|
EP0092574B1
(en)
|
1981-10-23 |
1992-04-29 |
Molecular Biosystems, Inc. |
Oligonucleotide therapeutic agent and methods of making same
|
|
DE3329892A1
(de)
|
1983-08-18 |
1985-03-07 |
Köster, Hubert, Prof. Dr., 2000 Hamburg |
Verfahren zur herstellung von oligonucleotiden
|
|
JP3019994B2
(ja)
|
1987-11-30 |
2000-03-15 |
ユニバーシティ オブ アイオワ リサーチ ファウンデーション |
新規なオリゴデオキシヌクレオチド、それを使用した標的遺伝子の発現をブロックする方法、及び新規なオリゴデオキシヌクレオチド並びにそれを使用した標的遺伝子の発現を阻止する方法
|
|
US6753423B1
(en)
|
1990-01-11 |
2004-06-22 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for enhanced biostability and altered biodistribution of oligonucleotides in mammals
|
|
US5914396A
(en)
|
1990-01-11 |
1999-06-22 |
Isis Pharmaceuticals, Inc. |
2'-O-modified nucleosides and phosphoramidites
|
|
US6005087A
(en)
|
1995-06-06 |
1999-12-21 |
Isis Pharmaceuticals, Inc. |
2'-modified oligonucleotides
|
|
US5623065A
(en)
|
1990-08-13 |
1997-04-22 |
Isis Pharmaceuticals, Inc. |
Gapped 2' modified oligonucleotides
|
|
US6395492B1
(en)
|
1990-01-11 |
2002-05-28 |
Isis Pharmaceuticals, Inc. |
Derivatized oligonucleotides having improved uptake and other properties
|
|
US7015315B1
(en)
|
1991-12-24 |
2006-03-21 |
Isis Pharmaceuticals, Inc. |
Gapped oligonucleotides
|
|
WO1994008003A1
(en)
|
1991-06-14 |
1994-04-14 |
Isis Pharmaceuticals, Inc. |
ANTISENSE OLIGONUCLEOTIDE INHIBITION OF THE ras GENE
|
|
US5965722A
(en)
|
1991-05-21 |
1999-10-12 |
Isis Pharmaceuticals, Inc. |
Antisense inhibition of ras gene with chimeric and alternating oligonucleotides
|
|
US5661134A
(en)
|
1991-10-15 |
1997-08-26 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides for modulating Ha-ras or Ki-ras having phosphorothioate linkages of high chiral purity
|
|
US6831166B2
(en)
|
1992-10-23 |
2004-12-14 |
Isis Pharmaceuticals, Inc. |
Derivatized oligonucleotides having improved uptake and other properties
|
|
US8153602B1
(en)
|
1991-11-19 |
2012-04-10 |
Isis Pharmaceuticals, Inc. |
Composition and methods for the pulmonary delivery of nucleic acids
|
|
ATE515510T1
(de)
|
1991-12-24 |
2011-07-15 |
Isis Pharmaceuticals Inc |
Durch dna-abschnitte unterbrochene modifizierte oligonukleotide
|
|
US20070032446A1
(en)
|
1991-12-24 |
2007-02-08 |
Isis Pharmaceuticals, Inc. |
Gapped 2' modified oligonucleotides
|
|
US6346614B1
(en)
|
1992-07-23 |
2002-02-12 |
Hybridon, Inc. |
Hybrid oligonucleotide phosphorothioates
|
|
TW244371B
(enExample)
|
1992-07-23 |
1995-04-01 |
Tri Clover Inc |
|
|
US5652355A
(en)
|
1992-07-23 |
1997-07-29 |
Worcester Foundation For Experimental Biology |
Hybrid oligonucleotide phosphorothioates
|
|
JPH08502723A
(ja)
|
1992-07-27 |
1996-03-26 |
ハイブライドン インコーポレイテッド |
オリゴヌクレオチド・アルキルホスホノチオエート
|
|
US5574142A
(en)
|
1992-12-15 |
1996-11-12 |
Microprobe Corporation |
Peptide linkers for improved oligonucleotide delivery
|
|
DK0677056T3
(da)
|
1993-01-25 |
1996-08-05 |
Hybridon Inc |
Oligonukleotid-alkylphosphonater og -alkylphosphonothioater
|
|
US5734039A
(en)
*
|
1994-09-15 |
1998-03-31 |
Thomas Jefferson University |
Antisense oligonucleotides targeting cooperating oncogenes
|
|
US6608035B1
(en)
|
1994-10-25 |
2003-08-19 |
Hybridon, Inc. |
Method of down-regulating gene expression
|
|
DK0882061T3
(da)
|
1996-02-14 |
2004-09-27 |
Isis Pharmaceuticals Inc |
Sukkermodificerede gapped oligonukleotider
|
|
US6015710A
(en)
|
1996-04-09 |
2000-01-18 |
The University Of Texas System |
Modulation of mammalian telomerase by peptide nucleic acids
|
|
US5898031A
(en)
|
1996-06-06 |
1999-04-27 |
Isis Pharmaceuticals, Inc. |
Oligoribonucleotides for cleaving RNA
|
|
US20080119427A1
(en)
|
1996-06-06 |
2008-05-22 |
Isis Pharmaceuticals, Inc. |
Double Strand Compositions Comprising Differentially Modified Strands for Use in Gene Modulation
|
|
US5912332A
(en)
*
|
1996-07-26 |
1999-06-15 |
Hybridon, Inc. |
Affinity-based purification of oligonucleotides using soluble multimeric oligonucleotides
|
|
US6383808B1
(en)
|
2000-09-11 |
2002-05-07 |
Isis Pharmaceuticals, Inc. |
Antisense inhibition of clusterin expression
|
|
US7572582B2
(en)
|
1997-09-12 |
2009-08-11 |
Exiqon A/S |
Oligonucleotide analogues
|
|
CA2326823A1
(en)
|
1998-04-20 |
1999-10-28 |
Ribozyme Pharmaceuticals, Inc. |
Nucleic acid molecules with novel chemical compositions capable of modulating gene expression
|
|
EP0979869A1
(en)
|
1998-08-07 |
2000-02-16 |
Hoechst Marion Roussel Deutschland GmbH |
Short oligonucleotides for the inhibition of VEGF expression
|
|
US6228642B1
(en)
|
1998-10-05 |
2001-05-08 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide modulation of tumor necrosis factor-(α) (TNF-α) expression
|
|
US6210892B1
(en)
|
1998-10-07 |
2001-04-03 |
Isis Pharmaceuticals, Inc. |
Alteration of cellular behavior by antisense modulation of mRNA processing
|
|
US6465628B1
(en)
|
1999-02-04 |
2002-10-15 |
Isis Pharmaceuticals, Inc. |
Process for the synthesis of oligomeric compounds
|
|
KR20000065690A
(ko)
|
1999-04-08 |
2000-11-15 |
박종구 |
반응 특이성 및 안정성을 개선시킨 안티센스 올리고 뉴클레오타이드, 안티센스 ｄｎａ 및 그 제조방법
|
|
US6677445B1
(en)
|
1999-08-27 |
2004-01-13 |
Chiron Corporation |
Chimeric antisense oligonucleotides and cell transfecting formulations thereof
|
|
AU7406700A
(en)
|
1999-10-04 |
2001-05-10 |
Exiqon A/S |
Design of high affinity rnase h recruiting oligonucleotide
|
|
WO2001048190A2
(en)
|
1999-12-23 |
2001-07-05 |
Exiqon A/S |
Therapeutic uses of lna-modified oligonucleotides
|
|
US6602857B1
(en)
|
2000-01-18 |
2003-08-05 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of PTP1B expression
|
|
US6727355B2
(en)
|
2000-08-25 |
2004-04-27 |
Jcr Pharmaceuticals Co., Ltd. |
Pharmaceutical composition for treatment of Duchenne muscular dystrophy
|
|
CA2419563C
(en)
|
2000-09-06 |
2018-03-20 |
Mcgill University |
Chimeric antisense of arabinofuranose analogue and deoxyribose nucleotides
|
|
US20050054836A1
(en)
|
2000-11-09 |
2005-03-10 |
Cold Spring Harbor Laboratory |
Chimeric molecules to modulate gene expression
|
|
JP2005508634A
(ja)
*
|
2001-10-29 |
2005-04-07 |
マクギル・ユニヴァーシティ |
非環式リンカー含有オリゴヌクレオチド及びその用途
|
|
CA2475388A1
(en)
*
|
2002-02-14 |
2003-08-21 |
William J. Rutter |
Chimeric molecules for cleavage in a treated host
|
|
US20080207542A1
(en)
|
2002-03-26 |
2008-08-28 |
Sirna Therapeutics, Inc. |
RNA inteference mediated inhibition of hepatitis C virus (HVC) gene expression using short interfering nucleic acid (siNA)
|
|
ES2649817T3
(es)
|
2002-04-05 |
2018-01-15 |
Roche Innovation Center Copenhagen A/S |
Compuestos oligom¿¿ricos para la modulaci¿®n de la expresi¿®n de HIF-1¿Á
|
|
US20030228690A1
(en)
|
2002-06-10 |
2003-12-11 |
Isis Pharmaceuticals Inc. |
Antisense modulation of IL-1 receptor-associated kinase-1 expression
|
|
US7507808B2
(en)
|
2002-12-12 |
2009-03-24 |
Isis Pharmaceuticals, Inc. |
Modulation of endothelial lipase expression
|
|
US20050130924A1
(en)
|
2002-06-26 |
2005-06-16 |
Monia Brett P. |
Antisense inhibition via RNAse H-independent reduction in mRNA
|
|
US8604183B2
(en)
|
2002-11-05 |
2013-12-10 |
Isis Pharmaceuticals, Inc. |
Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
|
|
EP2284269B1
(en)
|
2002-11-18 |
2017-08-09 |
Roche Innovation Center Copenhagen A/S |
Antisense design
|
|
WO2004069992A2
(en)
|
2003-02-10 |
2004-08-19 |
Santaris Pharma A/S |
Oligomeric compounds for the modulation of ras expression
|
|
FR2853663B1
(fr)
|
2003-04-14 |
2007-08-31 |
Aventis Pharma Sa |
Procede d'obtention de lignees de mastocytes a partir de tissus de porcs et procede de production de molecules de type heparine
|
|
US20080124317A1
(en)
|
2003-06-25 |
2008-05-29 |
Orna Mor |
Diagnos and Treatment of Fibrosis Related Pathology
|
|
WO2005013901A2
(en)
|
2003-07-31 |
2005-02-17 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds and compositions for use in modulation of small non-coding rnas
|
|
US20050053981A1
(en)
|
2003-09-09 |
2005-03-10 |
Swayze Eric E. |
Gapped oligomeric compounds having linked bicyclic sugar moieties at the termini
|
|
NZ546275A
(en)
|
2003-10-30 |
2009-05-31 |
Coley Pharm Gmbh |
C-class oligonucleotides analogs with enhanced immunostimulatory potency
|
|
US7431915B2
(en)
*
|
2003-10-31 |
2008-10-07 |
The Regents Of The University Of California |
Peptides whose uptake by cells is controllable
|
|
ES2344566T3
(es)
*
|
2003-12-23 |
2010-08-31 |
Santaris Pharma A/S |
Compuestos oligomericos para la modulacion de bcl-2.
|
|
WO2005072527A2
(en)
|
2004-01-23 |
2005-08-11 |
Avi Biopharma, Inc. |
Antisense oligomers and methods for inducing immune tolerance and immunosuppression
|
|
WO2005072057A2
(en)
|
2004-01-30 |
2005-08-11 |
Quark Biotech, Inc. |
Oligoribonucleotides and methods of use thereof for treatment of fibrotic conditions and other diseases
|
|
US8314226B2
(en)
|
2004-03-29 |
2012-11-20 |
The General Hospital Corporation |
Oligonucleotide complex compositions and methods of use as gene alteration tools
|
|
CA2566286A1
(en)
|
2004-05-11 |
2005-12-08 |
Rnai Co., Ltd. |
Polynucleotide causing rna interfere and method of regulating gene expression with the use of the same
|
|
US7879992B2
(en)
|
2005-01-31 |
2011-02-01 |
Isis Pharmaceuticals, Inc. |
Modification of MyD88 splicing using modified oligonucleotides
|
|
WO2006086667A2
(en)
|
2005-02-09 |
2006-08-17 |
Avi Bio Pharma, Inc. |
Antisense composition and method for treating muscle atrophy
|
|
DE102005036654A1
(de)
|
2005-08-04 |
2007-02-15 |
Bayer Materialscience Ag |
Selbstvernetzende PUR-Dispersionen mit Uretdionstruktur
|
|
EP1951263A4
(en)
|
2005-11-21 |
2009-11-18 |
Johnson & Johnson Res Pty Ltd |
MULTITARGETING DISTURBING RNAS WITH TWO ACTIVE STRANDS AND DESIGN AND APPLICATION METHODS
|
|
US20090011004A1
(en)
|
2005-12-30 |
2009-01-08 |
Philadelphia Health & Education Corp., D/B/A/ Drexel University Of College Of Medicine |
Improved carriers for delivery of nucleic acid agents to cells and tissues
|
|
EP2388328A1
(en)
|
2006-01-27 |
2011-11-23 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds and compositions for the use in modulation of micrornas
|
|
US8362229B2
(en)
|
2006-02-08 |
2013-01-29 |
Quark Pharmaceuticals, Inc. |
Tandem siRNAS
|
|
CA3042781C
(en)
|
2006-04-03 |
2021-10-19 |
Roche Innovation Center Copenhagen A/S |
Pharmaceutical composition comprising anti-mirna antisense oligonucleotides
|
|
EP2505646A1
(en)
|
2006-05-05 |
2012-10-03 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating expression of CRP
|
|
WO2008029619A1
(fr)
|
2006-09-07 |
2008-03-13 |
Daiichi Sankyo Company, Limited |
Oligonucléotide antisens ena ayant une action spécifique de la séquence
|
|
EP2410053B2
(en)
|
2006-10-18 |
2020-07-15 |
Ionis Pharmaceuticals, Inc. |
Antisense compounds
|
|
WO2008109105A2
(en)
|
2007-03-06 |
2008-09-12 |
Flagship Ventures |
Methods and compositions for improved therapeutic effects with sirna
|
|
US8580756B2
(en)
|
2007-03-22 |
2013-11-12 |
Santaris Pharma A/S |
Short oligomer antagonist compounds for the modulation of target mRNA
|
|
JP2010536787A
(ja)
|
2007-08-15 |
2010-12-02 |
イデラ ファーマシューティカルズ インコーポレイテッド |
Ｔｏｌｌ様受容体モジュレータ
|
|
DK2205737T3
(da)
|
2007-10-04 |
2013-05-21 |
Santaris Pharma As |
Mikromirer
|
|
AU2008308499A1
(en)
|
2007-10-04 |
2009-04-09 |
Board Of Regents, The University Of Texas System |
Modulating gene expression with agRNA and gapmers targeting antisense transcripts
|
|
WO2009090182A1
(en)
|
2008-01-14 |
2009-07-23 |
Santaris Pharma A/S |
C4'-substituted - dna nucleotide gapmer oligonucleotides
|
|
EP2268811A1
(en)
|
2008-03-07 |
2011-01-05 |
Santaris Pharma A/S |
Pharmaceutical compositions for treatment of microrna related diseases
|
|
US8846639B2
(en)
|
2008-04-04 |
2014-09-30 |
Isis Pharmaceutical, Inc. |
Oligomeric compounds comprising bicyclic nucleosides and having reduced toxicity
|
|
AU2009235941A1
(en)
|
2008-04-07 |
2009-10-15 |
Riken |
RNA molecules and uses thereof
|
|
CA2635187A1
(en)
|
2008-06-05 |
2009-12-05 |
The Royal Institution For The Advancement Of Learning/Mcgill University |
Oligonucleotide duplexes and uses thereof
|
|
DK2310505T3
(en)
|
2008-06-30 |
2017-10-16 |
Roche Innovation Ct Copenhagen As |
ANTIDOT oligomers
|
|
MY188457A
(en)
|
2008-10-03 |
2021-12-10 |
Opko Curna Llc |
Treatment of apolipoprotein-a1 related diseases by inhibition of natural antisense transcript to apolipoprotein-a1
|
|
CN104382853A
(zh)
|
2008-10-16 |
2015-03-04 |
玛瑞纳生物技术有限公司 |
基因沉默治疗剂的脂质体有效递送方法和组合物
|
|
EP2405921A4
(en)
|
2009-01-26 |
2013-05-22 |
Protiva Biotherapeutics Inc |
COMPOSITIONS AND METHODS FOR VAPORING APOLIPOPROTIEN C-III EXPRESSION
|
|
WO2010090452A2
(ko)
|
2009-02-04 |
2010-08-12 |
성균관대학교산학협력단 |
세포 내 전달능이 증가된 작은 간섭 rna 복합체
|
|
WO2010093788A2
(en)
|
2009-02-11 |
2010-08-19 |
Dicerna Pharmaceuticals, Inc. |
Multiplex dicer substrate rna interference molecules having joining sequences
|
|
WO2010120969A1
(en)
*
|
2009-04-15 |
2010-10-21 |
Board Of Regents, The University Of Texas System |
Targeting of the mir-30 family and let-7 family as a treatment for heart disease
|
|
EP2456470A1
(en)
|
2009-07-22 |
2012-05-30 |
Cenix Bioscience GmbH |
Delivery system and conjugates for compound delivery via naturally occurring intracellular transport routes
|
|
HUE026020T2
(en)
*
|
2009-08-27 |
2016-05-30 |
Idera Pharmaceuticals Inc |
Preparation for inhibiting gene expression and its uses
|
|
US9364495B2
(en)
|
2009-10-20 |
2016-06-14 |
Roche Innovation Center Copenhagen A/S |
Oral delivery of therapeutically effective LNA oligonucleotides
|
|
AU2010335039B2
(en)
|
2009-12-24 |
2015-03-26 |
Academisch Ziekenhuis Leiden H.O.D.N. Lumc |
Molecule for treating an inflammatory disorder
|
|
WO2011117353A1
(en)
*
|
2010-03-24 |
2011-09-29 |
Mirrx Therapeutics A/S |
Bivalent antisense oligonucleotides
|
|
WO2011130371A1
(en)
|
2010-04-13 |
2011-10-20 |
Life Technologies Corporation |
Compositions and methods for inhibition of nucleic acids function
|
|
WO2011133886A2
(en)
*
|
2010-04-23 |
2011-10-27 |
Genentech, Inc. |
Production of heteromultimeric proteins
|
|
ES2625689T3
(es)
|
2010-04-29 |
2017-07-20 |
Ionis Pharmaceuticals, Inc. |
Modulación de la expresión de transtiretina
|
|
WO2011159836A2
(en)
|
2010-06-15 |
2011-12-22 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating interaction between proteins and target nucleic acids
|
|
GB201010557D0
(en)
|
2010-06-23 |
2010-08-11 |
Mina Therapeutics Ltd |
RNA molecules and uses thereof
|
|
ES2756326T3
(es)
|
2010-07-19 |
2020-04-27 |
Ionis Pharmaceuticals Inc |
Modulación de la expresión de distrofia miotónica-proteína quinasa (DMPK)
|
|
WO2012068340A2
(en)
|
2010-11-18 |
2012-05-24 |
Opko Curna Llc |
Antagonat compositions and methods of use
|
|
US8557787B2
(en)
|
2011-05-13 |
2013-10-15 |
The Board Of Trustees Of The Leland Stanford Junior University |
Diagnostic, prognostic and therapeutic uses of long non-coding RNAs for cancer and regenerative medicine
|
|
HK1200484A1
(zh)
|
2011-09-14 |
2015-08-07 |
Translate Bio Ma, Inc. |
多聚寡核苷酸化合物
|
|
EP3254700B1
(en)
|
2012-03-04 |
2019-10-23 |
Bonac Corporation |
Micro-rna inhibitor
|
|
EA201492120A1
(ru)
|
2012-05-16 |
2015-10-30 |
Рана Терапьютикс, Инк. |
Композиции и способы для модулирования экспрессии atp2a2
|
|
CN104583398A
(zh)
|
2012-05-16 |
2015-04-29 |
Rana医疗有限公司 |
用于调节基因表达的组合物和方法
|
|
EA201492118A1
(ru)
|
2012-05-16 |
2015-04-30 |
Рана Терапьютикс, Инк. |
Композиции и способы для модулирования экспрессии pten
|
|
CN104582737A
(zh)
|
2012-05-16 |
2015-04-29 |
Rana医疗有限公司 |
用于调节apoa1和abca1表达的组合物和方法
|
|
CN104583402A
(zh)
|
2012-05-16 |
2015-04-29 |
Rana医疗有限公司 |
用于调节mecp2表达的组合物和方法
|
|
US9567581B2
(en)
*
|
2012-08-07 |
2017-02-14 |
The General Hospital Corporation |
Selective reactivation of genes on the inactive X chromosome
|
|
US20150247141A1
(en)
|
2012-09-14 |
2015-09-03 |
Rana Therapeutics, Inc. |
Multimeric oligonucleotide compounds
|
|
CA2889044A1
(en)
|
2012-11-15 |
2014-05-22 |
Roche Innovation Center Copenhagen A/S |
Anti apob antisense conjugate compounds
|
|
AU2015346042A1
(en)
|
2014-11-14 |
2017-04-27 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for the modulation of proteins
|