JP2015519346A5 - - Google Patents
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- JP2015519346A5 JP2015519346A5 JP2015514189A JP2015514189A JP2015519346A5 JP 2015519346 A5 JP2015519346 A5 JP 2015519346A5 JP 2015514189 A JP2015514189 A JP 2015514189A JP 2015514189 A JP2015514189 A JP 2015514189A JP 2015519346 A5 JP2015519346 A5 JP 2015519346A5
- Authority
- JP
- Japan
- Prior art keywords
- lipid nanoparticle
- nanoparticle composition
- lipid
- cancer
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261650729P | 2012-05-23 | 2012-05-23 | |
| US61/650,729 | 2012-05-23 | ||
| US201361784892P | 2013-03-14 | 2013-03-14 | |
| US61/784,892 | 2013-03-14 | ||
| PCT/US2013/042454 WO2013177415A1 (en) | 2012-05-23 | 2013-05-23 | Lipid nanoparticle compositions for antisense oligonucleotides delivery |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017191221A Division JP2018002727A (ja) | 2012-05-23 | 2017-09-29 | アンチセンスオリゴヌクレオチドを送達するための脂質ナノ粒子組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015519346A JP2015519346A (ja) | 2015-07-09 |
| JP2015519346A5 true JP2015519346A5 (enExample) | 2016-07-14 |
| JP6220389B2 JP6220389B2 (ja) | 2017-10-25 |
Family
ID=48539454
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015514189A Expired - Fee Related JP6220389B2 (ja) | 2012-05-23 | 2013-05-23 | アンチセンスオリゴヌクレオチドを送達するための脂質ナノ粒子組成物 |
| JP2015514192A Pending JP2015525209A (ja) | 2012-05-23 | 2013-05-23 | 脂質ナノ粒子組成物と、それを作製する方法、及びそれを使用する方法 |
| JP2015514193A Active JP6228191B2 (ja) | 2012-05-23 | 2013-05-23 | 脂質コートされたアルブミンナノ粒子組成物と、それを作製する方法、及びそれを使用する方法 |
| JP2017191221A Pending JP2018002727A (ja) | 2012-05-23 | 2017-09-29 | アンチセンスオリゴヌクレオチドを送達するための脂質ナノ粒子組成物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015514192A Pending JP2015525209A (ja) | 2012-05-23 | 2013-05-23 | 脂質ナノ粒子組成物と、それを作製する方法、及びそれを使用する方法 |
| JP2015514193A Active JP6228191B2 (ja) | 2012-05-23 | 2013-05-23 | 脂質コートされたアルブミンナノ粒子組成物と、それを作製する方法、及びそれを使用する方法 |
| JP2017191221A Pending JP2018002727A (ja) | 2012-05-23 | 2017-09-29 | アンチセンスオリゴヌクレオチドを送達するための脂質ナノ粒子組成物 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US10307490B2 (enExample) |
| EP (3) | EP2852380A4 (enExample) |
| JP (4) | JP6220389B2 (enExample) |
| KR (3) | KR102169891B1 (enExample) |
| CN (3) | CN104428005B (enExample) |
| AU (4) | AU2013266232B2 (enExample) |
| BR (2) | BR112014027834A2 (enExample) |
| CA (3) | CA2874495A1 (enExample) |
| MX (3) | MX2014014196A (enExample) |
| WO (3) | WO2013177419A2 (enExample) |
Families Citing this family (108)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG190661A1 (en) | 2008-05-16 | 2013-06-28 | Taiga Biotechnologies Inc | Antibodies and processes for preparing the same |
| JP5812861B2 (ja) | 2008-08-28 | 2015-11-17 | タイガ バイオテクノロジーズ，インク． | Ｍｙｃの修飾物質、該ｍｙｃの修飾物質を使用する方法、およびｍｙｃを調節する薬剤を同定する方法 |
| US8822663B2 (en) | 2010-08-06 | 2014-09-02 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| DK4108671T3 (da) | 2010-10-01 | 2025-01-06 | Modernatx Inc | Modificerede nukleosider, nukleotider og nukleinsyrer samt anvendelser deraf |
| JP2014511687A (ja) | 2011-03-31 | 2014-05-19 | モデルナ セラピューティクス インコーポレイテッド | 工学操作された核酸の送達および製剤 |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| JP6113737B2 (ja) | 2011-10-03 | 2017-04-12 | モデルナティエックス インコーポレイテッドＭｏｄｅｒｎａＴＸ，Ｉｎｃ． | 修飾型のヌクレオシド、ヌクレオチドおよび核酸、ならびにそれらの使用方法 |
| KR20140102759A (ko) | 2011-12-16 | 2014-08-22 | 모더나 세라퓨틱스, 인코포레이티드 | 변형된 뉴클레오사이드, 뉴클레오타이드 및 핵산 조성물 |
| US9254311B2 (en) | 2012-04-02 | 2016-02-09 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| EP2834259A4 (en) | 2012-04-02 | 2016-08-24 | Moderna Therapeutics Inc | MODIFIED POLYNUCLEOTIDES |
| AU2013266232B2 (en) | 2012-05-23 | 2017-08-03 | The Ohio State University | Lipid nanoparticle compositions for antisense oligonucleotides delivery |
| SG11201500429QA (en) | 2012-07-20 | 2015-03-30 | Taiga Biotechnologies Inc | Enhanced reconstitution and autoreconstitution of the hematopoietic compartment |
| US9597380B2 (en) | 2012-11-26 | 2017-03-21 | Modernatx, Inc. | Terminally modified RNA |
| US10272115B2 (en) | 2013-03-11 | 2019-04-30 | Taiga Biotechnologies, Inc. | Production and use of red blood cells |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| WO2014178152A1 (ja) | 2013-04-30 | 2014-11-06 | Ｄｅｌｔａ－Ｆｌｙ Ｐｈａｒｍａ株式会社 | 局所投与用リポソームおよびその用途 |
| US9802967B2 (en) * | 2013-06-17 | 2017-10-31 | The University Of North Carolina At Chapel Hill | Polymer coated particles and methods thereof |
| WO2015013673A1 (en) | 2013-07-25 | 2015-01-29 | Aurasense Therapeutics, Llc | Spherical nucleic acid-based constructs as immunostimulatory agents for prophylactic and therapeutic use |
| US10023626B2 (en) | 2013-09-30 | 2018-07-17 | Modernatx, Inc. | Polynucleotides encoding immune modulating polypeptides |
| EP3052521A1 (en) | 2013-10-03 | 2016-08-10 | Moderna Therapeutics, Inc. | Polynucleotides encoding low density lipoprotein receptor |
| EP3556353A3 (en) | 2014-02-25 | 2020-03-18 | Merck Sharp & Dohme Corp. | Lipid nanoparticle vaccine adjuvants and antigen delivery systems |
| US9833416B2 (en) * | 2014-04-04 | 2017-12-05 | Ohio State Innovation Foundation | Oligonucleotide lipid nanoparticle compositions, methods of making and methods of using the same |
| WO2015175965A1 (en) * | 2014-05-15 | 2015-11-19 | The Research Foundation For Suny | Compositions targeting the interaction domain between p27kip1 and brk and methods of use thereof |
| AU2015269412B2 (en) | 2014-06-04 | 2020-03-12 | Exicure Operating Company | Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications |
| AU2015305482B2 (en) | 2014-08-19 | 2021-04-01 | Northwestern University | Protein/oligonucleotide core-shell nanoparticle therapeutics |
| KR101836877B1 (ko) * | 2014-10-30 | 2018-03-09 | 데루타-후라이 화마 가부시키가이샤 | 국소 투여용 리포플렉스의 신규 제조 방법 및 상기 리포플렉스를 사용하는 항 종양제 |
| US11213593B2 (en) | 2014-11-21 | 2022-01-04 | Northwestern University | Sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates |
| EP3247796A4 (en) * | 2015-01-14 | 2018-07-11 | Exicure, Inc. | Nucleic acid nanostructures with core motifs |
| WO2016160822A1 (en) * | 2015-03-30 | 2016-10-06 | Verily Life Sciences Llc | Functionalized nanoparticles, methods and in vivo diagnostic system |
| EP4353257A3 (en) | 2015-04-13 | 2024-08-07 | CureVac Manufacturing GmbH | Method for producing rna compositions |
| EP3303590A4 (en) * | 2015-06-05 | 2019-01-02 | Miragen Therapeutics, Inc. | Mir-155 inhibitors for treating cutaneous t cell lymphoma (ctcl) |
| EP3350157B1 (en) | 2015-09-17 | 2022-01-05 | Modernatx, Inc. | Compounds and compositions for intracellular delivery of therapeutic agents |
| CN105288647B (zh) * | 2015-10-10 | 2018-05-25 | 中国药科大学 | 功能化白蛋白及其纳米制剂的制备方法 |
| ES2924407T3 (es) | 2015-12-10 | 2022-10-06 | Modernatx Inc | Composiciones y procedimientos para el suministro de agentes terapéuticos |
| SI3394030T1 (sl) | 2015-12-22 | 2022-04-29 | Modernatx, Inc. | Sestave za doziranje sredstev v celice |
| WO2018039629A2 (en) | 2016-08-25 | 2018-03-01 | Northwestern University | Micellar spherical nucleic acids from thermoresponsive, traceless templates |
| CN112587504B (zh) * | 2016-10-17 | 2022-10-18 | 南京绿叶制药有限公司 | 一种抑制bcl-2的反义寡聚核酸的脂质纳米粒及其制备方法 |
| US12491261B2 (en) | 2016-10-26 | 2025-12-09 | Acuitas Therapeutics, Inc. | Lipid nanoparticle formulations |
| US11583504B2 (en) | 2016-11-08 | 2023-02-21 | Modernatx, Inc. | Stabilized formulations of lipid nanoparticles |
| AU2017367730A1 (en) | 2016-12-02 | 2019-06-06 | Taiga Biotechnologies, Inc. | Nanoparticle formulations |
| WO2018107061A1 (en) * | 2016-12-09 | 2018-06-14 | Board Of Regents, The University Of Texas System | Hybrid exosomal-polymeric (hexpo) nano-platform for delivery of rnai therapeutics |
| AU2017378226A1 (en) | 2016-12-14 | 2019-06-20 | Janssen Biotech, Inc. | CD8A-binding fibronectin type III domains |
| EP3554535A4 (en) | 2016-12-14 | 2020-10-21 | Janssen Biotech, Inc. | PD-L1 BINDING FIBRONECTIN TYPE III DOMAINS |
| EP3554561B1 (en) | 2016-12-14 | 2023-06-28 | Janssen Biotech, Inc. | Cd137 binding fibronectin type iii domains |
| WO2018114992A1 (en) * | 2016-12-22 | 2018-06-28 | Biotronik Ag | Drug releasing coatings for medical devices and methods of making same |
| US20180179577A1 (en) * | 2016-12-22 | 2018-06-28 | Jiaming HU | Lipid-polymer Hybrid Nanoparticle Biochip and Application Thereof |
| KR101916941B1 (ko) * | 2016-12-30 | 2018-11-08 | 주식회사 삼양바이오팜 | 플라스미드 디엔에이 전달용 고분자 나노입자 조성물 및 그의 제조방법 |
| ES2911186T3 (es) | 2017-03-15 | 2022-05-18 | Modernatx Inc | Formas cristalinas de aminolípidos |
| FI3596041T3 (fi) | 2017-03-15 | 2023-01-31 | Yhdiste ja koostumuksia terapeuttisten aineiden antamiseen solun sisään | |
| JP7332478B2 (ja) | 2017-03-15 | 2023-08-23 | モデルナティエックス インコーポレイテッド | 脂質ナノ粒子製剤 |
| EP3607074A4 (en) | 2017-04-05 | 2021-07-07 | Modernatx, Inc. | REDUCTION OR ELIMINATION OF IMMUNE RESPONSES TO NON-INTRAVENOUS THERAPEUTIC PROTEINS, FOR EXAMPLE SUBCUTANEOUSLY |
| WO2018201090A1 (en) | 2017-04-28 | 2018-11-01 | Exicure, Inc. | Synthesis of spherical nucleic acids using lipophilic moieties |
| US11433131B2 (en) | 2017-05-11 | 2022-09-06 | Northwestern University | Adoptive cell therapy using spherical nucleic acids (SNAs) |
| CN107184552B (zh) * | 2017-06-07 | 2021-03-30 | 东华大学 | 一种半乳糖化聚乙烯亚胺修饰的载药醇质体的制备方法 |
| EP3638678B1 (en) | 2017-06-14 | 2025-12-03 | ModernaTX, Inc. | Compounds and compositions for intracellular delivery of agents |
| US11786607B2 (en) | 2017-06-15 | 2023-10-17 | Modernatx, Inc. | RNA formulations |
| JP7231147B2 (ja) * | 2017-06-29 | 2023-03-01 | 国立大学法人東海国立大学機構 | Ｒｎａ導入試薬及びその利用 |
| CN118853394A (zh) * | 2017-07-18 | 2024-10-29 | 阿维塔斯有限公司 | 使用连续流动的流体系统进行跨细胞膜的有效装载的传递 |
| US10149898B2 (en) | 2017-08-03 | 2018-12-11 | Taiga Biotechnologies, Inc. | Methods and compositions for the treatment of melanoma |
| US20190062788A1 (en) * | 2017-08-22 | 2019-02-28 | Rubius Therapeutics, Inc. | Lipid nanoparticle methods and compositions for producing engineered erythroid cells |
| AU2018326799A1 (en) | 2017-08-31 | 2020-02-27 | Modernatx, Inc. | Methods of making lipid nanoparticles |
| CN107982537A (zh) * | 2017-11-17 | 2018-05-04 | 厦门大学 | 针对microRNA-155的治疗性药物及其应用 |
| KR102245539B1 (ko) * | 2018-02-12 | 2021-04-29 | 주식회사 지앤피바이오사이언스 | 코어-쉘 구조의 마이크로 입자를 유효성분으로 포함하는 성장인자 유전자 발현 증가용 조성물 |
| CN111971072B (zh) * | 2018-03-29 | 2023-06-13 | 中国医学科学院基础医学研究所 | 植物来源“汤剂体”的提取和“本草体”的人工制备及其相关产品 |
| US11603543B2 (en) * | 2018-04-18 | 2023-03-14 | Oisin Biotechnologies, Inc. | Fusogenic lipid nanoparticles for target cell-specific production of a therapeutic protein |
| CA3099815A1 (en) * | 2018-05-15 | 2019-11-21 | Flagship Pioneering Innovations Vi, Llc | Pest control compositions and uses thereof |
| WO2019231051A1 (ko) * | 2018-06-01 | 2019-12-05 | 서강대학교 산학협력단 | 지질을 이용한 표면 개질을 통해 세포 내 섭취 효율을 향상시킨 나노입자 복합체 및 이의 제조방법 |
| US10987428B2 (en) * | 2018-06-01 | 2021-04-27 | City Of Hope | Phosphorothioate-conjugated miRNAs and methods of using the same |
| US12357580B2 (en) | 2018-06-19 | 2025-07-15 | The Board Of Regents Of The University Of Texas System | Lipid nanoparticle compositions for delivery of mRNA and long nucleic acids |
| CN108743962B (zh) * | 2018-06-19 | 2021-07-02 | 东华大学 | 一种基于荧光碳点修饰的树状大分子的双载药靶向纳米平台的制备方法 |
| WO2020051220A1 (en) * | 2018-09-04 | 2020-03-12 | The Board of the Regents of the University of Texas System | Compositions and methods for organ specific delivery of nucleic acids |
| GB2592505B (en) | 2018-09-04 | 2023-05-03 | Univ Texas | Compositions and methods for organ specific delivery of nucleic acids |
| EP3853202A1 (en) | 2018-09-19 | 2021-07-28 | ModernaTX, Inc. | Compounds and compositions for intracellular delivery of therapeutic agents |
| US12090235B2 (en) | 2018-09-20 | 2024-09-17 | Modernatx, Inc. | Preparation of lipid nanoparticles and methods of administration thereof |
| TW202028222A (zh) | 2018-11-14 | 2020-08-01 | 美商Ionis製藥公司 | Foxp3表現之調節劑 |
| MX2021008146A (es) * | 2019-01-04 | 2021-10-13 | Oncorus Inc | Polinucleotidos de arn encapsulado y metodos de uso. |
| WO2020210231A1 (en) | 2019-04-08 | 2020-10-15 | Taiga Biotechnologies, Inc. | Compositions and methods for the cry opreservation of immune cells |
| CN114072166A (zh) | 2019-05-14 | 2022-02-18 | 泰加生物工艺学公司 | 用于治疗t细胞耗竭的组合物和方法 |
| BR112022004759A2 (pt) | 2019-09-19 | 2022-06-21 | Modernatx Inc | Composições e compostos lipídicos com cauda ramificada para entrega intracelular de agentes terapêuticos |
| EP4045061A4 (en) | 2019-10-14 | 2024-04-17 | ARO Biotherapeutics Company | CD71-BINDING FIBRONECTIN TYPE III DOMAINS |
| WO2021076574A2 (en) | 2019-10-14 | 2021-04-22 | Aro Biotherapeutics Company | Fn3 domain-sirna conjugates and uses thereof |
| US12491255B2 (en) | 2019-10-14 | 2025-12-09 | Aro Biotherapeutics Company | EPCAM binding fibronectin type III domains |
| CN115778904B (zh) * | 2019-10-29 | 2025-03-28 | 珠海丽凡达生物技术有限公司 | 一种用于体外转染和体内递送mRNA的制剂 |
| KR102198736B1 (ko) * | 2020-01-15 | 2021-01-05 | 이화여자대학교 산학협력단 | 생체 내 약물 전달을 위한 지질 나노입자 및 이의 용도 |
| CN115243724B (zh) * | 2020-02-19 | 2025-10-21 | 纳米医疗有限公司 | 可用于治疗癌症的经调配和/或共调配的含有TFGβ拮抗剂前药的脂质体组合物和其方法 |
| DK4182297T3 (da) | 2020-07-16 | 2025-12-01 | Acuitas Therapeutics Inc | Kationiske lipider til brug i lipid-nanopartikler |
| CN116171150A (zh) * | 2020-08-14 | 2023-05-26 | 阿克丘勒斯治疗公司 | 冻干脂质纳米颗粒的方法 |
| WO2022192674A1 (en) * | 2021-03-11 | 2022-09-15 | The Trustees Of The University Of Pennsylvania | Targeted therapeutic lipid nanoparticles and methods of use |
| CA3214552A1 (en) | 2021-04-14 | 2022-10-20 | Russell C. Addis | Cd71 binding fibronectin type iii domains |
| KR20240031947A (ko) | 2021-04-14 | 2024-03-08 | 에이알오 바이오테라퓨틱스 컴패니 | Fn3 도메인-시르나 접합체 및 이의 용도 |
| WO2022224257A1 (en) | 2021-04-20 | 2022-10-27 | Biond Biologics Ltd. | Intracellular delivery compositions |
| US20240417738A1 (en) * | 2021-10-22 | 2024-12-19 | Ohio State Innovation Foundation | Immunotherapies for the treatment of cancer |
| AU2022381929B2 (en) * | 2021-11-03 | 2025-07-03 | Biond Biologics Ltd. | Intracellular delivery compositions |
| WO2023114943A2 (en) | 2021-12-16 | 2023-06-22 | Acuitas Therapeutics, Inc. | Lipids for use in lipid nanoparticle formulations |
| CN114306369B (zh) * | 2021-12-23 | 2023-12-26 | 北京悦康科创医药科技股份有限公司 | 一种硫代寡核苷酸注射液及其制备方法 |
| EP4499045A4 (en) * | 2022-03-30 | 2026-03-25 | Univ Johns Hopkins | Lipid nanoparticle compositions for the delivery of plasma DNA to the liver and their preparation methods |
| US20260069541A1 (en) * | 2022-08-25 | 2026-03-12 | Ohio State Innovation Foundation | Compositions and methods for the delivery of active agents including nucleic acids |
| WO2024050310A1 (en) * | 2022-08-29 | 2024-03-07 | Sorrento Therapeutics, Inc. | Lipid-coated nanoparticles |
| WO2024136219A1 (ko) * | 2022-12-19 | 2024-06-27 | 주식회사 포스테라헬스사이언스 | 나노 입자를 포함하는 흡입 제형 및 이의 제조 방법 |
| EP4688003A2 (en) * | 2023-03-31 | 2026-02-11 | The Whiteoak Group, Inc. | Liposomal compositions of archexin |
| WO2025034965A1 (en) * | 2023-08-09 | 2025-02-13 | Board Of Regents, The University Of Texas System | Targeted therapeutic delivery of lipid nanoparticles |
| TWI880568B (zh) * | 2024-01-04 | 2025-04-11 | 訊聯生物科技股份有限公司 | 包含生物巨分子及奈米載體之組合物、包含其的醫藥組成物及其用途 |
| WO2025171027A1 (en) * | 2024-02-05 | 2025-08-14 | University Of Rhode Island Board Of Trustees | Phlip ®-lnp for targeted intracellular delivery of nucleic acid therapeutics |
| US12553050B2 (en) | 2024-03-22 | 2026-02-17 | Takeda Pharmaceutical Company Limited | Compositions and methods for inhibiting cytochrome P450 family 7 subfamily a member 1 (CYP7A1) expression |
| WO2025221397A1 (en) * | 2024-04-17 | 2025-10-23 | University Of Connecticut | Albumin nanoparticles for efficient vaccine delivery |
| KR20250157196A (ko) * | 2024-04-26 | 2025-11-04 | 한국과학기술원 | 핵산 분자의 흡입 전달용 지질 나노복합체 |
Family Cites Families (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US590877A (en) * | 1897-09-28 | Danger-signal for railway-crossings | ||
| US2003203A (en) * | 1933-05-15 | 1935-05-28 | Kim Young Wo | Game |
| US5725871A (en) | 1989-08-18 | 1998-03-10 | Danbiosyst Uk Limited | Drug delivery compositions comprising lysophosphoglycerolipid |
| US5707644A (en) | 1989-11-04 | 1998-01-13 | Danbiosyst Uk Limited | Small particle compositions for intranasal drug delivery |
| US5466468A (en) | 1990-04-03 | 1995-11-14 | Ciba-Geigy Corporation | Parenterally administrable liposome formulation comprising synthetic lipids |
| US5399363A (en) | 1991-01-25 | 1995-03-21 | Eastman Kodak Company | Surface modified anticancer nanoparticles |
| US5756353A (en) | 1991-12-17 | 1998-05-26 | The Regents Of The University Of California | Expression of cloned genes in the lung by aerosol-and liposome-based delivery |
| ES2105262T3 (es) | 1992-05-18 | 1997-10-16 | Minnesota Mining & Mfg | Dispositivo de suministro de farmaco a traves de las mucosas. |
| US5543158A (en) | 1993-07-23 | 1996-08-06 | Massachusetts Institute Of Technology | Biodegradable injectable nanoparticles |
| IE80468B1 (en) | 1995-04-04 | 1998-07-29 | Elan Corp Plc | Controlled release biodegradable nanoparticles containing insulin |
| US20020022264A1 (en) * | 1995-05-26 | 2002-02-21 | Sullivan Sean M. | Delivery vehicles comprising stable lipid/nucleic acid complexes |
| US5908777A (en) * | 1995-06-23 | 1999-06-01 | University Of Pittsburgh | Lipidic vector for nucleic acid delivery |
| US6248720B1 (en) * | 1996-07-03 | 2001-06-19 | Brown University Research Foundation | Method for gene therapy using nucleic acid loaded polymeric microparticles |
| US6056973A (en) * | 1996-10-11 | 2000-05-02 | Sequus Pharmaceuticals, Inc. | Therapeutic liposome composition and method of preparation |
| DE69820465T2 (de) | 1997-06-23 | 2004-09-16 | Alza Corp., Mountain View | Liposomen-umschlossene polynukleotidzusammensetzung sowie verfahren |
| US6395253B2 (en) * | 1998-04-23 | 2002-05-28 | The Regents Of The University Of Michigan | Microspheres containing condensed polyanionic bioactive agents and methods for their production |
| ATE324888T1 (de) * | 1999-06-14 | 2006-06-15 | Cancer Rec Tech Ltd | Krebstherapie |
| IL148359A0 (en) * | 1999-08-27 | 2002-09-12 | Inex Pharmaceuticals Corp | Pharmaceutical compositions containing an oligodeoxynucleotide |
| US7060291B1 (en) * | 1999-11-24 | 2006-06-13 | Transave, Inc. | Modular targeted liposomal delivery system |
| US6821955B2 (en) * | 2000-04-07 | 2004-11-23 | Baylor College Of Medicine | Macroaggregated protein conjugates as oral genetic immunization delivery agents |
| US6613308B2 (en) | 2000-09-19 | 2003-09-02 | Advanced Inhalation Research, Inc. | Pulmonary delivery in treating disorders of the central nervous system |
| WO2002088318A2 (en) * | 2001-04-30 | 2002-11-07 | Targeted Genetics Corporation | Lipid-comprising drug delivery complexes and methods for their production |
| US7025987B2 (en) * | 2001-05-30 | 2006-04-11 | The Scripps Research Institute | Delivery system for nucleic acids |
| JP2003088371A (ja) * | 2001-09-04 | 2003-03-25 | Mitsubishi Pharma Corp | 遺伝子導入用組成物 |
| KR100484371B1 (ko) | 2001-10-25 | 2005-04-20 | 가부시키가이샤 아텍스 | 히터선부착 시트체의 제조방법 |
| US20030125292A1 (en) * | 2001-11-07 | 2003-07-03 | Sean Semple | Mucoscal vaccine and methods for using the same |
| US7678386B2 (en) | 2002-07-15 | 2010-03-16 | Board Of Regents The University Of Texas | Liposomes coated with selected antibodies that bind to aminophospholipids |
| EP1546180B1 (en) * | 2002-08-16 | 2013-07-03 | Rexahn Pharmaceuticals, Inc. | Use of antisense oligonucleotides to inhibit the expression of akt-1 |
| WO2004064731A2 (en) * | 2003-01-14 | 2004-08-05 | University Of Washington | Lipid-drug formulations and methods for targeted delivery of lipid-drug complexes to lymlplhoid tissues |
| JP4546454B2 (ja) * | 2003-01-28 | 2010-09-15 | レクサーン・コーポレイション | Ｈｉｆ−１発現を抑制するアンチセンスオリゴヌクレオチド |
| US7205283B2 (en) | 2003-01-31 | 2007-04-17 | Rexahn Corporation | Antisense oligonucleotides that inhibit expression of HIF-1 |
| KR101164256B1 (ko) * | 2003-09-15 | 2012-07-10 | 프로티바 바이오쎄라퓨틱스, 인코포레이티드 | 폴리에틸렌글리콜 개질된 지질 화합물 및 그의 용도 |
| KR100638041B1 (ko) | 2003-12-24 | 2006-10-23 | 주식회사 삼양사 | 수용성 약물의 경구투여용 나노입자 조성물 및 그의제조방법 |
| JP2006111591A (ja) * | 2004-10-15 | 2006-04-27 | Anges Mg Inc | 核酸医薬を標的特異的に細胞内送達するための製剤 |
| JP2006298780A (ja) * | 2005-04-15 | 2006-11-02 | Tohoku Univ | Ｈｇｆ遺伝子と粗大凝集アルブミン−ポリエチレンイミン（ｍａａ−ｐｅｉ）との複合体 |
| US20070087045A1 (en) * | 2005-10-14 | 2007-04-19 | Industrial Technology Research Institute | Lipid carrier and method of preparing the same |
| TW200800235A (en) * | 2005-10-18 | 2008-01-01 | Otsuka Pharma Co Ltd | Carrier composition for nucleic acid transport |
| CN101346393B (zh) * | 2005-11-02 | 2015-07-22 | 普洛体维生物治疗公司 | 修饰的siRNA分子及其应用 |
| US8067380B2 (en) | 2005-12-19 | 2011-11-29 | Industrial Technology Research Institute | Glutathione-based delivery system |
| GB2450475A (en) * | 2007-06-12 | 2008-12-31 | Univ Nottingham Trent | Antimicrobial polymer nanocomposite |
| US20110177155A1 (en) | 2007-08-21 | 2011-07-21 | Immune Disease Institute, Inc. | Methods of delivery of agents to leukocytes and endothelial cells |
| PL208054B1 (pl) * | 2007-09-06 | 2011-03-31 | Akademia Medyczna Im Piastow Śląskich We Wrocławiu | Kompozycja lipidowa do wytwarzania lipidowego nośnika dla leków genetycznych i jej zastosowanie |
| US20100297242A1 (en) * | 2007-10-17 | 2010-11-25 | Tae-Gwan Park | Ldl-like cationic nanoparticles for deliverying nucleic acid gene, method for preparing thereof and method for deliverying nucleic acid gene using the same |
| EP2207903A4 (en) * | 2007-11-09 | 2012-02-15 | Univ Northeastern | SELF-STORING MICRICOUS NANOPARTICLES FOR SYSTEMIC GENERIC INTRODUCTION |
| US8916531B2 (en) * | 2007-11-20 | 2014-12-23 | Isis Pharmaceuticals, Inc. | Modulation of CD40 expression |
| WO2009120247A2 (en) * | 2007-12-27 | 2009-10-01 | The Ohio State University Research Foundation | Lipid nanoparticle compositions and methods of making and using the same |
| US8445021B2 (en) | 2008-04-04 | 2013-05-21 | The Regents Of The University Of California | Functionalized magnetic nanoparticles and methods of use thereof |
| US8222220B2 (en) | 2008-05-13 | 2012-07-17 | George Mason Intellectual Properties, Inc. | Nanogenomics for medicine: siRNA engineering |
| WO2009142892A1 (en) * | 2008-05-19 | 2009-11-26 | The University Of North Carolina At Chapel Hill | Methods and compositions comprising novel cationic lipids |
| US20090312402A1 (en) * | 2008-05-20 | 2009-12-17 | Contag Christopher H | Encapsulated nanoparticles for drug delivery |
| WO2010011895A1 (en) * | 2008-07-25 | 2010-01-28 | Alnylam Pharmaceuticals, Inc. | Enhancement of sirna silencing activity using universal bases or mismatches in the sense strand |
| WO2010014595A2 (en) | 2008-07-31 | 2010-02-04 | The Ohio State University Research Foundation | Methods and compositions for delivering therapeutic agents in the treatment of b-cell related disorders |
| US20110256059A1 (en) * | 2008-10-28 | 2011-10-20 | Universidade De Santiago De Compostela | Nanoparticulate systems prepared from anionic polymers |
| WO2010054384A1 (en) | 2008-11-10 | 2010-05-14 | Alnylam Pharmaceuticals, Inc. | Lipids and compositions for the delivery of therapeutics |
| EP2601934A1 (en) | 2009-01-22 | 2013-06-12 | Ludwig-Maximilians-Universität München | Vesicular phospholipid gels comprising proteinaceous substances |
| ES2351756B1 (es) * | 2009-07-28 | 2011-10-05 | Universidad Del Pais Vasco | Nanopartículas lipídicas para terapia génica. |
| JP5960060B2 (ja) * | 2009-11-23 | 2016-08-02 | ジ・オハイオ・ステート・ユニバーシティ | 腫瘍細胞の増殖、遊走および浸潤に影響を与えるために有用な物質および方法 |
| JP5931050B2 (ja) * | 2010-03-26 | 2016-06-08 | ジ・オハイオ・ステート・ユニバーシティ | ｍｉＲ−１５５によるミスマッチ修復およびゲノム安定性の調節に関連する材料および方法 |
| WO2011120053A1 (en) * | 2010-03-26 | 2011-09-29 | Mersana Therapeutics, Inc. | Modified polymers for delivery of polynucleotides, method of manufacture, and methods of use thereof |
| JP2013524811A (ja) | 2010-04-20 | 2013-06-20 | ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド | ナノザイム、ナノザイムの製造方法、およびナノザイムの使用方法 |
| US20130260460A1 (en) * | 2010-04-22 | 2013-10-03 | Isis Pharmaceuticals Inc | Conformationally restricted dinucleotide monomers and oligonucleotides |
| US20110319473A1 (en) * | 2010-06-29 | 2011-12-29 | Surmodics, Inc. | Compositions and methods for enhancement of nucleic acid delivery |
| US8691750B2 (en) * | 2011-05-17 | 2014-04-08 | Axolabs Gmbh | Lipids and compositions for intracellular delivery of biologically active compounds |
| CN102552105B (zh) * | 2011-10-17 | 2014-04-02 | 复旦大学 | 一种级联脑部靶向药物递送系统及其制备方法和用途 |
| AU2013266232B2 (en) | 2012-05-23 | 2017-08-03 | The Ohio State University | Lipid nanoparticle compositions for antisense oligonucleotides delivery |
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