JP2015508757A5 - - Google Patents
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- JP2015508757A5 JP2015508757A5 JP2014556052A JP2014556052A JP2015508757A5 JP 2015508757 A5 JP2015508757 A5 JP 2015508757A5 JP 2014556052 A JP2014556052 A JP 2014556052A JP 2014556052 A JP2014556052 A JP 2014556052A JP 2015508757 A5 JP2015508757 A5 JP 2015508757A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- antibody
- variable region
- heavy chain
- light chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261595902P | 2012-02-07 | 2012-02-07 | |
| US61/595,902 | 2012-02-07 | ||
| US201261625841P | 2012-04-18 | 2012-04-18 | |
| US61/625,841 | 2012-04-18 | ||
| PCT/EP2013/052439 WO2013117647A1 (en) | 2012-02-07 | 2013-02-07 | Mica binding agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015508757A JP2015508757A (ja) | 2015-03-23 |
| JP2015508757A5 true JP2015508757A5 (enExample) | 2016-03-31 |
| JP6405242B2 JP6405242B2 (ja) | 2018-10-17 |
Family
ID=47714068
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014556052A Active JP6405242B2 (ja) | 2012-02-07 | 2013-02-07 | Ｍｉｃａ結合剤 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US10577416B2 (enExample) |
| EP (1) | EP2812027A1 (enExample) |
| JP (1) | JP6405242B2 (enExample) |
| CN (1) | CN104244977A (enExample) |
| AU (1) | AU2013218017B2 (enExample) |
| BR (1) | BR112014019611A2 (enExample) |
| CA (1) | CA2862101A1 (enExample) |
| IL (1) | IL233793B (enExample) |
| RU (1) | RU2656183C2 (enExample) |
| SG (1) | SG11201404177PA (enExample) |
| WO (1) | WO2013117647A1 (enExample) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2760471T3 (en) | 2011-09-30 | 2017-05-08 | Dana Farber Cancer Inst Inc | THERAPEUTIC PEPTIDES |
| JP6405242B2 (ja) | 2012-02-07 | 2018-10-17 | イナート・ファルマ・ソシエテ・アノニムＩｎｎａｔｅ Ｐｈａｒｍａ Ｐｈａｒｍａ Ｓ．Ａ． | Ｍｉｃａ結合剤 |
| WO2014140904A2 (en) | 2013-03-15 | 2014-09-18 | Novelogics Biotechnology, Inc. | Antibodies to mica and micb proteins |
| WO2014144791A2 (en) * | 2013-03-15 | 2014-09-18 | Dana-Farber Cancer Institute, Inc. | Therapeutic peptides |
| MX371187B (es) * | 2013-12-06 | 2020-01-22 | Dana Farber Cancer Inst Inc | Péptidos terapéuticos. |
| EP3116903A2 (en) | 2014-03-14 | 2017-01-18 | Dana-Farber Cancer Institute, Inc. | Vaccine compositions and methods for restoring nkg2d pathway function against cancers |
| LT3227311T (lt) * | 2014-12-05 | 2022-02-25 | Xyphos Biosciences Inc. | Įterpiami variabilūs antikūnų fragmentai ir nkg2d ligandų modifikuoti a1-a2 domenai |
| WO2016154585A1 (en) | 2015-03-26 | 2016-09-29 | Charles Sentman | Anti-mica antigen binding fragments, fusion molecules, cells which express and methods of using |
| EP3325967B1 (en) | 2015-07-24 | 2019-12-04 | Innate Pharma | Methods for detecting tissue infiltrating nk cells |
| MX2018006785A (es) * | 2015-12-04 | 2018-11-09 | Dana Farber Cancer Inst Inc | Vacunacion con el dominio alfa 3 de mica/b para el tratamiento del cancer. |
| WO2017147247A1 (en) * | 2016-02-23 | 2017-08-31 | Pires Eusebio S | Anti-sas1b antibodies and methods of use |
| CA3016765A1 (en) | 2016-03-15 | 2017-09-21 | Innate Pharma | Anti-mica antibodies |
| CN107779433A (zh) * | 2016-08-30 | 2018-03-09 | 天津市康婷生物工程有限公司 | 便捷的刺激nk细胞增殖和分化的饲养层制备方法 |
| WO2018073648A1 (en) | 2016-10-19 | 2018-04-26 | Novelogics Biotechnology, Inc. | Antibodies to mica and micb proteins |
| CN107964041B (zh) * | 2016-10-20 | 2023-08-01 | 中国科学院广州生物医药与健康研究院 | 高稳定性和高亲和力的dmic及其制法 |
| EP3532091A2 (en) | 2016-10-29 | 2019-09-04 | H. Hoffnabb-La Roche Ag | Anti-mic antibidies and methods of use |
| US11787858B2 (en) | 2016-12-22 | 2023-10-17 | Icahn School Of Medicine At Mount Sinai | Anti-LILRB3 antibodies and methods of use thereof |
| WO2018141959A1 (en) | 2017-02-06 | 2018-08-09 | Innate Pharma | Immunomodulatory antibody drug conjugates binding to a human mica polypeptide |
| EP3661552A4 (en) * | 2017-05-22 | 2021-08-25 | Dana-Farber Cancer Institute, Inc. | COMPOSITIONS AND METHODS FOR INHIBITING MICA / B REJECTION |
| WO2019011852A1 (en) * | 2017-07-10 | 2019-01-17 | Innate Pharma | POLYTHERAPY USING ANTIBODY AGAINST SIGLEC-9 HUMAN AND ANTIBODY AGAINST NKG2A HUMAN FOR THE TREATMENT OF CANCER |
| AU2018346447B2 (en) * | 2017-10-06 | 2025-06-19 | Innate Pharma | Restoration of T cell activity via the CD39/CD73 axis |
| JP7351845B2 (ja) * | 2018-03-23 | 2023-09-27 | ブリストル－マイヤーズ スクイブ カンパニー | Ｍｉｃａおよび／またはｍｉｃｂに対する抗体ならびにそれらの使用 |
| KR102832008B1 (ko) * | 2018-07-31 | 2025-07-10 | 컬리난 미카 코퍼레이션 | Mica/b 유출을 차단하는 항-mica/b 항체 및 사용 방법 |
| WO2020035345A1 (en) | 2018-08-14 | 2020-02-20 | Innate Pharma | Treatment of colorectal cancer by a combination of an anti-mica antibody and an anti-nkg2a antibody |
| EP4017876A4 (en) * | 2019-08-23 | 2023-09-06 | Northwestern University | MATERIALS AND METHODS FOR ACTIVATING ANTIGEN-SPECIFIC T CELL RESPONSES |
| US20230272035A1 (en) * | 2019-12-05 | 2023-08-31 | Vycellix, Inc. | Modulators of the immune escape mechanism for universal cell therapy |
| CN111471099B (zh) * | 2020-03-31 | 2022-04-12 | 长沙学院 | MICA胞外区突变体及其筛选的方法、scFv-MICA融合抗体及其制备方法和应用 |
| CN111718416B (zh) * | 2020-06-25 | 2022-04-01 | 菲鹏生物股份有限公司 | 抗硫氧还蛋白的抗体、其应用和诊断试剂盒 |
| KR102594083B1 (ko) | 2020-07-07 | 2023-10-25 | 칸큐어 엘엘씨 | Mic 항체 및 결합제 및 이의 사용 방법 |
| CN116547301A (zh) | 2020-08-10 | 2023-08-04 | 先天制药公司 | 使用抗体进行的细胞表面mica和micb检测 |
| CN112694532B (zh) * | 2021-01-12 | 2023-04-18 | 倍而达药业（苏州）有限公司 | 抗Siglec-15的抗体或其抗原结合片段及应用 |
| US20240216554A1 (en) * | 2021-05-04 | 2024-07-04 | Actinium Pharmaceuticals, Inc. | Radioimmunoconjugates directed to nkg2d ligands for the treatment of cancer |
| CN113502265B (zh) * | 2021-05-25 | 2024-05-28 | 昭泰英基生物医药（香港）有限公司 | 将t细胞重编程为类nk细胞的诱导剂及其应用 |
| CN118307672B (zh) * | 2021-07-14 | 2026-04-17 | 浙江大学 | 一种抗人MICA/B α3区的抗体及其应用 |
| CN114369162B (zh) * | 2021-12-28 | 2023-05-30 | 合肥天港免疫药物有限公司 | 抗体及其应用 |
| CN114369161B (zh) * | 2021-12-28 | 2023-06-23 | 合肥天港免疫药物有限公司 | Mica抗体及其应用 |
| CN116789823A (zh) * | 2023-04-04 | 2023-09-22 | 浙江大学 | 用于检测mica脱落片段的结构域特异性抗体及其应用 |
| CN118027195B (zh) * | 2023-05-06 | 2025-07-04 | 合肥天港免疫药物有限公司 | 亲和力成熟的mica抗体及其应用 |
| CN121591887A (zh) * | 2025-11-27 | 2026-03-03 | 无锡傲锐东源生物科技有限公司 | 一种抗人CD235a兔单克隆抗体及其制备方法和应用 |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5567610A (en) | 1986-09-04 | 1996-10-22 | Bioinvent International Ab | Method of producing human monoclonal antibodies and kit therefor |
| US5229275A (en) | 1990-04-26 | 1993-07-20 | Akzo N.V. | In-vitro method for producing antigen-specific human monoclonal antibodies |
| WO1996030511A1 (en) * | 1995-03-29 | 1996-10-03 | The Immunogenetics Research Foundation Incorporated | Polymorphic and multicopy members of mhc gene families |
| EP0937258A2 (en) | 1996-10-29 | 1999-08-25 | Fred Hutchinson Cancer Research Center, Inc. | Cell stress regulated human mhc class i gene |
| US6277375B1 (en) | 1997-03-03 | 2001-08-21 | Board Of Regents, The University Of Texas System | Immunoglobulin-like domains with increased half-lives |
| JP4334141B2 (ja) | 1998-04-20 | 2009-09-30 | グリカート バイオテクノロジー アクチェンゲゼルシャフト | 抗体依存性細胞傷害性を改善するための抗体のグリコシル化操作 |
| GB9809951D0 (en) | 1998-05-08 | 1998-07-08 | Univ Cambridge Tech | Binding molecules |
| HUP0104865A3 (en) | 1999-01-15 | 2004-07-28 | Genentech Inc | Polypeptide variants with altered effector function |
| US7183387B1 (en) | 1999-01-15 | 2007-02-27 | Genentech, Inc. | Polypeptide variants with altered effector function |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| EP2275540B1 (en) | 1999-04-09 | 2016-03-23 | Kyowa Hakko Kirin Co., Ltd. | Method for controlling the activity of immunologically functional molecule |
| PL213948B1 (pl) | 2001-10-25 | 2013-05-31 | Genentech Inc | Kompozycje zawierajace glikoproteine, czasteczka kwasu nukleinowego kodujaca te glikoproteine, komórka gospodarza, sposób wytwarzania glikoproteiny, kompozycja do zastosowania do leczenia, zastosowanie kompozycji i zestaw zawierajacy kompozycje |
| US7317091B2 (en) | 2002-03-01 | 2008-01-08 | Xencor, Inc. | Optimized Fc variants |
| CA2483343A1 (en) | 2002-04-22 | 2003-10-30 | Fred Hutchinson Cancer Research Center | Soluble mic polypeptides as markers for diagnosis, prognosis and treatment of cancer and autoimmune diseases or conditions |
| PT1534335E (pt) | 2002-08-14 | 2012-02-28 | Macrogenics Inc | Anticorpos específicos de fcγriib e processos para a sua utilização |
| US7355008B2 (en) | 2003-01-09 | 2008-04-08 | Macrogenics, Inc. | Identification and engineering of antibodies with variant Fc regions and methods of using same |
| US7960512B2 (en) | 2003-01-09 | 2011-06-14 | Macrogenics, Inc. | Identification and engineering of antibodies with variant Fc regions and methods of using same |
| WO2005047327A2 (en) | 2003-11-12 | 2005-05-26 | Biogen Idec Ma Inc. | NEONATAL Fc RECEPTOR (FcRn)-BINDING POLYPEPTIDE VARIANTS, DIMERIC Fc BINDING PROTEINS AND METHODS RELATED THERETO |
| CA2565874C (en) | 2004-05-10 | 2017-10-03 | Macrogenics, Inc. | Humanized fc.gamma.riib-specific antibodies and methods of use thereof |
| AU2005335714B2 (en) | 2004-11-10 | 2012-07-26 | Macrogenics, Inc. | Engineering Fc antibody regions to confer effector function |
| KR20080032065A (ko) | 2005-06-03 | 2008-04-14 | 제넨테크, 인크. | 푸코실화 수준이 조절된 항체의 생성 방법 |
| DK2573114T3 (en) | 2005-08-10 | 2016-07-04 | Macrogenics Inc | The identification and production of antibodies with variant Fc regions, and methods of using same |
| EP1949107A1 (en) | 2005-11-03 | 2008-07-30 | Fred Hutchinson Cancer Research Center | Negative immunomodulation of immune responses by nkg2d-positive cd4-positive cells |
| FR2894982A1 (fr) | 2005-12-16 | 2007-06-22 | Lab Francais Du Fractionnement | Procede de preparation d'anticorps selectifs des recepteurs fc activateurs |
| MX2008009220A (es) | 2006-01-17 | 2008-10-10 | Biolex Therapeutics Inc | Composiciones y metodos para la humanizacion y optimizacion de n-glicanos en plantas. |
| JP2009529331A (ja) | 2006-03-10 | 2009-08-20 | マクロジェニクス，インコーポレーテッド | 変異型重鎖を有する抗体の同定および工学的改変ならびにその使用方法 |
| CA2660592C (en) | 2006-05-26 | 2016-07-12 | Macrogenics, Inc. | Humanized fc.gamma.riib-specific antibodies and methods of use thereof |
| EP2032159B1 (en) | 2006-06-26 | 2015-01-07 | MacroGenics, Inc. | Combination of fcgammariib antibodies and cd20-specific antibodies and methods of use thereof |
| EP1878747A1 (en) | 2006-07-11 | 2008-01-16 | greenovation Biotech GmbH | Glyco-engineered antibodies |
| US20100111973A1 (en) * | 2006-09-22 | 2010-05-06 | Glenn Dranoff | Methods for treating mica-related disorders |
| WO2008131406A2 (en) * | 2007-04-23 | 2008-10-30 | Fred Hutchinson Cancer Research Center | NEGATIVE IMMUNOMODULATION OF IMMUNE RESPONSES BY ERp5 |
| EP1995309A1 (en) | 2007-05-21 | 2008-11-26 | Vivalis | Recombinant protein production in avian EBx® cells |
| PH12012501751A1 (en) | 2010-03-04 | 2012-11-12 | Macrogenics Inc | Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof |
| SG191233A1 (en) | 2010-12-23 | 2013-07-31 | Janssen Biotech Inc | Active protease-resistant antibody fc mutants |
| DK2760471T3 (en) | 2011-09-30 | 2017-05-08 | Dana Farber Cancer Inst Inc | THERAPEUTIC PEPTIDES |
| JP6405242B2 (ja) | 2012-02-07 | 2018-10-17 | イナート・ファルマ・ソシエテ・アノニムＩｎｎａｔｅ Ｐｈａｒｍａ Ｐｈａｒｍａ Ｓ．Ａ． | Ｍｉｃａ結合剤 |
| CA3016765A1 (en) | 2016-03-15 | 2017-09-21 | Innate Pharma | Anti-mica antibodies |
-
2013
- 2013-02-07 JP JP2014556052A patent/JP6405242B2/ja active Active
- 2013-02-07 EP EP13704064.8A patent/EP2812027A1/en not_active Ceased
- 2013-02-07 RU RU2014131317A patent/RU2656183C2/ru active
- 2013-02-07 CN CN201380017820.5A patent/CN104244977A/zh active Pending
- 2013-02-07 WO PCT/EP2013/052439 patent/WO2013117647A1/en not_active Ceased
- 2013-02-07 US US14/377,274 patent/US10577416B2/en not_active Expired - Fee Related
- 2013-02-07 AU AU2013218017A patent/AU2013218017B2/en not_active Ceased
- 2013-02-07 BR BR112014019611A patent/BR112014019611A2/pt not_active Application Discontinuation
- 2013-02-07 CA CA2862101A patent/CA2862101A1/en not_active Abandoned
- 2013-02-07 SG SG11201404177PA patent/SG11201404177PA/en unknown
-
2014
- 2014-07-24 IL IL233793A patent/IL233793B/en active IP Right Grant
-
2020
- 2020-02-28 US US16/804,705 patent/US20200299380A1/en not_active Abandoned
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