IN2015KN00414A - - Google Patents

Info

Publication number
IN2015KN00414A
IN2015KN00414A IN414KON2015A IN2015KN00414A IN 2015KN00414 A IN2015KN00414 A IN 2015KN00414A IN 414KON2015 A IN414KON2015 A IN 414KON2015A IN 2015KN00414 A IN2015KN00414 A IN 2015KN00414A
Authority
IN
India
Prior art keywords
present
methods
interleukin
antagonist
antibody
Prior art date
Application number
Inventor
Marius Ardeleanu
Namita Gandhi
Neil Graham
Stephane C Kirkesseli
Sudeep Kundu
Allen Radin
Ross E Rocklin
Steven Weinstein
Hamilton Jennifer Davidson
Jeffrey Ming
Original Assignee
Sanofi Sa
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50148186&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IN2015KN00414(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Sa, Regeneron Pharma filed Critical Sanofi Sa
Publication of IN2015KN00414A publication Critical patent/IN2015KN00414A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/247—IL-4
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/521—Chemokines
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/12—Pulmonary diseases
    • G01N2800/122—Chronic or obstructive airway disorders, e.g. asthma COPD
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Mycology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Otolaryngology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Communicable Diseases (AREA)

Abstract

The present invention provides methods for treating or preventing asthma and associated conditions in a patient. The methods of the present invention comprise administering to a subject in need thereof a therapeutic composition comprising an interleukin 4 receptor (IL 4R) antagonist such as an anti IL 4R antibody.
IN414KON2015 2012-08-21 2013-08-20 IN2015KN00414A (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261691625P 2012-08-21 2012-08-21
US201361758097P 2013-01-29 2013-01-29
US201361761279P 2013-02-06 2013-02-06
US201361783796P 2013-03-14 2013-03-14
US201361805797P 2013-03-27 2013-03-27
FR1356994 2013-07-16
PCT/US2013/055747 WO2014031610A1 (en) 2012-08-21 2013-08-20 Methods for treating or preventing asthma by administering an il-4r antagonist

Publications (1)

Publication Number Publication Date
IN2015KN00414A true IN2015KN00414A (en) 2015-07-17

Family

ID=50148186

Family Applications (1)

Application Number Title Priority Date Filing Date
IN414KON2015 IN2015KN00414A (en) 2012-08-21 2013-08-20

Country Status (28)

Country Link
US (3) US9574004B2 (en)
EP (4) EP3470432B1 (en)
JP (3) JP6306588B2 (en)
KR (5) KR102386304B1 (en)
CN (2) CN104755495A (en)
AR (1) AR092177A1 (en)
AU (4) AU2013305945B2 (en)
BR (1) BR112015003590A8 (en)
CA (1) CA2882416A1 (en)
DK (1) DK2888281T3 (en)
ES (3) ES2701093T3 (en)
HK (1) HK1211605A1 (en)
HR (1) HRP20181963T1 (en)
HU (1) HUE064945T2 (en)
IL (3) IL293398B2 (en)
IN (1) IN2015KN00414A (en)
LT (1) LT2888281T (en)
MX (1) MX371344B (en)
NZ (3) NZ783258A (en)
PL (3) PL3470432T3 (en)
PT (2) PT4011915T (en)
RS (1) RS58091B1 (en)
RU (1) RU2690675C2 (en)
SG (2) SG11201500889TA (en)
SI (1) SI2888281T1 (en)
TW (1) TWI656880B (en)
UY (1) UY34984A (en)
WO (1) WO2014031610A1 (en)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7608693B2 (en) * 2006-10-02 2009-10-27 Regeneron Pharmaceuticals, Inc. High affinity human antibodies to human IL-4 receptor
PT2624865T (en) 2010-10-06 2018-11-05 Regeneron Pharma Stabilized formulations containing anti-interleukin-4 receptor (il-4r) antibodies
NZ783258A (en) 2012-08-21 2023-06-30 Regeneron Pharma Methods for treating or preventing asthma by administering an il-4r antagonist
SG10201912896YA (en) * 2012-08-21 2020-02-27 Sanofi Biotechnology Methods for treating or preventing asthma by administering an il-4r antagonist
TWI697334B (en) 2013-06-04 2020-07-01 美商再生元醫藥公司 Methods for treating allergy and enhancing allergen-specific immunotherapy by administering an il-4r inhibitor
SI3010539T1 (en) 2013-06-21 2019-11-29 Regeneron Pharma Methods for treating nasal polyposis by administering an il-4r antagonist
TWI634900B (en) 2013-07-11 2018-09-11 再生元醫藥公司 Methods for treating eosinophilic esophagitis by administering an il-4r inhibitor
US9962363B2 (en) 2014-02-10 2018-05-08 Patara Pharma, LLC Mast cell stabilizers treatment for systemic disorders
EP3725311A1 (en) 2014-02-10 2020-10-21 Respivant Sciences GmbH Methods for the treatment of lung diseases with mast cell stabilizers
IL247290B (en) * 2014-02-21 2021-06-30 Sanofi Biotechnology Methods for treating or preventing asthma by administering an il-4r antagonist
IL315136A (en) * 2014-02-21 2024-10-01 Sanofi Biotechnology Methods for treating or preventing asthma by administering an il-4rantagonist
AU2015222951B2 (en) 2014-02-28 2020-06-11 Regeneron Pharmaceuticals, Inc. Methods for treating skin infection by administering an IL-4R antagonist
NO2785538T3 (en) * 2014-05-07 2018-08-04
TW201628647A (en) * 2014-06-27 2016-08-16 賽諾菲公司 Anti-IL4-IL13 bispecific antibodies
MA40164A (en) * 2014-06-27 2017-05-03 Sanofi Sa Anti-il4-il 13 bispecific antibodies
WO2016077675A1 (en) 2014-11-14 2016-05-19 Sanofi Biotechnology Methods for treating chronic sinusitis with nasal polyps by administering an il-4r antagonist
HUE052606T2 (en) * 2014-12-09 2021-05-28 Regeneron Pharma Non-human animals having a humanized cluster of differentiation 274 gene
WO2017027402A1 (en) 2015-08-07 2017-02-16 Patara Pharma, LLC Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders
US10238625B2 (en) 2015-08-07 2019-03-26 Respivant Sciences Gmbh Methods for the treatment of mast cell related disorders with mast cell stabilizers
CN113372446A (en) 2016-06-08 2021-09-10 苏州康乃德生物医药有限公司 Antibodies for binding interleukin-4 receptor
US20180056018A1 (en) * 2016-08-31 2018-03-01 Cephalon, Inc. Inhalation Systems, Devices and Methods
EP3506893A4 (en) 2016-08-31 2020-01-22 Respivant Sciences GmbH Cromolyn compositions for treatment of chronic cough due to idiopathic pulmonary fibrosis
EP3506931B1 (en) * 2016-09-01 2024-07-31 Regeneron Pharmaceuticals, Inc. Methods for preventing or treating allergy by administering an il-4r antagonist
US10485844B2 (en) 2016-09-22 2019-11-26 Regeneron Pharmaceuticals, Inc. Methods for treating severe atopic dermatitis by administering an IL-4R inhibitor
CN109803724A (en) 2016-10-07 2019-05-24 瑞思皮万特科学有限责任公司 For treating the Cromoglycic acid composition of pulmonary fibrosis
EA201991096A1 (en) * 2016-10-31 2019-09-30 Вектура Лимитед INHALABLE POWDER COMPOSITION CONTAINING ANTI-IL-13-ANTIBODY
EP3610041A1 (en) 2017-04-13 2020-02-19 Regeneron Pharmaceuticals, Inc. Treatment and inhibition of inflammatory lung diseases in patients having risk alleles in the genes encoding il33 and il1rl1
CN110770250A (en) 2017-04-21 2020-02-07 金德雷德生物科学股份有限公司 IL4/IL13 receptor molecules for veterinary use
US11053309B2 (en) 2017-08-04 2021-07-06 Regeneron Pharmaceuticals, Inc. Methods for treating active eosinophilic esophagitis
EP3703818B1 (en) 2017-10-30 2023-11-01 Sanofi Biotechnology Il-4r antagonist for use in a method for treating or preventing asthma
US20200397343A1 (en) * 2017-11-15 2020-12-24 Venkata Satya Suresh ATTILI A device and method to determine the mean/average control of asthma/copd over time and compliance to treatment
MA52624A (en) 2018-05-13 2021-03-24 Regeneron Pharma METHODS OF TREATMENT OF ATOPIC DERMATITIS BY ADMINISTRATION OF AN IL-4R INHIBITOR
BR112021002989A2 (en) 2018-08-24 2021-05-11 Jiangsu Hengrui Medicine Co., Ltd. antibody for human il-4r binding, fragment for antigen binding and medical use thereof
CN110872349A (en) 2018-09-04 2020-03-10 三生国健药业（上海）股份有限公司 Antibodies that bind human IL-4R, methods of making, and uses thereof
CN111057721B (en) 2018-10-12 2021-03-16 百奥赛图(北京)医药科技股份有限公司 Preparation method and application of humanized IL-4 and/or IL-4R alpha modified animal model
CN110746507B (en) 2018-12-25 2020-06-26 江苏荃信生物医药有限公司 human interleukin 4 receptor α monoclonal antibody and its application
WO2020135710A1 (en) * 2018-12-27 2020-07-02 中山康方生物医药有限公司 Antibody against human il-4ra and use thereof
US20200283518A1 (en) * 2019-03-06 2020-09-10 Regeneron Pharmaceuticals, Inc. Il-4/il-13 pathway inhibitors for enhanced efficacy in treating cancer
EP3941589A1 (en) 2019-03-21 2022-01-26 Regeneron Pharmaceuticals, Inc. Combination of il-4/il-13 pathway inhibitors and plasma cell ablation for treating allergy
JP2022530533A (en) * 2019-05-01 2022-06-29 サノフィ・バイオテクノロジー Methods for treating or preventing asthma by administering IL-33 antagonists
CN111592597B (en) * 2019-05-29 2022-04-26 山东博安生物技术股份有限公司 Interleukin 4 receptor (IL-4R) binding proteins and uses thereof
CA3147436A1 (en) * 2019-07-16 2021-01-21 Sanofi Biotechnology Methods for treating or preventing asthma by administering an il-4r antagonist
US12090201B2 (en) 2019-08-05 2024-09-17 Regeneron Pharmaceuticals, Inc. Methods for treating atopic dermatitis by administering an IL-4R antagonist antibody
AU2020325021B2 (en) 2019-08-05 2024-05-30 Regeneron Pharmaceuticals, Inc. Methods for treating allergy and enhancing allergen-specific immunotherapy by administering an IL-4R antagonist
IL293487A (en) 2019-12-09 2022-08-01 Sanofi Biotechnology Methods for treating digitally-identified il-4/il-13 related disorders
EP3992974A1 (en) 2020-11-02 2022-05-04 Sanofi Biotechnology Methods for treating digitally-identified il-4/il-13 related disorders
CA3169959A1 (en) 2020-02-21 2021-08-26 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Pharmaceutical composition containing anti-il-4r antibody and use thereof
CN113527485A (en) * 2020-04-17 2021-10-22 上海麦济生物技术有限公司 Anti-human interleukin-4 receptor alpha antibody and preparation method and application thereof
CN111690066B (en) * 2020-06-22 2022-07-22 南京融捷康生物科技有限公司 anti-IL-4R alpha single-domain antibody and application and medicament thereof
US20240075158A1 (en) 2020-12-22 2024-03-07 Jiangsu Hengrui Pharmaceutical Co., Ltd. Complex of anti-il-4r antibody or antigen-binding fragment thereof and medical use thereof
CN118678972A (en) 2022-01-29 2024-09-20 上海盛迪医药有限公司 Pharmaceutical conjugates of glucocorticoids

Family Cites Families (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1356994A (en) 1963-02-08 1964-04-03 Decorative objects and process for their manufacture
GB8808015D0 (en) 1988-04-06 1988-05-05 Ritter M A Chemical compounds
WO1990005183A1 (en) 1988-10-31 1990-05-17 Immunex Corporation Interleukin-4 receptors
CA2108886A1 (en) 1991-05-03 1992-11-04 Thasia G. Woodworth Interleukin receptor targeted molecules for treatment of inflammatory arthritis
JP3315427B2 (en) 1992-03-05 2002-08-19 大日本除蟲菊株式会社 Dermatitis treatment
US5714146A (en) 1992-08-26 1998-02-03 Board Of Regents Of The University Of Washington IL-4 bone therapy
EP0604693A1 (en) 1992-12-29 1994-07-06 Schering-Plough Monoclonal antibodies against the human interleukin-4 receptor and hybridomas producing the same
ZA946875B (en) 1993-09-07 1995-07-06 Smithkline Beecham Corp Recombinant il4 antibodies useful in treatment of il4 mediated disorders
AU766492B2 (en) 1998-09-18 2003-10-16 Dynavax Technologies Corporation Methods of treating IgE-associated disorders and compositions for use therein
US6927044B2 (en) 1998-09-25 2005-08-09 Regeneron Pharmaceuticals, Inc. IL-1 receptor based cytokine traps
WO2001092340A2 (en) 2000-05-26 2001-12-06 Immunex Corporation Use of interleukin-4 antagonists and compositions thereof
US7879328B2 (en) 2000-06-16 2011-02-01 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to B lymphocyte stimulator
DE60130466T2 (en) 2000-07-26 2008-06-12 Hououdou Co. Ltd. ANTIPRURITIC COMPOSITIONS AND WOUND HEALING COMPOSITIONS
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
ATE293109T1 (en) 2001-01-31 2005-04-15 Pfizer Prod Inc NICOTINIC ACID AMIDE DERIVATIVES AND THEIR MIMETICS AS INHIBITORS OF PDE4 ISOZYMS
US8178098B2 (en) 2001-04-03 2012-05-15 National Jewish Health Method to inhibit airway hyperresponsiveness using aerosolized T cell receptor antibodies
US20030103938A1 (en) 2001-05-09 2003-06-05 Alk-Abello A/S Pharmaceutical compositions for preventing or treating Th1 and Th2 cell related diseases by modulating the Th1/Th2 ratio
US20050031609A1 (en) 2001-05-11 2005-02-10 Thomas Hultsch Compositions for use in treating ige-associated disorders
AU2002339121B2 (en) 2001-05-23 2007-03-22 Duotol Ab Suppression of allergic reactions by transdermal administration of allergens in conjunction with or conjugated to toxin subunits or fragments thereof
ATE517855T1 (en) 2001-11-30 2011-08-15 Biogen Idec Inc ANTIBODIES TO CHEMOTACTIC MONOCYTE PROTEINS
CA2479927C (en) 2002-03-29 2013-03-12 Schering Corporation Human monoclonal antibodies to interleukin-5 and methods and compositions comprising same
AU2003280324A1 (en) 2002-11-26 2004-06-18 Alk-Abello A/S Pharmaceutical allergen product
JP2006516408A (en) 2003-02-01 2006-07-06 タノックス インコーポレーテッド Method for generating high affinity antibodies
US7923209B2 (en) 2003-03-14 2011-04-12 Anergis, S.A. Allergen peptide fragments and use thereof
US7208579B2 (en) 2003-05-30 2007-04-24 The Regents Of The University Of California IL4 receptor antagonists for horse, dog and cat
CN1856325A (en) * 2003-09-23 2006-11-01 Pdl生物制药股份有限公司 Treatment of respiratory diseases with anti-IL-2 receptor antibodies
AU2004290017B2 (en) 2003-11-07 2012-05-03 Immunex Corporation Antibodies that bind interleukin-4 receptor
CA2550933A1 (en) 2003-12-22 2005-07-14 Amgen Inc. Methods for identifying functional antibodies
DE602005006758D1 (en) 2004-02-27 2008-06-26 Regeneron Pharma IL-4 / IL-13-specific polypeptides and their therapeutic use
US20090098142A1 (en) 2004-06-09 2009-04-16 Kasaian Marion T Methods and compositions for treating and monitoring treatment of IL-13-associated disorders
TWI307630B (en) 2004-07-01 2009-03-21 Glaxo Group Ltd Immunoglobulins
JP5234445B2 (en) 2004-10-05 2013-07-10 源一郎 杣 Drug
WO2006083390A2 (en) 2004-12-07 2006-08-10 Children's Hospital Medical Center Eotaxin-3 in eosinophilic esophagitis
TW200902555A (en) 2005-01-03 2009-01-16 Hoffmann La Roche Antibodies against IL-13 receptor alpha 1 and uses thereof
US8679545B2 (en) 2005-11-12 2014-03-25 The Regents Of The University Of California Topical corticosteroids for the treatment of inflammatory diseases of the gastrointestinal tract
US8324192B2 (en) 2005-11-12 2012-12-04 The Regents Of The University Of California Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract
WO2007085815A2 (en) 2006-01-24 2007-08-02 Domantis Limited Ligands that bind il-4 and/or il-13
RS52176B (en) 2006-06-02 2012-08-31 Regeneron Pharmaceuticals Inc. High affinity antibodies to human il-6 receptor
JP5395662B2 (en) 2006-07-21 2014-01-22 ビーエーエスエフ コーポレーション Synthetic mica-based ferrite-containing pearlescent pigments
JP4221018B2 (en) 2006-08-31 2009-02-12 トヨタ自動車株式会社 Head protection airbag device
MY149079A (en) 2006-10-02 2013-07-15 Regeneron Pharma High affinity human antibodies to human il-4 receptor
US7608693B2 (en) * 2006-10-02 2009-10-27 Regeneron Pharmaceuticals, Inc. High affinity human antibodies to human IL-4 receptor
US20100144646A1 (en) 2006-11-03 2010-06-10 Blake Paterson Method of diagnosing and treating asthma
EP2022507A1 (en) 2007-08-07 2009-02-11 Universität Hamburg Antibody compositions specific for lgE, lgG4 and lgA epitopes as tools for the design of hypoallergenic molecules for specific immunotherapy
US20090062168A1 (en) 2007-08-27 2009-03-05 Joseph Timar Process for making a two-cycle gasoline engine lubricant
EP2050764A1 (en) 2007-10-15 2009-04-22 sanofi-aventis Novel polyvalent bispecific antibody format and uses thereof
US8637239B2 (en) 2007-11-05 2014-01-28 The Board Of Trustees Of The University Of Illinois Minimally-invasive measurement of esophageal inflammation
ES2518415T3 (en) 2007-12-21 2014-11-05 Medimmune Limited Binding elements for interleukin-4 alpha receptor (IL-4Ralfa)
US8092804B2 (en) 2007-12-21 2012-01-10 Medimmune Limited Binding members for interleukin-4 receptor alpha (IL-4Rα)-173
US20110008326A1 (en) 2008-04-02 2011-01-13 Oliver Hill Binding agents directed against il-4 receptor for the treatment of tumors, inflammatory and immunological disorders
DE202008006598U1 (en) 2008-04-11 2008-10-02 Alk-Abelló A/S Allergy vaccine formulation for mucosal administration
US20090264392A1 (en) 2008-04-21 2009-10-22 Meritage Pharma, Inc. Treating eosinophilic esophagitis
US20120004205A1 (en) 2008-12-01 2012-01-05 Cincinnati Children's Hospital Medical Center Il-13 induced gene signature for eosinophilic esophagitis
EP2414520A2 (en) 2009-03-31 2012-02-08 Altair Therapeutics, Inc. Methods of modulating an immune response to a viral infection
US8497528B2 (en) 2010-05-06 2013-07-30 Taiwan Semiconductor Manufacturing Company, Ltd. Method for fabricating a strained structure
EP2475382B1 (en) 2009-09-07 2015-01-14 DBV Technologies Method of treating eosinophilic esophagitis
CN102859288B (en) 2010-03-16 2016-09-28 阿桑尼特有限责任公司 It is applicable to reduce and is exposed to anaphylactogen and other airborne subparticle in personal breathing district and improves the temperature control type laminar airflow of sleep quality
WO2011156000A2 (en) 2010-06-07 2011-12-15 Aerovance, Inc. Use of il-4/il-13 antagonists to treat eosinophilic disorders
KR20130050952A (en) 2010-06-16 2013-05-16 브루스 챈들러 메이 Use of levocetirizine and montelukast in the treatment of influenza, common cold and inflammation
ES2894936T3 (en) 2010-06-24 2022-02-16 Viropharma Biologics Llc Treatment methods for inflammation of the esophagus
PT2624865T (en) 2010-10-06 2018-11-05 Regeneron Pharma Stabilized formulations containing anti-interleukin-4 receptor (il-4r) antibodies
UA111731C2 (en) 2010-10-06 2016-06-10 Рідженерон Фармасьютікалз, Інк. STABILIZED COMPOSITION CONTAINING ANTIBODY TO INTERLAYKIN-4 (IL-4R) RECEPTOR, OPTIONS
WO2012049278A1 (en) * 2010-10-15 2012-04-19 Medimmune Limited Therapies for improving pulmonary function
CA2824043A1 (en) 2011-01-06 2012-07-12 Marc E. Rothenberg Esophageal cytokine expression profiles in eosinophilic esophagitis
US20130052190A1 (en) 2011-02-22 2013-02-28 Oxagen Limited CRTH2 Antagonists for Treatment of Eosinophilic Diseases and Conditions
US9928344B2 (en) 2011-06-21 2018-03-27 Children's Hospital Medical Center Diagnostic methods of eosinophilic esophagitis
KR20130011821A (en) 2011-07-22 2013-01-30 삼성전자주식회사 Method and apparatus for providing transaction related service
US20140303067A1 (en) 2011-10-06 2014-10-09 N.V. Nutricia Treatment of eosinophilic esophagitis
CA2853858A1 (en) 2011-11-01 2013-05-10 Medimmune, Llc Methods for reducing the frequency and severity of acute exacerbations of asthma
WO2013088109A1 (en) 2011-12-16 2013-06-20 Oxagen Limited Combination of crth2 antagonist and a proton pump inhibitor for the treatment of eosinophilic esophagitis
EP2677838B1 (en) 2012-06-18 2017-12-06 Whirlpool Corporation Microwave heating apparatus
NZ783258A (en) 2012-08-21 2023-06-30 Regeneron Pharma Methods for treating or preventing asthma by administering an il-4r antagonist
SG10201701798TA (en) 2012-09-07 2017-04-27 Regeneron Pharma Methods for treating atopic dermatitis by administering an il-4r antagonist
CN103674979B (en) 2012-09-19 2016-12-21 同方威视技术股份有限公司 A kind of luggage and articles CT safe examination system and detector assembly thereof
US10132809B2 (en) 2012-10-10 2018-11-20 Rhote Island Hospital Differential expression of protein markers for the diagnosis and treatment of eosinophilic esophagitis
JO3532B1 (en) 2013-03-13 2020-07-05 Regeneron Pharma Anti-il-33 antibodies and uses thereof
TWI697334B (en) 2013-06-04 2020-07-01 美商再生元醫藥公司 Methods for treating allergy and enhancing allergen-specific immunotherapy by administering an il-4r inhibitor
SI3010539T1 (en) 2013-06-21 2019-11-29 Regeneron Pharma Methods for treating nasal polyposis by administering an il-4r antagonist
TWI634900B (en) 2013-07-11 2018-09-11 再生元醫藥公司 Methods for treating eosinophilic esophagitis by administering an il-4r inhibitor
IL315136A (en) 2014-02-21 2024-10-01 Sanofi Biotechnology Methods for treating or preventing asthma by administering an il-4rantagonist
AU2015222951B2 (en) 2014-02-28 2020-06-11 Regeneron Pharmaceuticals, Inc. Methods for treating skin infection by administering an IL-4R antagonist
WO2016077675A1 (en) 2014-11-14 2016-05-19 Sanofi Biotechnology Methods for treating chronic sinusitis with nasal polyps by administering an il-4r antagonist
CN109069625A (en) 2016-02-19 2018-12-21 瑞泽恩制药公司 Enhance the method for efficacy of vaccines by application IL-4R antagonist
EP3506931B1 (en) 2016-09-01 2024-07-31 Regeneron Pharmaceuticals, Inc. Methods for preventing or treating allergy by administering an il-4r antagonist
US10485844B2 (en) 2016-09-22 2019-11-26 Regeneron Pharmaceuticals, Inc. Methods for treating severe atopic dermatitis by administering an IL-4R inhibitor
TWI784988B (en) 2016-12-01 2022-12-01 美商再生元醫藥公司 Methods of treating inflammatory conditions
US11053309B2 (en) 2017-08-04 2021-07-06 Regeneron Pharmaceuticals, Inc. Methods for treating active eosinophilic esophagitis
EP3703818B1 (en) 2017-10-30 2023-11-01 Sanofi Biotechnology Il-4r antagonist for use in a method for treating or preventing asthma
US20210214794A1 (en) 2018-05-22 2021-07-15 Ald-Abelló A/S Biomarker methods for treatment of atopic disease by immunotherapy
CN113166259A (en) 2018-11-09 2021-07-23 亚洲大学校产学协力团 Human antibodies with high affinity for human IL-4 receptor alpha and uses thereof
JP2022530533A (en) 2019-05-01 2022-06-29 サノフィ・バイオテクノロジー Methods for treating or preventing asthma by administering IL-33 antagonists
CA3147436A1 (en) 2019-07-16 2021-01-21 Sanofi Biotechnology Methods for treating or preventing asthma by administering an il-4r antagonist
IL293487A (en) 2019-12-09 2022-08-01 Sanofi Biotechnology Methods for treating digitally-identified il-4/il-13 related disorders
EP4225436A1 (en) 2020-10-05 2023-08-16 Sanofi Biotechnology Methods for treating asthma in pediatric subjects by administering an il-4r antagonist
WO2023009437A1 (en) 2021-07-26 2023-02-02 Sanofi Biotechnology Methods for treating chronic spontaneous urticaria by administering an il-4r antagonist
WO2023069976A1 (en) 2021-10-20 2023-04-27 Sanofi Biotechnology Methods for treating prurigo nodularis by administering an il-4r antagonist

Also Published As

Publication number Publication date
EP4011915B1 (en) 2023-10-11
IL293398A (en) 2022-07-01
RU2018128137A (en) 2018-10-08
CN110624107A (en) 2019-12-31
PL4011915T3 (en) 2024-04-08
MX2015002292A (en) 2015-10-09
TWI656880B (en) 2019-04-21
US20180016343A1 (en) 2018-01-18
RS58091B1 (en) 2019-02-28
IL312711A (en) 2024-07-01
US11845800B2 (en) 2023-12-19
CA2882416A1 (en) 2014-02-27
MX371344B (en) 2020-01-27
KR20150044909A (en) 2015-04-27
UY34984A (en) 2014-03-31
EP2888281B1 (en) 2018-09-19
HRP20181963T1 (en) 2019-02-08
EP4011915B8 (en) 2023-11-15
NZ744109A (en) 2023-01-27
NZ631562A (en) 2017-03-31
KR102679182B1 (en) 2024-06-28
SG10201701331SA (en) 2017-04-27
KR102386304B1 (en) 2022-04-14
PL2888281T3 (en) 2019-03-29
SG11201500889TA (en) 2015-03-30
AU2013305945A1 (en) 2015-03-12
RU2690675C2 (en) 2019-06-05
BR112015003590A2 (en) 2017-08-22
WO2014031610A8 (en) 2014-11-20
EP4324479A2 (en) 2024-02-21
EP4011915A1 (en) 2022-06-15
AR092177A1 (en) 2015-03-25
AU2024205683A1 (en) 2024-09-19
PL3470432T3 (en) 2022-02-07
RU2015109716A (en) 2016-10-10
EP3470432B1 (en) 2021-10-06
PT4011915T (en) 2024-01-02
ES2900342T3 (en) 2022-03-16
AU2020277207A1 (en) 2020-12-24
LT2888281T (en) 2018-12-27
IL293398B1 (en) 2024-06-01
EP3470432A1 (en) 2019-04-17
US20240199751A1 (en) 2024-06-20
PT3470432T (en) 2021-12-14
JP2018109056A (en) 2018-07-12
TW201420116A (en) 2014-06-01
NZ727717A (en) 2021-09-24
AU2018253544B2 (en) 2020-09-17
EP4324479A3 (en) 2024-04-24
KR20220049621A (en) 2022-04-21
ES2701093T3 (en) 2019-02-20
US20140056920A1 (en) 2014-02-27
IL237258A0 (en) 2015-04-30
JP6306588B2 (en) 2018-04-04
AU2020277207B2 (en) 2024-05-16
SI2888281T1 (en) 2019-03-29
AU2013305945B2 (en) 2018-07-26
JP2015527364A (en) 2015-09-17
KR102502640B1 (en) 2023-02-23
WO2014031610A1 (en) 2014-02-27
HK1211605A1 (en) 2016-05-27
IL293398B2 (en) 2024-10-01
US9574004B2 (en) 2017-02-21
HUE064945T2 (en) 2024-04-28
JP2023052457A (en) 2023-04-11
AU2018253544A1 (en) 2018-11-22
KR102307248B1 (en) 2021-10-01
NZ783258A (en) 2023-06-30
ES2971088T3 (en) 2024-06-03
EP2888281A1 (en) 2015-07-01
KR20240101727A (en) 2024-07-02
KR20210118976A (en) 2021-10-01
RU2018128137A3 (en) 2022-02-10
IL237258B (en) 2019-12-31
CN104755495A (en) 2015-07-01
DK2888281T3 (en) 2019-01-07
BR112015003590A8 (en) 2017-10-31
KR20230028592A (en) 2023-02-28

Similar Documents

Publication Publication Date Title
IN2015KN00414A (en)
MX2020010535A (en) Methods of treating cancer.
MX2021008113A (en) Methods for treating or preventing asthma by administering an il-4r antagonist.
MX2013011908A (en) Compositions and therapeutic uses of ikk-related kinase epsilon and tankbinding kinase 1 inhibitors.
MX2021002406A (en) Methods for treating eosinophilic esophagitis by administering an il-4r inhibitor.
IN2014DN10386A (en)
PH12015500825A1 (en) Substituted benzene compounds
NZ707086A (en) Anti-cd40 antibodies and methods of use
MX344530B (en) Substituted benzene compounds.
PH12014501351A1 (en) Fluorinated estrogen receptor modulators and uses thereof
MD20150035A2 (en) Bruton's tyrosine kinase inhibitors
SG194701A1 (en) Anti-cd40 antibodies and methods of use
IN2015DN03219A (en)
MX370017B (en) Heterobicyclo-substituted-[1,2,4]triazolo[1,5-c]quinazolin-5-ami ne compounds with a2a antagonist properties.
JO3784B1 (en) Combined use of anti pd-1 and anti m-csf antibodies in the treatment of cancer
MX2019001977A (en) Methods and compositions for treating multiple sclerosis and related disorders.
MX2014000964A (en) Substituted heterocyclic aza derivatives.
MX2013002118A (en) Substituted 2-oxy-quinoline-3-carboxamides as kcnq2/3 modulators.
MX342459B (en) Substituted 2-oxo- and 2-thioxo-dihydroquinoline-3-carboxamides as kcnq2/3 modulators.
MX2013002295A (en) Substituted 1-oxo-dihydroisoquinoline-3-carboxamides as kcnq2/3 modulators.
MX2019009243A (en) Methods for treating or preventing asthma by administering an il-4r antagonist.
NZ745950A (en) Methods and compositions for treating multiple sclerosis and related disorders