JP2015518854A - 多発性硬化症の治療のための組成物および方法 - Google Patents
多発性硬化症の治療のための組成物および方法 Download PDFInfo
- Publication number
- JP2015518854A JP2015518854A JP2015513319A JP2015513319A JP2015518854A JP 2015518854 A JP2015518854 A JP 2015518854A JP 2015513319 A JP2015513319 A JP 2015513319A JP 2015513319 A JP2015513319 A JP 2015513319A JP 2015518854 A JP2015518854 A JP 2015518854A
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- Prior art keywords
- formula
- administration
- compound
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 0 C*OC(C)ON Chemical compound C*OC(C)ON 0.000 description 8
- UMYXTUXOQSJVIJ-UHFFFAOYSA-N CC(CC(C[N](C)(C)C)O)=O Chemical compound CC(CC(C[N](C)(C)C)O)=O UMYXTUXOQSJVIJ-UHFFFAOYSA-N 0.000 description 2
- AOKCDAVWJLOAHG-UHFFFAOYSA-N CNCCCC(O)=O Chemical compound CNCCCC(O)=O AOKCDAVWJLOAHG-UHFFFAOYSA-N 0.000 description 2
- QZIWDCLHLOADPK-ZETCQYMHSA-N CN[C@@H](Cc(cc1)cc(O)c1O)C(O)=O Chemical compound CN[C@@H](Cc(cc1)cc(O)c1O)C(O)=O QZIWDCLHLOADPK-ZETCQYMHSA-N 0.000 description 2
- OKSWVTAWGNJXCG-UHFFFAOYSA-N CC(C)(C)OCCNC(SC)=O Chemical compound CC(C)(C)OCCNC(SC)=O OKSWVTAWGNJXCG-UHFFFAOYSA-N 0.000 description 1
- OIFGOMVFYLWIEK-NSHDSACASA-N CC(C)(CO)[C@@](C(NCCC(C)=O)=O)(N=C)O Chemical compound CC(C)(CO)[C@@](C(NCCC(C)=O)=O)(N=C)O OIFGOMVFYLWIEK-NSHDSACASA-N 0.000 description 1
- MJDTYNAFJVLFAP-UHFFFAOYSA-N CC(C)NCCSCCNC Chemical compound CC(C)NCCSCCNC MJDTYNAFJVLFAP-UHFFFAOYSA-N 0.000 description 1
- DYRIBFOWRXHQNS-UHFFFAOYSA-N CC(NCCCOC)=O Chemical compound CC(NCCCOC)=O DYRIBFOWRXHQNS-UHFFFAOYSA-N 0.000 description 1
- SKPWGBMKZNVXFF-UHFFFAOYSA-N CC(NCCOC(C)=O)=O Chemical compound CC(NCCOC(C)=O)=O SKPWGBMKZNVXFF-UHFFFAOYSA-N 0.000 description 1
- GCCQNSQKSSOQIR-LURJTMIESA-N CC([C@H](CCCNC(N)=N)N)=O Chemical compound CC([C@H](CCCNC(N)=N)N)=O GCCQNSQKSSOQIR-LURJTMIESA-N 0.000 description 1
- GSVDZENISSRBGR-LURJTMIESA-N CC([C@H](CS)NC(C)=O)=O Chemical compound CC([C@H](CS)NC(C)=O)=O GSVDZENISSRBGR-LURJTMIESA-N 0.000 description 1
- XMOLEHZEMRNQDS-NSHDSACASA-N CC([C@H](Cc1c[nH]c(cc2)c1cc2O)N)=O Chemical compound CC([C@H](Cc1c[nH]c(cc2)c1cc2O)N)=O XMOLEHZEMRNQDS-NSHDSACASA-N 0.000 description 1
- PVFABNCZFTZPHF-UHFFFAOYSA-N CCNCCc1c[nH]c(cc2)c1cc2O Chemical compound CCNCCc1c[nH]c(cc2)c1cc2O PVFABNCZFTZPHF-UHFFFAOYSA-N 0.000 description 1
- BWIUETHITADAOC-BMWLSMNBSA-N CNC(/C=C/C(OC(COC)COI)=N)=O Chemical compound CNC(/C=C/C(OC(COC)COI)=N)=O BWIUETHITADAOC-BMWLSMNBSA-N 0.000 description 1
- NTNWOCRCBQPEKQ-YFKPBYRVSA-N CNC(NCCC[C@@H](C(O)=O)N)=N Chemical compound CNC(NCCC[C@@H](C(O)=O)N)=N NTNWOCRCBQPEKQ-YFKPBYRVSA-N 0.000 description 1
- BCKXMQIYWWTZDP-UHFFFAOYSA-N CNC(c(cccc1)c1O)=O Chemical compound CNC(c(cccc1)c1O)=O BCKXMQIYWWTZDP-UHFFFAOYSA-N 0.000 description 1
- ZYVXHFWBYUDDBM-UHFFFAOYSA-N CNC(c1cccnc1)=O Chemical compound CNC(c1cccnc1)=O ZYVXHFWBYUDDBM-UHFFFAOYSA-N 0.000 description 1
- BPOJHKFBHRYIHZ-UHFFFAOYSA-N CNCCOCCN(C)C Chemical compound CNCCOCCN(C)C BPOJHKFBHRYIHZ-UHFFFAOYSA-N 0.000 description 1
- KIQLLHYPNCPLAJ-UHFFFAOYSA-N CNCCSCCNC Chemical compound CNCCSCCNC KIQLLHYPNCPLAJ-UHFFFAOYSA-N 0.000 description 1
- HOKKHZGPKSLGJE-VKHMYHEASA-N CN[C@@H](CC(O)=O)C(O)=O Chemical compound CN[C@@H](CC(O)=O)C(O)=O HOKKHZGPKSLGJE-VKHMYHEASA-N 0.000 description 1
- WWJHSKHOCSUEHQ-SNVBAGLBSA-N C[C@]1(CCCCC(OC)=O)SSCC1 Chemical compound C[C@]1(CCCCC(OC)=O)SSCC1 WWJHSKHOCSUEHQ-SNVBAGLBSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/02—Five-membered rings
- C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN2063/CHE/2012 | 2012-05-23 | ||
| IN2063CH2012 | 2012-05-23 | ||
| PCT/IB2013/054012 WO2013175359A2 (en) | 2012-05-23 | 2013-05-16 | Compositions and methods for the treatment of multiple sclerosis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015518854A true JP2015518854A (ja) | 2015-07-06 |
| JP2015518854A5 JP2015518854A5 (https=) | 2015-08-13 |
Family
ID=54193694
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015513319A Pending JP2015518854A (ja) | 2012-05-23 | 2013-05-16 | 多発性硬化症の治療のための組成物および方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9580383B2 (https=) |
| EP (1) | EP2852569B1 (https=) |
| JP (1) | JP2015518854A (https=) |
| CN (1) | CN104603097A (https=) |
| AU (1) | AU2013264896A1 (https=) |
| CA (1) | CA2873098A1 (https=) |
| SG (1) | SG11201407322QA (https=) |
| WO (1) | WO2013175359A2 (https=) |
| ZA (1) | ZA201408062B (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2651962T3 (es) * | 2013-12-05 | 2018-01-30 | Ratiopharm Gmbh | Derivados de bis-MMF |
| JP6698643B2 (ja) * | 2014-09-29 | 2020-05-27 | セリックス バイオ プライヴェート リミテッドＣｅｌｌｉｘ Ｂｉｏ Ｐｒｉｖａｔｅ Ｌｉｍｉｔｅｄ | 多発性硬化症の治療のための組成物及び方法 |
| AU2014414316B2 (en) * | 2014-10-27 | 2020-04-09 | Cellix Bio Private Limited | Three component salts of fumaric acid monomethyl ester with piperazine or ethylene diamine for the treatment of multiple sclerosis |
| SG11201704282UA (en) * | 2014-12-01 | 2017-06-29 | Cellix Bio Private Ltd | Compositions and methods for the treatment of multiple sclerosis |
| CN116445137B (zh) * | 2023-03-02 | 2024-08-16 | 西南石油大学 | 一种钻井液用改性碳球润滑剂及其制备方法及应用 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11286441A (ja) * | 1998-01-02 | 1999-10-19 | Mcneil Ppc Inc | イブプロフェン組成物 |
| JP2002530324A (ja) * | 1998-11-19 | 2002-09-17 | フーマファーム アーゲー | ジアルキルフマレートの使用 |
| JP2004523511A (ja) * | 2001-01-12 | 2004-08-05 | フーマファーム アーゲー | フマル酸アミド類 |
| JP2012500285A (ja) * | 2008-08-19 | 2012-01-05 | ゼノポート，インコーポレイティド | メチル水素フマレートのプロドラッグ、その医薬組成物及び使用方法 |
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| US9580383B2 (en) | 2017-02-28 |
| EP2852569A2 (en) | 2015-04-01 |
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| EP2852569B1 (en) | 2020-10-14 |
| CA2873098A1 (en) | 2013-11-28 |
| US20160122291A1 (en) | 2016-05-05 |
| ZA201408062B (en) | 2016-04-28 |
| AU2013264896A1 (en) | 2014-11-27 |
| CN104603097A (zh) | 2015-05-06 |
| WO2013175359A3 (en) | 2014-02-20 |
| EP2852569A4 (en) | 2015-12-02 |
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