JP2015527364A5 - - Google Patents
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- JP2015527364A5 JP2015527364A5 JP2015528576A JP2015528576A JP2015527364A5 JP 2015527364 A5 JP2015527364 A5 JP 2015527364A5 JP 2015528576 A JP2015528576 A JP 2015528576A JP 2015528576 A JP2015528576 A JP 2015528576A JP 2015527364 A5 JP2015527364 A5 JP 2015527364A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- antibody
- antigen
- binding fragment
- asthma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261691625P | 2012-08-21 | 2012-08-21 | |
| US61/691,625 | 2012-08-21 | ||
| US201361758097P | 2013-01-29 | 2013-01-29 | |
| US61/758,097 | 2013-01-29 | ||
| US201361761279P | 2013-02-06 | 2013-02-06 | |
| US61/761,279 | 2013-02-06 | ||
| US201361783796P | 2013-03-14 | 2013-03-14 | |
| US61/783,796 | 2013-03-14 | ||
| US201361805797P | 2013-03-27 | 2013-03-27 | |
| US61/805,797 | 2013-03-27 | ||
| FR1356994 | 2013-07-16 | ||
| FR1356994 | 2013-07-16 | ||
| PCT/US2013/055747 WO2014031610A1 (en) | 2012-08-21 | 2013-08-20 | Methods for treating or preventing asthma by administering an il-4r antagonist |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018040279A Division JP2018109056A (ja) | 2012-08-21 | 2018-03-07 | Ｉｌ−４ｒアンタゴニストを投与することにより喘息を処置又は予防するための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015527364A JP2015527364A (ja) | 2015-09-17 |
| JP2015527364A5 true JP2015527364A5 (https=) | 2016-09-29 |
| JP6306588B2 JP6306588B2 (ja) | 2018-04-04 |
Family
ID=50148186
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015528576A Active JP6306588B2 (ja) | 2012-08-21 | 2013-08-20 | Ｉｌ−４ｒアンタゴニストを投与することにより喘息を処置又は予防するための方法 |
| JP2018040279A Pending JP2018109056A (ja) | 2012-08-21 | 2018-03-07 | Ｉｌ−４ｒアンタゴニストを投与することにより喘息を処置又は予防するための方法 |
| JP2023005561A Active JP7609901B2 (ja) | 2012-08-21 | 2023-01-18 | Ｉｌ－４ｒアンタゴニストを投与することにより喘息を処置又は予防するための方法 |
| JP2024221236A Pending JP2025038127A (ja) | 2012-08-21 | 2024-12-18 | Ｉｌ－４ｒアンタゴニストを投与することにより喘息を処置又は予防するための方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018040279A Pending JP2018109056A (ja) | 2012-08-21 | 2018-03-07 | Ｉｌ−４ｒアンタゴニストを投与することにより喘息を処置又は予防するための方法 |
| JP2023005561A Active JP7609901B2 (ja) | 2012-08-21 | 2023-01-18 | Ｉｌ－４ｒアンタゴニストを投与することにより喘息を処置又は予防するための方法 |
| JP2024221236A Pending JP2025038127A (ja) | 2012-08-21 | 2024-12-18 | Ｉｌ－４ｒアンタゴニストを投与することにより喘息を処置又は予防するための方法 |
Country Status (28)
| Country | Link |
|---|---|
| US (4) | US9574004B2 (https=) |
| EP (4) | EP3470432B1 (https=) |
| JP (4) | JP6306588B2 (https=) |
| KR (6) | KR102386304B1 (https=) |
| CN (2) | CN104755495A (https=) |
| AR (1) | AR092177A1 (https=) |
| AU (4) | AU2013305945B2 (https=) |
| BR (1) | BR112015003590A8 (https=) |
| CA (2) | CA2882416A1 (https=) |
| DK (1) | DK2888281T3 (https=) |
| ES (3) | ES2971088T3 (https=) |
| HR (1) | HRP20181963T1 (https=) |
| HU (1) | HUE064945T2 (https=) |
| IL (3) | IL293398B2 (https=) |
| IN (1) | IN2015KN00414A (https=) |
| LT (1) | LT2888281T (https=) |
| MX (1) | MX371344B (https=) |
| NZ (3) | NZ744109A (https=) |
| PL (3) | PL3470432T3 (https=) |
| PT (2) | PT3470432T (https=) |
| PY (1) | PY1337526A (https=) |
| RS (1) | RS58091B1 (https=) |
| RU (1) | RU2690675C2 (https=) |
| SG (2) | SG11201500889TA (https=) |
| SI (1) | SI2888281T1 (https=) |
| TW (1) | TWI656880B (https=) |
| UY (1) | UY34984A (https=) |
| WO (1) | WO2014031610A1 (https=) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7608693B2 (en) * | 2006-10-02 | 2009-10-27 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human IL-4 receptor |
| BR112013008366B1 (pt) | 2010-10-06 | 2022-02-08 | Regeneron Pharmaceuticals, Inc | Formulações farmacêuticas líquidas estáveis contendo anticorpos anti-receptor de interleucina-4 humana alfa, e recipiente contendo as referidas formulações |
| JP6306588B2 (ja) | 2012-08-21 | 2018-04-04 | サノフィ・バイオテクノロジー | Ｉｌ−４ｒアンタゴニストを投与することにより喘息を処置又は予防するための方法 |
| HUE042117T2 (hu) * | 2012-08-21 | 2019-06-28 | Sanofi Biotechnology | Eljárások asztma kezelésére vagy megelõzésére IL-4R antagonista beadásával |
| PL2892927T3 (pl) | 2012-09-07 | 2018-11-30 | Regeneron Pharmaceuticals, Inc. | Sposoby leczenia atopowego zapalenia skóry przez podawanie antagonisty IL-4R |
| TWI755763B (zh) | 2013-06-04 | 2022-02-21 | 美商再生元醫藥公司 | 藉由投與il-4r抑制劑以治療過敏及增強過敏原-特異之免疫療法的方法 |
| AU2014284235C1 (en) | 2013-06-21 | 2025-07-31 | Regeneron Pharmaceuticals, Inc. | Methods for treating nasal polyposis by administering an IL-4R antagonist |
| TWI634900B (zh) | 2013-07-11 | 2018-09-11 | 再生元醫藥公司 | 藉由投與ｉｌ－４ｒ抑制劑治療嗜酸性食道炎的方法 |
| WO2015120389A1 (en) | 2014-02-10 | 2015-08-13 | Patara Pharma, LLC | Mast cell stabilizers treatment for systemic disorders |
| PL3104854T3 (pl) | 2014-02-10 | 2020-11-30 | Respivant Sciences Gmbh | Stabilizatory komórek tucznych do leczenia choroby płuc |
| IL247290B (en) * | 2014-02-21 | 2021-06-30 | Sanofi Biotechnology | Methods of treating or preventing asthma by adding an il-4r antagonist |
| IL315136A (en) * | 2014-02-21 | 2024-10-01 | Sanofi Biotechnology | Methods for treating or preventing asthma by administering an il-4rantagonist |
| KR102695088B1 (ko) | 2014-02-28 | 2024-08-16 | 리제너론 파아마슈티컬스, 인크. | Ｉｌ-4ｒ 길항제의 투여에 의한 피부 감염의 치료 방법 |
| NO2785538T3 (https=) * | 2014-05-07 | 2018-08-04 | ||
| TW201628647A (zh) | 2014-06-27 | 2016-08-16 | 賽諾菲公司 | 抗－ｉｌ４－ｉｌ１３雙特異性抗體 |
| MA40164A (fr) * | 2014-06-27 | 2017-05-03 | Sanofi Sa | Anticorps bispécifiques anti-il4-il13 |
| CA3246946A1 (en) | 2014-11-14 | 2025-11-29 | Sanofi Biotechnology | Methods for treating chronic sinusitis with nasal polyps by administering an il-4r antagonist |
| HUE052606T2 (hu) * | 2014-12-09 | 2021-05-28 | Regeneron Pharma | Humanizált differenciációs klaszter 274 génnel rendelkezõ nem humán állatok |
| US10265296B2 (en) | 2015-08-07 | 2019-04-23 | Respivant Sciences Gmbh | Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders |
| WO2017027387A1 (en) | 2015-08-07 | 2017-02-16 | Patara Pharma, LLC | Methods for the treatment of mast cell related disorders with mast cell stabilizers |
| CN113372446A (zh) | 2016-06-08 | 2021-09-10 | 苏州康乃德生物医药有限公司 | 用于结合白细胞介素4受体的抗体 |
| EP3506893A4 (en) | 2016-08-31 | 2020-01-22 | Respivant Sciences GmbH | CROMOLYN COMPOSITIONS FOR THE TREATMENT OF CHRONIC COUGH DUE TO IDIOPATHIC PULMONAL FIBROSIS |
| US20180056018A1 (en) * | 2016-08-31 | 2018-03-01 | Cephalon, Inc. | Inhalation Systems, Devices and Methods |
| ES2994774T3 (en) * | 2016-09-01 | 2025-01-31 | Regeneron Pharma | Methods for preventing or treating allergy by administering an il-4r antagonist |
| WO2018057776A1 (en) | 2016-09-22 | 2018-03-29 | Regeneron Pharmaceuticals, Inc. | Methods for treating severe atopic dermatitis by administering an il-4r inhibitor |
| JP2019531308A (ja) | 2016-10-07 | 2019-10-31 | レシュピファント サイエンシス ゲゼルシャフト ミット ベシュレンクター ハフトゥングＲｅｓｐｉｖａｎｔ Ｓｃｉｅｎｃｅｓ Ｇｍｂｈ | 肺線維症の治療のためのクロモリン組成物 |
| EP3532500A1 (en) * | 2016-10-31 | 2019-09-04 | Vectura Limited | Inhalable powder composition comprising il-13 antibody |
| TWI857389B (zh) * | 2016-12-01 | 2024-10-01 | 美商再生元醫藥公司 | 治療發炎症狀的方法 |
| ES3052989T3 (en) * | 2017-04-13 | 2026-01-16 | Regeneron Pharma | Treatment and inhibition of inflammatory lung diseases in patients having risk alleles in the genes encoding il33 and il1rl1 |
| US11970526B2 (en) * | 2017-04-21 | 2024-04-30 | Elanco Us Inc. | IL4/IL13 receptor molecule for veterinary use |
| US11053309B2 (en) | 2017-08-04 | 2021-07-06 | Regeneron Pharmaceuticals, Inc. | Methods for treating active eosinophilic esophagitis |
| KR102694419B1 (ko) * | 2017-10-30 | 2024-08-09 | 사노피 바이오테크놀로지 | Il-4r 길항제를 투여하여 천식을 치료 또는 예방하는 방법 |
| WO2019097534A1 (en) * | 2017-11-15 | 2019-05-23 | Venkata Satya Suresh Attili | A device and method to determine the mean/average control of asthma/copd over time and compliance to treatment |
| BR112020020387A2 (pt) | 2018-05-13 | 2021-01-19 | Regeneron Pharmaceuticals, Inc. | Métodos para o tratamento de dermatite atópica por administração de um inibidor de il-4r |
| CN115991781A (zh) | 2018-08-24 | 2023-04-21 | 江苏恒瑞医药股份有限公司 | 结合人il-4r的抗体、其抗原结合片段及其医药用途 |
| CN110872349A (zh) * | 2018-09-04 | 2020-03-10 | 三生国健药业（上海）股份有限公司 | 结合人il-4r的抗体、其制备方法和用途 |
| CN111057721B (zh) | 2018-10-12 | 2021-03-16 | 百奥赛图(北京)医药科技股份有限公司 | 人源化IL-4和/或IL-4Rα改造动物模型的制备方法及应用 |
| US12428466B2 (en) | 2018-10-25 | 2025-09-30 | Elanco Us Inc. | IL4/IL13 receptor molecule for veterinary use |
| CN110746507B (zh) | 2018-12-25 | 2020-06-26 | 江苏荃信生物医药有限公司 | 抗人白介素4受体α单克隆抗体及其应用 |
| CN116813770A (zh) * | 2018-12-27 | 2023-09-29 | 中山康方生物医药有限公司 | 抗人il-4ra的抗体及其用途 |
| MA55204A (fr) * | 2019-03-06 | 2022-01-12 | Regeneron Pharma | Inhibiteurs de la voie il-4/il-13 pour une efficacité améliorée dans le traitement du cancer |
| CN113597328B (zh) | 2019-03-21 | 2025-10-31 | 瑞泽恩制药公司 | 用于治疗过敏症的il-4/il-13途径抑制剂和浆细胞消融的组合 |
| SG11202111255YA (en) * | 2019-05-01 | 2021-11-29 | Sanofi Biotechnology | Methods for treating or preventing asthma by administering an il-33 antagonist |
| CN112010977B (zh) * | 2019-05-29 | 2022-04-26 | 山东博安生物技术股份有限公司 | 抗白介素4受体(il-4r)的抗体及其应用 |
| WO2021011614A1 (en) * | 2019-07-16 | 2021-01-21 | Sanofi Biotechnology | Methods for treating or preventing asthma by administering an il-4r antagonist |
| JP7836754B2 (ja) | 2019-08-05 | 2026-03-27 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Ｉｌ－４ｒアンタゴニストを投与することによりアレルギーを治療しアレルゲン特異的免疫療法を増強するための方法 |
| CN114173816A (zh) | 2019-08-05 | 2022-03-11 | 瑞泽恩制药公司 | 通过施用il-4r拮抗剂治疗特应性皮炎的方法 |
| EP3992974A1 (en) | 2020-11-02 | 2022-05-04 | Sanofi Biotechnology | Methods for treating digitally-identified il-4/il-13 related disorders |
| KR20220110829A (ko) | 2019-12-09 | 2022-08-09 | 사노피 바이오테크놀로지 | 디지털 식별된 il-4/il-13 관련 장애의 치료 방법 |
| CA3169959A1 (en) | 2020-02-21 | 2021-08-26 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Pharmaceutical composition containing anti-il-4r antibody and use thereof |
| CN113527485B (zh) * | 2020-04-17 | 2024-11-15 | 湖南麦济生物技术股份有限公司 | 抗人白细胞介素-4受体α抗体及其制备方法和应用 |
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| WO2025026216A1 (zh) | 2023-07-28 | 2025-02-06 | 江苏恒瑞医药股份有限公司 | 一种含有糖皮质激素的抗体药物偶联物的药物组合物 |
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