BR112016011078B1 - Derivados de 1-(5-terc-butil-2-aril-pirazol-3-il)-3-[2-flúor-4-[(3- oxo-4h-pirido[2,3-b]pirazin-8-il) óxi]fenil]ureia, seus usos, sua composição farmacêutica, método para preparar a mesma e método in vitro para inibir a função raf em uma célula - Google Patents

Derivados de 1-(5-terc-butil-2-aril-pirazol-3-il)-3-[2-flúor-4-[(3- oxo-4h-pirido[2,3-b]pirazin-8-il) óxi]fenil]ureia, seus usos, sua composição farmacêutica, método para preparar a mesma e método in vitro para inibir a função raf em uma célula Download PDF

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BR112016011078B1
BR112016011078B1 BR112016011078-1A BR112016011078A BR112016011078B1 BR 112016011078 B1 BR112016011078 B1 BR 112016011078B1 BR 112016011078 A BR112016011078 A BR 112016011078A BR 112016011078 B1 BR112016011078 B1 BR 112016011078B1
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compound
cancer
braf
treatment
cell
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BR112016011078-1A
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Portuguese (pt)
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BR112016011078A8 (pt
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Caroline Joy Springer
Richard Marais
Romina GIROTTI
Dan Niculescu-Duvaz
Ion Niculescu-Duvaz
Alfonso Zambon
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Cancer Research Technology Limited
Institute Of Cancer Research: Royal Cancer Hospital (The)
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Publication of BR112016011078A8 publication Critical patent/BR112016011078A8/pt
Publication of BR112016011078B1 publication Critical patent/BR112016011078B1/pt

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    • C07ORGANIC CHEMISTRY
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    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
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    • A61K31/4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • C07ORGANIC CHEMISTRY
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    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
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BR112016011078-1A 2013-11-25 2014-11-25 Derivados de 1-(5-terc-butil-2-aril-pirazol-3-il)-3-[2-flúor-4-[(3- oxo-4h-pirido[2,3-b]pirazin-8-il) óxi]fenil]ureia, seus usos, sua composição farmacêutica, método para preparar a mesma e método in vitro para inibir a função raf em uma célula BR112016011078B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1320729.5A GB201320729D0 (en) 2013-11-25 2013-11-25 Therapeutic compounds and their use
GB1320729.5 2013-11-25
PCT/GB2014/053490 WO2015075483A1 (en) 2013-11-25 2014-11-25 1 -(5-tert-butyl-2-aryl-pyrazol-3-yl)-3-[2-fluoro-4-[(3-oxo-4h-pyrido[2, 3-b]pyrazin-8-yl)oxy]phenyl]urea derivatives as raf inhibitors for the treatment of cancer

Publications (2)

Publication Number Publication Date
BR112016011078A8 BR112016011078A8 (pt) 2020-04-22
BR112016011078B1 true BR112016011078B1 (pt) 2022-12-06

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BR112016011078-1A BR112016011078B1 (pt) 2013-11-25 2014-11-25 Derivados de 1-(5-terc-butil-2-aril-pirazol-3-il)-3-[2-flúor-4-[(3- oxo-4h-pirido[2,3-b]pirazin-8-il) óxi]fenil]ureia, seus usos, sua composição farmacêutica, método para preparar a mesma e método in vitro para inibir a função raf em uma célula

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US (2) US9725447B2 (https=)
EP (1) EP3074396B1 (https=)
JP (1) JP6389529B2 (https=)
KR (1) KR102327096B1 (https=)
CN (1) CN105793260B (https=)
AU (1) AU2014351571B2 (https=)
BR (1) BR112016011078B1 (https=)
CA (1) CA2928009C (https=)
DK (1) DK3074396T3 (https=)
EA (1) EA034216B1 (https=)
ES (1) ES2740325T3 (https=)
GB (1) GB201320729D0 (https=)
HU (1) HUE045596T2 (https=)
IL (1) IL245062B (https=)
MX (1) MX372942B (https=)
PL (1) PL3074396T3 (https=)
PT (1) PT3074396T (https=)
SA (1) SA516371189B1 (https=)
WO (1) WO2015075483A1 (https=)

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