JP2010540449A5 - - Google Patents

Download PDF

Info

Publication number
JP2010540449A5
JP2010540449A5 JP2010525989A JP2010525989A JP2010540449A5 JP 2010540449 A5 JP2010540449 A5 JP 2010540449A5 JP 2010525989 A JP2010525989 A JP 2010525989A JP 2010525989 A JP2010525989 A JP 2010525989A JP 2010540449 A5 JP2010540449 A5 JP 2010540449A5
Authority
JP
Japan
Prior art keywords
antibody
antagonist
medicament
fragment
vegf
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2010525989A
Other languages
English (en)
Japanese (ja)
Other versions
JP5615709B2 (ja
JP2010540449A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2008/076954 external-priority patent/WO2009039337A2/en
Publication of JP2010540449A publication Critical patent/JP2010540449A/ja
Publication of JP2010540449A5 publication Critical patent/JP2010540449A5/ja
Application granted granted Critical
Publication of JP5615709B2 publication Critical patent/JP5615709B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2010525989A 2007-09-21 2008-09-19 脈管形成の阻害 Expired - Fee Related JP5615709B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US97438207P 2007-09-21 2007-09-21
US60/974,382 2007-09-21
US8307108P 2008-07-23 2008-07-23
US61/083,071 2008-07-23
PCT/US2008/076954 WO2009039337A2 (en) 2007-09-21 2008-09-19 Inhibition of angiogenesis

Publications (3)

Publication Number Publication Date
JP2010540449A JP2010540449A (ja) 2010-12-24
JP2010540449A5 true JP2010540449A5 (https=) 2011-11-04
JP5615709B2 JP5615709B2 (ja) 2014-10-29

Family

ID=40030248

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010525989A Expired - Fee Related JP5615709B2 (ja) 2007-09-21 2008-09-19 脈管形成の阻害

Country Status (19)

Country Link
US (1) US9284369B2 (https=)
EP (1) EP2203479B1 (https=)
JP (1) JP5615709B2 (https=)
KR (1) KR101578945B1 (https=)
CN (1) CN102037015B (https=)
AR (1) AR068532A1 (https=)
AU (1) AU2008302214B2 (https=)
CA (1) CA2700276A1 (https=)
CL (1) CL2008002782A1 (https=)
CO (1) CO6270370A2 (https=)
ES (1) ES2568881T3 (https=)
IL (1) IL204502A (https=)
MX (1) MX2010003013A (https=)
NZ (1) NZ584787A (https=)
PE (1) PE20091197A1 (https=)
RU (2) RU2471498C2 (https=)
TW (1) TWI457349B (https=)
WO (1) WO2009039337A2 (https=)
ZA (1) ZA201001868B (https=)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2311960A3 (en) * 2001-08-29 2011-06-01 Genentech, Inc. Bv8 nucleic acids and polypeptides with mitogenic activity
JP4912144B2 (ja) 2003-03-12 2012-04-11 ジェネンテック, インコーポレイテッド 造血促進のためのbv8及び/又はeg−vegfの使用
EP2121924A1 (en) * 2007-03-02 2009-11-25 MDRNA, Inc. Nucleic acid compounds for inhibiting vegf family gene expression and uses thereof
NZ597531A (en) 2009-07-31 2014-05-30 Genentech Inc Inhibition of tumor metastasis using bv8- or g-csf-antagonists
CA2777068C (en) 2009-10-14 2020-05-26 Humanigen, Inc. Antibodies to epha3
EP2516465B1 (en) * 2009-12-23 2016-05-18 F.Hoffmann-La Roche Ag Anti-bv8 antibodies and uses thereof
EP2536432B1 (en) * 2010-02-19 2018-08-08 Cornell University Method to treat autoimmune demyelinating diseases and other autoimmune or inflammatory diseases
EP2718326B1 (en) 2011-06-13 2020-08-19 CSL Limited Antibodies against g-csfr and uses thereof
KR20140068877A (ko) * 2011-08-17 2014-06-09 제넨테크, 인크. 불응성 종양에서의 혈관신생의 억제
WO2013082511A1 (en) 2011-12-02 2013-06-06 Genentech, Inc. Methods for overcoming tumor resistance to vegf antagonists
WO2013148285A1 (en) * 2012-03-30 2013-10-03 The General Hospital Corporation Methods of inhibiting cell proliferation
TWI498425B (zh) * 2013-01-08 2015-09-01 Nat Univ Tsing Hua 層析濾紙型酵素連結免疫吸附分析法
US20160030558A1 (en) * 2013-03-13 2016-02-04 Health Research, Inc. Enhancement of vaccines
EP3072519B1 (en) * 2013-11-22 2020-08-19 Gemvax & Kael Co., Ltd. Peptide having angiogenesis inhibitory activity and composition containing same
CN104237223B (zh) * 2014-10-08 2017-04-12 江苏奥赛康药业股份有限公司 测定铁‑碳水化合物络合物中不稳定铁含量的方法
CN104587469A (zh) * 2015-01-19 2015-05-06 马洁 G-csf拮抗剂在治疗慢性炎症、预防炎症相关肿瘤中的应用
EP3384029B1 (en) * 2015-12-03 2022-01-05 National Health Research Institutes Heterodimeric vascular endothelial growth factor and use thereof
WO2018108862A1 (en) * 2016-12-12 2018-06-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Antagonist of prokineticin receptor 2 for use as a medicament for treating an eg-vegf-related cancer
US20210179721A1 (en) * 2017-11-29 2021-06-17 Csl Limited Method of treating or preventing ischemia-reperfusion injury
AU2019212622B2 (en) 2018-01-26 2024-05-23 The Regents Of The University Of California Methods and compositions for treatment of angiogenic disorders using anti-VEGF agents
US12281160B2 (en) 2018-03-23 2025-04-22 Csl Limited Method of treating asthma
EP3886946A1 (en) 2019-06-05 2021-10-06 Regeneron Pharmaceuticals, Inc. Devices and methods for precision dose delivery
BR112022010113A2 (pt) 2019-11-25 2022-09-06 Univ California Inibidores de vegf de longa ação para neovascularização intraocular
US12583929B2 (en) 2020-06-04 2026-03-24 CSL Innovation Pty Ltd Method of treating acute respiratory distress syndrome
USD1120314S1 (en) 2022-11-30 2026-03-24 Regeneron Pharmaceuticals, Inc. Dose delivery device
IL325176A (en) 2023-07-05 2026-02-01 CSL Innovation Pty Ltd Methods for treating or preventing a complication of sickle cell disease
CN117054649A (zh) * 2023-08-04 2023-11-14 广州中医药大学第一附属医院 一种慢性萎缩性胃炎向胃癌转化标志物及其应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9704545D0 (sv) * 1997-12-05 1997-12-05 Astra Pharma Prod Novel compounds
EP2311960A3 (en) * 2001-08-29 2011-06-01 Genentech, Inc. Bv8 nucleic acids and polypeptides with mitogenic activity
US7323479B2 (en) * 2002-05-17 2008-01-29 Celgene Corporation Methods for treatment and management of brain cancer using 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-methylisoindoline
JP4912144B2 (ja) * 2003-03-12 2012-04-11 ジェネンテック, インコーポレイテッド 造血促進のためのbv8及び/又はeg−vegfの使用
CN1802169A (zh) * 2003-03-12 2006-07-12 健泰科生物技术公司 Bv8和/或EG-VEGF促进造血的用途
UA101945C2 (uk) * 2003-05-30 2013-05-27 Дженентек, Инк. Лікування злоякісного новоутворення за допомогою бевацизумабу
CA2622575A1 (en) * 2005-09-13 2007-03-22 Zymogenetics, Inc. Prok2 antagonists and methods of use
ITRM20070182A1 (it) * 2007-04-03 2008-10-04 Univ Roma Antagonisti dei recettori delle prochineticine derivati di essi e loro uso

Similar Documents

Publication Publication Date Title
JP2010540449A5 (https=)
RU2010115755A (ru) Ингибирование ангиогенеза
Kienast et al. Ang-2-VEGF-A CrossMab, a novel bispecific human IgG1 antibody blocking VEGF-A and Ang-2 functions simultaneously, mediates potent antitumor, antiangiogenic, and antimetastatic efficacy
Li et al. Dual blockade of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (FGF-2) exhibits potent anti-angiogenic effects
CN108348575B (zh) 用于治疗癌症或血管生成相关疾病的药物组合物和融合蛋白的用途
JP6519090B2 (ja) 血管内皮成長因子融合タンパク質
EP3553083A1 (en) Combination therapy for the treatment of ovarian cancer
Lee et al. Options for second-line treatment in metastatic colorectal cancer
WO2016122996A1 (en) Vegfa/ang2 compounds
JP2014522828A (ja) Irs−1およびvegfの阻害剤を含む組成物
Bagley et al. sFLT01: a novel fusion protein with antiangiogenic activity
US12409178B2 (en) Methods and compositions comprising a KRasG12C inhibitor and a VEGF inhibitor for treating solid tumors
JP2025093924A (ja) 固形腫瘍を治療するためのkrasg12c阻害剤及びegfr阻害剤を含む方法及び組成物
Bocci et al. The possible role of chemotherapy in antiangiogenic drug resistance
RU2740849C2 (ru) Способ, включающий фиксированное дробное дозирование цедираниба
IL295093A (en) Combination therapy for treatment of cancer and cancer metastasis
Kou et al. A bispecific antibody effectively inhibits tumor growth and metastasis by simultaneous blocking vascular endothelial growth factor A and osteopontin
Grela-Wojewoda et al. De-escalation of the systemic therapy in advanced colorectal cancer–justified clinical practice from the point of view of efficiency and safety
Oh et al. Antibodies that inhibit specific cellular pathways in gastric cancer
Boruta et al. PRO: Patients With Recurrent Ovarian Cancer Should be Treated With Antiangiogenic Agents in Combination With Chemotherapy
RINI et al. Ligand-Binding Agents
Wainberg et al. Using an anti-VEGF monoclonal antibody to treat cancer