JP2015519890A5 - - Google Patents
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- JP2015519890A5 JP2015519890A5 JP2015509079A JP2015509079A JP2015519890A5 JP 2015519890 A5 JP2015519890 A5 JP 2015519890A5 JP 2015509079 A JP2015509079 A JP 2015509079A JP 2015509079 A JP2015509079 A JP 2015509079A JP 2015519890 A5 JP2015519890 A5 JP 2015519890A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- natural killer
- culturing
- item
- serum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 238000000034 method Methods 0.000 claims description 63
- 210000000130 stem cell Anatomy 0.000 claims description 33
- 210000000822 natural killer cell Anatomy 0.000 claims description 32
- 238000012258 culturing Methods 0.000 claims description 29
- 239000012679 serum free medium Substances 0.000 claims description 29
- 210000002242 embryoid body Anatomy 0.000 claims description 20
- 210000004027 cell Anatomy 0.000 claims description 19
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims description 15
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims description 15
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims description 11
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims description 10
- 238000004519 manufacturing process Methods 0.000 claims description 10
- 108010049955 Bone Morphogenetic Protein 4 Proteins 0.000 claims description 8
- 102100024505 Bone morphogenetic protein 4 Human genes 0.000 claims description 8
- 102000003812 Interleukin-15 Human genes 0.000 claims description 8
- 108090000172 Interleukin-15 Proteins 0.000 claims description 8
- 102000000588 Interleukin-2 Human genes 0.000 claims description 8
- 108010002350 Interleukin-2 Proteins 0.000 claims description 8
- 102000000646 Interleukin-3 Human genes 0.000 claims description 8
- 108010002386 Interleukin-3 Proteins 0.000 claims description 8
- 102000000704 Interleukin-7 Human genes 0.000 claims description 8
- 108010002586 Interleukin-7 Proteins 0.000 claims description 8
- 102000002698 KIR Receptors Human genes 0.000 claims description 8
- 108010043610 KIR Receptors Proteins 0.000 claims description 8
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims description 8
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims description 8
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims description 8
- 229940076264 interleukin-3 Drugs 0.000 claims description 8
- 229940100994 interleukin-7 Drugs 0.000 claims description 8
- 210000002536 stromal cell Anatomy 0.000 claims description 8
- 102100020715 Fms-related tyrosine kinase 3 ligand protein Human genes 0.000 claims description 7
- 101710162577 Fms-related tyrosine kinase 3 ligand protein Proteins 0.000 claims description 7
- 238000004220 aggregation Methods 0.000 claims description 7
- 230000002776 aggregation Effects 0.000 claims description 7
- 210000001778 pluripotent stem cell Anatomy 0.000 claims description 7
- 101000608935 Homo sapiens Leukosialin Proteins 0.000 claims description 5
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 claims description 5
- 102100039564 Leukosialin Human genes 0.000 claims description 5
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 claims description 5
- 210000000612 antigen-presenting cell Anatomy 0.000 claims description 5
- 238000003501 co-culture Methods 0.000 claims description 5
- 210000001671 embryonic stem cell Anatomy 0.000 claims description 5
- 239000002609 medium Substances 0.000 claims description 5
- 241000701022 Cytomegalovirus Species 0.000 claims description 4
- 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 claims description 4
- 101000917839 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-B Proteins 0.000 claims description 4
- 101001109501 Homo sapiens NKG2-D type II integral membrane protein Proteins 0.000 claims description 4
- 101000589305 Homo sapiens Natural cytotoxicity triggering receptor 2 Proteins 0.000 claims description 4
- 101000581981 Homo sapiens Neural cell adhesion molecule 1 Proteins 0.000 claims description 4
- 241000701085 Human alphaherpesvirus 3 Species 0.000 claims description 4
- 241000701044 Human gammaherpesvirus 4 Species 0.000 claims description 4
- 241000725303 Human immunodeficiency virus Species 0.000 claims description 4
- 102100029185 Low affinity immunoglobulin gamma Fc region receptor III-B Human genes 0.000 claims description 4
- 102100022680 NKG2-D type II integral membrane protein Human genes 0.000 claims description 4
- 108010004217 Natural Cytotoxicity Triggering Receptor 1 Proteins 0.000 claims description 4
- 102100032870 Natural cytotoxicity triggering receptor 1 Human genes 0.000 claims description 4
- 102100032851 Natural cytotoxicity triggering receptor 2 Human genes 0.000 claims description 4
- 102100027347 Neural cell adhesion molecule 1 Human genes 0.000 claims description 4
- 102000036366 SCF complex Human genes 0.000 claims description 4
- 108091007047 SCF complex Proteins 0.000 claims description 4
- 241000700584 Simplexvirus Species 0.000 claims description 4
- 230000004931 aggregating effect Effects 0.000 claims description 4
- 239000003102 growth factor Substances 0.000 claims description 4
- 239000002243 precursor Substances 0.000 claims description 4
- 241000700721 Hepatitis B virus Species 0.000 claims description 3
- 238000009169 immunotherapy Methods 0.000 claims description 3
- 230000001939 inductive effect Effects 0.000 claims description 3
- 206010028980 Neoplasm Diseases 0.000 claims description 2
- 208000036142 Viral infection Diseases 0.000 claims description 2
- 201000011510 cancer Diseases 0.000 claims description 2
- 230000000415 inactivating effect Effects 0.000 claims description 2
- 208000015181 infectious disease Diseases 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 230000009385 viral infection Effects 0.000 claims description 2
- 241000711549 Hepacivirus C Species 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 108091000080 Phosphotransferase Proteins 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 102000020233 phosphotransferase Human genes 0.000 claims 1
- 230000004523 agglutinating effect Effects 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261637592P | 2012-04-24 | 2012-04-24 | |
| US61/637,592 | 2012-04-24 | ||
| PCT/US2013/037782 WO2013163171A1 (en) | 2012-04-24 | 2013-04-23 | Method for developing natural killer cells from stem cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017115944A Division JP6529541B2 (ja) | 2012-04-24 | 2017-06-13 | 幹細胞よりナチュラルキラー細胞を発生させる方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015519890A JP2015519890A (ja) | 2015-07-16 |
| JP2015519890A5 true JP2015519890A5 (enExample) | 2016-06-23 |
| JP6339998B2 JP6339998B2 (ja) | 2018-06-06 |
Family
ID=48289670
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015509079A Active JP6339998B2 (ja) | 2012-04-24 | 2013-04-23 | 幹細胞よりナチュラルキラー細胞を発生させる方法 |
| JP2017115944A Active JP6529541B2 (ja) | 2012-04-24 | 2017-06-13 | 幹細胞よりナチュラルキラー細胞を発生させる方法 |
| JP2019091121A Pending JP2019122415A (ja) | 2012-04-24 | 2019-05-14 | 幹細胞よりナチュラルキラー細胞を発生させる方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017115944A Active JP6529541B2 (ja) | 2012-04-24 | 2017-06-13 | 幹細胞よりナチュラルキラー細胞を発生させる方法 |
| JP2019091121A Pending JP2019122415A (ja) | 2012-04-24 | 2019-05-14 | 幹細胞よりナチュラルキラー細胞を発生させる方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9260696B2 (enExample) |
| EP (2) | EP2841563B1 (enExample) |
| JP (3) | JP6339998B2 (enExample) |
| AU (3) | AU2013251785B2 (enExample) |
| WO (1) | WO2013163171A1 (enExample) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013163171A1 (en) * | 2012-04-24 | 2013-10-31 | Kaufman Dan S | Method for developing natural killer cells from stem cells |
| DK2981607T3 (da) * | 2013-04-03 | 2020-11-16 | Memorial Sloan Kettering Cancer Center | Effektiv generering af tumormålrettede t-celler afledt af pluripotente stamceller |
| US10626372B1 (en) * | 2015-01-26 | 2020-04-21 | Fate Therapeutics, Inc. | Methods and compositions for inducing hematopoietic cell differentiation |
| WO2016143826A1 (ja) * | 2015-03-09 | 2016-09-15 | 学校法人慶應義塾 | 多能性幹細胞を所望の細胞型へ分化する方法 |
| CN105517672B (zh) * | 2015-05-26 | 2019-06-21 | 中国科学院广州生物医药与健康研究院 | 一种人原代细胞培养基及其应用 |
| PL412787A1 (pl) * | 2015-06-22 | 2017-01-02 | Magdalena Król | Oparty na makrofagach celowany system dostarczania związków związanych z ferrytyną |
| US10736963B2 (en) * | 2015-07-24 | 2020-08-11 | Innate Pharma | Methods for detecting tissue infiltrating NK cells |
| ES2922475T3 (es) * | 2015-09-08 | 2022-09-15 | Sumitomo Pharma Co Ltd | Método para producir células epiteliales pigmentarias de la retina |
| CN108473961B (zh) | 2015-11-04 | 2022-11-29 | 菲特治疗公司 | 用于诱导造血细胞分化的方法和组合物 |
| KR20250141836A (ko) | 2015-11-04 | 2025-09-29 | 페이트 세러퓨틱스, 인코포레이티드 | 만능 세포의 유전자 조작 |
| CN105296428A (zh) * | 2015-12-03 | 2016-02-03 | 广州医科大学附属第三医院 | 一种提高诱导多能干细胞的体外分化造血效率的方法 |
| EP3827838B1 (en) | 2015-12-16 | 2023-06-07 | The Walter and Eliza Hall Institute of Medical Research | Inhibition of cytokine-induced sh2 protein in nk cells |
| US20190161726A1 (en) * | 2016-07-29 | 2019-05-30 | Daikin Industries, Ltd. | Differentiated cell production method and culture bag used therefor |
| WO2018047941A1 (ja) * | 2016-09-08 | 2018-03-15 | 協和発酵バイオ株式会社 | 幹細胞培養用培地、幹細胞の培養方法、幹細胞の増殖促進剤、並びに細胞組成物およびその製造方法 |
| WO2018147801A1 (en) * | 2017-02-07 | 2018-08-16 | Agency For Science, Technology And Research | Methods and kits for generating mimetic innate immune cells from pluripotent stem cells |
| US11696927B2 (en) * | 2017-02-28 | 2023-07-11 | University Of Central Florida Research Foundation, Inc. | PM21 particles to improve bone marrow homing of NK cells |
| CA3055706A1 (en) | 2017-03-08 | 2018-09-13 | Sumitomo Dainippon Pharma Co., Ltd. | Method for producing retinal pigment epithelial cells |
| CN119955724A (zh) * | 2017-03-21 | 2025-05-09 | 法国血液机构 | 改进造血移植物的方法 |
| KR102167548B1 (ko) * | 2017-09-21 | 2020-10-19 | 한국생명공학연구원 | 자연살해세포의 제조방법 및 그의 용도 |
| KR102833956B1 (ko) * | 2017-12-08 | 2025-07-15 | 주노 쎄러퓨티크스 인코퍼레이티드 | 세포를 배양하기 위한 무혈청 배지 제형 및 이의 사용 방법 |
| EP3746095A4 (en) | 2018-02-01 | 2021-04-21 | Nkmax Co., Ltd. | Method of producing natural killer cells and composition for treating cancer |
| DK3755347T3 (da) * | 2018-02-21 | 2025-08-04 | Univ Texas | Universelle antigenpræsenterende celler og anvendelser deraf |
| EP3755349A4 (en) | 2018-02-21 | 2021-11-17 | Board of Regents, The University of Texas System | PROCESS FOR ACTIVATION AND EXPANSION OF NATURAL KILLER CELLS AND THEIR USES |
| WO2020037303A1 (en) | 2018-08-16 | 2020-02-20 | The Regents Of The University Of California | Chemically and photochemically initiated cell membrane blebbing to induce cell vesicle production, modifications thereof, and uses thereof |
| KR20210052494A (ko) | 2018-08-27 | 2021-05-10 | 아피메트 게엠베하 | 항체 구조물이 사전 로드된 동결 보존된 nk 세포 |
| CA3109546A1 (en) * | 2018-09-07 | 2020-03-12 | Wisconsin Alumni Research Foundation | Generation of hematopoietic progenitor cells from human pluripotent stem cells |
| WO2020180744A1 (en) * | 2019-03-01 | 2020-09-10 | The Regents Of The University Of California | Natural killer cell induced cellular vesicles for cancer therapy |
| CN113874493B (zh) * | 2019-03-28 | 2024-05-10 | 韩国生命工学研究院 | 用于产生引入了car基因的nk细胞的方法及其用途 |
| RU2731293C1 (ru) | 2019-04-12 | 2020-09-01 | Игорь Петрович Белецкий | Способ получения генно-модифицированных линий клеток натуральных киллеров с нокаутированным геном PD-1 и повышенной экспрессией белков семейства Фактора Некроза Опухолей для иммунотерапии онкологических заболеваний |
| US20220154144A1 (en) * | 2019-04-26 | 2022-05-19 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Artificial antigen presenting cells comprising ligands for nkg2d for expanding immune cells for immunotherapy |
| JP7479466B2 (ja) * | 2019-11-13 | 2024-05-08 | カリス バイオ インコーポレイテッド | 血管内皮細胞純粋分離方法、血管内皮細胞特性維持培地及びそれを含む培養方法 |
| CN111235105B (zh) * | 2020-03-06 | 2021-08-10 | 安徽中盛溯源生物科技有限公司 | 一种从人多能干细胞分化为自然杀伤细胞的方法及应用 |
| JP2023517220A (ja) * | 2020-03-11 | 2023-04-24 | リサーチ インスティテュート アット ネイションワイド チルドレンズ ホスピタル | 微生物感染症の治療のためのｎｋ細胞およびそれらの使用 |
| US11547726B2 (en) | 2020-03-26 | 2023-01-10 | Honed Life Sciences, Llc | Enhancement of production of NK cells from stem cells |
| JPWO2021256522A1 (enExample) | 2020-06-17 | 2021-12-23 | ||
| CA3174380A1 (en) * | 2020-07-27 | 2022-02-03 | Stemcell Technologies Canada Inc. | Systems and methods for differentiating hematopoietic cells |
| US11591381B2 (en) | 2020-11-30 | 2023-02-28 | Crispr Therapeutics Ag | Gene-edited natural killer cells |
| CN112608895B (zh) * | 2020-12-18 | 2024-02-27 | 深圳市济因生物科技有限公司 | 一种人多能干细胞分化的自然杀伤细胞及其制备方法与应用 |
| EP4271798A1 (en) | 2020-12-30 | 2023-11-08 | CRISPR Therapeutics AG | Compositions and methods for differentiating stem cells into nk cells |
| WO2022226337A1 (en) * | 2021-04-22 | 2022-10-27 | Artec Biotech, Inc. | Method for producing hematopoietic cells from stem cells using vascular organoids |
| US20230016422A1 (en) | 2021-06-23 | 2023-01-19 | Crispr Therapeutics Ag | Engineered cells with improved protection from natural killer cell killing |
| CN115261318B (zh) * | 2021-09-29 | 2024-05-28 | 苏州艾凯利元生物科技有限公司 | 产生自然杀伤细胞的方法 |
| WO2023076348A1 (en) * | 2021-10-27 | 2023-05-04 | The Regents Of The University Of California | Combination of human natural killer cells and macrophages for cancer therapy |
| CN113957048A (zh) * | 2021-10-29 | 2022-01-21 | 深圳市默赛尔生物医学科技发展有限公司 | 一种利用脐带血单个核细胞生产自然杀伤细胞的方法 |
| CN119137261A (zh) | 2021-12-17 | 2024-12-13 | 优莫佳生物制药股份有限公司 | 细胞毒性先天淋巴样细胞及其用途 |
| CN114507641B (zh) * | 2022-04-20 | 2022-07-12 | 山东兴瑞生物科技有限公司 | 一种由人胚胎干细胞诱导分化为nk细胞的方法 |
| WO2023233342A2 (en) | 2022-06-01 | 2023-12-07 | Crispr Therapeutics Ag | Gene-edited natural killer cells |
| IL317466A (en) * | 2022-06-09 | 2025-02-01 | Umoja Biopharma Inc | Compounds and methods for NK cell differentiation |
| CN115058387B (zh) * | 2022-06-11 | 2023-12-01 | 重庆医科大学 | 一种人胚胎干细胞与前列腺癌细胞共培养制备抗前列腺癌药物的方法 |
| CN119923463A (zh) * | 2022-07-27 | 2025-05-02 | 优莫佳生物制药股份有限公司 | 在悬浮培养中分化干细胞 |
| WO2024101862A1 (ko) * | 2022-11-07 | 2024-05-16 | 마루테라퓨틱스 주식회사 | Nk 세포의 분화 효율 및 기능성 증가를 위한 배양 방법 |
| WO2024101863A1 (ko) * | 2022-11-07 | 2024-05-16 | 마루테라퓨틱스 주식회사 | 줄기세포 기원 및 발현 마커에 따른 nk 세포 분화 효율 증진 방법 |
| WO2024101919A1 (ko) * | 2022-11-10 | 2024-05-16 | 의료법인 성광의료재단 | 전분화능 줄기세포에서 자연살해세포로의 분화 유도용 배지 조성물 및 이를 이용한 분화 방법 |
| TW202506996A (zh) * | 2023-04-27 | 2025-02-16 | 日商武田藥品工業股份有限公司 | 擴增ｃｄ５６＋／ｃｄ３－細胞之方法 |
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| EP0187371B1 (en) | 1984-12-27 | 1991-06-19 | Asahi Kasei Kogyo Kabushiki Kaisha | Substituted isoquinolinesulfonyl compounds |
| US6355476B1 (en) | 1988-11-07 | 2002-03-12 | Advanced Research And Technologyinc | Nucleic acid encoding MIP-1α Lymphokine |
| ES2201177T3 (es) | 1995-03-08 | 2004-03-16 | The Scripps Research Institute | Sistema de presentacion de antigenos y activacion de celulas-t. |
| CA2254975C (en) | 1996-05-23 | 2008-12-16 | The Scripps Research Institute | Mhc class ii antigen-presenting systems and methods for activating cd4+ t cells |
| EP0986635A4 (en) | 1997-01-10 | 2001-11-07 | Life Technologies Inc | SERUM SUBSTITUTE FOR EMBRYONIC STEM CELLS |
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| GB0206860D0 (en) | 2002-03-22 | 2002-05-01 | Glaxo Group Ltd | Compounds |
| CA2785889A1 (en) | 2002-04-22 | 2003-10-30 | The Board Of Trustees Of The Leland Stanford Junior University | Peptide inhibitors of protein kinase c |
| ES2383813T3 (es) | 2004-09-08 | 2012-06-26 | Wisconsin Alumni Research Foundation | Método de cultivo y cultivo de células madre embrionarias |
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| JP5543207B2 (ja) | 2006-10-04 | 2014-07-09 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 不活性化された人工抗原提示細胞の調製および細胞治療におけるそれらの使用 |
| WO2009135206A1 (en) | 2008-05-02 | 2009-11-05 | Stem Cell Products, Inc. | Method for production of mast cells from stem cells |
| KR101720961B1 (ko) | 2009-02-27 | 2017-03-29 | 셀룰러 다이내믹스 인터내셔널, 인코포레이티드 | 다능성 세포의 분화 |
| RU2012127811A (ru) * | 2009-12-04 | 2014-01-10 | Стем Селл Энд Ридженерэйтив Медсин Интернэшнл, Инк. | Способ получения клеток-натуральных киллеров и дендритных клеток из человеческих эмбриональных гемангиобластов, полученных из стволовых клеток |
| WO2013163171A1 (en) * | 2012-04-24 | 2013-10-31 | Kaufman Dan S | Method for developing natural killer cells from stem cells |
-
2013
- 2013-04-23 WO PCT/US2013/037782 patent/WO2013163171A1/en not_active Ceased
- 2013-04-23 EP EP13720688.4A patent/EP2841563B1/en active Active
- 2013-04-23 EP EP19179319.9A patent/EP3567102A1/en active Pending
- 2013-04-23 US US13/868,785 patent/US9260696B2/en active Active
- 2013-04-23 JP JP2015509079A patent/JP6339998B2/ja active Active
- 2013-04-23 AU AU2013251785A patent/AU2013251785B2/en not_active Ceased
-
2017
- 2017-06-13 JP JP2017115944A patent/JP6529541B2/ja active Active
-
2018
- 2018-07-18 AU AU2018206749A patent/AU2018206749A1/en not_active Abandoned
-
2019
- 2019-05-14 JP JP2019091121A patent/JP2019122415A/ja active Pending
-
2020
- 2020-11-06 AU AU2020264375A patent/AU2020264375B2/en not_active Ceased
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