MX2015008624A - PROCESO PARA PREPARAR 6A, 14A-ETENOMORFINANOS 7ß SUSTITUIDOS Y 6A, 14A-ETANOMORFINANOS 7ß-SUSTITUIDOS. - Google Patents

PROCESO PARA PREPARAR 6A, 14A-ETENOMORFINANOS 7ß SUSTITUIDOS Y 6A, 14A-ETANOMORFINANOS 7ß-SUSTITUIDOS.

Info

Publication number
MX2015008624A
MX2015008624A MX2015008624A MX2015008624A MX2015008624A MX 2015008624 A MX2015008624 A MX 2015008624A MX 2015008624 A MX2015008624 A MX 2015008624A MX 2015008624 A MX2015008624 A MX 2015008624A MX 2015008624 A MX2015008624 A MX 2015008624A
Authority
MX
Mexico
Prior art keywords
substituted
preparing
ethanomorphinans
ethenomorphinans
epimer
Prior art date
Application number
MX2015008624A
Other languages
English (en)
Inventor
Helge Alfred Reisch
Original Assignee
Rhodes Tech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhodes Tech filed Critical Rhodes Tech
Publication of MX2015008624A publication Critical patent/MX2015008624A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
    • C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

La solicitud está dirigida a un proceso para aumentar la proporción del epímero 7ß en una mezcla de los epímeros 7a/7ß de un 6a,14a-etenomorfinano 7-sustituido o un 6a,14a-etanomorfinano 7-sustituido, y específicamente de compuestos de Fórmula I (ver Fórmula) Donde G, R2-R4, y / están definidos como se estableció en la memoria descriptiva. La solicitud también está dirigida a un proceso de purificación del epímero 7ß de una mezcla de los epímeros 7a/7ß de un 6a,14a-etenomorfinano 7-sustituido o un 6a,14a-etanomorfinano 7- sustituido. La solicitud también está dirigida a un proceso para la preparación de compuestos 7ß-sustituidos de Formula Vb (ver Fórmula) donde G y R2-R5 están definidos como se señala en la memoria descriptiva.
MX2015008624A 2012-12-31 2013-12-23 PROCESO PARA PREPARAR 6A, 14A-ETENOMORFINANOS 7ß SUSTITUIDOS Y 6A, 14A-ETANOMORFINANOS 7ß-SUSTITUIDOS. MX2015008624A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261747741P 2012-12-31 2012-12-31
US201361789269P 2013-03-15 2013-03-15
PCT/IB2013/002877 WO2014102591A1 (en) 2012-12-31 2013-12-23 PROCESS FOR PREPARING 7β-SUBSTITUTED 6α,14α -ETHENOMORPHINANS AND 7β-SUBSTITUTED 6α,14α-ETHANOMORPHINANS

Publications (1)

Publication Number Publication Date
MX2015008624A true MX2015008624A (es) 2016-12-08

Family

ID=50000019

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015008624A MX2015008624A (es) 2012-12-31 2013-12-23 PROCESO PARA PREPARAR 6A, 14A-ETENOMORFINANOS 7ß SUSTITUIDOS Y 6A, 14A-ETANOMORFINANOS 7ß-SUSTITUIDOS.

Country Status (9)

Country Link
US (1) US9834562B2 (es)
EP (1) EP2941433B1 (es)
JP (2) JP6181770B2 (es)
AU (1) AU2013369037C1 (es)
CA (1) CA2896919C (es)
ES (1) ES2748803T3 (es)
IL (1) IL239654B (es)
MX (1) MX2015008624A (es)
WO (1) WO2014102591A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107660207B (zh) 2015-03-10 2020-09-29 罗德科技公司 丁丙诺啡乙酸盐及用于制备丁丙诺啡的方法
JP2021104932A (ja) * 2018-03-30 2021-07-26 日本ケミファ株式会社 モルヒナン誘導体の製造方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB937214A (en) 1961-06-02 1963-09-18 J F Macfarlan & Company Ltd Oripavine derivatives
GB902659A (en) 1961-02-02 1962-08-09 J F Macfarlan & Company Ltd A process for the production of a derivative of thebaine
US3562279A (en) * 1969-05-15 1971-02-09 American Cyanamid Co Substituted 7,8-dihydro - 6 - methoxy-6,14-endo(etheno or ethano)morphide - 7-ketones and n-cycloalkylmethyl - 7,8-dihydro - 6 - methoxy-6,14-endo(etheno or ethano) norcodide-7-ketones
US3634430A (en) 1969-06-13 1972-01-11 American Cyanamid Co Substituted 7-heterocyclic - 7 8-dihydro-6-(hydroxy or methoxy)-6 14-endo(etheno or ethano)codides and morphides
JPH08504189A (ja) 1992-09-21 1996-05-07 キン、ボーイ 低／非たんでき性オピオイド鎮痛剤の確認及び使用方法
KR100204659B1 (ko) 1996-05-28 1999-06-15 강재헌 신규한 부프레노핀계 진통제용 화합물
US6067749A (en) 1996-07-11 2000-05-30 Tasmanian Alkaloids Pty. Ltd. Papaver somniferum strain with high concentration of thebaine and oripavine
US5869669A (en) 1996-07-26 1999-02-09 Penick Corporation Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
ATE377602T1 (de) 1997-03-27 2007-11-15 Toray Industries Morphinanderivate und ihre medizinische anwendung
US6359139B1 (en) 2000-11-07 2002-03-19 Celgene Corporation Methods for production of piperidyl acetamide stereoisomers
GB0421687D0 (en) 2004-09-30 2004-11-03 Johnson Matthey Plc Preparation of opiate analgesics
JP2008530163A (ja) 2005-02-16 2008-08-07 マイクロメット アクツィエン ゲゼルシャフト タンパク質およびポリペプチド多量体の分離のための活性化型ポリマーの使用
CZ300995B6 (cs) * 2005-12-20 2009-10-07 Zentiva, A. S. Zpusob výroby (2S,7´R)-2-[17´-(cyklopropylmethyl)-3´-hydroxy-4´,5´-epoxy-6´-methoxy-6´,14´-endoethanomorfinan-7´-yl]-3,3-dimethylbutan-2-olu
US20080125592A1 (en) * 2006-10-17 2008-05-29 Penick Corporation Process for preparing oxymorphone, naltrexone, and buprenorphine
CA2674915C (en) 2006-10-17 2015-06-30 Penick Corporation Process for preparing oxymorphone
US8017777B2 (en) 2007-12-17 2011-09-13 Mallinckrodt Llc Process for the preparation of buprenorphine and derivatives for buprenorphine
US8273887B2 (en) 2008-09-30 2012-09-25 Mallinckrodt Llc Processes for synthesis of opiate alkaloid derivatives
US8232396B2 (en) 2008-09-30 2012-07-31 Mallinckrodt Llc Processes for the synthesis of opiates alkaloids with reduced impurity formation
PL2344509T3 (pl) 2008-09-30 2016-04-29 SpecGx LLC Sposoby wytwarzania buprenorfiny przy zmniejszonym tworzeniu zanieczyszczeń
TWI630208B (zh) 2008-12-08 2018-07-21 歐陸斯迪公司 二氫羥戊甲嗎啡
AU2011263416B2 (en) 2010-06-11 2014-04-10 Rhodes Technologies Process for N-dealkylation of tertiary amines

Also Published As

Publication number Publication date
JP2016504346A (ja) 2016-02-12
CA2896919A1 (en) 2014-07-03
AU2013369037B2 (en) 2016-11-24
EP2941433A1 (en) 2015-11-11
US20160068538A1 (en) 2016-03-10
IL239654A0 (en) 2015-08-31
JP2017193549A (ja) 2017-10-26
WO2014102591A1 (en) 2014-07-03
EP2941433B1 (en) 2019-08-07
JP6181770B2 (ja) 2017-08-16
US9834562B2 (en) 2017-12-05
ES2748803T3 (es) 2020-03-18
AU2013369037C1 (en) 2017-06-08
IL239654B (en) 2018-11-29
CA2896919C (en) 2019-01-29
AU2013369037A1 (en) 2015-07-23

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