JP2016510763A5 - - Google Patents
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- JP2016510763A5 JP2016510763A5 JP2015561740A JP2015561740A JP2016510763A5 JP 2016510763 A5 JP2016510763 A5 JP 2016510763A5 JP 2015561740 A JP2015561740 A JP 2015561740A JP 2015561740 A JP2015561740 A JP 2015561740A JP 2016510763 A5 JP2016510763 A5 JP 2016510763A5
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- 108090000765 processed proteins & peptides Proteins 0.000 claims description 84
- 229920001184 polypeptide Polymers 0.000 claims description 79
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 79
- 150000001413 amino acids Chemical group 0.000 claims description 36
- 238000000034 method Methods 0.000 claims description 36
- 206010003246 arthritis Diseases 0.000 claims description 14
- 239000008194 pharmaceutical composition Substances 0.000 claims description 13
- 210000001612 chondrocyte Anatomy 0.000 claims description 10
- 210000001503 joint Anatomy 0.000 claims description 10
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims description 6
- 230000002648 chondrogenic effect Effects 0.000 claims description 5
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 4
- 206010071155 Autoimmune arthritis Diseases 0.000 claims description 4
- 102000005720 Glutathione transferase Human genes 0.000 claims description 4
- 108010070675 Glutathione transferase Proteins 0.000 claims description 4
- 102000008100 Human Serum Albumin Human genes 0.000 claims description 4
- 108091006905 Human Serum Albumin Proteins 0.000 claims description 4
- 101710175625 Maltose/maltodextrin-binding periplasmic protein Proteins 0.000 claims description 4
- 206010048873 Traumatic arthritis Diseases 0.000 claims description 4
- 230000004069 differentiation Effects 0.000 claims description 4
- 229920002674 hyaluronan Polymers 0.000 claims description 4
- 229960003160 hyaluronic acid Drugs 0.000 claims description 4
- 230000001939 inductive effect Effects 0.000 claims description 4
- 201000008482 osteoarthritis Diseases 0.000 claims description 4
- 206010039073 rheumatoid arthritis Diseases 0.000 claims description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 2
- 102100022544 Bone morphogenetic protein 7 Human genes 0.000 claims description 2
- 102000008186 Collagen Human genes 0.000 claims description 2
- 108010035532 Collagen Proteins 0.000 claims description 2
- 102100035323 Fibroblast growth factor 18 Human genes 0.000 claims description 2
- 244000068988 Glycine max Species 0.000 claims description 2
- 235000010469 Glycine max Nutrition 0.000 claims description 2
- 101000899361 Homo sapiens Bone morphogenetic protein 7 Proteins 0.000 claims description 2
- 101000878128 Homo sapiens Fibroblast growth factor 18 Proteins 0.000 claims description 2
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims description 2
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims description 2
- 102100029438 Nitric oxide synthase, inducible Human genes 0.000 claims description 2
- 101710089543 Nitric oxide synthase, inducible Proteins 0.000 claims description 2
- 244000025272 Persea americana Species 0.000 claims description 2
- 235000008673 Persea americana Nutrition 0.000 claims description 2
- 102000002933 Thioredoxin Human genes 0.000 claims description 2
- 101710120037 Toxin CcdB Proteins 0.000 claims description 2
- 239000002260 anti-inflammatory agent Substances 0.000 claims description 2
- 229940121363 anti-inflammatory agent Drugs 0.000 claims description 2
- 210000004899 c-terminal region Anatomy 0.000 claims description 2
- BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 claims description 2
- 229960003773 calcitonin (salmon synthetic) Drugs 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 229920001436 collagen Polymers 0.000 claims description 2
- 239000012634 fragment Substances 0.000 claims description 2
- 239000003112 inhibitor Substances 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims description 2
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims description 2
- 229920002704 polyhistidine Polymers 0.000 claims description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 108010068072 salmon calcitonin Proteins 0.000 claims description 2
- 230000003637 steroidlike Effects 0.000 claims description 2
- 150000003431 steroids Chemical class 0.000 claims description 2
- 108060008226 thioredoxin Proteins 0.000 claims description 2
- 229940094937 thioredoxin Drugs 0.000 claims description 2
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 claims description 2
- 239000011159 matrix material Substances 0.000 description 6
- 238000001356 surgical procedure Methods 0.000 description 6
- 238000002054 transplantation Methods 0.000 description 4
- 210000001185 bone marrow Anatomy 0.000 description 3
- 210000000845 cartilage Anatomy 0.000 description 3
- 230000000638 stimulation Effects 0.000 description 3
- 238000002513 implantation Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019140222A JP6918871B2 (ja) | 2013-03-08 | 2019-07-30 | 関節損傷の治療のためのペプチドおよび組成物 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361775400P | 2013-03-08 | 2013-03-08 | |
| US61/775,400 | 2013-03-08 | ||
| US201461938123P | 2014-02-10 | 2014-02-10 | |
| US61/938,123 | 2014-02-10 | ||
| PCT/US2014/022102 WO2014138687A1 (en) | 2013-03-08 | 2014-03-07 | Peptides and compositions for treatment of joint damage |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019140222A Division JP6918871B2 (ja) | 2013-03-08 | 2019-07-30 | 関節損傷の治療のためのペプチドおよび組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016510763A JP2016510763A (ja) | 2016-04-11 |
| JP2016510763A5 true JP2016510763A5 (enExample) | 2017-04-13 |
| JP6567429B2 JP6567429B2 (ja) | 2019-08-28 |
Family
ID=50390286
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015561740A Active JP6567429B2 (ja) | 2013-03-08 | 2014-03-07 | 関節損傷の治療のためのペプチドおよび組成物 |
| JP2019140222A Active JP6918871B2 (ja) | 2013-03-08 | 2019-07-30 | 関節損傷の治療のためのペプチドおよび組成物 |
| JP2021119517A Pending JP2021178841A (ja) | 2013-03-08 | 2021-07-20 | 関節損傷の治療のためのペプチドおよび組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019140222A Active JP6918871B2 (ja) | 2013-03-08 | 2019-07-30 | 関節損傷の治療のためのペプチドおよび組成物 |
| JP2021119517A Pending JP2021178841A (ja) | 2013-03-08 | 2021-07-20 | 関節損傷の治療のためのペプチドおよび組成物 |
Country Status (38)
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20160507A1 (es) | 2009-07-14 | 2016-05-20 | Scripps Research Inst | Diferenciacion de celulas madre mesenquimales |
| US9301971B2 (en) | 2013-03-08 | 2016-04-05 | Novartis Ag | Peptides and compositions for treatment of joint damage |
| UY35368A (es) | 2013-03-08 | 2014-10-31 | Irm Llc | Péptidos y composiciones para el tratamiento de daño articular |
| KR102117501B1 (ko) | 2016-10-24 | 2020-06-01 | 스미또모 가가꾸 가부시키가이샤 | 세퍼레이터 및 세퍼레이터를 포함하는 이차 전지 |
| JP6991593B2 (ja) * | 2016-11-09 | 2022-01-12 | アイシーエム・カンパニー、リミテッド | Ｎｋｘ３．２断片及び活性成分としてＮｋｘ３．２断片を含む医薬組成物 |
| IL266361B2 (en) * | 2016-11-14 | 2024-02-01 | Novartis Ag | Methods and preparations for the treatment of cartilage damage and arthritis |
| CN108530619B (zh) * | 2017-03-01 | 2020-12-08 | 北京大学第三医院 | 功能化氨基酸、制备方法及由其制得的功能化氨基酸水凝胶 |
| JOP20190245A1 (ar) | 2017-04-20 | 2019-10-15 | Novartis Ag | أنظمة توصيل إطلاق مستدام تتضمن روابط بلا أثر لنقطة الربط |
| CN112424207B (zh) | 2018-07-25 | 2024-03-19 | 诺华股份有限公司 | Nlrp3炎性小体抑制剂 |
| AR116566A1 (es) | 2018-10-03 | 2021-05-19 | Novartis Ag | Administración sostenida de polipéptidos similares a la angiopoyetina 3 |
| UY38687A (es) | 2019-05-17 | 2023-05-15 | Novartis Ag | Inhibidores del inflamasoma nlrp3, composiciones, combinaciones de los mismos y métodos para su uso |
| WO2021001804A1 (en) * | 2019-07-04 | 2021-01-07 | Cadila Healthcare Limited | Angptl3 based vaccine for the treatment of liver disease |
| KR102577697B1 (ko) * | 2019-11-13 | 2023-09-14 | 주식회사 나이벡 | 염증 및 상처 치료용 펩타이드 |
| JP7298496B2 (ja) | 2020-01-31 | 2023-06-27 | トヨタ自動車株式会社 | 車両 |
| TW202306970A (zh) | 2021-05-24 | 2023-02-16 | 瑞士商諾華公司 | 用於治療骨關節炎之方法 |
| CN117355323A (zh) | 2021-05-24 | 2024-01-05 | 诺华股份有限公司 | 用于治疗骨关节炎的方法 |
| CN113683681B (zh) * | 2021-09-15 | 2023-10-03 | 山西锦波生物医药股份有限公司 | 一种重组i型人源化胶原蛋白c1l3t及其制备方法和用途 |
| CN113683678B (zh) * | 2021-09-15 | 2023-11-24 | 山西锦波生物医药股份有限公司 | 一种重组i型人源化胶原蛋白c1l2t及其制备方法和用途 |
| EP4430395A1 (en) | 2021-11-10 | 2024-09-18 | Novartis AG | Methods for determining the biological activity of angptl polypeptides |
| CN114377202B (zh) * | 2021-12-16 | 2023-01-24 | 方向前 | 适用于软骨再生的功能化自组装miRNA/多肽复合水凝胶及其制备方法 |
| UY40374A (es) | 2022-08-03 | 2024-02-15 | Novartis Ag | Inhibidores de inflamasoma nlrp3 |
| KR20240087877A (ko) * | 2022-12-09 | 2024-06-20 | (주)케어젠 | 연골 재생용 펩타이드 및 이의 용도 |
| WO2025169047A1 (en) | 2024-02-05 | 2025-08-14 | Novartis Ag | Improved production of angptl3 mimetics |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8308236D0 (en) * | 1983-03-25 | 1983-05-05 | Celltech Ltd | Dna vectors |
| US5462990A (en) | 1990-10-15 | 1995-10-31 | Board Of Regents, The University Of Texas System | Multifunctional organic polymers |
| US5288931A (en) | 1991-12-06 | 1994-02-22 | Genentech, Inc. | Method for refolding insoluble, misfolded insulin-like growth factor-I into an active conformation |
| US6447796B1 (en) | 1994-05-16 | 2002-09-10 | The United States Of America As Represented By The Secretary Of The Army | Sustained release hydrophobic bioactive PLGA microspheres |
| WO1999058660A1 (en) | 1998-05-12 | 1999-11-18 | Human Genome Sciences, Inc. | 97 human secreted proteins |
| US6030831A (en) | 1997-09-19 | 2000-02-29 | Genetech, Inc. | Tie ligand homologues |
| AU3661199A (en) | 1998-04-27 | 1999-11-16 | Zymogenetics Inc. | Novel polypeptide growth factors and materials and methods for making them |
| AU4643699A (en) | 1998-06-24 | 2000-01-10 | Compugen Ltd. | Angiopoietin-like growth factor sequences |
| AU768694B2 (en) | 1999-03-08 | 2004-01-08 | Genentech Inc. | Promotion or inhibition of angiogenesis and cardiovascularization |
| EP1159441B8 (en) | 1999-03-10 | 2008-10-29 | Marie Curie Cancer Care | Delivery of nucleic acids and proteins to cells |
| GB9912350D0 (en) | 1999-05-26 | 1999-07-28 | European Molecular Biology Lab Embl | Modified cytokine |
| AU4011300A (en) | 1999-07-20 | 2001-02-05 | Genentech Inc. | Compositions and methods for the treatment of immune related diseases |
| US20030013649A1 (en) | 2000-01-31 | 2003-01-16 | Rosen Craig A. | Nucleic acids, proteins, and antibodies |
| US20030120056A1 (en) | 2000-10-16 | 2003-06-26 | Audrey Goddard | TIE ligand homologues |
| AU2437702A (en) | 2000-10-16 | 2002-04-29 | Genentech Inc | Methods of treatment using wisp polypeptides |
| US20020130430A1 (en) | 2000-12-29 | 2002-09-19 | Castor Trevor Percival | Methods for making polymer microspheres/nanospheres and encapsulating therapeutic proteins and other products |
| US20030027751A1 (en) | 2001-04-10 | 2003-02-06 | Genvec, Inc. | VEGF fusion proteins |
| EP1490483B1 (en) | 2001-04-19 | 2015-06-03 | The Scripps Research Institute | In vivo incorporation of unnatural amino acids |
| US20030194798A1 (en) | 2001-05-24 | 2003-10-16 | Surber Mark W. | Minicell compositions and methods |
| FI117667B (fi) | 2001-07-05 | 2007-01-15 | Univ Zuerich | Farmaseuttinen koostumus, joka soveltuu käytettäväksi ortopediassa ja hammaslääketieteessä |
| ES2429034T3 (es) | 2001-11-16 | 2013-11-12 | Genentech, Inc. | Uso de antagonistas de ANGPTL3 para el tratamiento de enfermedades hepáticas |
| US7060498B1 (en) | 2001-11-28 | 2006-06-13 | Genta Salus Llc | Polycationic water soluble copolymer and method for transferring polyanionic macromolecules across biological barriers |
| US7141540B2 (en) | 2001-11-30 | 2006-11-28 | Genta Salus Llc | Cyclodextrin grafted biocompatible amphilphilic polymer and methods of preparation and use thereof |
| GEP20074193B (en) | 2002-09-09 | 2007-09-10 | Nektar Therapeutics Al Corp | Water-soluble polymer alkanals |
| KR20050073559A (ko) | 2002-10-16 | 2005-07-14 | 더 스크립스 리서치 인스티튜트 | 당단백질 합성 |
| DK1578949T3 (da) | 2002-10-16 | 2009-07-27 | Scripps Research Inst | Stedspecifik optagelse af keto-aminnosyrer hos proteiner |
| CN103289960B (zh) | 2003-04-17 | 2017-04-26 | 斯克利普斯研究院 | 扩展真核生物遗传密码 |
| DE602004011789T2 (de) | 2003-07-07 | 2009-02-12 | The Scripps Research Institute, La Jolla | Zusammensetzungen der orthogonalen Lysyl-tRNA und Aminoacyl-tRNA Synthetase Paaren und ihre Verwendungen |
| WO2005007870A2 (en) | 2003-07-07 | 2005-01-27 | The Scripps Research Institute | COMPOSITIONS OF ORTHOGONAL LEUCYL-tRNA AND AMINOACYL-tRNA SYNTHETASE PAIRS AND USES THEREOF |
| WO2005007624A2 (en) | 2003-07-07 | 2005-01-27 | The Scripps Research Institute | Compositions of orthogonal glutamyl-trna and aminoacyl trna synthetase pairs and uses thereof |
| EP1794323B1 (en) | 2004-09-21 | 2014-08-06 | The Scripps Research Institute | In vivo incorporation of alkynyl amino acids into proteins in eubacteria |
| AU2005330514B2 (en) | 2004-10-27 | 2011-05-12 | The Scripps Research Institute | Orthogonal translation components for the in vivo incorporation of unnatural amino acids |
| US20110097330A1 (en) | 2005-03-11 | 2011-04-28 | Genentech, Inc. | Novel Gene Disruptions, Compostitions and Methods Relating Thereto |
| WO2006127809A2 (en) | 2005-05-24 | 2006-11-30 | Whitehead Institute For Biomedical Research | Methods for expansion and analysis of cultured hematopoietic stem cells |
| CA2638763A1 (en) | 2006-03-09 | 2007-09-13 | The Scripps Research Institute | System for the expression of orthogonal translation components in eubacterial host cells |
| AU2007328871B2 (en) | 2006-12-06 | 2013-11-21 | Seikagaku Corporation | Pharmaceutical agent having long-lasting effect of treating arthritic disorders |
| CA2672049C (en) | 2006-12-08 | 2016-05-10 | Lexicon Pharmaceuticals, Inc. | Monoclonal antibodies against angptl3 |
| EP2118150B1 (en) | 2007-02-14 | 2015-09-23 | Biocompatibles UK Limited | Derivatisation of biological molecules |
| WO2008137641A2 (en) | 2007-05-04 | 2008-11-13 | Whitehead Institute For Biomedical Research | Ex vivo expansion of human hematopoietic stem cells |
| PE20160507A1 (es) * | 2009-07-14 | 2016-05-20 | Scripps Research Inst | Diferenciacion de celulas madre mesenquimales |
| US9732143B2 (en) | 2011-02-03 | 2017-08-15 | Xoma Technology Ltd. | Methods and materials for enhancing functional protein expression in bacteria |
| US9464065B2 (en) | 2011-03-24 | 2016-10-11 | The Scripps Research Institute | Compounds and methods for inducing chondrogenesis |
| WO2014004465A1 (en) | 2012-06-25 | 2014-01-03 | The Brigham And Women's Hospital, Inc. | Targeted therapeutics |
| US9301971B2 (en) | 2013-03-08 | 2016-04-05 | Novartis Ag | Peptides and compositions for treatment of joint damage |
| UY35368A (es) | 2013-03-08 | 2014-10-31 | Irm Llc | Péptidos y composiciones para el tratamiento de daño articular |
-
2014
- 2014-03-06 UY UY0001035368A patent/UY35368A/es active IP Right Grant
- 2014-03-06 JO JOP/2014/0076A patent/JO3564B1/ar active
- 2014-03-07 LT LTEP14713728.5T patent/LT2964250T/lt unknown
- 2014-03-07 RS RS20180794A patent/RS57446B1/sr unknown
- 2014-03-07 MY MYPI2015702657A patent/MY173172A/en unknown
- 2014-03-07 KR KR1020157027474A patent/KR102267341B1/ko active Active
- 2014-03-07 NZ NZ711037A patent/NZ711037A/en unknown
- 2014-03-07 CA CA2903448A patent/CA2903448C/en active Active
- 2014-03-07 DK DK14713728.5T patent/DK2964250T3/da active
- 2014-03-07 SI SI201430757T patent/SI2964250T1/sl unknown
- 2014-03-07 HU HUE14713728A patent/HUE038499T2/hu unknown
- 2014-03-07 US US14/772,209 patent/US9649359B2/en active Active
- 2014-03-07 EP EP18170788.6A patent/EP3391900A1/en active Pending
- 2014-03-07 TW TW103108047A patent/TWI634124B/zh active
- 2014-03-07 CN CN201480012768.9A patent/CN105025917B/zh active Active
- 2014-03-07 EA EA201591661A patent/EA035158B1/ru not_active IP Right Cessation
- 2014-03-07 WO PCT/US2014/022102 patent/WO2014138687A1/en not_active Ceased
- 2014-03-07 ES ES14713728.5T patent/ES2684349T3/es active Active
- 2014-03-07 MX MX2015011963A patent/MX365157B/es active IP Right Grant
- 2014-03-07 PT PT14713728T patent/PT2964250T/pt unknown
- 2014-03-07 CR CR20200290A patent/CR20200290A/es unknown
- 2014-03-07 BR BR112015021269-7A patent/BR112015021269B1/pt active IP Right Grant
- 2014-03-07 CU CUP2015000097A patent/CU24301B1/xx unknown
- 2014-03-07 AU AU2014225348A patent/AU2014225348B2/en active Active
- 2014-03-07 PE PE2015001873A patent/PE20151528A1/es active IP Right Grant
- 2014-03-07 CN CN202010722284.0A patent/CN111808182A/zh active Pending
- 2014-03-07 JP JP2015561740A patent/JP6567429B2/ja active Active
- 2014-03-07 EP EP14713728.5A patent/EP2964250B1/en active Active
- 2014-03-07 AP AP2015008675A patent/AP2015008675A0/xx unknown
- 2014-03-07 SG SG11201506490TA patent/SG11201506490TA/en unknown
- 2014-03-07 BR BR122016021558-0A patent/BR122016021558B1/pt active IP Right Grant
- 2014-03-07 PL PL14713728T patent/PL2964250T3/pl unknown
- 2014-03-07 HR HRP20181269TT patent/HRP20181269T1/hr unknown
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2015
- 2015-08-18 ZA ZA2015/05966A patent/ZA201505966B/en unknown
- 2015-08-20 IL IL240727A patent/IL240727B/en active IP Right Grant
- 2015-08-31 CL CL2015002443A patent/CL2015002443A1/es unknown
- 2015-09-03 TN TN2015000385A patent/TN2015000385A1/en unknown
- 2015-09-07 PH PH12015501983A patent/PH12015501983B1/en unknown
- 2015-09-08 CO CO15210900A patent/CO7461145A2/es unknown
- 2015-09-08 CR CR20150466A patent/CR20150466A/es unknown
- 2015-10-08 EC ECIEPI201542898A patent/ECSP15042898A/es unknown
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2016
- 2016-05-11 AU AU2016203028A patent/AU2016203028C1/en active Active
- 2016-12-21 AU AU2016277608A patent/AU2016277608B2/en active Active
-
2017
- 2017-03-13 US US15/457,656 patent/US10328126B2/en active Active
-
2018
- 2018-08-07 CY CY181100821T patent/CY1120729T1/el unknown
-
2019
- 2019-05-06 US US16/403,677 patent/US11179442B2/en active Active
- 2019-07-30 JP JP2019140222A patent/JP6918871B2/ja active Active
-
2021
- 2021-07-20 JP JP2021119517A patent/JP2021178841A/ja active Pending
- 2021-11-08 US US17/453,960 patent/US20220184182A1/en not_active Abandoned
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