JP2016505240A5 - - Google Patents
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- JP2016505240A5 JP2016505240A5 JP2015540826A JP2015540826A JP2016505240A5 JP 2016505240 A5 JP2016505240 A5 JP 2016505240A5 JP 2015540826 A JP2015540826 A JP 2015540826A JP 2015540826 A JP2015540826 A JP 2015540826A JP 2016505240 A5 JP2016505240 A5 JP 2016505240A5
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- seq
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- amino acid
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001413 amino acids Chemical group 0.000 claims 54
- 230000001404 mediated effect Effects 0.000 claims 33
- 230000002829 reductive effect Effects 0.000 claims 33
- 102000016917 Complement C1 Human genes 0.000 claims 32
- 108010028774 Complement C1 Proteins 0.000 claims 32
- 230000000295 complement effect Effects 0.000 claims 32
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 29
- 238000000034 method Methods 0.000 claims 29
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 26
- 239000008194 pharmaceutical composition Substances 0.000 claims 22
- 210000001519 tissue Anatomy 0.000 claims 19
- 239000012472 biological sample Substances 0.000 claims 16
- 201000010099 disease Diseases 0.000 claims 13
- 208000035475 disorder Diseases 0.000 claims 13
- 230000009467 reduction Effects 0.000 claims 12
- 230000024203 complement activation Effects 0.000 claims 10
- 210000000056 organ Anatomy 0.000 claims 10
- 239000000243 solution Substances 0.000 claims 9
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 8
- 239000000178 monomer Substances 0.000 claims 8
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- 230000002401 inhibitory effect Effects 0.000 claims 7
- 210000003743 erythrocyte Anatomy 0.000 claims 6
- 238000004519 manufacturing process Methods 0.000 claims 6
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- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 claims 4
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims 4
- 238000000338 in vitro Methods 0.000 claims 4
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- 239000002126 C01EB10 - Adenosine Substances 0.000 claims 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 2
- 241000282693 Cercopithecidae Species 0.000 claims 2
- 229940123457 Free radical scavenger Drugs 0.000 claims 2
- 108010024636 Glutathione Proteins 0.000 claims 2
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 claims 2
- 229920001612 Hydroxyethyl starch Polymers 0.000 claims 2
- 108091005804 Peptidases Proteins 0.000 claims 2
- 239000004365 Protease Substances 0.000 claims 2
- MUPFEKGTMRGPLJ-RMMQSMQOSA-N Raffinose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MUPFEKGTMRGPLJ-RMMQSMQOSA-N 0.000 claims 2
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 2
- MUPFEKGTMRGPLJ-UHFFFAOYSA-N UNPD196149 Natural products OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(COC2C(C(O)C(O)C(CO)O2)O)O1 MUPFEKGTMRGPLJ-UHFFFAOYSA-N 0.000 claims 2
- 230000004913 activation Effects 0.000 claims 2
- 229960005305 adenosine Drugs 0.000 claims 2
- OFCNXPDARWKPPY-UHFFFAOYSA-N allopurinol Chemical compound OC1=NC=NC2=C1C=NN2 OFCNXPDARWKPPY-UHFFFAOYSA-N 0.000 claims 2
- 229960003459 allopurinol Drugs 0.000 claims 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 230000008499 blood brain barrier function Effects 0.000 claims 2
- 210000001218 blood-brain barrier Anatomy 0.000 claims 2
- 239000011575 calcium Substances 0.000 claims 2
- 229910052791 calcium Inorganic materials 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 238000003776 cleavage reaction Methods 0.000 claims 2
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- 239000003814 drug Substances 0.000 claims 2
- 229960003180 glutathione Drugs 0.000 claims 2
- 210000003630 histaminocyte Anatomy 0.000 claims 2
- 229940050526 hydroxyethylstarch Drugs 0.000 claims 2
- 210000002540 macrophage Anatomy 0.000 claims 2
- 210000004498 neuroglial cell Anatomy 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 239000001301 oxygen Substances 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- BIRNWOIQDVFTSP-WWNCWODVSA-M potassium (2R,3R,4R,5R)-2,3,5,6-tetrahydroxy-4-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhexanoate Chemical compound [K+].OC[C@@H](O)[C@@H](O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O)[C@H](O)[C@@H](O)C([O-])=O BIRNWOIQDVFTSP-WWNCWODVSA-M 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 239000002516 radical scavenger Substances 0.000 claims 2
- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 230000007017 scission Effects 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 210000003491 skin Anatomy 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 229920001059 synthetic polymer Polymers 0.000 claims 2
- 238000002054 transplantation Methods 0.000 claims 2
- 108010028778 Complement C4 Proteins 0.000 claims 1
- 208000016192 Demyelinating disease Diseases 0.000 claims 1
- 206010012305 Demyelination Diseases 0.000 claims 1
- 206010014950 Eosinophilia Diseases 0.000 claims 1
- 208000034826 Genetic Predisposition to Disease Diseases 0.000 claims 1
- 206010018910 Haemolysis Diseases 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 206010033799 Paralysis Diseases 0.000 claims 1
- 208000003251 Pruritus Diseases 0.000 claims 1
- 206010039509 Scab Diseases 0.000 claims 1
- 206010040840 Skin erosion Diseases 0.000 claims 1
- 208000007536 Thrombosis Diseases 0.000 claims 1
- 208000007502 anemia Diseases 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 210000001130 astrocyte Anatomy 0.000 claims 1
- 210000000601 blood cell Anatomy 0.000 claims 1
- 210000004204 blood vessel Anatomy 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 230000020411 cell activation Effects 0.000 claims 1
- 230000006727 cell loss Effects 0.000 claims 1
- 230000006037 cell lysis Effects 0.000 claims 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 1
- 239000003638 chemical reducing agent Substances 0.000 claims 1
- 238000005345 coagulation Methods 0.000 claims 1
- 230000015271 coagulation Effects 0.000 claims 1
- 230000003920 cognitive function Effects 0.000 claims 1
- 239000002872 contrast media Substances 0.000 claims 1
- 210000004087 cornea Anatomy 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 230000013872 defecation Effects 0.000 claims 1
- 210000004443 dendritic cell Anatomy 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 238000002651 drug therapy Methods 0.000 claims 1
- 210000003722 extracellular fluid Anatomy 0.000 claims 1
- 210000001508 eye Anatomy 0.000 claims 1
- 210000004700 fetal blood Anatomy 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 230000007277 glial cell activation Effects 0.000 claims 1
- 210000002216 heart Anatomy 0.000 claims 1
- 210000003709 heart valve Anatomy 0.000 claims 1
- 230000008588 hemolysis Effects 0.000 claims 1
- 229960001340 histamine Drugs 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 210000000936 intestine Anatomy 0.000 claims 1
- 210000004153 islets of langerhan Anatomy 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 230000003907 kidney function Effects 0.000 claims 1
- 210000000265 leukocyte Anatomy 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
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- 206010025135 lupus erythematosus Diseases 0.000 claims 1
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- 238000002595 magnetic resonance imaging Methods 0.000 claims 1
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- 230000027939 micturition Effects 0.000 claims 1
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- 230000031978 negative regulation of complement activation Effects 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 210000002569 neuron Anatomy 0.000 claims 1
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- 239000002773 nucleotide Substances 0.000 claims 1
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- 231100000862 numbness Toxicity 0.000 claims 1
- 210000004248 oligodendroglia Anatomy 0.000 claims 1
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- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
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- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 238000002600 positron emission tomography Methods 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 210000003296 saliva Anatomy 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
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- 210000002784 stomach Anatomy 0.000 claims 1
- 230000004083 survival effect Effects 0.000 claims 1
- 210000001179 synovial fluid Anatomy 0.000 claims 1
- 210000002435 tendon Anatomy 0.000 claims 1
- 210000001541 thymus gland Anatomy 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
- 230000008728 vascular permeability Effects 0.000 claims 1
- 210000003462 vein Anatomy 0.000 claims 1
- 230000004304 visual acuity Effects 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261721916P | 2012-11-02 | 2012-11-02 | |
| US61/721,916 | 2012-11-02 | ||
| US201361754123P | 2013-01-18 | 2013-01-18 | |
| US61/754,123 | 2013-01-18 | ||
| US201361779180P | 2013-03-13 | 2013-03-13 | |
| US61/779,180 | 2013-03-13 | ||
| US201361846402P | 2013-07-15 | 2013-07-15 | |
| US61/846,402 | 2013-07-15 | ||
| PCT/US2013/068095 WO2014071206A1 (en) | 2012-11-02 | 2013-11-01 | Anti-complement c1s antibodies and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019111910A Division JP6860618B2 (ja) | 2012-11-02 | 2019-06-17 | 抗補体Ｃ１ｓ抗体とそれらの用途 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016505240A JP2016505240A (ja) | 2016-02-25 |
| JP2016505240A5 true JP2016505240A5 (enExample) | 2016-12-22 |
| JP6543572B2 JP6543572B2 (ja) | 2019-07-10 |
Family
ID=50622568
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015540826A Active JP6543572B2 (ja) | 2012-11-02 | 2013-11-01 | 抗補体Ｃ１ｓ抗体とそれらの用途 |
| JP2019111910A Active JP6860618B2 (ja) | 2012-11-02 | 2019-06-17 | 抗補体Ｃ１ｓ抗体とそれらの用途 |
| JP2021052645A Active JP7210629B2 (ja) | 2012-11-02 | 2021-03-26 | 抗補体Ｃ１ｓ抗体とそれらの用途 |
| JP2023002363A Withdrawn JP2023052318A (ja) | 2012-11-02 | 2023-01-11 | 抗補体Ｃ１ｓ抗体とそれらの用途 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019111910A Active JP6860618B2 (ja) | 2012-11-02 | 2019-06-17 | 抗補体Ｃ１ｓ抗体とそれらの用途 |
| JP2021052645A Active JP7210629B2 (ja) | 2012-11-02 | 2021-03-26 | 抗補体Ｃ１ｓ抗体とそれらの用途 |
| JP2023002363A Withdrawn JP2023052318A (ja) | 2012-11-02 | 2023-01-11 | 抗補体Ｃ１ｓ抗体とそれらの用途 |
Country Status (21)
| Country | Link |
|---|---|
| US (10) | US8945562B2 (enExample) |
| EP (2) | EP2914291B1 (enExample) |
| JP (4) | JP6543572B2 (enExample) |
| CN (3) | CN104884088B (enExample) |
| AU (4) | AU2013337638B2 (enExample) |
| CA (1) | CA2889197A1 (enExample) |
| DK (1) | DK2914291T3 (enExample) |
| ES (1) | ES2912396T3 (enExample) |
| FI (1) | FIC20230015I1 (enExample) |
| FR (1) | FR23C1019I2 (enExample) |
| GB (1) | GB2509260B (enExample) |
| HR (1) | HRP20220637T1 (enExample) |
| HU (1) | HUS2300017I1 (enExample) |
| LT (2) | LT2914291T (enExample) |
| LU (1) | LUC00303I2 (enExample) |
| NL (1) | NL301232I2 (enExample) |
| NO (1) | NO2023018I1 (enExample) |
| PL (1) | PL2914291T3 (enExample) |
| PT (1) | PT2914291T (enExample) |
| RS (1) | RS63212B1 (enExample) |
| WO (1) | WO2014071206A1 (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9555032B2 (en) * | 2007-06-13 | 2017-01-31 | Research Development Foundation | Methods for treatment and prevention of tauopathies and amyloid beta amyloidosis by modulating CRF receptor signaling |
| US8921314B2 (en) | 2008-10-15 | 2014-12-30 | Angiochem, Inc. | Conjugates of GLP-1 agonists and uses thereof |
| JP6774164B2 (ja) | 2012-08-24 | 2020-10-21 | 中外製薬株式会社 | マウスＦｃγＲＩＩ特異的Ｆｃ抗体 |
| EP2912065A4 (en) | 2012-10-25 | 2016-10-19 | True North Therapeutics Inc | ANTI COMPLEMENT C1S ANTIBODIES AND USES THEREOF |
| WO2014071206A1 (en) | 2012-11-02 | 2014-05-08 | True North Therapeutics, Inc. | Anti-complement c1s antibodies and uses thereof |
| CA2908350C (en) | 2013-04-02 | 2023-08-08 | Futa Mimoto | Fc region variant |
| WO2014186599A2 (en) * | 2013-05-15 | 2014-11-20 | Annexon, Inc. | Anti-complement factor c1s antibodies and uses thereof |
| MX375500B (es) | 2013-07-09 | 2025-03-06 | Annexon Inc | Anticuerpos anti-factor del complemento c1q y uso de los mismos. |
| EP3222291B1 (en) * | 2014-10-24 | 2020-08-19 | University of Science and Technology of China | Angiopeptin conjugates for amyloid protein targeting |
| AU2015343029B2 (en) | 2014-11-05 | 2021-07-29 | Annexon, Inc. | Humanized anti-complement factor C1q antibodies and uses thereof |
| AU2016246452B2 (en) * | 2015-04-06 | 2022-03-10 | Bioverativ Usa Inc. | Humanized anti-C1s antibodies and methods of use thereof |
| JP6823055B2 (ja) | 2015-06-15 | 2021-01-27 | アンジオケム インコーポレーテッド | 軟髄膜癌腫症の治療方法 |
| CN108348600A (zh) * | 2015-06-26 | 2018-07-31 | 比奥贝拉蒂美国公司 | 治疗自身免疫病症和同种免疫病症的方法 |
| CN108779171B (zh) | 2015-11-24 | 2022-07-05 | 安尼艾克松股份有限公司 | 抗补体因子c1q的fab片段及其应用 |
| EP3407915A4 (en) * | 2016-01-25 | 2019-11-20 | President and Fellows of Harvard College | METHOD AND COMPOSITIONS FOR DETECTING AND TREATING SCHIZOPHRENIA |
| EA201892225A1 (ru) | 2016-04-04 | 2019-09-30 | БИОВЕРАТИВ ЮЭсЭй ИНК. | АНТИТЕЛА К ФАКТОРУ Bb КОМПЛЕМЕНТА И ИХ ПРИМЕНЕНИЕ |
| US20190151414A1 (en) * | 2016-05-10 | 2019-05-23 | Annexon, Inc. | Anti-complement factor c4/c4b antibodies and uses thereof |
| LT3525583T (lt) * | 2016-10-12 | 2025-11-10 | Anti-c1s antikūnai ir jų naudojimo būdai | |
| AU2018236267B2 (en) * | 2017-03-14 | 2025-03-13 | Recordati UK Limited | Methods for treating complement-mediated diseases and disorders |
| JP7731196B2 (ja) * | 2017-11-14 | 2025-08-29 | 中外製薬株式会社 | 抗Ｃ１ｓ抗体および使用方法 |
| US20210318335A1 (en) * | 2018-08-28 | 2021-10-14 | Duke University | Biomarkers, compositions, and methods for diagnosing and treating subjects exposed to protein/heparin complexes |
| EP3893924B1 (en) * | 2018-12-13 | 2024-08-21 | argenx BV | Antibodies to human complement factor c2b and methods of use |
| KR20220016865A9 (ko) | 2019-05-15 | 2022-02-21 | 추가이 세이야쿠 가부시키가이샤 | 항원 결합 분자, 약학 조성물, 및 방법 |
| WO2021026609A1 (en) * | 2019-08-12 | 2021-02-18 | CSL Innovation Pty Ltd | Complement c2 binding proteins and uses thereof |
| JP6845973B1 (ja) | 2019-11-20 | 2021-03-24 | 中外製薬株式会社 | 抗体含有製剤 |
| US11242382B2 (en) | 2020-04-20 | 2022-02-08 | Genzyme Corporation | Humanized anti-complement factor Bb antibodies |
| JP2023527684A (ja) * | 2020-05-11 | 2023-06-30 | ジェネンテック， インコーポレイテッド | 神経疾患を治療するための補体成分ｃ１ｓ阻害剤、並びにそれを使用する関連組成物、システム及び方法 |
| CN116724236A (zh) | 2020-08-06 | 2023-09-08 | 美国比奥维拉迪维股份有限公司 | 患有补体介导的疾病的受试者中的炎性细胞因子和疲劳 |
| CA3206197A1 (en) * | 2021-01-14 | 2022-07-21 | The Board Of Trustees Of The Leland Stanford Junior University | Active delivery of radiotracers across the blood brain barrier |
| WO2022212645A1 (en) | 2021-03-31 | 2022-10-06 | Bioverativ Usa Inc. | Reducing surgery-associated hemolysis in cold agglutinin disease patients |
| JP2024518844A (ja) * | 2021-05-20 | 2024-05-07 | ダイアンサス セラピューティクス オプコ， インコーポレイテッド | Ｃ１ｓに結合する抗体およびその使用 |
| US11958899B2 (en) | 2021-07-13 | 2024-04-16 | Mabwell Therapeutics Inc. | Anti-C1s antibodies and uses thereof |
| US12486322B2 (en) | 2021-12-13 | 2025-12-02 | Annexon, Inc. | Anti-complement factor C1q antibodies with single binding arms and uses thereof |
| CN114874329A (zh) * | 2022-05-19 | 2022-08-09 | 江苏大学 | 一种补体活化C1s酶荧光检测试剂盒及检测方法与应用 |
| WO2024112734A1 (en) * | 2022-11-21 | 2024-05-30 | Dianthus Therapeutics Opco, Inc. | Antibodies that bind to c1s and uses thereof |
| WO2025129535A1 (en) * | 2023-12-20 | 2025-06-26 | Dianthus Therapeutics Opco, Inc. | Pharmaceutical compositions comprising antibodies for treatment of c1s mediated disorders and methods of using the same |
| WO2025137473A1 (en) * | 2023-12-20 | 2025-06-26 | Dianthus Therapeutics Opco, Inc. | Pharmaceutical compositions comprising antibodies for treatment of c1s mediated disorders and methods of using the same |
| CN118259018B (zh) * | 2024-03-21 | 2024-10-29 | 泰州市人民医院 | C1s抗体制备及其在ITP诊断中的应用 |
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| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JPS60192263A (ja) | 1984-03-13 | 1985-09-30 | Teijin Ltd | 免疫複合体測定用標準物質及びそれを用いた免疫複合体の測定法 |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| CA1276103C (en) | 1984-10-02 | 1990-11-13 | Fumiaki Taguchi | Substance-conjugated complement component c1q |
| JPS61271455A (ja) | 1985-05-28 | 1986-12-01 | Olympus Optical Co Ltd | 免疫学的分析方法 |
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- 2013-11-01 CN CN202211418763.9A patent/CN116063483A/zh active Pending
- 2013-11-01 LT LTEPPCT/US2013/068095T patent/LT2914291T/lt unknown
- 2013-11-01 US US14/070,186 patent/US8945562B2/en active Active
- 2013-11-01 JP JP2015540826A patent/JP6543572B2/ja active Active
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2014
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2015
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2016
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2019
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2024
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2025
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