JP2015533176A5 - - Google Patents
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- JP2015533176A5 JP2015533176A5 JP2015537018A JP2015537018A JP2015533176A5 JP 2015533176 A5 JP2015533176 A5 JP 2015533176A5 JP 2015537018 A JP2015537018 A JP 2015537018A JP 2015537018 A JP2015537018 A JP 2015537018A JP 2015533176 A5 JP2015533176 A5 JP 2015533176A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- ezh2
- pharmaceutically acceptable
- compound according
- item
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261714145P | 2012-10-15 | 2012-10-15 | |
| US201261714140P | 2012-10-15 | 2012-10-15 | |
| US61/714,140 | 2012-10-15 | ||
| US61/714,145 | 2012-10-15 | ||
| US201361780703P | 2013-03-13 | 2013-03-13 | |
| US61/780,703 | 2013-03-13 | ||
| US201361786277P | 2013-03-14 | 2013-03-14 | |
| US61/786,277 | 2013-03-14 | ||
| PCT/US2013/065126 WO2014062732A1 (en) | 2012-10-15 | 2013-10-15 | Substituted benzene compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018028891A Division JP2018087238A (ja) | 2012-10-15 | 2018-02-21 | 置換ベンゼン化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015533176A JP2015533176A (ja) | 2015-11-19 |
| JP2015533176A5 true JP2015533176A5 (enExample) | 2016-12-01 |
| JP6461802B2 JP6461802B2 (ja) | 2019-01-30 |
Family
ID=50475881
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015537018A Expired - Fee Related JP6461802B2 (ja) | 2012-10-15 | 2013-10-15 | 置換ベンゼン化合物 |
| JP2015537019A Expired - Fee Related JP6461803B2 (ja) | 2012-10-15 | 2013-10-15 | 置換ベンゼン化合物 |
| JP2018028907A Active JP6559275B2 (ja) | 2012-10-15 | 2018-02-21 | 置換ベンゼン化合物 |
| JP2018028891A Withdrawn JP2018087238A (ja) | 2012-10-15 | 2018-02-21 | 置換ベンゼン化合物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015537019A Expired - Fee Related JP6461803B2 (ja) | 2012-10-15 | 2013-10-15 | 置換ベンゼン化合物 |
| JP2018028907A Active JP6559275B2 (ja) | 2012-10-15 | 2018-02-21 | 置換ベンゼン化合物 |
| JP2018028891A Withdrawn JP2018087238A (ja) | 2012-10-15 | 2018-02-21 | 置換ベンゼン化合物 |
Country Status (23)
| Country | Link |
|---|---|
| US (8) | US9006242B2 (enExample) |
| EP (4) | EP2906538A4 (enExample) |
| JP (4) | JP6461802B2 (enExample) |
| KR (2) | KR102057366B1 (enExample) |
| CN (3) | CN105102431B (enExample) |
| AR (1) | AR093244A1 (enExample) |
| AU (2) | AU2013331381B2 (enExample) |
| BR (2) | BR112015008487B1 (enExample) |
| CA (2) | CA2888021A1 (enExample) |
| CL (2) | CL2015000944A1 (enExample) |
| HK (2) | HK1213264A1 (enExample) |
| IL (4) | IL238135B (enExample) |
| MX (2) | MX2015004721A (enExample) |
| MY (1) | MY180311A (enExample) |
| NZ (2) | NZ706738A (enExample) |
| PE (2) | PE20150887A1 (enExample) |
| PH (2) | PH12015500800B1 (enExample) |
| RU (2) | RU2658919C2 (enExample) |
| SG (3) | SG10201705989YA (enExample) |
| TW (2) | TWI651303B (enExample) |
| UA (2) | UA115074C2 (enExample) |
| WO (2) | WO2014062732A1 (enExample) |
| ZA (2) | ZA201502526B (enExample) |
Families Citing this family (56)
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| EP2780013A4 (en) | 2011-11-18 | 2015-07-01 | Constellation Pharmaceuticals Inc | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF |
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| KR20150095779A (ko) | 2012-12-13 | 2015-08-21 | 글락소스미스클라인 엘엘씨 | 제스트 인핸서 상동체 2 억제제 |
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| JO3509B1 (ar) | 2013-03-14 | 2020-07-05 | Janssen Pharmaceutica Nv | معدلات p2x7 |
| EP2970305B1 (en) | 2013-03-15 | 2017-02-22 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
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| US10150764B2 (en) | 2013-07-19 | 2018-12-11 | Epizyme, Inc. | Substituted benzene compounds |
| EP3033334A1 (en) | 2013-08-15 | 2016-06-22 | Constellation Pharmaceuticals, Inc. | Indole derivatives as modulators of methyl modifying enzymes, compositions and uses thereof |
| EP4324525A3 (en) | 2013-10-16 | 2024-07-17 | Epizyme, Inc. | Hydrochloride salt form for ezh2 inhibition |
| WO2015085325A1 (en) | 2013-12-06 | 2015-06-11 | Epizyme, Inc. | Combination therapy for treating cancer |
| KR20230031963A (ko) | 2014-06-17 | 2023-03-07 | 에피자임, 인코포레이티드 | 림프종 치료를 위한 ｅｚｈ2 억제제 |
| CA2960968A1 (en) | 2014-09-12 | 2016-03-17 | Janssen Pharmaceutica Nv | P2x7 modulators |
| AU2015315693B2 (en) | 2014-09-12 | 2020-01-16 | Janssen Pharmaceutica Nv | P2X7 modulating n-acyl-triazolopyrazines |
| CN108047240B (zh) | 2014-09-12 | 2020-08-04 | 勃林格殷格翰国际有限公司 | 组织蛋白酶c的螺环化合物抑制剂 |
| CN106794177A (zh) * | 2014-10-16 | 2017-05-31 | Epizyme股份有限公司 | 治疗癌症的方法 |
| KR20240035908A (ko) | 2014-11-17 | 2024-03-18 | 에피자임, 인코포레이티드 | 암을 치료하기 위한 방법 |
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| WO2016172199A1 (en) | 2015-04-20 | 2016-10-27 | Epizyme, Inc. | Combination therapy for treating cancer |
| CA2988816A1 (en) * | 2015-06-10 | 2016-12-15 | Epizyme, Inc. | Ezh2 inhibitors for treating lymphoma |
| US10493076B2 (en) | 2015-08-24 | 2019-12-03 | Epizyme, Inc. | Method for treating cancer |
| TW201718598A (zh) | 2015-08-27 | 2017-06-01 | 美國禮來大藥廠 | Ｅｚｈ２抑制劑 |
| WO2017040190A1 (en) | 2015-08-28 | 2017-03-09 | Constellation Pharmaceuticals, Inc. | Crystalline forms of (r)-n-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1h-indole-3-carboxamide |
| US11951108B2 (en) * | 2016-01-29 | 2024-04-09 | Epizyme, Inc. | Combination therapy for treating cancer |
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| JP7121660B2 (ja) | 2016-06-01 | 2022-08-18 | エピザイム，インコーポレイティド | 癌を処置するためのｅｚｈ２阻害剤の使用 |
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| EP3529242A1 (en) | 2016-10-19 | 2019-08-28 | Constellation Pharmaceuticals, Inc. | Synthesis of inhibitors of ezh2 |
| CN108699002B (zh) * | 2016-11-11 | 2021-11-09 | 上海海雁医药科技有限公司 | 1,5,7-三取代的异喹啉衍生物、其制法与医药上的用途 |
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| JP2020522687A (ja) | 2017-06-02 | 2020-07-30 | エピザイム，インコーポレイティド | 癌を処置するためのｅｚｈ２阻害剤の使用 |
| CA3074720A1 (en) | 2017-09-05 | 2019-03-14 | Epizyme, Inc. | Combination therapy for treating cancer |
| FI4043466T3 (fi) | 2018-01-31 | 2024-10-30 | Mirati Therapeutics Inc | Prc2:n estäjiä |
| CA3104209A1 (en) | 2018-07-09 | 2020-01-16 | Fondation Asile Des Aveugles | Inhibition of prc2 subunits to treat eye disorders |
| MA53722A (fr) | 2018-09-28 | 2022-03-30 | Janssen Pharmaceutica Nv | Modulateurs de la monoacylglycérol lipase |
| WO2020065613A1 (en) | 2018-09-28 | 2020-04-02 | Janssen Pharmaceutica Nv | Monoacylglycerol lipase modulators |
| JP7624404B2 (ja) | 2019-04-22 | 2025-01-30 | ミラティ セラピューティクス，インク． | Ｐｒｃ２阻害剤としてのナフチリジン誘導体 |
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| JP2022545467A (ja) | 2019-08-22 | 2022-10-27 | ジュノー セラピューティクス インコーポレイテッド | Ｔ細胞療法とｚｅｓｔｅホモログ２エンハンサー（ＥＺＨ２）阻害剤との併用療法および関連方法 |
| EP4038070B1 (en) | 2019-09-30 | 2025-07-09 | Janssen Pharmaceutica NV | Radiolabelled mgl pet ligands |
| CN111303133A (zh) * | 2020-03-25 | 2020-06-19 | 清华大学 | 降解ezh2蛋白的小分子化合物 |
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