CA2862101A1 - Mica binding agents - Google Patents
Mica binding agents Download PDFInfo
- Publication number
- CA2862101A1 CA2862101A1 CA2862101A CA2862101A CA2862101A1 CA 2862101 A1 CA2862101 A1 CA 2862101A1 CA 2862101 A CA2862101 A CA 2862101A CA 2862101 A CA2862101 A CA 2862101A CA 2862101 A1 CA2862101 A1 CA 2862101A1
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- Prior art keywords
- antibody
- mica
- seq
- amino acid
- polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56977—HLA or MHC typing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
- G01N2333/70539—MHC-molecules, e.g. HLA-molecules
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (5)
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| US201261595902P | 2012-02-07 | 2012-02-07 | |
| US61/595,902 | 2012-02-07 | ||
| US201261625841P | 2012-04-18 | 2012-04-18 | |
| US61/625,841 | 2012-04-18 | ||
| PCT/EP2013/052439 WO2013117647A1 (en) | 2012-02-07 | 2013-02-07 | Mica binding agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2862101A1 true CA2862101A1 (en) | 2013-08-15 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CA2862101A Abandoned CA2862101A1 (en) | 2012-02-07 | 2013-02-07 | Mica binding agents |
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| Country | Link |
|---|---|
| US (2) | US10577416B2 (enExample) |
| EP (1) | EP2812027A1 (enExample) |
| JP (1) | JP6405242B2 (enExample) |
| CN (1) | CN104244977A (enExample) |
| AU (1) | AU2013218017B2 (enExample) |
| BR (1) | BR112014019611A2 (enExample) |
| CA (1) | CA2862101A1 (enExample) |
| IL (1) | IL233793B (enExample) |
| RU (1) | RU2656183C2 (enExample) |
| SG (1) | SG11201404177PA (enExample) |
| WO (1) | WO2013117647A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110267678A (zh) * | 2016-10-29 | 2019-09-20 | 霍夫曼-拉罗奇有限公司 | 抗mic抗体和使用方法 |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EP3210625B1 (en) * | 2011-09-30 | 2019-08-28 | Dana-Farber Cancer Institute, Inc. | Therapeutic peptides comprising antibodies binding to mhc class 1 polypeptide related sequence a (mica) |
| BR112014019611A2 (pt) | 2012-02-07 | 2017-06-27 | Innate Pharma | agentes de ligação mica |
| CA2906356A1 (en) | 2013-03-15 | 2014-09-18 | Novelogics Biotechnology, Inc. | Antibodies to mica and micb proteins |
| WO2014144791A2 (en) | 2013-03-15 | 2014-09-18 | Dana-Farber Cancer Institute, Inc. | Therapeutic peptides |
| WO2015085210A1 (en) | 2013-12-06 | 2015-06-11 | Dana-Farber Cancer Institute, Inc. | Therapeutic peptides |
| WO2015139020A2 (en) | 2014-03-14 | 2015-09-17 | Dana-Farber Cancer Institute, Inc. | Vaccine compositions and methods for restoring nkg2d pathway function against cancers |
| US11453713B2 (en) * | 2014-12-05 | 2022-09-27 | Xyphos Biosciences Inc. | Insertable variable fragments of antibodies and modified A1-A2 domains of NKG2D ligands |
| WO2016154585A1 (en) | 2015-03-26 | 2016-09-29 | Charles Sentman | Anti-mica antigen binding fragments, fusion molecules, cells which express and methods of using |
| US10736963B2 (en) | 2015-07-24 | 2020-08-11 | Innate Pharma | Methods for detecting tissue infiltrating NK cells |
| TN2018000187A1 (en) * | 2015-12-04 | 2019-10-04 | Dana Farber Cancer Inst Inc | Vaccination with mica/b alpha 3 domain for the treatment of cancer |
| WO2017147247A1 (en) * | 2016-02-23 | 2017-08-31 | Pires Eusebio S | Anti-sas1b antibodies and methods of use |
| WO2017157895A1 (en) | 2016-03-15 | 2017-09-21 | Innate Pharma | Anti-mica antibodies |
| CN107779433A (zh) * | 2016-08-30 | 2018-03-09 | 天津市康婷生物工程有限公司 | 便捷的刺激nk细胞增殖和分化的饲养层制备方法 |
| JP2020502042A (ja) | 2016-10-19 | 2020-01-23 | ノヴェロジックス・バイオテクノロジー，インコーポレーテッド | Ｍｉｃａおよびｍｉｃｂタンパク質に対する抗体 |
| CN107964041B (zh) * | 2016-10-20 | 2023-08-01 | 中国科学院广州生物医药与健康研究院 | 高稳定性和高亲和力的dmic及其制法 |
| CA3047833A1 (en) * | 2016-12-22 | 2018-06-28 | Icahn School Of Medicine At Mount Sinai | Anti-lilrb3 antibodies and methods of use thereof |
| WO2018141959A1 (en) | 2017-02-06 | 2018-08-09 | Innate Pharma | Immunomodulatory antibody drug conjugates binding to a human mica polypeptide |
| EP3661552A4 (en) * | 2017-05-22 | 2021-08-25 | Dana-Farber Cancer Institute, Inc. | COMPOSITIONS AND METHODS FOR INHIBITING THE ELIMINATION OF MICA / B |
| JP2020527144A (ja) * | 2017-07-10 | 2020-09-03 | イナート・ファルマ・ソシエテ・アノニムＩｎｎａｔｅ Ｐｈａｒｍａ Ｐｈａｒｍａ Ｓ．Ａ． | 癌を処置するためのヒトｓｉｇｌｅｃ−９に対する抗体およびヒトｎｋｇ２ａに対する抗体を使用する組み合わせ療法 |
| JP7274469B2 (ja) * | 2017-10-06 | 2023-05-16 | イナート・ファルマ・ソシエテ・アノニム | Ｃｄ３９／ｃｄ７３軸によるｔ細胞活性の回復 |
| JP7351845B2 (ja) * | 2018-03-23 | 2023-09-27 | ブリストル－マイヤーズ スクイブ カンパニー | Ｍｉｃａおよび／またはｍｉｃｂに対する抗体ならびにそれらの使用 |
| IL280487B2 (en) * | 2018-07-31 | 2025-07-01 | Cullinan Mica Corp | Anti-mica/b antibodies that block mica/b shedding and methods of use |
| WO2020035345A1 (en) | 2018-08-14 | 2020-02-20 | Innate Pharma | Treatment of colorectal cancer by a combination of an anti-mica antibody and an anti-nkg2a antibody |
| CA3148318A1 (en) * | 2019-08-23 | 2021-03-04 | Jennifer D. Wu | Materials and methods for activating antigen-specific t cell responses |
| KR20220137882A (ko) * | 2019-12-05 | 2022-10-12 | 바이셀릭스, 인크. | 보편적 세포 요법을 위한 면역 회피 기작의 조절제 |
| CN111471099B (zh) * | 2020-03-31 | 2022-04-12 | 长沙学院 | MICA胞外区突变体及其筛选的方法、scFv-MICA融合抗体及其制备方法和应用 |
| CN111718416B (zh) * | 2020-06-25 | 2022-04-01 | 菲鹏生物股份有限公司 | 抗硫氧还蛋白的抗体、其应用和诊断试剂盒 |
| TW202216776A (zh) | 2020-07-07 | 2022-05-01 | 美商康愈有限責任公司 | Mic抗體及結合劑以及其使用方法 |
| EP4192876A1 (en) | 2020-08-10 | 2023-06-14 | Innate Pharma | Cell surface mica and micb detection using antibodies |
| CN112694532B (zh) * | 2021-01-12 | 2023-04-18 | 倍而达药业（苏州）有限公司 | 抗Siglec-15的抗体或其抗原结合片段及应用 |
| CN113502265B (zh) * | 2021-05-25 | 2024-05-28 | 昭泰英基生物医药（香港）有限公司 | 将t细胞重编程为类nk细胞的诱导剂及其应用 |
| CN115611982B (zh) * | 2021-07-14 | 2024-05-10 | 浙江大学 | 一种抗人MICA/Bα3区的单克隆抗体及其应用 |
| CN114369161B (zh) * | 2021-12-28 | 2023-06-23 | 合肥天港免疫药物有限公司 | Mica抗体及其应用 |
| CN114369162B (zh) * | 2021-12-28 | 2023-05-30 | 合肥天港免疫药物有限公司 | 抗体及其应用 |
| CN118027195B (zh) * | 2023-05-06 | 2025-07-04 | 合肥天港免疫药物有限公司 | 亲和力成熟的mica抗体及其应用 |
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| US5567610A (en) | 1986-09-04 | 1996-10-22 | Bioinvent International Ab | Method of producing human monoclonal antibodies and kit therefor |
| US5229275A (en) | 1990-04-26 | 1993-07-20 | Akzo N.V. | In-vitro method for producing antigen-specific human monoclonal antibodies |
| WO1996030511A1 (en) * | 1995-03-29 | 1996-10-03 | The Immunogenetics Research Foundation Incorporated | Polymorphic and multicopy members of mhc gene families |
| CA2275141A1 (en) | 1996-10-29 | 1998-05-07 | Thomas Spies | Cell stress regulated human mhc class i gene |
| US6277375B1 (en) | 1997-03-03 | 2001-08-21 | Board Of Regents, The University Of Texas System | Immunoglobulin-like domains with increased half-lives |
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-
2013
- 2013-02-07 BR BR112014019611A patent/BR112014019611A2/pt not_active Application Discontinuation
- 2013-02-07 CN CN201380017820.5A patent/CN104244977A/zh active Pending
- 2013-02-07 US US14/377,274 patent/US10577416B2/en not_active Expired - Fee Related
- 2013-02-07 RU RU2014131317A patent/RU2656183C2/ru active
- 2013-02-07 JP JP2014556052A patent/JP6405242B2/ja active Active
- 2013-02-07 AU AU2013218017A patent/AU2013218017B2/en not_active Ceased
- 2013-02-07 CA CA2862101A patent/CA2862101A1/en not_active Abandoned
- 2013-02-07 EP EP13704064.8A patent/EP2812027A1/en not_active Ceased
- 2013-02-07 SG SG11201404177PA patent/SG11201404177PA/en unknown
- 2013-02-07 WO PCT/EP2013/052439 patent/WO2013117647A1/en not_active Ceased
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2014
- 2014-07-24 IL IL233793A patent/IL233793B/en active IP Right Grant
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2020
- 2020-02-28 US US16/804,705 patent/US20200299380A1/en not_active Abandoned
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110267678A (zh) * | 2016-10-29 | 2019-09-20 | 霍夫曼-拉罗奇有限公司 | 抗mic抗体和使用方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| RU2656183C2 (ru) | 2018-05-31 |
| WO2013117647A1 (en) | 2013-08-15 |
| SG11201404177PA (en) | 2014-08-28 |
| AU2013218017B2 (en) | 2017-12-07 |
| US10577416B2 (en) | 2020-03-03 |
| AU2013218017A1 (en) | 2014-09-11 |
| AU2013218017A2 (en) | 2014-10-16 |
| US20200299380A1 (en) | 2020-09-24 |
| IL233793B (en) | 2020-04-30 |
| JP6405242B2 (ja) | 2018-10-17 |
| EP2812027A1 (en) | 2014-12-17 |
| JP2015508757A (ja) | 2015-03-23 |
| BR112014019611A2 (pt) | 2017-06-27 |
| US20150191542A1 (en) | 2015-07-09 |
| CN104244977A (zh) | 2014-12-24 |
| IL233793A0 (en) | 2014-09-30 |
| RU2014131317A (ru) | 2016-03-27 |
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