SG11201404177PA - Mica binding agents - Google Patents

Mica binding agents

Info

Publication number
SG11201404177PA
SG11201404177PA SG11201404177PA SG11201404177PA SG11201404177PA SG 11201404177P A SG11201404177P A SG 11201404177PA SG 11201404177P A SG11201404177P A SG 11201404177PA SG 11201404177P A SG11201404177P A SG 11201404177PA SG 11201404177P A SG11201404177P A SG 11201404177PA
Authority
SG
Singapore
Prior art keywords
binding agents
mica binding
mica
agents
binding
Prior art date
Application number
SG11201404177PA
Inventor
Mathieu Blery
Laurent Gauthier
Ivan Perrot
Cécile Bonnafous
Original Assignee
Innate Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innate Pharma filed Critical Innate Pharma
Publication of SG11201404177PA publication Critical patent/SG11201404177PA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56977—HLA or MHC typing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70539—MHC-molecules, e.g. HLA-molecules
SG11201404177PA 2012-02-07 2013-02-07 Mica binding agents SG11201404177PA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261595902P 2012-02-07 2012-02-07
US201261625841P 2012-04-18 2012-04-18
PCT/EP2013/052439 WO2013117647A1 (en) 2012-02-07 2013-02-07 Mica binding agents

Publications (1)

Publication Number Publication Date
SG11201404177PA true SG11201404177PA (en) 2014-08-28

Family

ID=47714068

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201404177PA SG11201404177PA (en) 2012-02-07 2013-02-07 Mica binding agents

Country Status (11)

Country Link
US (2) US10577416B2 (en)
EP (1) EP2812027A1 (en)
JP (1) JP6405242B2 (en)
CN (1) CN104244977A (en)
AU (1) AU2013218017B2 (en)
BR (1) BR112014019611A2 (en)
CA (1) CA2862101A1 (en)
IL (1) IL233793B (en)
RU (1) RU2656183C2 (en)
SG (1) SG11201404177PA (en)
WO (1) WO2013117647A1 (en)

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JP6944925B2 (en) 2015-07-24 2021-10-06 イナート・ファルマ・ソシエテ・アノニムＩｎｎａｔｅ Ｐｈａｒｍａ Ｐｈａｒｍａ Ｓ．Ａ． How to detect tissue-infiltrating NK cells
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CN107964041B (en) * 2016-10-20 2023-08-01 中国科学院广州生物医药与健康研究院 High stability and high affinity DMIC and its preparing process
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EP3559042A4 (en) * 2016-12-22 2020-11-25 Icahn School of Medicine at Mount Sinai Anti-lilrb3 antibodies and methods of use thereof
WO2018141959A1 (en) 2017-02-06 2018-08-09 Innate Pharma Immunomodulatory antibody drug conjugates binding to a human mica polypeptide
US11421032B2 (en) 2017-05-22 2022-08-23 Dana-Farber Cancer Institute, Inc. Compositions and methods for inhibition of MICA/B shedding
BR112019027353A2 (en) * 2017-07-10 2020-07-14 Innate Pharma agents, antibody, pharmaceutical composition, kits, lymphocyte modulation method, in vitro lymphocyte activity modulation method and composition
EP3692068B1 (en) * 2017-10-06 2022-12-07 Innate Pharma Restoration of t cell activity via the cd39/cd73 axis
WO2019183551A1 (en) * 2018-03-23 2019-09-26 Bristol-Myers Squibb Company Antibodies against mica and/or micb and uses thereof
WO2020028428A2 (en) * 2018-07-31 2020-02-06 Pdi Therapeutics, Inc. Anti-mica/b antibodies that block mica/b shedding and methods of use
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US20220288225A1 (en) * 2019-08-23 2022-09-15 Northwestern University Materials and methods for activating antigen-specific t cell responses
EP4069748A4 (en) * 2019-12-05 2023-11-15 Vycellix, Inc. Modulators of the immune escape mechanism for universal cell therapy
CN111471099B (en) * 2020-03-31 2022-04-12 长沙学院 MICA extracellular domain mutant and screening method thereof, scFv-MICA fusion antibody and preparation method and application thereof
CN111718416B (en) * 2020-06-25 2022-04-01 菲鹏生物股份有限公司 Anti-thioredoxin antibody, application thereof and diagnostic kit
CN116547301A (en) 2020-08-10 2023-08-04 先天制药公司 Cell surface MICA and MICB detection using antibodies
CN112694532B (en) * 2021-01-12 2023-04-18 倍而达药业（苏州）有限公司 Antibody against Siglec-15 or antigen binding fragment thereof and application
CN115611982A (en) * 2021-07-14 2023-01-17 浙江大学 Monoclonal antibody resisting human MICA/B alpha 3 region and application thereof
CN114369162B (en) * 2021-12-28 2023-05-30 合肥天港免疫药物有限公司 Antibodies and uses thereof
CN114369161B (en) * 2021-12-28 2023-06-23 合肥天港免疫药物有限公司 MICA antibodies and uses thereof

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Also Published As

Publication number Publication date
CA2862101A1 (en) 2013-08-15
EP2812027A1 (en) 2014-12-17
WO2013117647A1 (en) 2013-08-15
JP6405242B2 (en) 2018-10-17
US20200299380A1 (en) 2020-09-24
JP2015508757A (en) 2015-03-23
IL233793B (en) 2020-04-30
RU2014131317A (en) 2016-03-27
IL233793A0 (en) 2014-09-30
AU2013218017A2 (en) 2014-10-16
US10577416B2 (en) 2020-03-03
AU2013218017A1 (en) 2014-09-11
US20150191542A1 (en) 2015-07-09
CN104244977A (en) 2014-12-24
RU2656183C2 (en) 2018-05-31
BR112014019611A2 (en) 2017-06-27
AU2013218017B2 (en) 2017-12-07

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