JP2017008114A5 - - Google Patents

Info

Publication number

JP2017008114A5

JP2017008114A5 JP2016203842A JP2016203842A JP2017008114A5 JP 2017008114 A5 JP2017008114 A5 JP 2017008114A5 JP 2016203842 A JP2016203842 A JP 2016203842A JP 2016203842 A JP2016203842 A JP 2016203842A JP 2017008114 A5 JP2017008114 A5 JP 2017008114A5

Authority

JP

Japan

Prior art keywords

lipid

aminoglycoside

liposomal

formulation

acceptable salt

Prior art date

2016-10-17

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 229940126575 aminoglycoside Drugs 0.000 claims 33
• 150000002632 lipids Chemical class 0.000 claims 22
• 239000000203 mixture Substances 0.000 claims 22
• 238000009472 formulation Methods 0.000 claims 21
• 239000000243 solution Substances 0.000 claims 11
• 150000003839 salts Chemical class 0.000 claims 10
• 239000007864 aqueous solution Substances 0.000 claims 8
• 239000003960 organic solvent Substances 0.000 claims 4
• KILNVBDSWZSGLL-KXQOOQHDSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 claims 3
• 239000000693 micelle Substances 0.000 claims 3
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical group CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
• 239000012267 brine Substances 0.000 claims 2
• HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
• 238000007865 diluting Methods 0.000 claims 2
• 229940079593 drug Drugs 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 150000003904 phospholipids Chemical class 0.000 claims 2
• HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 claims 2
• UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 claims 2
• 239000004094 surface-active agent Substances 0.000 claims 2
• 239000000725 suspension Substances 0.000 claims 2
• YWMSSKBMOFPBDM-UHFFFAOYSA-N 4-carbamoylbenzenesulfonyl chloride Chemical group NC(=O)C1=CC=C(S(Cl)(=O)=O)C=C1 YWMSSKBMOFPBDM-UHFFFAOYSA-N 0.000 claims 1
• 229930182566 Gentamicin Natural products 0.000 claims 1
• CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 claims 1
• 229930182558 Sterol Natural products 0.000 claims 1
• 229960004821 amikacin Drugs 0.000 claims 1
• LKCWBDHBTVXHDL-RMDFUYIESA-N amikacin Chemical compound O([C@@H]1[C@@H](N)C[C@H]([C@@H]([C@H]1O)O[C@@H]1[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O1)O)NC(=O)[C@@H](O)CCN)[C@H]1O[C@H](CN)[C@@H](O)[C@H](O)[C@H]1O LKCWBDHBTVXHDL-RMDFUYIESA-N 0.000 claims 1
• 229960001656 amikacin sulfate Drugs 0.000 claims 1
• 235000012000 cholesterol Nutrition 0.000 claims 1
• 238000005354 coacervation Methods 0.000 claims 1
• 229960002518 gentamicin Drugs 0.000 claims 1
• 229960000318 kanamycin Drugs 0.000 claims 1
• 229930027917 kanamycin Natural products 0.000 claims 1
• SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 claims 1
• 229930182823 kanamycin A Natural products 0.000 claims 1
• 239000002502 liposome Substances 0.000 claims 1
• 229960000808 netilmicin Drugs 0.000 claims 1
• ZBGPYVZLYBDXKO-HILBYHGXSA-N netilmycin Chemical compound O([C@@H]1[C@@H](N)C[C@H]([C@@H]([C@H]1O)O[C@@H]1[C@]([C@H](NC)[C@@H](O)CO1)(C)O)NCC)[C@H]1OC(CN)=CC[C@H]1N ZBGPYVZLYBDXKO-HILBYHGXSA-N 0.000 claims 1
• 239000011833 salt mixture Substances 0.000 claims 1
• 150000003432 sterols Chemical class 0.000 claims 1
• 235000003702 sterols Nutrition 0.000 claims 1
• 229960005322 streptomycin Drugs 0.000 claims 1
• 229960000707 tobramycin Drugs 0.000 claims 1
• NLVFBUXFDBBNBW-PBSUHMDJSA-N tobramycin Chemical compound N[C@@H]1C[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N NLVFBUXFDBBNBW-PBSUHMDJSA-N 0.000 claims 1
• 238000003260 vortexing Methods 0.000 claims 1