JP2016538344A - 癌処置としてのstingアゴニストの使用 - Google Patents
癌処置としてのstingアゴニストの使用 Download PDFInfo
- Publication number
- JP2016538344A JP2016538344A JP2016554555A JP2016554555A JP2016538344A JP 2016538344 A JP2016538344 A JP 2016538344A JP 2016554555 A JP2016554555 A JP 2016554555A JP 2016554555 A JP2016554555 A JP 2016554555A JP 2016538344 A JP2016538344 A JP 2016538344A
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- tumor
- sting
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- cells
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361906330P | 2013-11-19 | 2013-11-19 | |
US61/906,330 | 2013-11-19 | ||
PCT/US2014/066436 WO2015077354A1 (en) | 2013-11-19 | 2014-11-19 | Use of sting agonist as cancer treatment |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2016538344A true JP2016538344A (ja) | 2016-12-08 |
JP2016538344A5 JP2016538344A5 (hr) | 2018-02-01 |
Family
ID=53180098
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2016554555A Pending JP2016538344A (ja) | 2013-11-19 | 2014-11-19 | 癌処置としてのstingアゴニストの使用 |
Country Status (4)
Country | Link |
---|---|
US (2) | US20160287623A1 (hr) |
EP (1) | EP3071209A4 (hr) |
JP (1) | JP2016538344A (hr) |
WO (1) | WO2015077354A1 (hr) |
Cited By (7)
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JP2020505016A (ja) * | 2017-01-06 | 2020-02-20 | シンロジック オペレーティング カンパニー インコーポレイテッド | 腫瘍細胞において免疫モジュレーターおよび抗がん治療剤を産生するようにプログラムされた微生物 |
JP2020530838A (ja) * | 2017-08-04 | 2020-10-29 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | がん治療のためのベンゾ[b]チオフェンSTINGアゴニスト |
JP2020532542A (ja) * | 2017-08-31 | 2020-11-12 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | 抗癌剤としての環状ジヌクレオチド |
JP2020532529A (ja) * | 2017-08-31 | 2020-11-12 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | 抗癌剤としての環状ジヌクレオチド |
JP2021520345A (ja) * | 2018-04-03 | 2021-08-19 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | Stingアゴニストとしてのベンゾチオフェン類及び関連する化合物 |
JP2022500476A (ja) * | 2018-09-21 | 2022-01-04 | シャンハイ ドーァ ノボ ファーマテック カンパニー,リミティド | 環状ジヌクレオチド類似体、その医薬組成物及び使用 |
US11723932B2 (en) | 2016-01-11 | 2023-08-15 | Synlogic Operating Company, Inc. | Microorganisms programmed to produce immune modulators and anti-cancer therapeutics in tumor cells |
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WO2013158673A1 (en) | 2012-04-16 | 2013-10-24 | President And Fellows Of Harvard College | Mesoporous silica compositions for modulating immune responses |
JP6333843B2 (ja) | 2012-12-13 | 2018-05-30 | アデュロ バイオテック,インコーポレイテッド | 明確な立体化学を有する環状プリンジヌクレオチドを含む組成物ならびにそれらの調製および使用方法 |
EP2943565B1 (en) | 2013-01-14 | 2018-03-28 | Fred Hutchinson Cancer Research Center | Compositions and methods for delivery of immune cells to treat un-resectable or non-resected tumor cells and tumor relapse |
WO2014179335A1 (en) | 2013-04-29 | 2014-11-06 | Memorial Sloan Kettering Cancer Center | Compositions and methods for altering second messenger signaling |
EP2992000B1 (en) | 2013-05-03 | 2020-07-08 | The Regents of The University of California | Cyclic di-nucleotide induction of type i interferon |
US9549944B2 (en) | 2013-05-18 | 2017-01-24 | Aduro Biotech, Inc. | Compositions and methods for inhibiting “stimulator of interferon gene”—dependent signalling |
PT2996473T (pt) | 2013-05-18 | 2019-11-18 | Univ California | Composições e métodos para a ativação da sinalização dependente do ''estimulador de genes de interferão'' |
US10176292B2 (en) | 2013-07-31 | 2019-01-08 | Memorial Sloan-Kettering Cancer Center | STING crystals and modulators |
CN107073090A (zh) | 2014-04-30 | 2017-08-18 | 哈佛学院董事会 | 结合的疫苗装置和杀死癌细胞的方法 |
MX2016015928A (es) | 2014-06-04 | 2017-03-20 | Glaxosmithkline Ip Dev Ltd | Dinucleotidos ciclicos como moduladores de sting. |
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GB201501462D0 (en) | 2015-01-29 | 2015-03-18 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
AR103894A1 (es) | 2015-03-10 | 2017-06-14 | Aduro Biotech Inc | Composiciones y métodos para activar la señalización dependiente del estimulador del gen interferón |
KR20180002679A (ko) | 2015-05-07 | 2018-01-08 | 베이롤 칼리지 오브 메드신 | 수지상 세포 면역요법 |
WO2017011444A1 (en) * | 2015-07-13 | 2017-01-19 | The Wistar Institute Of Anatomy And Biology | Methods and compositions for treating b cell cancers |
US11453697B1 (en) | 2015-08-13 | 2022-09-27 | Merck Sharp & Dohme Llc | Cyclic di-nucleotide compounds as sting agonists |
GEP20207182B (en) | 2015-08-13 | 2020-11-25 | Merck Sharp & Dohme | Cyclic di-nucleotide compounds as sting agonists |
US10322177B2 (en) | 2015-10-07 | 2019-06-18 | Nant Holdings Ip, Llc | Activation of immune-related signaling pathways in cells via optofection |
WO2017075477A1 (en) | 2015-10-28 | 2017-05-04 | Aduro Biotech, Inc. | Compositions and methods for activating "stimulator of interferon gene"-dependent signalling |
RU2020113165A (ru) | 2015-12-03 | 2020-06-09 | Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед | Циклические пуриновые динуклеотиды в качестве модуляторов sting |
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US11471494B2 (en) | 2017-01-06 | 2022-10-18 | Synlogic Operating Company, Inc. | Microorganisms programmed to produce immune modulators and anti-cancer therapeutics in tumor cells |
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JP2020532542A (ja) * | 2017-08-31 | 2020-11-12 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | 抗癌剤としての環状ジヌクレオチド |
JP2020532529A (ja) * | 2017-08-31 | 2020-11-12 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | 抗癌剤としての環状ジヌクレオチド |
JP2021520345A (ja) * | 2018-04-03 | 2021-08-19 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | Stingアゴニストとしてのベンゾチオフェン類及び関連する化合物 |
JP7326319B2 (ja) | 2018-04-03 | 2023-08-15 | メルク・シャープ・アンド・ドーム・エルエルシー | Stingアゴニストとしてのベンゾチオフェン類及び関連する化合物 |
JP2022500476A (ja) * | 2018-09-21 | 2022-01-04 | シャンハイ ドーァ ノボ ファーマテック カンパニー,リミティド | 環状ジヌクレオチド類似体、その医薬組成物及び使用 |
JP7218431B2 (ja) | 2018-09-21 | 2023-02-06 | シャンハイ ドーァ ノボ ファーマテック カンパニー,リミティド | 環状ジヌクレオチド類似体、その医薬組成物及び使用 |
Also Published As
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EP3071209A4 (en) | 2017-08-16 |
WO2015077354A1 (en) | 2015-05-28 |
US20180028553A1 (en) | 2018-02-01 |
US20160287623A1 (en) | 2016-10-06 |
EP3071209A1 (en) | 2016-09-28 |
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