AU2013339040A1 - Processes for production of intermediates for 2-alkyl cephem compounds - Google Patents

Processes for production of intermediates for 2-alkyl cephem compounds Download PDF

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Publication number
AU2013339040A1
AU2013339040A1 AU2013339040A AU2013339040A AU2013339040A1 AU 2013339040 A1 AU2013339040 A1 AU 2013339040A1 AU 2013339040 A AU2013339040 A AU 2013339040A AU 2013339040 A AU2013339040 A AU 2013339040A AU 2013339040 A1 AU2013339040 A1 AU 2013339040A1
Authority
AU
Australia
Prior art keywords
compound
formula
salt
pct
chemical formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2013339040A
Other languages
English (en)
Inventor
Toshiaki Aoki
Mikito ASAI
Shinya Hisakawa
Masatoshi TAKEO
Kenji Yamawaki
Katsuki Yokoo
Yutaka Yokota
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Publication of AU2013339040A1 publication Critical patent/AU2013339040A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/18—7-Aminocephalosporanic or substituted 7-aminocephalosporanic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/59—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3 with hetero atoms directly attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2013339040A 2012-10-29 2013-10-29 Processes for production of intermediates for 2-alkyl cephem compounds Abandoned AU2013339040A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261719523P 2012-10-29 2012-10-29
US61/719,523 2012-10-29
US201261720520P 2012-10-31 2012-10-31
US61/720,520 2012-10-31
PCT/JP2013/079803 WO2014069649A1 (en) 2012-10-29 2013-10-29 Processes for production of intermediates for 2-alkyl cephem compounds

Publications (1)

Publication Number Publication Date
AU2013339040A1 true AU2013339040A1 (en) 2015-04-30

Family

ID=50627541

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2013339040A Abandoned AU2013339040A1 (en) 2012-10-29 2013-10-29 Processes for production of intermediates for 2-alkyl cephem compounds

Country Status (10)

Country Link
US (1) US9527866B2 (enExample)
EP (1) EP2912040A4 (enExample)
JP (1) JP2015535210A (enExample)
KR (1) KR20150076223A (enExample)
CN (1) CN104854113A (enExample)
AU (1) AU2013339040A1 (enExample)
BR (1) BR112015008905A2 (enExample)
CA (1) CA2888543A1 (enExample)
RU (1) RU2015120084A (enExample)
WO (1) WO2014069649A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY35103A (es) 2012-10-29 2014-05-30 Glaxo Group Ltd Compuestos de cefem 2-sustituidos
JP6783497B2 (ja) * 2014-09-04 2020-11-11 塩野義製薬株式会社 セファロスポリン誘導体の中間体およびその製造方法
CN107848968B (zh) * 2015-08-20 2021-06-18 荷兰联合利华有限公司 从乙醛酸制备内酰胺的方法
CN110590811B (zh) * 2019-09-27 2022-05-03 广州白云山天心制药股份有限公司 一种头孢呋辛酯-3-烯异构体的制备方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3487079A (en) 1966-01-14 1969-12-30 Bristol Myers Co Certain alpha-amino bicyclic beta-lactam carboxylic acids
US3660396A (en) 1970-03-04 1972-05-02 Lilly Co Eli Cephalosporin intermediates and process therefor
JPS5259186A (en) * 1975-11-11 1977-05-16 Shionogi & Co Ltd Preparation of 3-cephem compounds by reduction
JPS56118085A (en) 1980-02-25 1981-09-16 Takeda Chem Ind Ltd 2-methylcephalosporin derivative and its preparation
JPH0228185A (ja) 1988-04-14 1990-01-30 Tanabe Seiyaku Co Ltd セファロスポリン化合物及びその合成中間体
PH25965A (en) 1988-06-06 1992-01-13 Fujisawa Pharmaceutical Co New cephem compounds which have antimicrobial activities
GB8813945D0 (en) 1988-06-13 1988-07-20 Fujisawa Pharmaceutical Co New cephem compounds & process for preparation thereof
GB8817653D0 (en) 1988-07-25 1988-09-01 Fujisawa Pharmaceutical Co New cephem compounds & processes for preparation thereof
US5143910A (en) 1989-09-07 1992-09-01 Shionogi & Co., Ltd. Piperaziniocephalosporins
GB9005246D0 (en) 1990-03-08 1990-05-02 Fujisawa Pharmaceutical Co New cephem compounds and processes for preparation thereof
US5095012A (en) 1990-08-23 1992-03-10 Bristol-Myers Squibb Company Antibiotic c-7 catechol-substituted cephalosporin compounds, compositions, and method of use thereof
GB9111406D0 (en) 1991-05-28 1991-07-17 Fujisawa Pharmaceutical Co New cephem compounds and processes for preparation thereof
GB9118672D0 (en) 1991-08-30 1991-10-16 Fujisawa Pharmaceutical Co New cephem compounds and processes for preparation thereof
TW200305422A (en) 2002-03-18 2003-11-01 Shionogi & Co Broad spectrum cefem compounds
JP4326471B2 (ja) * 2002-10-02 2009-09-09 日本曹達株式会社 有機化合物の製造方法
WO2007096740A2 (en) 2006-02-20 2007-08-30 Orchid Research Laboratories Limited Novel cephalosporins
EP1994035A1 (en) 2006-03-16 2008-11-26 Astellas Pharma Inc. Cephem compounds and use as antimicrobial agents
KR101655961B1 (ko) 2008-10-31 2016-09-08 시오노기세야쿠 가부시키가이샤 카테콜기를 갖는 세팔로스포린류
US8883773B2 (en) 2010-04-05 2014-11-11 Shionogi & Co., Ltd. Cephem compound having pseudo-catechol group
IN2012CN09242A (enExample) 2010-04-05 2015-08-21 Shionogi & Co
US9085589B2 (en) 2010-04-28 2015-07-21 Shionogi & Co., Ltd. Cephem derivative
UY35103A (es) * 2012-10-29 2014-05-30 Glaxo Group Ltd Compuestos de cefem 2-sustituidos

Also Published As

Publication number Publication date
US20150291619A1 (en) 2015-10-15
EP2912040A1 (en) 2015-09-02
BR112015008905A2 (pt) 2017-07-04
CA2888543A1 (en) 2014-05-08
RU2015120084A (ru) 2016-12-27
EP2912040A4 (en) 2016-06-01
WO2014069649A1 (en) 2014-05-08
US9527866B2 (en) 2016-12-27
CN104854113A (zh) 2015-08-19
JP2015535210A (ja) 2015-12-10
KR20150076223A (ko) 2015-07-06

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Legal Events

Date Code Title Description
MK5 Application lapsed section 142(2)(e) - patent request and compl. specification not accepted