EA201391522A1 - Способ получения соединений для применения в качестве ингибиторов sglt2 - Google Patents

Способ получения соединений для применения в качестве ингибиторов sglt2

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Publication number
EA201391522A1
EA201391522A1 EA201391522A EA201391522A EA201391522A1 EA 201391522 A1 EA201391522 A1 EA 201391522A1 EA 201391522 A EA201391522 A EA 201391522A EA 201391522 A EA201391522 A EA 201391522A EA 201391522 A1 EA201391522 A1 EA 201391522A1
Authority
EA
Eurasian Patent Office
Prior art keywords
formula
mixture
compound
application
zinc
Prior art date
Application number
EA201391522A
Other languages
English (en)
Other versions
EA028946B1 (ru
Inventor
Иоаннес Николаос Хоупис
Себастьен Франсуа Эмманюэль Лемэр
Original Assignee
Янссен Фармацевтика Нв
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Янссен Фармацевтика Нв filed Critical Янссен Фармацевтика Нв
Publication of EA201391522A1 publication Critical patent/EA201391522A1/ru
Publication of EA028946B1 publication Critical patent/EA028946B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C07H13/06—Fatty acids

Abstract

Настоящее изобретение относится к новому способу получения соединений формулы (I) и их фармацевтически приемлемых солей и сольватов, содержащему взаимодействие соединения формулы (V), где LGпредставляет собой уходящую группу, со смесью соли цинка и литийорганического реагента в первом углеводородном растворителе; при температуре в диапазоне от приблизительно -78°С до приблизительно комнатной температуры; для получения смеси соответствующего соединения формулы (VI), где Мпредставляет собой литий, и соли цинка; примешивание к смеси соединения формулы (VI) и соли цинка первого эфирного растворителя; для получения соответствующего соединения формулы (VII), где Мпредставляет собой реакционноспособную частицу цинка.
EA201391522A 2011-04-13 2012-04-12 Способ получения соединений для применения в качестве ингибиторов sglt2 EA028946B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161474936P 2011-04-13 2011-04-13
PCT/EP2012/056649 WO2012140120A1 (en) 2011-04-13 2012-04-12 Process for the preparation of compounds useful as inhibitors of sglt2

Publications (2)

Publication Number Publication Date
EA201391522A1 true EA201391522A1 (ru) 2014-03-31
EA028946B1 EA028946B1 (ru) 2018-01-31

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EA201391522A EA028946B1 (ru) 2011-04-13 2012-04-12 Способ получения соединений для применения в качестве ингибиторов sglt2

Country Status (20)

Country Link
US (1) US10544135B2 (ru)
EP (1) EP2697218B1 (ru)
JP (1) JP5973551B2 (ru)
KR (1) KR101913587B1 (ru)
CN (1) CN103596944B (ru)
AU (1) AU2012241897C1 (ru)
CA (1) CA2832938C (ru)
CY (1) CY1117989T1 (ru)
DK (1) DK2697218T3 (ru)
EA (1) EA028946B1 (ru)
ES (1) ES2586846T3 (ru)
HR (1) HRP20161062T1 (ru)
HU (1) HUE030116T2 (ru)
ME (1) ME02469B (ru)
PL (1) PL2697218T3 (ru)
PT (1) PT2697218T (ru)
RS (1) RS55056B1 (ru)
SI (1) SI2697218T1 (ru)
SM (1) SMT201600274B (ru)
WO (1) WO2012140120A1 (ru)

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JP6173427B2 (ja) * 2013-02-26 2017-08-02 田辺三菱製薬株式会社 α−ハロテトラアシルグルコースの製造方法
CN104557894A (zh) * 2013-10-18 2015-04-29 上海信谊药厂有限公司 坎格列汀晶型及其制备方法
CN104672227A (zh) * 2013-11-28 2015-06-03 镇江新元素医药科技有限公司 一类新型sglt2抑制剂化合物及其药物组合物
EP2918579A1 (en) * 2014-03-14 2015-09-16 LEK Pharmaceuticals d.d. Synthesis of 2-arylmethyl-5-aryl-thiophene
CN103980262B (zh) * 2014-04-01 2016-06-22 天津大学 卡格列净的b晶型及其结晶制备方法
CN103936725B (zh) * 2014-04-01 2016-07-27 天津大学 卡格列净的c晶型及其结晶制备方法
CN103980261B (zh) * 2014-04-01 2016-06-29 天津大学 卡格列净的a晶型及其结晶制备方法
CN103980263B (zh) * 2014-04-17 2016-08-03 海门瑞一医药科技有限公司 卡格列净的合成工艺
EP2933255A1 (en) 2014-04-17 2015-10-21 LEK Pharmaceuticals d.d. Novel crystalline form of 1-(beta-D-glucopyranosyl)-4- methyl-3-[5-(4-fluorophenyl)-2-thienylmethyl]benzene
EP2947077A1 (en) 2014-05-19 2015-11-25 LEK Pharmaceuticals d.d. Stereoselective synthesis of intermediates in the preparation of ß-C-arylglucosides
CN104109157B (zh) * 2014-08-04 2016-05-25 山东康美乐医药科技有限公司 卡格列净的制备方法
CN105440025B (zh) * 2014-09-25 2019-02-12 深圳翰宇药业股份有限公司 一种制备卡格列净及其中间体的方法及所述中间体
CN104817554A (zh) * 2014-11-10 2015-08-05 镇江新元素医药科技有限公司 一类葡萄糖苷衍生物及其药物组合物
CN104557895B (zh) * 2015-01-27 2017-10-31 江苏嘉逸医药有限公司 1‑(β‑D‑吡喃葡糖基)‑4‑甲基‑3‑[5‑(4‑氟苯基)‑2‑噻吩基甲基]苯的合成工艺
CN105884755B (zh) * 2015-02-14 2019-05-28 正大天晴药业集团股份有限公司 氘修饰的碳甙衍生物
CN106188022A (zh) * 2015-04-30 2016-12-07 上海医药工业研究院 伊格列净的制备方法
CN105153137A (zh) * 2015-09-17 2015-12-16 上海应用技术学院 一种艾格列净的制备方法
CN105503845A (zh) * 2015-12-01 2016-04-20 北京普德康利医药科技发展有限公司 去氟卡格列净化合物及其制备方法和应用
CN109988128B (zh) * 2017-12-29 2022-08-19 江苏扬农化工股份有限公司 一种呋喃醇衍生物的合成方法
CN110054657B (zh) * 2018-01-18 2021-06-29 亚宝药业集团股份有限公司 吡喃葡萄糖取代的吡唑化合物及其制备方法
CN109111490B (zh) * 2018-08-09 2021-02-23 浙江大学 卤代新戊酰基吡喃葡萄糖及其用于sglt2抑制剂的制备方法
CN114591313A (zh) * 2020-12-04 2022-06-07 南京圣鼎医药科技有限公司 一种卡格列净的制备方法

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