JP2015535210A - ２−アルキルセフェム化合物のための中間体の製造法 - Google Patents

２−アルキルセフェム化合物のための中間体の製造法 Download PDF

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Publication number
JP2015535210A
JP2015535210A JP2015521169A JP2015521169A JP2015535210A JP 2015535210 A JP2015535210 A JP 2015535210A JP 2015521169 A JP2015521169 A JP 2015521169A JP 2015521169 A JP2015521169 A JP 2015521169A JP 2015535210 A JP2015535210 A JP 2015535210A
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formula
compound
salt
compound represented
same meaning
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JP2015521169A
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Japanese (ja)
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JP2015535210A5 (enExample
Inventor
克己 横尾
克己 横尾
伸也 久川
伸也 久川
健二 山脇
健二 山脇
俊明 青木
俊明 青木
優貴 横田
優貴 横田
正敏 竹尾
正敏 竹尾
幹人 浅井
幹人 浅井
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Shionogi and Co Ltd
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Shionogi and Co Ltd
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Publication of JP2015535210A publication Critical patent/JP2015535210A/ja
Publication of JP2015535210A5 publication Critical patent/JP2015535210A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/18—7-Aminocephalosporanic or substituted 7-aminocephalosporanic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/59—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3 with hetero atoms directly attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2015521169A 2012-10-29 2013-10-29 ２−アルキルセフェム化合物のための中間体の製造法 Pending JP2015535210A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261719523P 2012-10-29 2012-10-29
US61/719,523 2012-10-29
US201261720520P 2012-10-31 2012-10-31
US61/720,520 2012-10-31
PCT/JP2013/079803 WO2014069649A1 (en) 2012-10-29 2013-10-29 Processes for production of intermediates for 2-alkyl cephem compounds

Publications (2)

Publication Number Publication Date
JP2015535210A true JP2015535210A (ja) 2015-12-10
JP2015535210A5 JP2015535210A5 (enExample) 2016-12-08

Family

ID=50627541

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015521169A Pending JP2015535210A (ja) 2012-10-29 2013-10-29 ２−アルキルセフェム化合物のための中間体の製造法

Country Status (10)

Country Link
US (1) US9527866B2 (enExample)
EP (1) EP2912040A4 (enExample)
JP (1) JP2015535210A (enExample)
KR (1) KR20150076223A (enExample)
CN (1) CN104854113A (enExample)
AU (1) AU2013339040A1 (enExample)
BR (1) BR112015008905A2 (enExample)
CA (1) CA2888543A1 (enExample)
RU (1) RU2015120084A (enExample)
WO (1) WO2014069649A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY35103A (es) 2012-10-29 2014-05-30 Glaxo Group Ltd Compuestos de cefem 2-sustituidos
WO2016035847A1 (ja) * 2014-09-04 2016-03-10 塩野義製薬株式会社 セファロスポリン誘導体の中間体およびその製造方法
BR112018003067B1 (pt) * 2015-08-20 2021-11-30 Unilever Ip Holdings B.V. Processo para a síntese de uma lactama
CN110590811B (zh) * 2019-09-27 2022-05-03 广州白云山天心制药股份有限公司 一种头孢呋辛酯-3-烯异构体的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5515479B1 (enExample) * 1970-03-04 1980-04-23
JPS56118085A (en) * 1980-02-25 1981-09-16 Takeda Chem Ind Ltd 2-methylcephalosporin derivative and its preparation

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3487079A (en) 1966-01-14 1969-12-30 Bristol Myers Co Certain alpha-amino bicyclic beta-lactam carboxylic acids
JPS5259186A (en) * 1975-11-11 1977-05-16 Shionogi & Co Ltd Preparation of 3-cephem compounds by reduction
JPH0228185A (ja) 1988-04-14 1990-01-30 Tanabe Seiyaku Co Ltd セファロスポリン化合物及びその合成中間体
PH25965A (en) 1988-06-06 1992-01-13 Fujisawa Pharmaceutical Co New cephem compounds which have antimicrobial activities
GB8813945D0 (en) 1988-06-13 1988-07-20 Fujisawa Pharmaceutical Co New cephem compounds & process for preparation thereof
GB8817653D0 (en) 1988-07-25 1988-09-01 Fujisawa Pharmaceutical Co New cephem compounds & processes for preparation thereof
US5143910A (en) 1989-09-07 1992-09-01 Shionogi & Co., Ltd. Piperaziniocephalosporins
GB9005246D0 (en) 1990-03-08 1990-05-02 Fujisawa Pharmaceutical Co New cephem compounds and processes for preparation thereof
US5095012A (en) 1990-08-23 1992-03-10 Bristol-Myers Squibb Company Antibiotic c-7 catechol-substituted cephalosporin compounds, compositions, and method of use thereof
GB9111406D0 (en) 1991-05-28 1991-07-17 Fujisawa Pharmaceutical Co New cephem compounds and processes for preparation thereof
GB9118672D0 (en) 1991-08-30 1991-10-16 Fujisawa Pharmaceutical Co New cephem compounds and processes for preparation thereof
TW200305422A (en) 2002-03-18 2003-11-01 Shionogi & Co Broad spectrum cefem compounds
CN100519563C (zh) * 2002-10-02 2009-07-29 日本曹达株式会社 有机化合物的制造方法
WO2007096740A2 (en) 2006-02-20 2007-08-30 Orchid Research Laboratories Limited Novel cephalosporins
JP2009530228A (ja) 2006-03-16 2009-08-27 アステラス製薬株式会社 セフェム化合物および抗菌薬としての利用
MX2011004636A (es) 2008-10-31 2011-06-20 Shionogi & Co Cefarosporinas que tienen un grupo catecol.
MX2012011521A (es) 2010-04-05 2013-03-08 Shionogi & Co Compuestos cefem que tienen un grupo catecol.
US8883773B2 (en) 2010-04-05 2014-11-11 Shionogi & Co., Ltd. Cephem compound having pseudo-catechol group
JP5852562B2 (ja) 2010-04-28 2016-02-03 塩野義製薬株式会社 新規なセフェム誘導体
UY35103A (es) * 2012-10-29 2014-05-30 Glaxo Group Ltd Compuestos de cefem 2-sustituidos

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5515479B1 (enExample) * 1970-03-04 1980-04-23
JPS56118085A (en) * 1980-02-25 1981-09-16 Takeda Chem Ind Ltd 2-methylcephalosporin derivative and its preparation

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHEM. PHARM. BULL., vol. 31(5), JPN6017032836, 1983, pages 1482 - 1493, ISSN: 0003629440 *
J. HETEROCYCLIC CHEM., vol. 26(2), JPN6017032834, 1989, pages 461 - 464, ISSN: 0003629439 *
LIEBIGS ANN. CHEM., vol. (3), JPN6017032833, 1990, pages 311 - 312, ISSN: 0003629438 *

Also Published As

Publication number Publication date
US9527866B2 (en) 2016-12-27
EP2912040A4 (en) 2016-06-01
US20150291619A1 (en) 2015-10-15
WO2014069649A1 (en) 2014-05-08
CA2888543A1 (en) 2014-05-08
RU2015120084A (ru) 2016-12-27
KR20150076223A (ko) 2015-07-06
CN104854113A (zh) 2015-08-19
AU2013339040A1 (en) 2015-04-30
EP2912040A1 (en) 2015-09-02
BR112015008905A2 (pt) 2017-07-04

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