KR20250099415A - Il-4r 길항제의 투여에 의한 천식의 치료 또는 예방 방법 - Google Patents

Il-4r 길항제의 투여에 의한 천식의 치료 또는 예방 방법 Download PDF

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Publication number
KR20250099415A
KR20250099415A KR1020257021022A KR20257021022A KR20250099415A KR 20250099415 A KR20250099415 A KR 20250099415A KR 1020257021022 A KR1020257021022 A KR 1020257021022A KR 20257021022 A KR20257021022 A KR 20257021022A KR 20250099415 A KR20250099415 A KR 20250099415A
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ser
gly
pharmaceutical composition
leu
level
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Korean (ko)
Inventor
마리우스 아르델리누
나미타 간디
네일 그레이엄
스테판 씨. 커크쎌리
수딥 쿤두
알렌 라딘
로쓰 이. 로클린
스티븐 와인스타인
제니퍼 데이빗슨 해밀턴
제프리 밍
Original Assignee
사노피 바이오테크놀로지
리제너론 파아마슈티컬스, 인크.
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Application filed by 사노피 바이오테크놀로지, 리제너론 파아마슈티컬스, 인크. filed Critical 사노피 바이오테크놀로지
Publication of KR20250099415A publication Critical patent/KR20250099415A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/247—IL-4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
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    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/521—Chemokines
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  • General Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
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  • Pathology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Otolaryngology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Heart & Thoracic Surgery (AREA)
KR1020257021022A 2012-08-21 2013-08-20 Il-4r 길항제의 투여에 의한 천식의 치료 또는 예방 방법 Pending KR20250099415A (ko)

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
US201261691625P 2012-08-21 2012-08-21
US61/691,625 2012-08-21
US201361758097P 2013-01-29 2013-01-29
US61/758,097 2013-01-29
US201361761279P 2013-02-06 2013-02-06
US61/761,279 2013-02-06
US201361783796P 2013-03-14 2013-03-14
US61/783,796 2013-03-14
US201361805797P 2013-03-27 2013-03-27
US61/805,797 2013-03-27
FR1356994 2013-07-16
FR1356994 2013-07-16
PCT/US2013/055747 WO2014031610A1 (en) 2012-08-21 2013-08-20 Methods for treating or preventing asthma by administering an il-4r antagonist
KR1020247021031A KR20240101727A (ko) 2012-08-21 2013-08-20 Il-4r 길항제의 투여에 의한 천식의 치료 또는 예방 방법

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020247021031A Division KR20240101727A (ko) 2012-08-21 2013-08-20 Il-4r 길항제의 투여에 의한 천식의 치료 또는 예방 방법

Publications (1)

Publication Number Publication Date
KR20250099415A true KR20250099415A (ko) 2025-07-01

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ID=50148186

Family Applications (6)

Application Number Title Priority Date Filing Date
KR1020257021022A Pending KR20250099415A (ko) 2012-08-21 2013-08-20 Il-4r 길항제의 투여에 의한 천식의 치료 또는 예방 방법
KR1020227011842A Active KR102502640B1 (ko) 2012-08-21 2013-08-20 Il-4r 길항제의 투여에 의한 천식의 치료 또는 예방 방법
KR1020157005821A Active KR102307248B1 (ko) 2012-08-21 2013-08-20 Il-4r 길항제의 투여에 의한 천식의 치료 또는 예방 방법
KR1020237005762A Active KR102679182B1 (ko) 2012-08-21 2013-08-20 Il-4r 길항제의 투여에 의한 천식의 치료 또는 예방 방법
KR1020217030423A Active KR102386304B1 (ko) 2012-08-21 2013-08-20 Il-4r 길항제의 투여에 의한 천식의 치료 또는 예방 방법
KR1020247021031A Ceased KR20240101727A (ko) 2012-08-21 2013-08-20 Il-4r 길항제의 투여에 의한 천식의 치료 또는 예방 방법

Family Applications After (5)

Application Number Title Priority Date Filing Date
KR1020227011842A Active KR102502640B1 (ko) 2012-08-21 2013-08-20 Il-4r 길항제의 투여에 의한 천식의 치료 또는 예방 방법
KR1020157005821A Active KR102307248B1 (ko) 2012-08-21 2013-08-20 Il-4r 길항제의 투여에 의한 천식의 치료 또는 예방 방법
KR1020237005762A Active KR102679182B1 (ko) 2012-08-21 2013-08-20 Il-4r 길항제의 투여에 의한 천식의 치료 또는 예방 방법
KR1020217030423A Active KR102386304B1 (ko) 2012-08-21 2013-08-20 Il-4r 길항제의 투여에 의한 천식의 치료 또는 예방 방법
KR1020247021031A Ceased KR20240101727A (ko) 2012-08-21 2013-08-20 Il-4r 길항제의 투여에 의한 천식의 치료 또는 예방 방법

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US (4) US9574004B2 (https=)
EP (4) EP2888281B1 (https=)
JP (4) JP6306588B2 (https=)
KR (6) KR20250099415A (https=)
CN (2) CN110624107A (https=)
AR (1) AR092177A1 (https=)
AU (4) AU2013305945B2 (https=)
BR (1) BR112015003590A8 (https=)
CA (2) CA3296213A1 (https=)
DK (1) DK2888281T3 (https=)
ES (3) ES2971088T3 (https=)
HR (1) HRP20181963T1 (https=)
HU (1) HUE064945T2 (https=)
IL (3) IL312711A (https=)
IN (1) IN2015KN00414A (https=)
LT (1) LT2888281T (https=)
MX (1) MX371344B (https=)
NZ (3) NZ631562A (https=)
PL (3) PL3470432T3 (https=)
PT (2) PT4011915T (https=)
PY (1) PY1337526A (https=)
RS (1) RS58091B1 (https=)
RU (1) RU2690675C2 (https=)
SG (2) SG11201500889TA (https=)
SI (1) SI2888281T1 (https=)
TW (1) TWI656880B (https=)
UY (1) UY34984A (https=)
WO (1) WO2014031610A1 (https=)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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