JP2016538345A5 - - Google Patents
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- JP2016538345A5 JP2016538345A5 JP2016554928A JP2016554928A JP2016538345A5 JP 2016538345 A5 JP2016538345 A5 JP 2016538345A5 JP 2016554928 A JP2016554928 A JP 2016554928A JP 2016554928 A JP2016554928 A JP 2016554928A JP 2016538345 A5 JP2016538345 A5 JP 2016538345A5
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1320729.5A GB201320729D0 (en) | 2013-11-25 | 2013-11-25 | Therapeutic compounds and their use |
| GB1320729.5 | 2013-11-25 | ||
| PCT/GB2014/053490 WO2015075483A1 (en) | 2013-11-25 | 2014-11-25 | 1 -(5-tert-butyl-2-aryl-pyrazol-3-yl)-3-[2-fluoro-4-[(3-oxo-4h-pyrido[2, 3-b]pyrazin-8-yl)oxy]phenyl]urea derivatives as raf inhibitors for the treatment of cancer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016538345A JP2016538345A (ja) | 2016-12-08 |
| JP2016538345A5 true JP2016538345A5 (https=) | 2017-12-28 |
| JP6389529B2 JP6389529B2 (ja) | 2018-09-12 |
Family
ID=49918123
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016554928A Active JP6389529B2 (ja) | 2013-11-25 | 2014-11-25 | 癌の治療のためのＲＡＦ阻害剤としての１−（５−ｔｅｒｔ−ブチル−２−アリール−ピラゾール−３−イル）−３−［２−フルオロ−４−［３−オキソ−４Ｈ−ピリド［２，３−ｂ］ピラジン−８−イル）オキシ］フェニル］尿素誘導体 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US9725447B2 (https=) |
| EP (1) | EP3074396B1 (https=) |
| JP (1) | JP6389529B2 (https=) |
| KR (1) | KR102327096B1 (https=) |
| CN (1) | CN105793260B (https=) |
| AU (1) | AU2014351571B2 (https=) |
| BR (1) | BR112016011078B1 (https=) |
| CA (1) | CA2928009C (https=) |
| DK (1) | DK3074396T3 (https=) |
| EA (1) | EA034216B1 (https=) |
| ES (1) | ES2740325T3 (https=) |
| GB (1) | GB201320729D0 (https=) |
| HU (1) | HUE045596T2 (https=) |
| IL (1) | IL245062B (https=) |
| MX (1) | MX372942B (https=) |
| PL (1) | PL3074396T3 (https=) |
| PT (1) | PT3074396T (https=) |
| SA (1) | SA516371189B1 (https=) |
| WO (1) | WO2015075483A1 (https=) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ586418A (en) | 2007-12-19 | 2012-09-28 | Cancer Rec Tech Ltd | Pyrido[2,3-b]pyrazine-8-substituted compounds and their use |
| JP5760010B2 (ja) | 2010-02-01 | 2015-08-05 | キャンサー・リサーチ・テクノロジー・リミテッド | １−（５−ｔｅｒｔ−ブチル−２−フェニル−２Ｈ−ピラゾール−３−イル）−３−［２−フルオロ−４−（１−メチル−２−オキソ−２，３−ジヒドロ−１Ｈ−イミダゾ［４，５−Ｂ］ピリジン−７−イルオキシ）−フェニル］−尿素および関連化合物ならびに治療におけるそれらの使用 |
| GB201320729D0 (en) | 2013-11-25 | 2014-01-08 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| GB201320732D0 (en) | 2013-11-25 | 2014-01-08 | Cancer Rec Tech Ltd | Methods of chemical synthesis |
| BR112018006817A2 (pt) * | 2015-10-08 | 2018-10-23 | Macrogenics Inc | método de tratamento do câncer |
| KR20180118141A (ko) * | 2016-02-05 | 2018-10-30 | 에볼 사이언스 엘엘씨 | 암 치료를 위한 조합 |
| CN109069462A (zh) | 2016-02-23 | 2018-12-21 | 癌症研究科技有限公司 | 缺乏至少两种非必需氨基酸的膳食产品 |
| KR20180134347A (ko) | 2016-04-15 | 2018-12-18 | 제넨테크, 인크. | 암의 진단 및 치료 방법 |
| KR101796684B1 (ko) * | 2016-05-19 | 2017-11-10 | 건국대학교 산학협력단 | 케라틴 8 인산화 억제제를 포함하는 황반변성 예방 또는 치료용 약학 조성물 및 황반변성 치료제의 스크리닝 방법 |
| CN110366550A (zh) | 2016-12-22 | 2019-10-22 | 美国安进公司 | 作为用于治疗肺癌、胰腺癌或结直肠癌的KRAS G12C抑制剂的苯并异噻唑、异噻唑并[3,4-b]吡啶、喹唑啉、酞嗪、吡啶并[2,3-d]哒嗪和吡啶并[2,3-d]嘧啶衍生物 |
| ES2928773T3 (es) | 2017-01-17 | 2022-11-22 | Heparegenix Gmbh | Inhibidores de proteína cinasas para fomentar la regeneración hepática o reducir o prevenir la muerte de hepatocitos |
| HUE057337T2 (hu) * | 2017-02-10 | 2022-05-28 | Novartis Ag | 1-(4-amino-5-bróm-6-(1H-pirazol-1-il)pirimidin-2-il)-1H-pirazol-4-ol és alkalmazása rák kezelésében |
| CN106986860A (zh) * | 2017-05-19 | 2017-07-28 | 南京大学 | 一类含酰胺键的吡唑类抗肿瘤化合物的设计、合成 |
| AU2018273356B2 (en) | 2017-05-22 | 2021-09-16 | Amgen Inc. | KRAS G12C inhibitors and methods of using the same |
| KR20200037820A (ko) * | 2017-08-07 | 2020-04-09 | 에볼 사이언스 엘엘씨 | 암을 치료하기 위한 조합 |
| KR102811888B1 (ko) | 2017-09-08 | 2025-05-27 | 에프. 호프만-라 로슈 아게 | 암의 진단 및 치료 방법 |
| AU2018329920B2 (en) * | 2017-09-08 | 2022-12-01 | Amgen Inc. | Inhibitors of KRAS G12C and methods of using the same |
| WO2019084026A1 (en) | 2017-10-24 | 2019-05-02 | Genentech, Inc. | (4-HYDROXYPYRROLIDIN-2-YL) -HETEROCYCLIC COMPOUNDS AND METHODS OF USE |
| WO2019084030A1 (en) | 2017-10-24 | 2019-05-02 | Genentech, Inc. | (4-HYDROXYPYRROLIDIN-2-YL) -HYDROXAMATE COMPOUNDS AND METHODS OF USE |
| CA3119300A1 (en) | 2017-11-13 | 2019-05-16 | Cancer Research Technology Ltd. | Dietary product |
| EP3752200A1 (en) | 2018-02-13 | 2020-12-23 | Vib Vzw | Targeting minimal residual disease in cancer with rxr antagonists |
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