BR112016011078B1 - Derivados de 1-(5-terc-butil-2-aril-pirazol-3-il)-3-[2-flúor-4-[(3- oxo-4h-pirido[2,3-b]pirazin-8-il) óxi]fenil]ureia, seus usos, sua composição farmacêutica, método para preparar a mesma e método in vitro para inibir a função raf em uma célula - Google Patents
Derivados de 1-(5-terc-butil-2-aril-pirazol-3-il)-3-[2-flúor-4-[(3- oxo-4h-pirido[2,3-b]pirazin-8-il) óxi]fenil]ureia, seus usos, sua composição farmacêutica, método para preparar a mesma e método in vitro para inibir a função raf em uma célula Download PDFInfo
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Landscapes
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1320729.5A GB201320729D0 (en) | 2013-11-25 | 2013-11-25 | Therapeutic compounds and their use |
| GB1320729.5 | 2013-11-25 | ||
| PCT/GB2014/053490 WO2015075483A1 (en) | 2013-11-25 | 2014-11-25 | 1 -(5-tert-butyl-2-aryl-pyrazol-3-yl)-3-[2-fluoro-4-[(3-oxo-4h-pyrido[2, 3-b]pyrazin-8-yl)oxy]phenyl]urea derivatives as raf inhibitors for the treatment of cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112016011078A8 BR112016011078A8 (pt) | 2020-04-22 |
| BR112016011078B1 true BR112016011078B1 (pt) | 2022-12-06 |
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| JP2014528928A (ja) | 2011-09-01 | 2014-10-30 | ノバルティス アーゲー | ヌーナン症候群の治療のための有機化合物の使用 |
| CN103917536B (zh) | 2011-10-03 | 2016-07-06 | 瑞斯比维特有限公司 | 1-吡唑基-3-(4-((2-(苯氨基)嘧啶-4-基)氧基)萘-1-基)脲用作p38 MAP激酶抑制剂 |
| EP2578582A1 (en) | 2011-10-03 | 2013-04-10 | Respivert Limited | 1-Pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl)oxy)napththalen-1-yl)ureas as p38 MAP kinase inhibitors |
| GB201214750D0 (en) | 2012-08-17 | 2012-10-03 | Respivert Ltd | Compounds |
| US20150210722A1 (en) | 2012-08-29 | 2015-07-30 | Respivert Limited | Kinase inhibitors |
| US20150225373A1 (en) | 2012-08-29 | 2015-08-13 | Respivert Limited | Kinase inhibitors |
| EP2890701B1 (en) | 2012-08-29 | 2017-03-29 | Respivert Limited | Kinase inhibitors |
| GB201215357D0 (en) | 2012-08-29 | 2012-10-10 | Respivert Ltd | Compounds |
| WO2014076484A1 (en) | 2012-11-16 | 2014-05-22 | Respivert Limited | Kinase inhibitors |
| EP2970190A1 (en) | 2013-03-14 | 2016-01-20 | Respivert Limited | Kinase inhibitors |
| JO3279B1 (ar) | 2013-03-15 | 2018-09-16 | Respivert Ltd | مشتقات 2-((4- امينو -3- (3- فلورو-5- هيدروكسي فينيل)-h1- بيرازولو [d-3,4] بيرمدين-1-يل )ميثيل )- 3- (2- تراي فلورو ميثيل ) بينزيل ) كوينازولين -4 (h3)- واحد واستخدامها كمثبطات فوسفواينوسيتايد 3- كاينيز |
| US9771353B2 (en) | 2013-04-02 | 2017-09-26 | Topivert Pharma Limited | Kinase inhibitors based upon N-alkyl pyrazoles |
| KR102283876B1 (ko) | 2013-04-02 | 2021-07-29 | 옥슬러 액퀴지션즈 리미티드 | 키나제 저해제로서 유용한 우레아 유도체 |
| GB201320729D0 (en) * | 2013-11-25 | 2014-01-08 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| EP3083604A1 (en) | 2013-12-20 | 2016-10-26 | Respivert Limited | Urea derivatives useful as kinase inhibitors |
| ES2677595T3 (es) | 2014-02-14 | 2018-08-03 | Respivert Limited | Compuestos heterocíclicos aromáticos como compuestos antiinflamatorios |
| MA40774A (fr) | 2014-10-01 | 2017-08-08 | Respivert Ltd | Dérivés de diaryle-urée en tant qu'inhibiteurs de kinase p38 |
| EP3201189A1 (en) | 2014-10-01 | 2017-08-09 | Respivert Limited | N-phenyl-3-quinazolin-6-yl-benzamide derivatives as p38 kinase inhibitors |
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| DK3074396T3 (da) | 2019-07-29 |
| EP3074396B1 (en) | 2019-05-01 |
| PL3074396T3 (pl) | 2019-11-29 |
| IL245062B (en) | 2019-09-26 |
| GB201320729D0 (en) | 2014-01-08 |
| JP6389529B2 (ja) | 2018-09-12 |
| MX372942B (es) | 2020-04-03 |
| IL245062A0 (en) | 2016-06-30 |
| KR20160079792A (ko) | 2016-07-06 |
| CA2928009A1 (en) | 2015-05-28 |
| AU2014351571A1 (en) | 2016-05-19 |
| US20170298066A1 (en) | 2017-10-19 |
| US20160355510A1 (en) | 2016-12-08 |
| MX2016006119A (es) | 2016-12-14 |
| JP2016538345A (ja) | 2016-12-08 |
| WO2015075483A1 (en) | 2015-05-28 |
| EP3074396A1 (en) | 2016-10-05 |
| EA201690531A1 (ru) | 2016-08-31 |
| CN105793260A (zh) | 2016-07-20 |
| US9725447B2 (en) | 2017-08-08 |
| CA2928009C (en) | 2022-08-30 |
| US10167282B2 (en) | 2019-01-01 |
| PT3074396T (pt) | 2019-08-06 |
| BR112016011078A8 (pt) | 2020-04-22 |
| SA516371189B1 (ar) | 2018-06-30 |
| CN105793260B (zh) | 2018-04-10 |
| HUE045596T2 (hu) | 2020-01-28 |
| AU2014351571B2 (en) | 2019-02-14 |
| KR102327096B1 (ko) | 2021-11-16 |
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