US20100074949A1
(en)
|
2008-08-13 |
2010-03-25 |
William Rowe |
Pharmaceutical composition and administration thereof
|
MXPA06002567A
(es)
|
2003-09-06 |
2006-09-04 |
Vertex Pharma |
Moduladores de transportadores con casete de union de atp.
|
US7977322B2
(en)
|
2004-08-20 |
2011-07-12 |
Vertex Pharmaceuticals Incorporated |
Modulators of ATP-binding cassette transporters
|
ES2656017T3
(es)
|
2004-06-24 |
2018-02-22 |
Vertex Pharmaceuticals Incorporated |
Moduladores de transportadores del casete de unión a ATP
|
KR20080053297A
(ko)
|
2005-08-11 |
2008-06-12 |
버텍스 파마슈티칼스 인코포레이티드 |
낭포성 섬유종 트랜스막 전도도 조정자의 조절자
|
EP1945632B1
(en)
|
2005-11-08 |
2013-09-18 |
Vertex Pharmaceuticals Incorporated |
Heterocyclic modulators of atp-binding cassette transporters
|
DK3219705T3
(da)
|
2005-12-28 |
2020-04-14 |
Vertex Pharma |
Farmaceutiske sammensætninger af den amorfe form af n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinolin-3-carboxamid
|
EP2016065B1
(en)
|
2005-12-28 |
2012-09-19 |
Vertex Pharmaceuticals Incorporated |
1-(benzo[d][1,3]dioxol-5-yl)-n-(phenyl)cyclopropane-carboxamide derivatives and related compounds as modulators of atp-binding cassette transporters for the treatment of cystic fibrosis
|
US10022352B2
(en)
|
2006-04-07 |
2018-07-17 |
Vertex Pharmaceuticals Incorporated |
Modulators of ATP-binding cassette transporters
|
US7645789B2
(en)
|
2006-04-07 |
2010-01-12 |
Vertex Pharmaceuticals Incorporated |
Indole derivatives as CFTR modulators
|
CA2869945C
(en)
|
2006-04-07 |
2018-01-23 |
Vertex Pharmaceuticals Incorporated |
Modulators of atp-binding cassette transporters
|
US8563573B2
(en)
*
|
2007-11-02 |
2013-10-22 |
Vertex Pharmaceuticals Incorporated |
Azaindole derivatives as CFTR modulators
|
EP2789606B1
(en)
|
2007-05-09 |
2017-11-15 |
Vertex Pharmaceuticals Incorporated |
Modulators of CFTR
|
CA2696298C
(en)
|
2007-08-24 |
2016-09-06 |
Vertex Pharmaceuticals Incorporated |
Modulators of cystic fibrosis transmembrane conductance regulator
|
EP3012250B1
(en)
|
2007-11-16 |
2017-11-08 |
Vertex Pharmaceuticals Incorporated |
Isoquinoline modulators of atp-binding cassette transporters
|
US20100036130A1
(en)
|
2007-12-07 |
2010-02-11 |
Vertex Pharmaceuticals Incorporated |
Processes for producing cycloalkylcarboxamido-pyridine benzoic acids
|
NZ612635A
(en)
|
2007-12-07 |
2015-06-26 |
Vertex Pharma |
Processes for producing cycloalkylcarboxamido-pyridine benzoic acids
|
EP3683218B1
(en)
|
2007-12-07 |
2024-09-18 |
Vertex Pharmaceuticals Incorporated |
Solid forms of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl) benzoic acid
|
CA2931134C
(en)
|
2008-02-28 |
2019-07-30 |
Vertex Pharmaceuticals Incorporated |
Heteroaryl derivatives as cftr modulators
|
SI2615085T1
(sl)
|
2008-03-31 |
2015-11-30 |
Vertex Pharmaceuticals Incorporated |
Piridilni derivati kot cftr-modulatorji
|
JP2012504143A
(ja)
|
2008-09-29 |
2012-02-16 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
3−(6−(1−(2,2−ジフルオロベンゾ[d][1,3]ジオキソール−5−イル)シクロプロパンカルボキサミド)−3−メチルピリジン−2−イル)安息香酸の用量単位
|
EP3330255B1
(en)
|
2009-03-20 |
2020-12-09 |
Vertex Pharmaceuticals Incorporated |
Process for making modulators of cystic fibrosis transmembrane conductance regulator
|
US8802868B2
(en)
|
2010-03-25 |
2014-08-12 |
Vertex Pharmaceuticals Incorporated |
Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
|
MX2012011655A
(es)
|
2010-04-07 |
2012-11-23 |
Vertex Pharma |
Formas solidas de acido 3-(6-(1-(2,2-difluorobenzo [d][1-3]dioxol-5-il]ciclopropanocarboxamido)-3-metilpiridin-2-il) benzoico.
|
HRP20211752T1
(hr)
|
2010-04-07 |
2022-02-18 |
Vertex Pharmaceuticals Incorporated |
Farmaceutski pripravci 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioksol-5-il)ciklopropankarboksamido)-3-metilpiridin-2-il)benzojeve kiseline i njihova primjena
|
ES2858351T3
(es)
*
|
2010-04-22 |
2021-09-30 |
Vertex Pharma |
Compuesto intermedio para proceso de producción de compuestos de cicloalquilcaraboxamido-indol
|
US8563593B2
(en)
|
2010-06-08 |
2013-10-22 |
Vertex Pharmaceuticals Incorporated |
Formulations of (R)-1-(2,2-difluorobenzo[D] [1,3] dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide
|
CA2852991C
(en)
|
2011-11-08 |
2019-12-31 |
Vertex Pharmaceuticals Incorporated |
Modulators of atp-binding cassette transporters
|
US20130172375A1
(en)
*
|
2011-12-13 |
2013-07-04 |
Hoffmann-La Roche Inc. |
Pharmaceutical composition
|
AU2013226076B2
(en)
|
2012-02-27 |
2017-11-16 |
Vertex Pharmaceuticals Incorporated |
Pharmaceutical composition and administration thereof
|
US8674108B2
(en)
|
2012-04-20 |
2014-03-18 |
Vertex Pharmaceuticals Incorporated |
Solid forms of N-[2,4-bis(1,1-dimethylethy)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
|
EP2872122A1
(en)
|
2012-07-16 |
2015-05-20 |
Vertex Pharmaceuticals Incorporated |
Pharmaceutical compositions of (r)-1-(2,2-diflurorbenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide and administration thereof
|
CA2906008C
(en)
|
2013-03-13 |
2019-07-09 |
Flatley Discovery Lab, Llc |
Pyridazinone compounds and methods for the treatment of cystic fibrosis
|
CN104415345A
(zh)
*
|
2013-08-30 |
2015-03-18 |
天津药物研究院 |
一种多元复合物及其制备方法
|
US10231932B2
(en)
|
2013-11-12 |
2019-03-19 |
Vertex Pharmaceuticals Incorporated |
Process of preparing pharmaceutical compositions for the treatment of CFTR mediated diseases
|
RU2744460C2
(ru)
|
2014-04-15 |
2021-03-09 |
Вертекс Фармасьютикалз Инкорпорейтед |
Фармацевтические композиции для лечения заболеваний, опосредованных муковисцидозным трансмембранным регулятором проводимости
|
CN112250627B
(zh)
|
2014-10-06 |
2024-02-02 |
弗特克斯药品有限公司 |
囊性纤维化跨膜转导调节因子调节剂
|
JP6746569B2
(ja)
|
2014-10-07 |
2020-08-26 |
バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated |
嚢胞性線維症膜貫通コンダクタンス制御因子のモジュレーターの共結晶
|
ES2830279T3
(es)
*
|
2014-10-31 |
2021-06-03 |
Abbvie Overseas Sarl |
Cromanos sustituidos y método de uso
|
SG11201703963QA
(en)
|
2014-11-18 |
2017-06-29 |
Vertex Pharma |
Process of conducting high throughput testing high performance liquid chromatography
|
EP3240539A4
(en)
|
2014-12-31 |
2018-07-25 |
Auspex Pharmaceuticals, Inc. |
Cyclopropanecarboxamide modulators of cystic fibrosis transmembrane conductance regulator
|
WO2016160945A1
(en)
|
2015-03-31 |
2016-10-06 |
Concert Pharmaceuticals, Inc. |
Deuterated vx-661
|
CN105130949B
(zh)
*
|
2015-09-02 |
2019-01-29 |
阜新奥瑞凯新材料有限公司 |
1-(2,2-二氟苯并[d][1,3]二氧杂环戊烯-5-基)环丙基腈的制备方法
|
US10047077B2
(en)
|
2016-04-13 |
2018-08-14 |
Skyline Antiinfectives, Inc. |
Deuterated O-sulfated beta-lactam hydroxamic acids and deuterated N-sulfated beta-lactams
|
HUP1600271A2
(hu)
|
2016-04-25 |
2017-10-30 |
Druggability Tech Ip Holdco Ltd |
Ivacaftor és Lumacaftor sóinak és származékainak komplexei, eljárás azok elõállítására és azok gyógyszerészetileg elfogadható készítményei
|
HUP1600270A2
(hu)
|
2016-04-25 |
2017-10-30 |
Druggability Tech Ip Holdco Ltd |
Ivacaftornak, sóinak és származékainak komplexei, eljárás azok elõállítására és azok gyógyszerészetileg elfogadott készítményei
|
US10206915B2
(en)
|
2016-04-25 |
2019-02-19 |
Druggability Technologies Ip Holdco Limited |
Complexes of Ivacaftor and its salts and derivatives, process for the preparation thereof and pharmaceutical compositions containing them
|
US10383865B2
(en)
|
2016-04-25 |
2019-08-20 |
Druggability Technologies Ip Holdco Limited |
Pharmaceutical combination composition comprising complex formulations of Ivacaftor and Lumacaftor and their salts and derivatives, process for their preparation thereof and pharmaceutical compositions containing them
|
RS62670B1
(sr)
|
2016-09-30 |
2021-12-31 |
Vertex Pharma |
Modulator transmembranskog regulatora provodnosti cistične fibroze, farmaceutske kompozicije, metode lečenja i proces izrade modulatora
|
US10399940B2
(en)
|
2016-10-07 |
2019-09-03 |
Abbvie S.Á.R.L. |
Substituted pyrrolidines and methods of use
|
MX2019006637A
(es)
|
2016-12-09 |
2019-08-21 |
Vertex Pharma |
Modulador del regulador de conductancia transmembrana de fibrosis quistica composiciones farmaceuticas metodos de tratamiento y proceso para producir el modulador.
|
AU2018279646B2
(en)
|
2017-06-08 |
2023-04-06 |
Vertex Pharmaceuticals Incorporated |
Methods of treatment for cystic fibrosis
|
US20210069174A1
(en)
|
2017-07-01 |
2021-03-11 |
Vertex Pharmaceuticals Incorporated |
Compositions and methods for treatment of cystic fibrosis
|
MA49631A
(fr)
|
2017-07-17 |
2020-05-27 |
Vertex Pharma |
Méthodes de traitement de la fibrose kystique
|
CA3069225A1
(en)
|
2017-07-17 |
2019-01-24 |
Vertex Pharmaceuticals Incorporated |
Methods of treatment for cystic fibrosis
|
CA3071278A1
(en)
|
2017-08-02 |
2019-02-07 |
Vertex Pharmaceuticals Incorporated |
Processes for preparing pyrrolidine compounds
|
CA3078893A1
(en)
|
2017-10-19 |
2019-04-25 |
Vertex Pharmaceuticals Incorporated |
Crystalline forms and compositions of cftr modulators
|
CN107880011B
(zh)
*
|
2017-11-27 |
2019-08-16 |
山东省医学科学院药物研究所 |
鲁玛卡托关键中间体的合成方法
|
US20210228489A1
(en)
|
2017-12-04 |
2021-07-29 |
Vertex Pharmaceuticals Incorporated |
Compositions for treating cystic fibrosis
|
MX2020005753A
(es)
|
2017-12-08 |
2020-08-20 |
Vertex Pharma |
Procesos para producir moduladores de regulador de conductancia transmembranal de fibrosis quistica.
|
TWI810243B
(zh)
|
2018-02-05 |
2023-08-01 |
美商維泰克斯製藥公司 |
用於治療囊腫纖化症之醫藥組合物
|
US11066417B2
(en)
|
2018-02-15 |
2021-07-20 |
Vertex Pharmaceuticals Incorporated |
Modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulators
|
CN110193012B
(zh)
*
|
2018-02-27 |
2022-02-08 |
江苏恒瑞医药股份有限公司 |
一种氧代吡啶酰胺类衍生物的药物组合物及其制备方法
|
US20210139514A1
(en)
|
2018-04-05 |
2021-05-13 |
Vertex Pharmaceuticals Incorporated |
Modulators of cystic fibrosis transmembrane conductance regulator
|
WO2019200246A1
(en)
|
2018-04-13 |
2019-10-17 |
Alexander Russell Abela |
Modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator
|
LT3880197T
(lt)
|
2018-11-14 |
2023-05-10 |
Vertex Pharmaceuticals Incorporated |
Cistinės fibrozės gydymo būdai
|
CA3067611A1
(en)
|
2019-01-15 |
2020-07-15 |
Apotex Inc. |
Processes for the preparation of tezacaftor and intermediates thereof
|
AR118555A1
(es)
|
2019-04-03 |
2021-10-20 |
Vertex Pharma |
Agentes moduladores del regulador de la conductancia transmembrana de la fibrosis quística
|
WO2020214921A1
(en)
|
2019-04-17 |
2020-10-22 |
Vertex Pharmaceuticals Incorporated |
Solid forms of modulators of cftr
|
UY38696A
(es)
|
2019-05-14 |
2020-11-30 |
Vertex Pharma |
Moduladores de alfa-1 antitripsina
|
WO2020242935A1
(en)
|
2019-05-29 |
2020-12-03 |
Vertex Pharmaceuticals Incorporated |
Methods of treatment for cystic fibrosis
|
TW202120517A
(zh)
|
2019-08-14 |
2021-06-01 |
美商維泰克斯製藥公司 |
製備cftr調節劑之方法
|
CA3150738A1
(en)
|
2019-08-14 |
2021-02-18 |
Vertex Pharmaceuticals Incorporated |
Modulators of cystic fibrosis transmembrane conductance regulator
|
MX2022001828A
(es)
|
2019-08-14 |
2022-06-08 |
Vertex Pharma |
Formas cristalinas de moduladores del regulador de conductancia transmembrana de la fibrosis quistica (cftr).
|
TW202115092A
(zh)
|
2019-08-14 |
2021-04-16 |
美商維泰克斯製藥公司 |
囊腫纖維化跨膜傳導調節蛋白之調節劑
|
WO2021140525A1
(en)
*
|
2020-01-07 |
2021-07-15 |
Msn Laboratories Private Limited, R&D Center |
Novel crystalline form of 1-(2,2-difluoro-2h-1,3benzo dioxol-5-yl)-n-{1-[(2r)-2,3-dihydroxypropyl]-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl}cyclopropane-1-carboxamide and its process for the preparation thereof
|
WO2021176064A1
(en)
|
2020-03-06 |
2021-09-10 |
Química Sintética, S.A. |
Solid forms of tezacaftor and processes for the preparation thereof
|
WO2022194399A1
(en)
|
2020-07-13 |
2022-09-22 |
Idorsia Pharmaceuticals Ltd |
Macrocycles as cftr modulators
|
CR20230120A
(es)
|
2020-08-07 |
2023-09-01 |
Vertex Pharma |
Moduladores del regulador de la conductancia transmembrana de la fibrosis quística
|
MX2023001744A
(es)
|
2020-08-13 |
2023-04-19 |
Vertex Pharma |
Formas cristalinas de moduladores de regulador de conductancia transmembrana de la fibrosis quística (cftr).
|
KR20230104619A
(ko)
|
2020-10-07 |
2023-07-10 |
버텍스 파마슈티칼스 인코포레이티드 |
낭성 섬유증 막관통 전도도 조절자의 조절제
|
WO2022076621A1
(en)
|
2020-10-07 |
2022-04-14 |
Vertex Pharmaceuticals Incorporated |
Modulators of cystic fibrosis transmembrane conductance regulator
|
EP4225763A1
(en)
|
2020-10-07 |
2023-08-16 |
Vertex Pharmaceuticals Incorporated |
Modulators of cystic fibrosis transmembrane conductance regulator
|
JP2023545081A
(ja)
|
2020-10-07 |
2023-10-26 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
嚢胞性線維症膜コンダクタンス制御因子モジュレーター
|
EP4225750A1
(en)
|
2020-10-07 |
2023-08-16 |
Vertex Pharmaceuticals Incorporated |
Modulators of cystic fibrosis transmembrane conductance regulator
|
WO2022076628A1
(en)
|
2020-10-07 |
2022-04-14 |
Vertex Pharmaceuticals Incorporated |
Modulators of cystic fibrosis transmembrane conductance regulator
|
WO2022076627A1
(en)
|
2020-10-07 |
2022-04-14 |
Vertex Pharmaceuticals Incorporated |
Modulators of cystic fibrosis transmembrane conductance regulator
|
US20230374038A1
(en)
|
2020-10-07 |
2023-11-23 |
Vertex Pharmaceuticals Incorporated |
Modulators of cystic fibrosis transmembrane conductance regulator
|
US20230365587A1
(en)
|
2020-10-07 |
2023-11-16 |
Vertex Pharmaceuticals Incorporated |
Modulators of cystic fibrosis transmembrane conductance regulator
|
CR20230198A
(es)
|
2020-10-07 |
2023-07-03 |
Vertex Pharma |
Moduladores del regulador de la conductancia transmembrana de la fibrosis quística
|
CN116897157A
(zh)
|
2020-11-17 |
2023-10-17 |
弗特克斯药品有限公司 |
4-(5-(4-氟苯基)-6-(四氢-2h-吡喃-4-基)-1,5-二氢吡咯并[2,3-f]吲唑-7-基)苯甲酸的固体形式
|
CA3204725A1
(en)
|
2020-12-10 |
2022-06-16 |
Vertex Pharmaceuticals Incorporated |
Methods of treatment for cystic fibrosis
|
TW202333699A
(zh)
|
2022-02-03 |
2023-09-01 |
美商維泰克斯製藥公司 |
囊腫纖維化之治療方法
|
AU2023215372A1
(en)
|
2022-02-03 |
2024-08-22 |
Vertex Pharmaceuticals Incorporated |
Methods of preparing and crystalline forms of (6a,12a)-17-amino-12-methyl-6,15-bis(trifluoromethyl)-13,19-dioxa-3,4,18-triazatricyclo[ 12.3.1.12,5]nonadeca-1(18),2,4,14,16-pentaen-6-ol
|
AU2023218262A1
(en)
|
2022-02-08 |
2024-08-22 |
Vertex Pharmaceuticals Incorporated |
Modulators of cystic fibrosis transmembrane conductance regulator
|
AU2023249173A1
(en)
|
2022-04-06 |
2024-10-03 |
Vertex Pharmaceuticals Incorporated |
Modulators of cystic fibrosis transmembrane conductance regulator
|
WO2023224924A1
(en)
|
2022-05-16 |
2023-11-23 |
Vertex Pharmaceuticals Incorporated |
Solid forms of a macrocyclic compounds as cftr modulators and their preparation
|
WO2023224931A1
(en)
|
2022-05-16 |
2023-11-23 |
Vertex Pharmaceuticals Incorporated |
Methods of treatment for cystic fibrosis
|
WO2024031081A1
(en)
|
2022-08-04 |
2024-02-08 |
Vertex Pharmaceuticals Incorporated |
Compositions for the treatment of cftr-mediated diseases
|
WO2024056779A1
(en)
|
2022-09-15 |
2024-03-21 |
Idorsia Pharmaceuticals Ltd |
Crystalline form of (3s,7s,10r,13r)-13-benzyl-20-fluoro-7-isobutyl-n-(2-(3-methoxy-1,2,4-oxadiazol-5-yl)ethyl)-6,9-dimethyl-1,5,8,11-tetraoxo-10-(2,2,2-trifluoroethyl)-1,2,3,4,5,6,7,8,9,10,11,12,13,14-tetradecahydro-[1]oxa[4,7,10,14]tetraazacycloheptadecino[16,17-f]quinoline-3-carboxamide
|
WO2024056798A1
(en)
|
2022-09-15 |
2024-03-21 |
Idorsia Pharmaceuticals Ltd |
Macrocyclic cftr modulators
|
TW202421102A
(zh)
|
2022-09-15 |
2024-06-01 |
瑞士商愛杜西亞製藥有限公司 |
巨環cftr調節劑與cftr校正子及/或cftr增效劑之組合
|