JP2020527144A5 - - Google Patents
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- Publication number
- JP2020527144A5 JP2020527144A5 JP2020501379A JP2020501379A JP2020527144A5 JP 2020527144 A5 JP2020527144 A5 JP 2020527144A5 JP 2020501379 A JP2020501379 A JP 2020501379A JP 2020501379 A JP2020501379 A JP 2020501379A JP 2020527144 A5 JP2020527144 A5 JP 2020527144A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- siglec
- seq
- variable region
- light chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 101000863883 Homo sapiens Sialic acid-binding Ig-like lectin 9 Proteins 0.000 claims 14
- 230000002401 inhibitory effect Effects 0.000 claims 13
- 102100029965 Sialic acid-binding Ig-like lectin 9 Human genes 0.000 claims 9
- 229920001184 polypeptide Polymers 0.000 claims 8
- 102000004196 processed proteins & peptides Human genes 0.000 claims 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims 8
- 101000863882 Homo sapiens Sialic acid-binding Ig-like lectin 7 Proteins 0.000 claims 7
- 102000007073 Sialic Acid Binding Immunoglobulin-like Lectins Human genes 0.000 claims 6
- 108010047827 Sialic Acid Binding Immunoglobulin-like Lectins Proteins 0.000 claims 6
- 102100029946 Sialic acid-binding Ig-like lectin 7 Human genes 0.000 claims 6
- 210000004027 cell Anatomy 0.000 claims 6
- 102000045929 human SIGLEC9 Human genes 0.000 claims 5
- 210000000822 natural killer cell Anatomy 0.000 claims 5
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 102000056982 human CD33 Human genes 0.000 claims 4
- 230000003211 malignant effect Effects 0.000 claims 4
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 claims 3
- 239000003446 ligand Substances 0.000 claims 3
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 claims 3
- 101150069255 KLRC1 gene Proteins 0.000 claims 2
- 101100404845 Macaca mulatta NKG2A gene Proteins 0.000 claims 2
- 102100022682 NKG2-A/NKG2-B type II integral membrane protein Human genes 0.000 claims 2
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 2
- 231100000135 cytotoxicity Toxicity 0.000 claims 2
- 230000003013 cytotoxicity Effects 0.000 claims 2
- 230000000779 depleting effect Effects 0.000 claims 2
- 210000005260 human cell Anatomy 0.000 claims 2
- 230000003472 neutralizing effect Effects 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 102100028970 HLA class I histocompatibility antigen, alpha chain E Human genes 0.000 claims 1
- 101000986085 Homo sapiens HLA class I histocompatibility antigen, alpha chain E Proteins 0.000 claims 1
- 101001109508 Homo sapiens NKG2-A/NKG2-B type II integral membrane protein Proteins 0.000 claims 1
- 102000009490 IgG Receptors Human genes 0.000 claims 1
- 108010073807 IgG Receptors Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 1
- 108010029180 Sialic Acid Binding Ig-like Lectin 3 Proteins 0.000 claims 1
- 102100027093 Sialic acid-binding Ig-like lectin 12 Human genes 0.000 claims 1
- 101710143288 Sialic acid-binding Ig-like lectin 12 Proteins 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000000112 colonic effect Effects 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 231100000433 cytotoxic Toxicity 0.000 claims 1
- 230000001472 cytotoxic effect Effects 0.000 claims 1
- 238000002784 cytotoxicity assay Methods 0.000 claims 1
- 231100000263 cytotoxicity test Toxicity 0.000 claims 1
- 230000007423 decrease Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 102000057310 human KLRC1 Human genes 0.000 claims 1
- 102000050701 human SIGLEC7 Human genes 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 206010038038 rectal cancer Diseases 0.000 claims 1
- 201000001275 rectum cancer Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762530454P | 2017-07-10 | 2017-07-10 | |
| US62/530,454 | 2017-07-10 | ||
| PCT/EP2018/068532 WO2019011852A1 (en) | 2017-07-10 | 2018-07-09 | POLYTHERAPY USING ANTIBODY AGAINST SIGLEC-9 HUMAN AND ANTIBODY AGAINST NKG2A HUMAN FOR THE TREATMENT OF CANCER |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020527144A JP2020527144A (ja) | 2020-09-03 |
| JP2020527144A5 true JP2020527144A5 (enExample) | 2021-04-30 |
Family
ID=62981177
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020501379A Pending JP2020527144A (ja) | 2017-07-10 | 2018-07-09 | 癌を処置するためのヒトｓｉｇｌｅｃ−９に対する抗体およびヒトｎｋｇ２ａに対する抗体を使用する組み合わせ療法 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US11447545B2 (enExample) |
| EP (1) | EP3652207A1 (enExample) |
| JP (1) | JP2020527144A (enExample) |
| KR (1) | KR20200026254A (enExample) |
| CN (1) | CN111465614A (enExample) |
| AU (1) | AU2018298673A1 (enExample) |
| BR (1) | BR112019027353A2 (enExample) |
| CA (1) | CA3066571A1 (enExample) |
| WO (1) | WO2019011852A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10053513B2 (en) * | 2009-11-30 | 2018-08-21 | Janssen Biotech, Inc. | Antibody Fc mutants with ablated effector functions |
| CN111234027A (zh) | 2015-05-21 | 2020-06-05 | 哈普恩治疗公司 | 三特异性结合蛋白质及使用方法 |
| US11623958B2 (en) | 2016-05-20 | 2023-04-11 | Harpoon Therapeutics, Inc. | Single chain variable fragment CD3 binding proteins |
| CA3063359A1 (en) | 2017-05-12 | 2018-11-15 | Harpoon Therapeutics, Inc. | Mesothelin binding proteins |
| JP7293188B2 (ja) | 2017-07-10 | 2023-06-19 | イナート・ファルマ・ソシエテ・アノニム | Ｓｉｇｌｅｃ－９中和抗体 |
| UA129446C2 (uk) | 2017-10-13 | 2025-04-30 | Гарпун Терап'Ютікс, Інк. | Триспецифічні білки і способи їх застосування |
| IL315737A (en) | 2017-10-13 | 2024-11-01 | Harpoon Therapeutics Inc | B-cell maturation antigen-binding proteins |
| US12195544B2 (en) | 2018-09-21 | 2025-01-14 | Harpoon Therapeutics, Inc. | EGFR binding proteins and methods of use |
| EP3856771A4 (en) | 2018-09-25 | 2022-06-29 | Harpoon Therapeutics, Inc. | Dll3 binding proteins and methods of use |
| WO2021024020A1 (en) | 2019-08-06 | 2021-02-11 | Astellas Pharma Inc. | Combination therapy involving antibodies against claudin 18.2 and immune checkpoint inhibitors for treatment of cancer |
| CN114667298A (zh) | 2019-11-04 | 2022-06-24 | 艾利妥 | Siglec-9 ecd融合分子及其使用方法 |
| CN114787189A (zh) * | 2019-11-14 | 2022-07-22 | 备忘录疗法股份公司 | 抗Siglec-9抗体分子 |
| MX2023000197A (es) | 2020-07-07 | 2023-02-22 | BioNTech SE | Arn terapeutico para el cancer positivo para vph. |
| US12178880B2 (en) * | 2020-12-04 | 2024-12-31 | Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd. | Antibody-drug conjugate, and intermediate thereof, preparation method therefor, and application thereof |
| TW202245808A (zh) | 2020-12-21 | 2022-12-01 | 德商拜恩迪克公司 | 用於治療癌症之治療性ｒｎａ |
| WO2022135667A1 (en) | 2020-12-21 | 2022-06-30 | BioNTech SE | Therapeutic rna for treating cancer |
| WO2022135666A1 (en) | 2020-12-21 | 2022-06-30 | BioNTech SE | Treatment schedule for cytokine proteins |
| CA3225254A1 (en) | 2021-07-13 | 2023-01-19 | BioNTech SE | Multispecific binding agents against cd40 and cd137 in combination therapy for cancer |
| TW202333802A (zh) | 2021-10-11 | 2023-09-01 | 德商拜恩迪克公司 | 用於肺癌之治療性rna(二) |
| AU2023393653A1 (en) | 2022-12-14 | 2025-05-22 | Astellas Pharma Europe Bv | Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and immune checkpoint inhibitors |
| WO2025120866A1 (en) | 2023-12-08 | 2025-06-12 | Astellas Pharma Inc. | Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and agents stabilizing or increasing expression of cldn18.2 |
| WO2025121445A1 (en) | 2023-12-08 | 2025-06-12 | Astellas Pharma Inc. | Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and agents stabilizing or increasing expression of cldn18.2 |
| WO2025120867A1 (en) | 2023-12-08 | 2025-06-12 | Astellas Pharma Inc. | Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and anti-vegfr2 antibodies |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5567610A (en) | 1986-09-04 | 1996-10-22 | Bioinvent International Ab | Method of producing human monoclonal antibodies and kit therefor |
| US6673986B1 (en) | 1990-01-12 | 2004-01-06 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| US5229275A (en) | 1990-04-26 | 1993-07-20 | Akzo N.V. | In-vitro method for producing antigen-specific human monoclonal antibodies |
| US5776427A (en) | 1992-03-05 | 1998-07-07 | Board Of Regents, The University Of Texas System | Methods for targeting the vasculature of solid tumors |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| IT1307826B1 (it) | 1999-12-16 | 2001-11-19 | Dipartimento Di Medicina Speri | Metodo diagnostico per il riconoscimento di cellule mieloidi normali eleucemiche, ligandi utilizzati in detto metodo e formulazioni ad uso |
| JP4524181B2 (ja) | 2002-05-30 | 2010-08-11 | マクロジェニクス，インコーポレーテッド | Ｃｄ１６ａ結合タンパク質および免疫障害治療のための使用 |
| MX2008015830A (es) | 2006-06-30 | 2009-01-09 | Novo Nordisk As | Anticuerpos anti-nkg2a y usos de los mismos. |
| US8187801B2 (en) * | 2008-04-24 | 2012-05-29 | Wisconsin Alumni Research Foundation | Methods and kits to detect and monitor ovarian cancer and preeclampsia |
| SI2506871T1 (sl) | 2009-11-30 | 2016-12-30 | Janssen Biotech, Inc. | Mutanti Fc protitelesa z odstranjenimi efektorskimi funkcijami |
| AR083847A1 (es) | 2010-11-15 | 2013-03-27 | Novartis Ag | Variantes de fc (fragmento constante) silenciosas de los anticuerpos anti-cd40 |
| BR112014019611A2 (pt) * | 2012-02-07 | 2017-06-27 | Innate Pharma | agentes de ligação mica |
| WO2016038064A1 (en) * | 2014-09-10 | 2016-03-17 | Innate Pharma | Cross reactive siglec antibodies |
| EP4368205A1 (en) * | 2014-09-16 | 2024-05-15 | Innate Pharma | Neutralization of inhibitory pathways in lymphocytes |
| SG11201701387SA (en) * | 2014-09-16 | 2017-03-30 | Innate Pharma | Treatment regimens using anti-nkg2a antibodies |
| WO2016062851A1 (en) | 2014-10-23 | 2016-04-28 | Innate Pharma | Treatment of cancers using anti-nkg2a agents |
| EP3402516A4 (en) | 2016-01-12 | 2020-01-08 | Palleon Pharmaceuticals Inc. | USE OF ANTIBODIES DIRECTED AGAINST SIGLEC-7 OR SIGLEC-9 IN THE TREATMENT OF CANCER |
| CN108699158B (zh) * | 2016-03-08 | 2022-06-03 | 依奈特制药公司 | Siglec中和抗体 |
| US11773162B2 (en) | 2016-08-05 | 2023-10-03 | Allakos, Inc. | Anti-Siglec-7 antibodies for the treatment of cancer |
| JP7293188B2 (ja) | 2017-07-10 | 2023-06-19 | イナート・ファルマ・ソシエテ・アノニム | Ｓｉｇｌｅｃ－９中和抗体 |
| CN114127121B (zh) * | 2019-08-12 | 2025-04-11 | 北京恩瑞尼生物科技股份有限公司 | 用于通过cd39表达细胞的adcc靶向促进和增强t细胞介导的免疫反应的方法和组合物 |
| US11795223B2 (en) * | 2019-10-18 | 2023-10-24 | Forty Seven, Inc. | Combination therapies for treating myelodysplastic syndromes and acute myeloid leukemia |
| CA3189616A1 (en) * | 2020-09-10 | 2022-03-17 | Purinomia Biotech, Inc. | Methods and compositions for potentiating antitumoral immune responses through targeting of ntpdase3 |
-
2018
- 2018-07-09 JP JP2020501379A patent/JP2020527144A/ja active Pending
- 2018-07-09 KR KR1020207001758A patent/KR20200026254A/ko not_active Withdrawn
- 2018-07-09 CA CA3066571A patent/CA3066571A1/en active Pending
- 2018-07-09 AU AU2018298673A patent/AU2018298673A1/en not_active Abandoned
- 2018-07-09 CN CN201880046184.1A patent/CN111465614A/zh active Pending
- 2018-07-09 BR BR112019027353-0A patent/BR112019027353A2/pt not_active IP Right Cessation
- 2018-07-09 US US16/629,585 patent/US11447545B2/en active Active
- 2018-07-09 EP EP18743424.6A patent/EP3652207A1/en not_active Withdrawn
- 2018-07-09 WO PCT/EP2018/068532 patent/WO2019011852A1/en not_active Ceased
-
2022
- 2022-09-19 US US17/933,133 patent/US20230085847A1/en not_active Abandoned
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