-10 | 다이이찌 산쿄 가부시키가이샤 | 항 CDH6 항체-약물 콘주게이트와 HIF-2α 저해제의 조합 |
| TW202506190A (zh) | 2023-04-05 | 2025-02-16 | 日商第一三共股份有限公司 | 利用抗ｍｕｃ１抗體－藥物結合物投予的藥劑低敏感性癌之治療方法 |
| JPWO2024214685A1 (enExample) | 2023-04-10 | 2024-10-17 | ||
| CN121175072A (zh) | 2023-04-11 | 2025-12-19 | 浙江博锐生物制药有限公司 | 抗ror1抗体及其药物偶联物 |
| KR20250175330A (ko) | 2023-04-19 | 2025-12-16 | 다이이찌 산쿄 가부시키가이샤 | 항체-약물 콘주게이트와 다른 약제의 조합 |
| TW202508639A (zh) | 2023-06-30 | 2025-03-01 | 日商第一三共股份有限公司 | 包含使用活性碳材料之純化步驟的抗體-藥物結合物之製造方法 |
| WO2025019254A1 (en) | 2023-07-14 | 2025-01-23 | Guardant Health, Inc. | Classification of breast tumors using dna methylation from liquid biopsy |
| CN121487754A (zh) | 2023-07-25 | 2026-02-06 | 江苏恒瑞医药股份有限公司 | 靶向c-Met的抗体-药物偶联物及其医药用途 |
| CN121568722A (zh) * | 2023-07-28 | 2026-02-24 | 江苏恒瑞医药股份有限公司 | 一种含有糖皮质激素的抗体药物偶联物的药物组合物 |
| CN119490559A (zh) * | 2023-08-16 | 2025-02-21 | 中山康方生物医药有限公司 | 化合物以及含有该化合物的抗体偶联药物 |
| WO2025054707A1 (en) * | 2023-09-11 | 2025-03-20 | Theratechnologies Inc. | Peptide conjugates of camptothecin analogs and uses thereof |
| WO2025054996A1 (en) * | 2023-09-15 | 2025-03-20 | Duality Biologics (Suzhou) Co., Ltd. | Antibody-drug conjugate |
| CN117417347A (zh) * | 2023-09-28 | 2024-01-19 | 杭州爱科瑞思生物医药有限公司 | 卤素取代的依沙替康的酰胺衍生物及其制备方法和应用 |
| WO2025078841A2 (en) | 2023-10-11 | 2025-04-17 | Antikor Biopharma Limited | Antibodies, conjugates, and uses thereof |
| WO2025088496A1 (en) | 2023-10-24 | 2025-05-01 | Astrazeneca Uk Limited | Combination of antibody-drug conjugate and anti-pd-1/tim-3 bispecific binding protein |
| TW202535479A (zh) | 2023-12-05 | 2025-09-16 | 英商阿斯特捷利康英國股份有限公司 | 抗體藥物結合物與血腦屏障穿透性ｐａｒｐ１選擇性抑制劑之組合 |
| WO2025176180A1 (zh) * | 2024-02-23 | 2025-08-28 | 江苏恒瑞医药股份有限公司 | 艾日布林衍生物药物偶联物用于治疗肿瘤的用途 |
| WO2025209545A1 (zh) * | 2024-04-03 | 2025-10-09 | 上海药明合联生物技术有限公司 | 用于抗体药物偶联物的连接子、其用途和由其制备的抗体药物偶联物 |
| WO2025238587A1 (en) | 2024-05-16 | 2025-11-20 | Daiichi Sankyo Company, Limited | Combination of anti-b7-h3 antibody-drug conjugate and androgen receptor signaling inhibitor |
| WO2025242090A1 (zh) * | 2024-05-21 | 2025-11-27 | 康诺亚生物医药科技（成都）有限公司 | 喜树碱衍生物及其中间体的制备方法 |
| WO2025252189A1 (zh) * | 2024-06-06 | 2025-12-11 | 海思科医药集团股份有限公司 | 喜树碱类衍生物及其用途 |
| WO2026025013A2 (en) | 2024-07-26 | 2026-01-29 | Pfizer Inc. | Combination therapy using cdk4 inhibitors for cancer treatments |
| WO2026052764A1 (en) | 2024-09-06 | 2026-03-12 | Astrazeneca Uk Limited | A scoring method for an anti-trop2 antibody drug conjugate therapy |
Family Cites Families (86)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1989006692A1 (en) | 1988-01-12 | 1989-07-27 | Genentech, Inc. | Method of treating tumor cells by inhibiting growth factor receptor function |
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| JPH06508511A (ja) | 1990-07-10 | 1994-09-29 | ケンブリッジ アンティボディー テクノロジー リミティド | 特異的な結合ペアーの構成員の製造方法 |
| US5637770A (en) | 1991-01-16 | 1997-06-10 | Daiichi Pharmaceutical Co., Ltd. | Hexa-cyclic compound |
| JP3008226B2 (ja) | 1991-01-16 | 2000-02-14 | 第一製薬株式会社 | 六環性化合物 |
| EP0940468A1 (en) | 1991-06-14 | 1999-09-08 | Genentech, Inc. | Humanized antibody variable domain |
| ATE181571T1 (de) | 1991-09-23 | 1999-07-15 | Medical Res Council | Methoden zur herstellung humanisierter antikörper |
| ATE463573T1 (de) | 1991-12-02 | 2010-04-15 | Medimmune Ltd | Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken |
| EP0656941B1 (en) | 1992-03-24 | 2005-06-01 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| JP3359955B2 (ja) | 1992-07-16 | 2002-12-24 | 第一製薬株式会社 | 抗腫瘍剤 |
| US6214345B1 (en) | 1993-05-14 | 2001-04-10 | Bristol-Myers Squibb Co. | Lysosomal enzyme-cleavable antitumor drug conjugates |
| GB9313509D0 (en) | 1993-06-30 | 1993-08-11 | Medical Res Council | Chemisynthetic libraries |
| EP0731842A1 (en) | 1993-12-03 | 1996-09-18 | Medical Research Council | Recombinant binding proteins and peptides |
| US6504029B1 (en) | 1995-04-10 | 2003-01-07 | Daiichi Pharmaceutical Co., Ltd. | Condensed-hexacyclic compounds and a process therefor |
| JPH08337584A (ja) | 1995-04-10 | 1996-12-24 | Dai Ichi Seiyaku Co Ltd | 縮合六環式アミノ化合物、これを含有する医薬及びその製法 |
| SG50747A1 (en) | 1995-08-02 | 1998-07-20 | Tanabe Seiyaku Co | Comptothecin derivatives |
| CA2192725C (en) | 1995-12-28 | 2004-04-20 | Kenji Tsujihara | Camptothecin derivatives |
| JPH1095802A (ja) | 1995-12-28 | 1998-04-14 | Tanabe Seiyaku Co Ltd | カンプトテシン誘導体 |
| TW409058B (en) | 1996-06-06 | 2000-10-21 | Daiichi Seiyaku Co | Method for preparation of a drug complex |
| TW527183B (en) * | 1996-06-06 | 2003-04-11 | Daiichi Seiyaku Co | Drug complex |
| JPH1171280A (ja) | 1997-06-26 | 1999-03-16 | Tanabe Seiyaku Co Ltd | 医薬組成物 |
| JPH1192405A (ja) | 1997-09-19 | 1999-04-06 | Dai Ichi Seiyaku Co Ltd | 薬物複合体 |
| ES2434961T5 (es) | 1998-04-20 | 2018-01-18 | Roche Glycart Ag | Ingeniería de glicosilación de anticuerpos para mejorar la citotoxicidad celular dependiente del anticuerpo |
| HK1040052B (zh) | 1998-05-22 | 2006-09-15 | 第一制药株式会社 | 药物复合物 |
| EP1619210A1 (en) | 1998-10-30 | 2006-01-25 | Daiichi Pharmaceutical Co., Ltd. | DDS compounds and method for assaying the same |
| EP1176195B1 (en) | 1999-04-09 | 2013-05-22 | Kyowa Hakko Kirin Co., Ltd. | Method for controlling the activity of immunologically functional molecule |
| ES2466715T3 (es) | 1999-06-25 | 2014-06-11 | Immunogen, Inc. | Métodos de tratamiento usando conjugados de anticuerpo anti-ErbB-maitansinoide |
| RU2270029C2 (ru) | 1999-06-25 | 2006-02-20 | Джинентех, Инк. | ГУМАНИЗИРОВАННОЕ АНТИТЕЛО, КОТОРОЕ ОБЛАДАЕТ СПОСОБНОСТЬЮ СВЯЗЫВАТЬ ErbB2 И БЛОКИРОВАТЬ АКТИВАЦИЮ ЛИГАНДОМ РЕЦЕПТОРА ErbB (ВАРИАНТЫ) И КОМПОЗИЦИЯ ДЛЯ ПРИМЕНЕНИЯ ПРИ ЛЕЧЕНИИ РАКА, СОДЕРЖАЩАЯ ЭТО АНТИТЕЛО |
| JP2002060351A (ja) | 2000-03-22 | 2002-02-26 | Dai Ichi Seiyaku Co Ltd | 水酸基を有する薬物を含むｄｄｓ化合物 |
| IL153505A0 (en) | 2000-06-29 | 2003-07-06 | Daiichi Seiyaku Co | Dds compound and process for the preparation thereof |
| BR0112417A (pt) | 2000-07-13 | 2003-07-01 | Daiichi Seiyaku Co | Composições farmacêuticas contendo composto dds |
| CN102311986B (zh) | 2000-10-06 | 2015-08-19 | 协和发酵麒麟株式会社 | 产生抗体组合物的细胞 |
| TWI313609B (en) | 2001-08-21 | 2009-08-21 | Mitsubishi Tanabe Pharma Corp | Pharmaceutical composition for inhibiting the metastasis or preventing the recurrence of malignant tumor |
| KR100573565B1 (ko) | 2001-08-29 | 2006-04-25 | 주식회사 포스코 | 요철부가 형성된 실린더 링과 이 실린더 링이 결합된 맨드릴 |
| KR20040081422A (ko) | 2001-11-01 | 2004-09-21 | 유에이비 리서치 파운데이션 | 종양 괴사 인자-관련 세포사멸-유도 리간드 수용체에선택적인 항체와 다른 치료제와의 복합물 |
| CA2467242A1 (en) | 2001-11-20 | 2003-05-30 | Seattle Genetics, Inc. | Treatment of immunological disorders using anti-cd30 antibodies |
| US8877901B2 (en) | 2002-12-13 | 2014-11-04 | Immunomedics, Inc. | Camptothecin-binding moiety conjugates |
| US9745380B2 (en) | 2002-03-01 | 2017-08-29 | Immunomedics, Inc. | RS7 antibodies |
| US20050276812A1 (en) | 2004-06-01 | 2005-12-15 | Genentech, Inc. | Antibody-drug conjugates and methods |
| CA2508831C (en) | 2002-12-13 | 2012-05-01 | Immunomedics, Inc. | Immunoconjugates with an intracellularly-cleavable linkage |
| US20040202666A1 (en) | 2003-01-24 | 2004-10-14 | Immunomedics, Inc. | Anti-cancer anthracycline drug-antibody conjugates |
| JP4942643B2 (ja) | 2004-03-02 | 2012-05-30 | シアトル ジェネティックス， インコーポレイテッド | 部分的に付加された抗体およびそれらの結合体化方法 |
| WO2005112919A2 (en) | 2004-05-19 | 2005-12-01 | Medarex, Inc. | Self-immolative linkers and drug conjugates |
| KR20110050567A (ko) | 2004-07-22 | 2011-05-13 | 제넨테크, 인크. | Ｈｅｒ２ 항체 조성물 |
| US8802820B2 (en) | 2004-11-12 | 2014-08-12 | Xencor, Inc. | Fc variants with altered binding to FcRn |
| WO2006065533A2 (en) | 2004-11-29 | 2006-06-22 | Seattle Genetics, Inc. | Engineered antibodies and immunoconjugates |
| UA94899C2 (ru) | 2005-01-21 | 2011-06-25 | Дженентек, Инк. | Фиксированное дозирование антител к her |
| DE102005009084A1 (de) | 2005-02-28 | 2006-08-31 | Ktb Tumorforschungsgesellschaft Mbh | Proteinbindende Anthrazyklin-Peptid-Derivate und diese enthaltende Arzneimittel |
| DE102005009099A1 (de) | 2005-02-28 | 2006-08-31 | Ktb Tumorforschungsgesellschaft Mbh | Proteinbindende Camptothecin-Peptid-Derivate und diese enthaltende Arzneimittel |
| US7833979B2 (en) | 2005-04-22 | 2010-11-16 | Amgen Inc. | Toxin peptide therapeutic agents |
| JP2006316040A (ja) * | 2005-05-13 | 2006-11-24 | Genentech Inc | Ｈｅｒｃｅｐｔｉｎ（登録商標）補助療法 |
| US20090226465A1 (en) | 2005-10-31 | 2009-09-10 | Jackson David Y | Macrocyclic depsipeptide antibody-drug conjugates and methods |
| US20080131428A1 (en) | 2006-02-24 | 2008-06-05 | Arius Research, Inc. | Cytotoxicity mediation of cells evidencing surface expression of TROP-2 |
| CL2007001536A1 (es) | 2006-05-30 | 2008-01-25 | Genentech Inc | Anticuerpos anti-cd22; polinucleotidos que los codifica; vector y celula huesped que los comprende; metodo de fabricacion; metodo de deteccion del anticuerpo en una muestra biologica; inmunoconjugado que comprende al anticuerpo; composicion que lo comprende y su uso para tratar trastornos proliferativos de celulas b. |
| CN101490087B (zh) | 2006-05-30 | 2013-11-06 | 健泰科生物技术公司 | 抗体和免疫偶联物及其用途 |
| ITMI20061473A1 (it) | 2006-07-26 | 2008-01-27 | Indena Spa | Derivati della camptotecina ad attivita antitumorale |
| HUE035184T2 (en) | 2008-03-18 | 2018-05-02 | Genentech Inc | Combinations of an anti-HER2 antibody-drug conjugate and docetaxel |
| HUE034763T2 (en) * | 2008-04-30 | 2018-02-28 | Immunogen Inc | Crosslinkers and their use |
| WO2009140242A1 (en) | 2008-05-13 | 2009-11-19 | Genentech, Inc. | Analysis of antibody drug conjugates by bead-based affinity capture and mass spectrometry |
| JP5677972B2 (ja) | 2008-11-18 | 2015-02-25 | メリマック ファーマシューティカルズ インコーポレーティッド | ヒト血清アルブミンリンカーおよびそのコンジュゲート |
| ES2738700T3 (es) | 2009-02-13 | 2020-01-24 | Immunomedics Inc | Inmunoconjugados con un enlace escindible intracelularmente |
| SG176073A1 (en) | 2009-05-29 | 2011-12-29 | Hoffmann La Roche | Modulators for her2 signaling in her2 expressing patients with gastric cancer |
| CN102481364A (zh) * | 2009-07-22 | 2012-05-30 | 安龙制药公司 | 用her2受体拮抗剂联合7-乙基-10-羟基喜树碱的多臂聚合缀合物治疗her2阳性癌症的方法 |
| CA2770847A1 (en) | 2009-08-18 | 2011-02-24 | Baker Hughes Incorporated | Methods of forming polycrystalline diamond elements, polycrystalline diamond elements, and earth-boring tools carrying such polycrystalline diamond elements |
| EP2480230A4 (en) | 2009-09-24 | 2015-06-10 | Seattle Genetics Inc | DR5 Ligand-HEILMITTELKONJUGATE |
| CA2782194C (en) | 2009-12-02 | 2018-01-16 | Immunomedics, Inc. | Combination of radiolabelled antibodies (rait) and antibody-drug conjugates (adc) for treatment of pancreatic cancer |
| EP2569000B1 (en) | 2010-05-13 | 2017-09-27 | Indiana University Research and Technology Corporation | Glucagon superfamily peptides exhibiting nuclear hormone receptor activity |
| EA201500220A1 (ru) | 2010-05-17 | 2015-10-30 | Ливтех, Инк. | Антитело против trop-2 человека, обладающее противоопухолевой активностью in vivo |
| CA2799202C (en) | 2010-05-18 | 2016-07-05 | Cerulean Pharma Inc. | Compositions and methods for treatment of autoimmune and other diseases |
| WO2011155579A1 (ja) | 2010-06-10 | 2011-12-15 | 北海道公立大学法人札幌医科大学 | 抗Ｔｒｏｐ－２抗体 |
| PE20130643A1 (es) | 2010-07-12 | 2013-06-07 | Covx Technologies Ireland Ltd | Conjugados de anticuerpos multifuncionales |
| WO2012019024A2 (en) | 2010-08-04 | 2012-02-09 | Immunogen, Inc. | Her3-binding molecules and immunoconjugates thereof |
| WO2012064733A2 (en) | 2010-11-09 | 2012-05-18 | Medimmune, Llc | Antibody scaffold for homogenous conjugation |
| ES2544608T3 (es) | 2010-11-17 | 2015-09-02 | Genentech, Inc. | Conjugados de anticuerpo y de alaninil-maitansinol |
| AR088693A1 (es) | 2011-11-11 | 2014-06-25 | Rinat Neuroscience Corp | Anticuerpos especificos para trop-2 y sus usos |
| US9427464B2 (en) | 2011-11-22 | 2016-08-30 | Chiome Bioscience Inc. | Anti-human TROP-2 antibody having an antitumor activity in vivo |
| RU2014128467A (ru) * | 2011-12-14 | 2016-02-10 | Сиэтл Дженетикс, Инк. | Новые коньюгаты связывающее соединение-активное соединение (adc) и их применение |
| US20130280282A1 (en) | 2012-04-24 | 2013-10-24 | Daiichi Sankyo Co., Ltd. | Dr5 ligand drug conjugates |
| CA2876706A1 (en) | 2012-06-14 | 2013-12-19 | Ambrx, Inc. | Anti-psma antibodies conjugated to nuclear receptor ligand polypeptides |
| IL294622B2 (en) | 2012-10-11 | 2023-10-01 | Daiichi Sankyo Co Ltd | Antibody-drug conjugates and methods for their preparation |
| US9872924B2 (en) | 2012-10-19 | 2018-01-23 | Daiichi Sankyo Company, Limited | Antibody-drug conjugate produced by binding through linker having hydrophilic structure |
| WO2014107024A1 (ko) * | 2013-01-03 | 2014-07-10 | 셀트리온 | 항체-링커-약물 결합체, 그의 제조방법 및 그를 포함하는 항암제 조성물 |
| DK3424955T3 (da) * | 2013-12-25 | 2025-06-16 | Daiichi Sankyo Co Ltd | Fremgangsmåde til fremstilling af anti-trop2 antistof-lægemiddelkonjugat |
| EP4212552B1 (en) * | 2014-01-31 | 2024-11-13 | Daiichi Sankyo Company, Limited | Anti-her2 antibody-drug conjugate |
| SG11201608309PA (en) | 2014-04-10 | 2016-11-29 | Daiichi Sankyo Co Ltd | Anti-her3 antibody-drug conjugate |
-
2015
- 2015-01-28 EP EP22198821.5A patent/EP4212552B1/en active Active
- 2015-01-28 KR KR1020217021044A patent/KR102314913B1/ko active Active
- 2015-01-28 SI SI201531748T patent/SI3466976T1/sl unknown
- 2015-01-28 HU HUE15743738 patent/HUE044389T2/hu unknown
- 2015-01-28 PT PT15743738T patent/PT3101032T/pt unknown
- 2015-01-28 HR HRP20241783TT patent/HRP20241783T1/hr unknown
- 2015-01-28 EP EP15743738.5A patent/EP3101032B1/en active Active
- 2015-01-28 KR KR1020207035147A patent/KR102238848B1/ko active Active
- 2015-01-28 SG SG10201800210TA patent/SG10201800210TA/en unknown
- 2015-01-28 IL IL310627A patent/IL310627B1/en unknown
- 2015-01-28 ES ES18204861T patent/ES2895254T3/es active Active
- 2015-01-28 PL PL15743738T patent/PL3101032T3/pl unknown
- 2015-01-28 CN CN201910768778.XA patent/CN110464847B/zh active Active
- 2015-01-28 MX MX2016006498A patent/MX375930B/es active IP Right Grant
- 2015-01-28 HR HRP20190431TT patent/HRP20190431T1/hr unknown
- 2015-01-28 HU HUE22198821A patent/HUE070620T2/hu unknown
- 2015-01-28 LT LTEP15743738.5T patent/LT3101032T/lt unknown
- 2015-01-28 KR KR1020237040108A patent/KR102881140B1/ko active Active
- 2015-01-28 ES ES15743738T patent/ES2727351T3/es active Active
- 2015-01-28 EP EP24202881.9A patent/EP4464707A3/en active Pending
- 2015-01-28 CN CN201580003121.4A patent/CN105829346B/zh active Active
- 2015-01-28 AU AU2015212265A patent/AU2015212265B2/en active Active
- 2015-01-28 RS RS20190280A patent/RS58415B1/sr unknown
- 2015-01-28 WO PCT/JP2015/000355 patent/WO2015115091A1/ja not_active Ceased
- 2015-01-28 RS RS20241442A patent/RS66412B1/sr unknown
- 2015-01-28 LT LTEP18204861.1T patent/LT3466976T/lt unknown
- 2015-01-28 HR HRP20211848TT patent/HRP20211848T1/hr unknown
- 2015-01-28 PL PL22198821.5T patent/PL4212552T3/pl unknown
- 2015-01-28 KR KR1020187031594A patent/KR102190548B1/ko active Active
- 2015-01-28 DK DK22198821.5T patent/DK4212552T3/da active
- 2015-01-28 HU HUE18204861A patent/HUE057464T2/hu unknown
- 2015-01-28 EP EP21187152.0A patent/EP3973995A1/en not_active Withdrawn
- 2015-01-28 SI SI201532047T patent/SI4212552T1/sl unknown
- 2015-01-28 KR KR1020217032820A patent/KR102362920B1/ko active Active
- 2015-01-28 JP JP2015542503A patent/JP5998289B2/ja active Active
- 2015-01-28 PL PL18204861T patent/PL3466976T3/pl unknown
- 2015-01-28 KR KR1020167015961A patent/KR101916553B1/ko active Active
- 2015-01-28 BR BR112016013482-6A patent/BR112016013482B1/pt active IP Right Grant
- 2015-01-28 PT PT18204861T patent/PT3466976T/pt unknown
- 2015-01-28 NZ NZ719202A patent/NZ719202A/en unknown
- 2015-01-28 KR KR1020237008409A patent/KR102557062B1/ko active Active
- 2015-01-28 ES ES22198821T patent/ES3005311T3/es active Active
- 2015-01-28 EP EP18204861.1A patent/EP3466976B1/en active Active
- 2015-01-28 KR KR1020217009854A patent/KR102275925B1/ko active Active
- 2015-01-28 KR KR1020227022459A patent/KR102465042B1/ko active Active
- 2015-01-28 SM SM20210659T patent/SMT202100659T1/it unknown
- 2015-01-28 LT LTEP22198821.5T patent/LT4212552T/lt unknown
- 2015-01-28 IL IL278891A patent/IL278891B2/en unknown
- 2015-01-28 KR KR1020257036448A patent/KR20250162923A/ko active Pending
- 2015-01-28 CA CA2928794A patent/CA2928794C/en active Active
- 2015-01-28 KR KR1020227004389A patent/KR102417312B1/ko active Active
- 2015-01-28 PT PT221988215T patent/PT4212552T/pt unknown
- 2015-01-28 SM SM20190211T patent/SMT201900211T1/it unknown
- 2015-01-28 DK DK18204861.1T patent/DK3466976T3/da active
- 2015-01-28 SM SM20250030T patent/SMT202500030T1/it unknown
- 2015-01-28 RS RS20211465A patent/RS62618B1/sr unknown
- 2015-01-28 PH PH1/2020/552271A patent/PH12020552271A1/en unknown
- 2015-01-28 SG SG11201603960XA patent/SG11201603960XA/en unknown
- 2015-01-28 KR KR1020237024073A patent/KR102606930B1/ko active Active
- 2015-01-28 KR KR1020227038845A patent/KR102510128B1/ko active Active
- 2015-01-28 DK DK15743738.5T patent/DK3101032T3/en active
- 2015-01-28 FI FIEP22198821.5T patent/FI4212552T3/fi active
- 2015-01-28 SI SI201530587T patent/SI3101032T1/sl unknown
- 2015-01-30 TW TW111122222A patent/TWI796243B/zh active
- 2015-01-30 TW TW111122223A patent/TWI796244B/zh active
- 2015-01-30 TW TW104103127A patent/TWI627967B/zh active
- 2015-01-30 TW TW112104986A patent/TWI848560B/zh active
- 2015-01-30 TW TW108114649A patent/TWI722422B/zh active
- 2015-01-30 TW TW111122225A patent/TWI796246B/zh active
- 2015-01-30 TW TW107116039A patent/TWI661839B/zh active
- 2015-01-30 TW TW113121616A patent/TWI870307B/zh active
- 2015-01-30 TW TW110104664A patent/TWI789700B/zh active
- 2015-01-30 TW TW111122224A patent/TWI796245B/zh active
- 2015-01-30 TW TW113147444A patent/TWI906070B/zh active
-
2016
- 2016-04-21 IL IL245252A patent/IL245252B/en active IP Right Grant
- 2016-04-22 ZA ZA2016/02802A patent/ZA201602802B/en unknown
- 2016-05-16 PH PH12016500904A patent/PH12016500904B1/en unknown
- 2016-05-18 MX MX2020010682A patent/MX2020010682A/es unknown
- 2016-07-28 US US15/221,851 patent/US10155821B2/en active Active
- 2016-08-29 JP JP2016166850A patent/JP6046301B1/ja active Active
- 2016-11-16 JP JP2016222861A patent/JP6466895B2/ja active Active
-
2017
- 2017-01-13 JP JP2017003826A patent/JP6105183B1/ja active Active
-
2018
- 2018-09-13 US US16/130,615 patent/US11795236B2/en active Active
-
2019
- 2019-01-10 JP JP2019002311A patent/JP6665325B2/ja active Active
- 2019-04-11 CY CY20191100406T patent/CY1121573T1/el unknown
- 2019-05-21 IL IL266790A patent/IL266790A/en active IP Right Grant
-
2020
- 2020-01-29 AU AU2020200596A patent/AU2020200596B2/en active Active
- 2020-02-19 JP JP2020025886A patent/JP6914380B2/ja active Active
- 2020-08-19 US US16/997,613 patent/US11584800B2/en active Active
-
2021
- 2021-07-06 HU HUS2100025C patent/HUS2100025I1/hu unknown
- 2021-07-06 NO NO2021027C patent/NO2021027I1/no unknown
- 2021-07-07 CY CY2021018C patent/CY2021018I2/el unknown
- 2021-07-12 FR FR21C1030C patent/FR21C1030I2/fr active Active
- 2021-07-13 JP JP2021115436A patent/JP7146031B2/ja active Active
- 2021-07-13 LT LTPA2021515C patent/LTC3101032I2/lt unknown
- 2021-07-16 NL NL301117C patent/NL301117I2/nl unknown
- 2021-11-30 CY CY20211101037T patent/CY1124774T1/el unknown
-
2022
- 2022-06-02 AU AU2022203818A patent/AU2022203818B2/en active Active
- 2022-09-20 JP JP2022149242A patent/JP7467557B2/ja active Active
-
2023
- 2023-09-12 US US18/367,446 patent/US20240026030A1/en active Pending
-
2024
- 2024-04-03 JP JP2024059913A patent/JP7703727B2/ja active Active
-
2025
- 2025-06-25 JP JP2025107304A patent/JP2025138756A/ja active Pending
- 2025-10-29 IL IL324322A patent/IL324322A/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017095457A5 (enExample) | ||
| FI4212552T3 (fi) | Anti-her2-vasta-aine-lääkeainekonjugaatti | |
| JP2015508074A5 (enExample) | ||
| FI3283521T3 (fi) | Lääkekonjugaatteja käsittäen vasta-aineita claudiinia 18.2 vastaan | |
| IL266563B (en) | Heterocyclic compounds useful as pdk1 inhibitors | |
| JPWO2020027100A5 (enExample) | ||
| NZ758176A (en) | Trifunctional constructs with tunable pharmacokinetics useful in imaging and anti-tumor therapies | |
| JPWO2020059772A5 (enExample) | ||
| JP2021503450A5 (enExample) | ||
| JP2014528480A5 (enExample) | ||
| JP2013166763A5 (enExample) | ||
| JP2018537975A5 (enExample) | ||
| JP2023103205A5 (enExample) | ||
| JP2020526584A5 (enExample) | ||
| HRP20211710T1 (hr) | Konjugacija specifična za mjesto spajanja lijekova za povezivanje s protutijelima i konjugati protutijela u lijeku koji nastaje kao rezultat | |
| JP2018508572A5 (enExample) | ||
| FI3345613T3 (fi) | Koostumus käytettäväksi syövän tai angiogeneesiin liittyvän sairauden hoidossa käsittäen tuumoriin penetroituvan peptidin ja VEGF-estäjän fuusioproteiinin | |
| HRP20211164T1 (hr) | Derivati hemiasterlina za konjugaciju i terapiju | |
| JP2017536344A5 (enExample) | ||
| JP2016519062A5 (enExample) | ||
| IL273387B2 (en) | Thylanstatin analogs | |
| JP2021503915A5 (enExample) | ||
| JPWO2021055295A5 (enExample) | ||
| JPWO2021260580A5 (enExample) | ||
| JP2010518158A5 (enExample) |