CA2916421A1 - Monoclonal antibodies against antithrombin beta complexed with heparin - Google Patents

Monoclonal antibodies against antithrombin beta complexed with heparin Download PDF

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Publication number
CA2916421A1
CA2916421A1 CA2916421A CA2916421A CA2916421A1 CA 2916421 A1 CA2916421 A1 CA 2916421A1 CA 2916421 A CA2916421 A CA 2916421A CA 2916421 A CA2916421 A CA 2916421A CA 2916421 A1 CA2916421 A1 CA 2916421A1
Authority
CA
Canada
Prior art keywords
seq
antibody
amino acids
amino acid
monoclonal antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2916421A
Other languages
English (en)
French (fr)
Inventor
Ye Jin
John E. Murphy
Terry Hermiston
Timothy MYLES
Frank Dittmer
Michael Strerath
Uwe Gritzan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Healthcare LLC
Original Assignee
Bayer Healthcare LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50680168&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2916421(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Healthcare LLC filed Critical Bayer Healthcare LLC
Publication of CA2916421A1 publication Critical patent/CA2916421A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482Serine endopeptidases (3.4.21)
    • A61K38/4846Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/38Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2916421A 2013-03-14 2014-03-14 Monoclonal antibodies against antithrombin beta complexed with heparin Abandoned CA2916421A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361784590P 2013-03-14 2013-03-14
US61/784,590 2013-03-14
PCT/US2014/029541 WO2014153195A1 (en) 2013-03-14 2014-03-14 Monoclonal antibodies against antithrombin beta complexed with heparin

Publications (1)

Publication Number Publication Date
CA2916421A1 true CA2916421A1 (en) 2014-09-25

Family

ID=50680168

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2916421A Abandoned CA2916421A1 (en) 2013-03-14 2014-03-14 Monoclonal antibodies against antithrombin beta complexed with heparin

Country Status (18)

Country Link
US (4) US9908942B2 (cg-RX-API-DMAC7.html)
EP (1) EP2970500A1 (cg-RX-API-DMAC7.html)
JP (1) JP2016519081A (cg-RX-API-DMAC7.html)
KR (1) KR20150127202A (cg-RX-API-DMAC7.html)
CN (1) CN105229033B (cg-RX-API-DMAC7.html)
AR (1) AR095499A1 (cg-RX-API-DMAC7.html)
AU (1) AU2014236198A1 (cg-RX-API-DMAC7.html)
BR (1) BR112015021399A2 (cg-RX-API-DMAC7.html)
CA (1) CA2916421A1 (cg-RX-API-DMAC7.html)
HK (1) HK1215261A1 (cg-RX-API-DMAC7.html)
MX (1) MX2015012441A (cg-RX-API-DMAC7.html)
PE (1) PE20160533A1 (cg-RX-API-DMAC7.html)
RU (1) RU2015143696A (cg-RX-API-DMAC7.html)
SG (1) SG11201506886TA (cg-RX-API-DMAC7.html)
TW (1) TW201529602A (cg-RX-API-DMAC7.html)
UY (1) UY35457A (cg-RX-API-DMAC7.html)
WO (1) WO2014153195A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201507628B (cg-RX-API-DMAC7.html)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
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BR112015021399A2 (pt) * 2013-03-14 2017-07-18 Bayer Healthcare Llc anticórpos monoclonais contra antitrombina beta complexada com heparina
EP3146759B1 (en) * 2014-05-19 2021-04-07 Nokia Solutions and Networks Oy Re-establishment procedure in dual connectivity networks
WO2016207240A1 (en) 2015-06-24 2016-12-29 F. Hoffmann-La Roche Ag Anti-transferrin receptor antibodies with tailored affinity
CN114057884A (zh) 2015-10-02 2022-02-18 豪夫迈·罗氏有限公司 双特异性抗人cd20/人转铁蛋白受体抗体及使用方法
AR106189A1 (es) 2015-10-02 2017-12-20 Hoffmann La Roche ANTICUERPOS BIESPECÍFICOS CONTRA EL A-b HUMANO Y EL RECEPTOR DE TRANSFERRINA HUMANO Y MÉTODOS DE USO
US20190100602A1 (en) * 2016-03-18 2019-04-04 INSERM (Institut National de la Santé et de la Recherche Médicale Anti-antithrombin single-domain antibodies and polypeptides comprising thereof

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Also Published As

Publication number Publication date
SG11201506886TA (en) 2015-09-29
WO2014153195A1 (en) 2014-09-25
PE20160533A1 (es) 2016-06-09
US10144784B2 (en) 2018-12-04
EP2970500A1 (en) 2016-01-20
CN105229033A (zh) 2016-01-06
US9908942B2 (en) 2018-03-06
BR112015021399A2 (pt) 2017-07-18
TW201529602A (zh) 2015-08-01
US20180244799A1 (en) 2018-08-30
KR20150127202A (ko) 2015-11-16
UY35457A (es) 2014-10-31
HK1215261A1 (zh) 2016-08-19
ZA201507628B (en) 2017-11-29
US20160024222A1 (en) 2016-01-28
MX2015012441A (es) 2016-08-08
US20140271660A1 (en) 2014-09-18
RU2015143696A (ru) 2017-04-19
US9593166B2 (en) 2017-03-14
AU2014236198A1 (en) 2015-10-15
CN105229033B (zh) 2019-04-23
JP2016519081A (ja) 2016-06-30
AR095499A1 (es) 2015-10-21
US20140271661A1 (en) 2014-09-18

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20200831