JP2016519081A5 - - Google Patents

Info

Publication number

JP2016519081A5

JP2016519081A5 JP2016503128A JP2016503128A JP2016519081A5 JP 2016519081 A5 JP2016519081 A5 JP 2016519081A5 JP 2016503128 A JP2016503128 A JP 2016503128A JP 2016503128 A JP2016503128 A JP 2016503128A JP 2016519081 A5 JP2016519081 A5 JP 2016519081A5

Authority

JP

Japan

Prior art keywords

seq

antibody

amino acids

sequence

group

Prior art date

2014-03-14

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 150000001413 amino acids Chemical class 0.000 claims 29
• 125000003275 alpha amino acid group Chemical group 0.000 claims 16
• 102100035361 Cerebellar degeneration-related protein 2 Human genes 0.000 claims 14
• 101000737796 Homo sapiens Cerebellar degeneration-related protein 2 Proteins 0.000 claims 14
• 101100112922 Candida albicans CDR3 gene Proteins 0.000 claims 12
• 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 claims 12
• 101000737793 Homo sapiens Cerebellar degeneration-related antigen 1 Proteins 0.000 claims 12
• 239000008194 pharmaceutical composition Substances 0.000 claims 9
• 230000014508 negative regulation of coagulation Effects 0.000 claims 7
• 150000007523 nucleic acids Chemical class 0.000 claims 4
• 102000039446 nucleic acids Human genes 0.000 claims 4
• 108020004707 nucleic acids Proteins 0.000 claims 4
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
• 102100022641 Coagulation factor IX Human genes 0.000 claims 3
• 206010053567 Coagulopathies Diseases 0.000 claims 3
• 208000015294 blood coagulation disease Diseases 0.000 claims 3
• 230000009852 coagulant defect Effects 0.000 claims 3
• 230000015271 coagulation Effects 0.000 claims 3
• 238000005345 coagulation Methods 0.000 claims 3
• 108010039209 Blood Coagulation Factors Proteins 0.000 claims 2
• 102000015081 Blood Coagulation Factors Human genes 0.000 claims 2
• 102100026735 Coagulation factor VIII Human genes 0.000 claims 2
• 201000003542 Factor VIII deficiency Diseases 0.000 claims 2
• 208000009292 Hemophilia A Diseases 0.000 claims 2
• 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 claims 2
• 239000003114 blood coagulation factor Substances 0.000 claims 2
• 208000011664 congenital factor XI deficiency Diseases 0.000 claims 2
• 201000007219 factor XI deficiency Diseases 0.000 claims 2
• 208000009429 hemophilia B Diseases 0.000 claims 2
• 108010076282 Factor IX Proteins 0.000 claims 1
• 108010054218 Factor VIII Proteins 0.000 claims 1
• 102000001690 Factor VIII Human genes 0.000 claims 1
• 108010054265 Factor VIIa Proteins 0.000 claims 1
• 208000032843 Hemorrhage Diseases 0.000 claims 1
• HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 1
• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
• 239000004019 antithrombin Substances 0.000 claims 1
• 230000000740 bleeding effect Effects 0.000 claims 1
• 239000008280 blood Substances 0.000 claims 1
• 210000004369 blood Anatomy 0.000 claims 1
• 230000023555 blood coagulation Effects 0.000 claims 1
• 230000007812 deficiency Effects 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 229960004222 factor ix Drugs 0.000 claims 1
• 229940012414 factor viia Drugs 0.000 claims 1
• 229960000301 factor viii Drugs 0.000 claims 1
• 229960002897 heparin Drugs 0.000 claims 1
• 229920000669 heparin Polymers 0.000 claims 1
• 208000014674 injury Diseases 0.000 claims 1
• 230000003248 secreting effect Effects 0.000 claims 1
• 238000004904 shortening Methods 0.000 claims 1
• 239000007787 solid Substances 0.000 claims 1
• 230000008733 trauma Effects 0.000 claims 1