KR20150076223A - 2-알킬 세펨 화합물을 위한 중간체의 제조 방법 - Google Patents

2-알킬 세펨 화합물을 위한 중간체의 제조 방법 Download PDF

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KR20150076223A
KR20150076223A KR1020157013522A KR20157013522A KR20150076223A KR 20150076223 A KR20150076223 A KR 20150076223A KR 1020157013522 A KR1020157013522 A KR 1020157013522A KR 20157013522 A KR20157013522 A KR 20157013522A KR 20150076223 A KR20150076223 A KR 20150076223A
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South Korea
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compound
formula
salt
defined above
symbol
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English (en)
Korean (ko)
Inventor
가츠키 요코
신야 히사카와
겐지 야마와키
도시아키 아오키
유타카 요코타
마사토시 다케오
미키토 아사이
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시오노기세야쿠 가부시키가이샤
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Publication of KR20150076223A publication Critical patent/KR20150076223A/ko
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/18—7-Aminocephalosporanic or substituted 7-aminocephalosporanic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/59—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3 with hetero atoms directly attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020157013522A 2012-10-29 2013-10-29 2-알킬 세펨 화합물을 위한 중간체의 제조 방법 Withdrawn KR20150076223A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261719523P 2012-10-29 2012-10-29
US61/719,523 2012-10-29
US201261720520P 2012-10-31 2012-10-31
US61/720,520 2012-10-31
PCT/JP2013/079803 WO2014069649A1 (en) 2012-10-29 2013-10-29 Processes for production of intermediates for 2-alkyl cephem compounds

Publications (1)

Publication Number Publication Date
KR20150076223A true KR20150076223A (ko) 2015-07-06

Family

ID=50627541

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020157013522A Withdrawn KR20150076223A (ko) 2012-10-29 2013-10-29 2-알킬 세펨 화합물을 위한 중간체의 제조 방법

Country Status (10)

Country Link
US (1) US9527866B2 (enExample)
EP (1) EP2912040A4 (enExample)
JP (1) JP2015535210A (enExample)
KR (1) KR20150076223A (enExample)
CN (1) CN104854113A (enExample)
AU (1) AU2013339040A1 (enExample)
BR (1) BR112015008905A2 (enExample)
CA (1) CA2888543A1 (enExample)
RU (1) RU2015120084A (enExample)
WO (1) WO2014069649A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY35103A (es) 2012-10-29 2014-05-30 Glaxo Group Ltd Compuestos de cefem 2-sustituidos
CN106661052B (zh) * 2014-09-04 2021-05-11 盐野义制药株式会社 头孢菌素衍生物的中间体及其制造方法
WO2017029104A1 (en) * 2015-08-20 2017-02-23 Unilever Plc Process for the preparation of lactams from glyoxylic acid
CN110590811B (zh) * 2019-09-27 2022-05-03 广州白云山天心制药股份有限公司 一种头孢呋辛酯-3-烯异构体的制备方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3487079A (en) 1966-01-14 1969-12-30 Bristol Myers Co Certain alpha-amino bicyclic beta-lactam carboxylic acids
US3660396A (en) * 1970-03-04 1972-05-02 Lilly Co Eli Cephalosporin intermediates and process therefor
JPS5259186A (en) * 1975-11-11 1977-05-16 Shionogi & Co Ltd Preparation of 3-cephem compounds by reduction
JPS56118085A (en) * 1980-02-25 1981-09-16 Takeda Chem Ind Ltd 2-methylcephalosporin derivative and its preparation
JPH0228185A (ja) 1988-04-14 1990-01-30 Tanabe Seiyaku Co Ltd セファロスポリン化合物及びその合成中間体
PH25965A (en) 1988-06-06 1992-01-13 Fujisawa Pharmaceutical Co New cephem compounds which have antimicrobial activities
GB8813945D0 (en) 1988-06-13 1988-07-20 Fujisawa Pharmaceutical Co New cephem compounds & process for preparation thereof
GB8817653D0 (en) 1988-07-25 1988-09-01 Fujisawa Pharmaceutical Co New cephem compounds & processes for preparation thereof
US5143910A (en) 1989-09-07 1992-09-01 Shionogi & Co., Ltd. Piperaziniocephalosporins
GB9005246D0 (en) 1990-03-08 1990-05-02 Fujisawa Pharmaceutical Co New cephem compounds and processes for preparation thereof
US5095012A (en) 1990-08-23 1992-03-10 Bristol-Myers Squibb Company Antibiotic c-7 catechol-substituted cephalosporin compounds, compositions, and method of use thereof
GB9111406D0 (en) 1991-05-28 1991-07-17 Fujisawa Pharmaceutical Co New cephem compounds and processes for preparation thereof
GB9118672D0 (en) 1991-08-30 1991-10-16 Fujisawa Pharmaceutical Co New cephem compounds and processes for preparation thereof
TW200305422A (en) 2002-03-18 2003-11-01 Shionogi & Co Broad spectrum cefem compounds
US7358356B2 (en) * 2002-10-02 2008-04-15 Asubio Pharma Co., Ltd. Processes for preparation of organic compounds
WO2007096740A2 (en) 2006-02-20 2007-08-30 Orchid Research Laboratories Limited Novel cephalosporins
JP2009530228A (ja) 2006-03-16 2009-08-27 アステラス製薬株式会社 セフェム化合物および抗菌薬としての利用
ES2564836T3 (es) 2008-10-31 2016-03-29 Shionogi & Co., Ltd. Cefalosporinas que tienen un grupo catecol
CN102918048A (zh) 2010-04-05 2013-02-06 盐野义制药株式会社 具有儿茶酚基团的头孢烯类化合物
US8883773B2 (en) 2010-04-05 2014-11-11 Shionogi & Co., Ltd. Cephem compound having pseudo-catechol group
US9085589B2 (en) 2010-04-28 2015-07-21 Shionogi & Co., Ltd. Cephem derivative
UY35103A (es) * 2012-10-29 2014-05-30 Glaxo Group Ltd Compuestos de cefem 2-sustituidos

Also Published As

Publication number Publication date
JP2015535210A (ja) 2015-12-10
US9527866B2 (en) 2016-12-27
AU2013339040A1 (en) 2015-04-30
US20150291619A1 (en) 2015-10-15
RU2015120084A (ru) 2016-12-27
CA2888543A1 (en) 2014-05-08
WO2014069649A1 (en) 2014-05-08
CN104854113A (zh) 2015-08-19
BR112015008905A2 (pt) 2017-07-04
EP2912040A1 (en) 2015-09-02
EP2912040A4 (en) 2016-06-01

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PA0105 International application

Patent event date: 20150522

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid