RU2015120084A - Способы получения промежуточных соединений для 2-алкилцефемовых соединений - Google Patents
Способы получения промежуточных соединений для 2-алкилцефемовых соединений Download PDFInfo
- Publication number
- RU2015120084A RU2015120084A RU2015120084A RU2015120084A RU2015120084A RU 2015120084 A RU2015120084 A RU 2015120084A RU 2015120084 A RU2015120084 A RU 2015120084A RU 2015120084 A RU2015120084 A RU 2015120084A RU 2015120084 A RU2015120084 A RU 2015120084A
- Authority
- RU
- Russia
- Prior art keywords
- formula
- compound
- salt
- chemical formula
- defined above
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims abstract 54
- 238000000034 method Methods 0.000 title claims abstract 21
- 150000003839 salts Chemical class 0.000 claims abstract 44
- 239000000126 substance Substances 0.000 claims abstract 33
- 125000004450 alkenylene group Chemical group 0.000 claims abstract 12
- 125000002947 alkylene group Chemical group 0.000 claims abstract 12
- 125000002252 acyl group Chemical group 0.000 claims abstract 9
- 125000000217 alkyl group Chemical group 0.000 claims abstract 9
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims abstract 6
- 125000006239 protecting group Chemical group 0.000 claims abstract 6
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims abstract 5
- 239000000203 mixture Substances 0.000 claims abstract 5
- 230000001590 oxidative effect Effects 0.000 claims abstract 4
- 238000004519 manufacturing process Methods 0.000 claims abstract 3
- 229910052736 halogen Inorganic materials 0.000 claims 7
- 239000013078 crystal Substances 0.000 claims 6
- 150000002367 halogens Chemical class 0.000 claims 5
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 4
- 230000003993 interaction Effects 0.000 claims 4
- 238000004458 analytical method Methods 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 238000000634 powder X-ray diffraction Methods 0.000 claims 3
- 239000012453 solvate Substances 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 150000001412 amines Chemical class 0.000 claims 2
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 238000006317 isomerization reaction Methods 0.000 claims 1
- 125000005948 methanesulfonyloxy group Chemical group 0.000 claims 1
- -1 p-toluenesulfonyloxy Chemical group 0.000 claims 1
- 125000005951 trifluoromethanesulfonyloxy group Chemical group 0.000 claims 1
- 0 *[C@@]1SC(C(C2=O)N)N2C(C(*)=O)=C1I* Chemical compound *[C@@]1SC(C(C2=O)N)N2C(C(*)=O)=C1I* 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/18—7-Aminocephalosporanic or substituted 7-aminocephalosporanic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/59—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3 with hetero atoms directly attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261719523P | 2012-10-29 | 2012-10-29 | |
| US61/719,523 | 2012-10-29 | ||
| US201261720520P | 2012-10-31 | 2012-10-31 | |
| US61/720,520 | 2012-10-31 | ||
| PCT/JP2013/079803 WO2014069649A1 (en) | 2012-10-29 | 2013-10-29 | Processes for production of intermediates for 2-alkyl cephem compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2015120084A true RU2015120084A (ru) | 2016-12-27 |
Family
ID=50627541
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015120084A RU2015120084A (ru) | 2012-10-29 | 2013-10-29 | Способы получения промежуточных соединений для 2-алкилцефемовых соединений |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9527866B2 (enExample) |
| EP (1) | EP2912040A4 (enExample) |
| JP (1) | JP2015535210A (enExample) |
| KR (1) | KR20150076223A (enExample) |
| CN (1) | CN104854113A (enExample) |
| AU (1) | AU2013339040A1 (enExample) |
| BR (1) | BR112015008905A2 (enExample) |
| CA (1) | CA2888543A1 (enExample) |
| RU (1) | RU2015120084A (enExample) |
| WO (1) | WO2014069649A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UY35103A (es) | 2012-10-29 | 2014-05-30 | Glaxo Group Ltd | Compuestos de cefem 2-sustituidos |
| CN106661052B (zh) * | 2014-09-04 | 2021-05-11 | 盐野义制药株式会社 | 头孢菌素衍生物的中间体及其制造方法 |
| WO2017029104A1 (en) * | 2015-08-20 | 2017-02-23 | Unilever Plc | Process for the preparation of lactams from glyoxylic acid |
| CN110590811B (zh) * | 2019-09-27 | 2022-05-03 | 广州白云山天心制药股份有限公司 | 一种头孢呋辛酯-3-烯异构体的制备方法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3487079A (en) | 1966-01-14 | 1969-12-30 | Bristol Myers Co | Certain alpha-amino bicyclic beta-lactam carboxylic acids |
| US3660396A (en) * | 1970-03-04 | 1972-05-02 | Lilly Co Eli | Cephalosporin intermediates and process therefor |
| JPS5259186A (en) * | 1975-11-11 | 1977-05-16 | Shionogi & Co Ltd | Preparation of 3-cephem compounds by reduction |
| JPS56118085A (en) * | 1980-02-25 | 1981-09-16 | Takeda Chem Ind Ltd | 2-methylcephalosporin derivative and its preparation |
| JPH0228185A (ja) | 1988-04-14 | 1990-01-30 | Tanabe Seiyaku Co Ltd | セファロスポリン化合物及びその合成中間体 |
| PH25965A (en) | 1988-06-06 | 1992-01-13 | Fujisawa Pharmaceutical Co | New cephem compounds which have antimicrobial activities |
| GB8813945D0 (en) | 1988-06-13 | 1988-07-20 | Fujisawa Pharmaceutical Co | New cephem compounds & process for preparation thereof |
| GB8817653D0 (en) | 1988-07-25 | 1988-09-01 | Fujisawa Pharmaceutical Co | New cephem compounds & processes for preparation thereof |
| US5143910A (en) | 1989-09-07 | 1992-09-01 | Shionogi & Co., Ltd. | Piperaziniocephalosporins |
| GB9005246D0 (en) | 1990-03-08 | 1990-05-02 | Fujisawa Pharmaceutical Co | New cephem compounds and processes for preparation thereof |
| US5095012A (en) | 1990-08-23 | 1992-03-10 | Bristol-Myers Squibb Company | Antibiotic c-7 catechol-substituted cephalosporin compounds, compositions, and method of use thereof |
| GB9111406D0 (en) | 1991-05-28 | 1991-07-17 | Fujisawa Pharmaceutical Co | New cephem compounds and processes for preparation thereof |
| GB9118672D0 (en) | 1991-08-30 | 1991-10-16 | Fujisawa Pharmaceutical Co | New cephem compounds and processes for preparation thereof |
| TW200305422A (en) | 2002-03-18 | 2003-11-01 | Shionogi & Co | Broad spectrum cefem compounds |
| US7358356B2 (en) * | 2002-10-02 | 2008-04-15 | Asubio Pharma Co., Ltd. | Processes for preparation of organic compounds |
| WO2007096740A2 (en) | 2006-02-20 | 2007-08-30 | Orchid Research Laboratories Limited | Novel cephalosporins |
| JP2009530228A (ja) | 2006-03-16 | 2009-08-27 | アステラス製薬株式会社 | セフェム化合物および抗菌薬としての利用 |
| ES2564836T3 (es) | 2008-10-31 | 2016-03-29 | Shionogi & Co., Ltd. | Cefalosporinas que tienen un grupo catecol |
| CN102918048A (zh) | 2010-04-05 | 2013-02-06 | 盐野义制药株式会社 | 具有儿茶酚基团的头孢烯类化合物 |
| US8883773B2 (en) | 2010-04-05 | 2014-11-11 | Shionogi & Co., Ltd. | Cephem compound having pseudo-catechol group |
| US9085589B2 (en) | 2010-04-28 | 2015-07-21 | Shionogi & Co., Ltd. | Cephem derivative |
| UY35103A (es) * | 2012-10-29 | 2014-05-30 | Glaxo Group Ltd | Compuestos de cefem 2-sustituidos |
-
2013
- 2013-10-29 BR BR112015008905A patent/BR112015008905A2/pt not_active IP Right Cessation
- 2013-10-29 AU AU2013339040A patent/AU2013339040A1/en not_active Abandoned
- 2013-10-29 RU RU2015120084A patent/RU2015120084A/ru not_active Application Discontinuation
- 2013-10-29 KR KR1020157013522A patent/KR20150076223A/ko not_active Withdrawn
- 2013-10-29 US US14/439,113 patent/US9527866B2/en not_active Expired - Fee Related
- 2013-10-29 JP JP2015521169A patent/JP2015535210A/ja active Pending
- 2013-10-29 CA CA2888543A patent/CA2888543A1/en not_active Abandoned
- 2013-10-29 CN CN201380066959.9A patent/CN104854113A/zh active Pending
- 2013-10-29 EP EP13851709.9A patent/EP2912040A4/en not_active Withdrawn
- 2013-10-29 WO PCT/JP2013/079803 patent/WO2014069649A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| JP2015535210A (ja) | 2015-12-10 |
| US9527866B2 (en) | 2016-12-27 |
| AU2013339040A1 (en) | 2015-04-30 |
| US20150291619A1 (en) | 2015-10-15 |
| KR20150076223A (ko) | 2015-07-06 |
| CA2888543A1 (en) | 2014-05-08 |
| WO2014069649A1 (en) | 2014-05-08 |
| CN104854113A (zh) | 2015-08-19 |
| BR112015008905A2 (pt) | 2017-07-04 |
| EP2912040A1 (en) | 2015-09-02 |
| EP2912040A4 (en) | 2016-06-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20180123 |