JP2015508281A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015508281A5 JP2015508281A5 JP2014541420A JP2014541420A JP2015508281A5 JP 2015508281 A5 JP2015508281 A5 JP 2015508281A5 JP 2014541420 A JP2014541420 A JP 2014541420A JP 2014541420 A JP2014541420 A JP 2014541420A JP 2015508281 A5 JP2015508281 A5 JP 2015508281A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- allele
- nucleic acid
- acid sequence
- snp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108700028369 Alleles Proteins 0.000 claims 56
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 48
- 150000007523 nucleic acids Chemical group 0.000 claims 47
- RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 claims 36
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 claims 24
- 229940113082 thymine Drugs 0.000 claims 18
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 16
- 235000004279 alanine Nutrition 0.000 claims 16
- 102100040999 Catechol O-methyltransferase Human genes 0.000 claims 12
- 108020002739 Catechol O-methyltransferase Proteins 0.000 claims 12
- 102100020756 D(2) dopamine receptor Human genes 0.000 claims 12
- 101000931901 Homo sapiens D(2) dopamine receptor Proteins 0.000 claims 12
- 102000002114 Reduced Folate Carrier Human genes 0.000 claims 12
- 108050009454 Reduced Folate Carrier Proteins 0.000 claims 12
- 238000003556 assay Methods 0.000 claims 12
- 108010030837 Methylenetetrahydrofolate Reductase (NADPH2) Proteins 0.000 claims 10
- 102100029684 Methylenetetrahydrofolate reductase Human genes 0.000 claims 10
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 9
- 102100027346 GTP cyclohydrolase 1 Human genes 0.000 claims 8
- 101710094136 GTP cyclohydrolase 1 Proteins 0.000 claims 8
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims 8
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims 8
- 102100031551 Methionine synthase Human genes 0.000 claims 6
- 230000001430 anti-depressive effect Effects 0.000 claims 6
- 239000000935 antidepressant agent Substances 0.000 claims 6
- 229940005513 antidepressants Drugs 0.000 claims 6
- 235000019152 folic acid Nutrition 0.000 claims 6
- 239000011724 folic acid Substances 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 238000011269 treatment regimen Methods 0.000 claims 6
- 208000008589 Obesity Diseases 0.000 claims 5
- 235000020824 obesity Nutrition 0.000 claims 5
- 102200124653 rs4680 Human genes 0.000 claims 5
- 102100024810 DNA (cytosine-5)-methyltransferase 3B Human genes 0.000 claims 4
- 102100025413 Formyltetrahydrofolate synthetase Human genes 0.000 claims 4
- 102100040287 GTP cyclohydrolase 1 feedback regulatory protein Human genes 0.000 claims 4
- 101710185324 GTP cyclohydrolase 1 feedback regulatory protein Proteins 0.000 claims 4
- 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 claims 4
- 101000909249 Homo sapiens DNA (cytosine-5)-methyltransferase 3B Proteins 0.000 claims 4
- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 claims 4
- 102100024614 Methionine synthase reductase Human genes 0.000 claims 4
- 229940104302 cytosine Drugs 0.000 claims 4
- 229940014144 folate Drugs 0.000 claims 4
- 102200088972 rs1801133 Human genes 0.000 claims 4
- JVJFIQYAHPMBBX-FNORWQNLSA-N (E)-4-hydroxynon-2-enal Chemical compound CCCCCC(O)\C=C\C=O JVJFIQYAHPMBBX-FNORWQNLSA-N 0.000 claims 3
- 108010075604 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase Proteins 0.000 claims 3
- 108010074051 C-Reactive Protein Proteins 0.000 claims 3
- JVJFIQYAHPMBBX-UHFFFAOYSA-N HNE Natural products CCCCCC(O)C=CC=O JVJFIQYAHPMBBX-UHFFFAOYSA-N 0.000 claims 3
- 101000867811 Homo sapiens Voltage-dependent L-type calcium channel subunit alpha-1C Proteins 0.000 claims 3
- 102100032574 Voltage-dependent L-type calcium channel subunit alpha-1C Human genes 0.000 claims 3
- 230000001419 dependent effect Effects 0.000 claims 3
- 102200141619 rs1051266 Human genes 0.000 claims 3
- 102200088640 rs2274976 Human genes 0.000 claims 3
- 102220113388 rs4633 Human genes 0.000 claims 3
- 102100029172 Choline-phosphate cytidylyltransferase A Human genes 0.000 claims 2
- 101710100763 Choline-phosphate cytidylyltransferase A Proteins 0.000 claims 2
- 108010044266 Dopamine Plasma Membrane Transport Proteins Proteins 0.000 claims 2
- 102100020765 Formimidoyltetrahydrofolate cyclodeaminase Human genes 0.000 claims 2
- 102000015436 Glutamate formimidoyltransferase Human genes 0.000 claims 2
- 108010064766 Glutamate formimidoyltransferase Proteins 0.000 claims 2
- 101001116314 Homo sapiens Methionine synthase reductase Proteins 0.000 claims 2
- 101000639972 Homo sapiens Sodium-dependent dopamine transporter Proteins 0.000 claims 2
- 108010010685 Methenyltetrahydrofolate cyclohydrolase Proteins 0.000 claims 2
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims 2
- XJLXINKUBYWONI-NNYOXOHSSA-O NADP(+) Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-NNYOXOHSSA-O 0.000 claims 2
- 102000005029 SLC6A3 Human genes 0.000 claims 2
- 102100033928 Sodium-dependent dopamine transporter Human genes 0.000 claims 2
- 108010042865 aquacobalamin reductase Proteins 0.000 claims 2
- 239000000090 biomarker Substances 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 229960000304 folic acid Drugs 0.000 claims 2
- 108010060923 formiminotetrahydrofolate cyclodeaminase Proteins 0.000 claims 2
- 238000003205 genotyping method Methods 0.000 claims 2
- 208000024714 major depressive disease Diseases 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 208000020401 Depressive disease Diseases 0.000 claims 1
- 230000003321 amplification Effects 0.000 claims 1
- 238000004458 analytical method Methods 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- -1 calcium nucleic acid Chemical class 0.000 claims 1
- 238000003199 nucleic acid amplification method Methods 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 210000003296 saliva Anatomy 0.000 claims 1
- 229940124834 selective serotonin reuptake inhibitor Drugs 0.000 claims 1
- 239000012896 selective serotonin reuptake inhibitor Substances 0.000 claims 1
- 238000011282 treatment Methods 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161559541P | 2011-11-14 | 2011-11-14 | |
| US61/559,541 | 2011-11-14 | ||
| PCT/US2012/065084 WO2013074676A2 (en) | 2011-11-14 | 2012-11-14 | Assays and methods for selecting a treatment regimen for a subject with depression |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015508281A JP2015508281A (ja) | 2015-03-19 |
| JP2015508281A5 true JP2015508281A5 (enExample) | 2016-01-14 |
| JP6285865B2 JP6285865B2 (ja) | 2018-02-28 |
Family
ID=47279072
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014541420A Expired - Fee Related JP6285865B2 (ja) | 2011-11-14 | 2012-11-14 | うつ病を有する対象のための処置レジメンを選択するためのアッセイ及び方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US9540691B2 (enExample) |
| EP (1) | EP2780467B1 (enExample) |
| JP (1) | JP6285865B2 (enExample) |
| KR (1) | KR102035877B1 (enExample) |
| CN (1) | CN104053785A (enExample) |
| AU (1) | AU2012340015B2 (enExample) |
| BR (1) | BR112014011491A2 (enExample) |
| CA (1) | CA2855640C (enExample) |
| IL (1) | IL232407B (enExample) |
| IN (1) | IN2014DN04226A (enExample) |
| MX (1) | MX354547B (enExample) |
| RU (1) | RU2622082C2 (enExample) |
| WO (1) | WO2013074676A2 (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2012340015B2 (en) * | 2011-11-14 | 2017-09-21 | Alfasigma S.P.A. | Assays for selecting a treatment regimen for a subject with depression and methods for treatment |
| RU2015143177A (ru) * | 2013-03-12 | 2017-04-18 | Нестек С.А. | Анализы и способы выбора схемы лечения для субъекта с депрессией |
| PE20200404A1 (es) | 2013-03-15 | 2020-02-26 | Janssen Pharmaceutica Nv | Composicion farmaceutica de clorhidrato de s-ketamina |
| US9549937B2 (en) * | 2013-12-05 | 2017-01-24 | Burvia, LLC. | Composition containing phospholipid-DHA and folate |
| US20150250813A1 (en) * | 2013-12-05 | 2015-09-10 | Buriva, LLC | Dietary supplement containing phospholipid-dha, folate, and n-acetyl-l-cysteine |
| US9610302B2 (en) * | 2013-12-05 | 2017-04-04 | Buriva, LLC. | Composition containing phospholipid-DHA and B vitamins |
| CN106536751A (zh) * | 2014-03-05 | 2017-03-22 | 武田药品工业株式会社 | 治疗抑郁症和重性抑郁障碍的方法 |
| WO2015136446A1 (en) * | 2014-03-11 | 2015-09-17 | Nestec S.A. | Methods for selecting antidepressant drug therapy to treat depression |
| KR101588119B1 (ko) * | 2014-05-16 | 2016-01-25 | 동아대학교 산학협력단 | Ｓｌｃ6ａ3 유전자의 다형성 소위성과 이를 이용한 ｄｎａ 타이핑 키트 및 상기 유전자 관련 질병의 진단키트 |
| CA2957926A1 (en) * | 2014-08-13 | 2016-02-18 | Janssen Pharmaceutica Nv | Method for the treatment of depression |
| KR20170054470A (ko) | 2014-09-15 | 2017-05-17 | 얀센 파마슈티카 엔.브이. | VAL66MET (SNP rs6265) 유전자형 특이적 투여 계획 및 우울증 치료 방법 |
| CN105671130A (zh) * | 2014-11-18 | 2016-06-15 | 武汉白原科技有限公司 | 一种心理性格检测试剂盒和方法 |
| US20160203591A1 (en) * | 2015-01-09 | 2016-07-14 | Umm Al-Qura University | System and process for monitoring the quality of food in a refrigerator |
| CN104655705B (zh) * | 2015-02-12 | 2017-03-08 | 江苏省原子医学研究所 | 一种用毛细管电泳快速检测生物样本中儿茶酚氧甲基转移酶comt活性的方法 |
| CN104789668A (zh) * | 2015-04-10 | 2015-07-22 | 浙江博惠生物科技有限公司 | 一种叶酸代谢能力评估的检测位点rs1801394的检测PCR扩增引物和单碱基延伸引物 |
| WO2016168685A1 (en) * | 2015-04-17 | 2016-10-20 | Mayo Foundation For Medical Education And Research | Modulating the aryl hydrocarbon receptor system to treat major depressive disorder |
| US20180137235A1 (en) * | 2015-04-28 | 2018-05-17 | Proove Biosciences, Inc. | System and method for processing genotype information relating to opioid risk |
| US20160332962A1 (en) | 2015-05-13 | 2016-11-17 | Janssen Pharmaceutica Nv | (s)-csa salt of s-ketamine, (r)-csa salt of s-ketamine and processes for the preparation of s-ketamine |
| US10067126B2 (en) * | 2015-05-25 | 2018-09-04 | Hunan SkyWorld Biotechnologies Co. LTD | Use of fluorescence for the quick and easy determination of s-adenosylmethionine, s-adenosylhomocysteine and homocysteine |
| US11313868B2 (en) | 2016-06-14 | 2022-04-26 | Board Of Regents, The University Of Texas System | Methods of detecting anti-folic acid antibodies and uses thereof |
| US20200049722A1 (en) * | 2016-09-26 | 2020-02-13 | Precision Medicine Holdings Pty Ltd | Diagnosis, prognosis and treatment for schizophrenia and schizoaffective psychosis |
| CN107245527A (zh) * | 2017-07-25 | 2017-10-13 | 重庆京因生物科技有限责任公司 | Mtrr基因多态性快速检测的引物、分子信标、试剂盒及其检测方法 |
| WO2019027568A1 (en) * | 2017-08-02 | 2019-02-07 | Glaxosmithkline Consumer Healthcare Holdings (Us) Llc | PORTABLE DEVICE AND APPLICATION FOR BEHAVIORAL CARRIER |
| US20200009081A1 (en) | 2017-09-13 | 2020-01-09 | Janssen Pharmaceutica N.V. | Delivery Of Esketamine For The Treatment Of Depression |
| IL275482B1 (en) | 2017-12-22 | 2025-03-01 | Janssen Pharmaceuticals Inc | Esketamine for the treatment of depression |
| CN108251522B (zh) * | 2018-04-09 | 2020-11-27 | 江苏硕世生物科技股份有限公司 | 人类mthfr和mtrr基因检测试剂盒及其用途 |
| CN108642138B (zh) * | 2018-05-02 | 2021-11-30 | 广东药科大学 | 一种检测叶酸代谢相关基因遗传信息的方法及试剂盒 |
| EP3788644A4 (en) | 2018-05-03 | 2023-03-01 | L. Pierre De Rochemont | HIGH-FAST/LOW-PERFORMANCE SERVER SYSTEMS AND SERVER NETWORKS |
| CA3102806A1 (en) | 2018-06-05 | 2019-12-12 | L. Pierre De Rochemont | Module with high peak bandwidth i/o channels |
| CN108823299A (zh) * | 2018-06-11 | 2018-11-16 | 苏州艾达康医疗科技有限公司 | 一种抑郁症用药相关基因的检测方法及试剂盒 |
| AU2019337088A1 (en) * | 2018-09-03 | 2021-05-06 | Visby Medical, Inc. | Devices and methods for antibiotic susceptibility testing |
| WO2020178653A1 (en) | 2019-03-05 | 2020-09-10 | Janssen Pharmaceuticals, Inc. | Esketamine for the treatment of depression |
| WO2020232125A1 (en) | 2019-05-14 | 2020-11-19 | Prometheus Biosciences, Inc. | Tl1a patient selection methods, systems, and devices |
| CN110148461B (zh) * | 2019-06-26 | 2021-09-21 | 周建勋 | 用于多参数测量的模块切换系统 |
| CN110693507A (zh) * | 2019-08-30 | 2020-01-17 | 中国民用航空飞行学院 | 一种民航飞行学员心理健康测试和心理援助系统 |
| CN111351945B (zh) * | 2020-03-18 | 2021-04-23 | 东南大学 | 维生素d结合蛋白作为标志物在精神疾病抑郁症诊断中的应用 |
| WO2022115277A1 (en) * | 2020-11-24 | 2022-06-02 | Genomind, Inc. | Methods and systems for reporting patient-and drug-specific medical data |
| CN116103385B (zh) * | 2021-11-11 | 2024-11-15 | 深圳理工大学 | 一种预测抑郁障碍患者对治疗反应的基因诊断试剂盒和系统 |
| CN116298233A (zh) * | 2022-03-16 | 2023-06-23 | 昱言科技(北京)有限公司 | 用于诊断双相障碍的生物标记物 |
| WO2023220213A1 (en) * | 2022-05-11 | 2023-11-16 | Higgins Evelyn | Methods for providing a personalized therapeutic treatment regime for addictions |
Family Cites Families (93)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US548257A (en) | 1895-10-22 | Hay rake and loader | ||
| US3837376A (en) | 1971-06-01 | 1974-09-24 | Metropolitan Pathology Labor I | Blood serum collection tube and method |
| US4336185A (en) | 1976-03-02 | 1982-06-22 | Rohm And Haas Company | Folic acid derivatives |
| US4120448A (en) | 1977-06-08 | 1978-10-17 | Baxter Travenol Laboratories, Inc. | Centrifugal liquid processing apparatus with automatically positioned collection port |
| US4656035A (en) | 1984-12-21 | 1987-04-07 | University Of Tennessee Research Corporation | Method of separating blood platelets |
| US4946773A (en) | 1985-12-23 | 1990-08-07 | President And Fellows Of Harvard College | Detection of base pair mismatches using RNAase A |
| US5322770A (en) | 1989-12-22 | 1994-06-21 | Hoffman-Laroche Inc. | Reverse transcription with thermostable DNA polymerases - high temperature reverse transcription |
| US6270961B1 (en) | 1987-04-01 | 2001-08-07 | Hyseq, Inc. | Methods and apparatus for DNA sequencing and DNA identification |
| US5202231A (en) | 1987-04-01 | 1993-04-13 | Drmanac Radoje T | Method of sequencing of genomes by hybridization of oligonucleotide probes |
| IL86724A (en) | 1987-06-19 | 1995-01-24 | Siska Diagnostics Inc | Methods and kits for amplification and testing of nucleic acid sequences |
| EP0359789B1 (en) | 1988-01-21 | 1993-08-04 | Genentech, Inc. | Amplification and detection of nucleic acid sequences |
| CA1340807C (en) | 1988-02-24 | 1999-11-02 | Lawrence T. Malek | Nucleic acid amplification process |
| WO1989010414A1 (en) | 1988-04-28 | 1989-11-02 | Robert Bruce Wallace | AMPLIFIED SEQUENCE POLYMORPHISMS (ASPs) |
| US5130238A (en) | 1988-06-24 | 1992-07-14 | Cangene Corporation | Enhanced nucleic acid amplification process |
| US5925525A (en) | 1989-06-07 | 1999-07-20 | Affymetrix, Inc. | Method of identifying nucleotide differences |
| GB2236186B (en) | 1989-08-22 | 1994-01-05 | Finnigan Mat Gmbh | Process and device for laser desorption of analyte molecular ions, especially of biomolecules |
| US5045694A (en) | 1989-09-27 | 1991-09-03 | The Rockefeller University | Instrument and method for the laser desorption of ions in mass spectrometry |
| US6013431A (en) | 1990-02-16 | 2000-01-11 | Molecular Tool, Inc. | Method for determining specific nucleotide variations by primer extension in the presence of mixture of labeled nucleotides and terminators |
| US5846710A (en) | 1990-11-02 | 1998-12-08 | St. Louis University | Method for the detection of genetic diseases and gene sequence variations by single nucleotide primer extension |
| DE69132905T2 (de) | 1990-12-06 | 2002-08-01 | Affymetrix, Inc. (N.D.Ges.D.Staates Delaware) | Detektion von Nukleinsäuresequenzen |
| US5169766A (en) | 1991-06-14 | 1992-12-08 | Life Technologies, Inc. | Amplification of nucleic acid molecules |
| US5994069A (en) | 1996-01-24 | 1999-11-30 | Third Wave Technologies, Inc. | Detection of nucleic acids by multiple sequential invasive cleavages |
| ATE242485T1 (de) | 1993-05-28 | 2003-06-15 | Baylor College Medicine | Verfahren und massenspektrometer zur desorption und ionisierung von analyten |
| US5858659A (en) | 1995-11-29 | 1999-01-12 | Affymetrix, Inc. | Polymorphism detection |
| US6136540A (en) | 1994-10-03 | 2000-10-24 | Ikonisys Inc. | Automated fluorescence in situ hybridization detection of genetic abnormalities |
| US5952172A (en) | 1993-12-10 | 1999-09-14 | California Institute Of Technology | Nucleic acid mediated electron transfer |
| US5851770A (en) | 1994-04-25 | 1998-12-22 | Variagenics, Inc. | Detection of mismatches by resolvase cleavage using a magnetic bead support |
| GB9410620D0 (en) | 1994-05-26 | 1994-07-13 | Univ Mcgill | cDNA for human mehylenetetrahydrofolate reductase |
| US6566065B1 (en) | 1994-05-26 | 2003-05-20 | Mcgill University | Method of diagnosing schizophrenia by detecting a mutation in the (MTHFR) gene |
| US6379897B1 (en) | 2000-11-09 | 2002-04-30 | Nanogen, Inc. | Methods for gene expression monitoring on electronic microarrays |
| US5849483A (en) | 1994-07-28 | 1998-12-15 | Ig Laboratories, Inc. | High throughput screening method for sequences or genetic alterations in nucleic acids |
| US5866337A (en) | 1995-03-24 | 1999-02-02 | The Trustees Of Columbia University In The City Of New York | Method to detect mutations in a nucleic acid using a hybridization-ligation procedure |
| US5704888A (en) | 1995-04-14 | 1998-01-06 | Cobe Laboratories, Inc. | Intermittent collection of mononuclear cells in a centrifuge apparatus |
| US5968740A (en) | 1995-07-24 | 1999-10-19 | Affymetrix, Inc. | Method of Identifying a Base in a Nucleic Acid |
| US6264970B1 (en) | 1996-06-26 | 2001-07-24 | Takeda Chemical Industries, Ltd. | Sustained-release preparation |
| US5928870A (en) | 1997-06-16 | 1999-07-27 | Exact Laboratories, Inc. | Methods for the detection of loss of heterozygosity |
| GB9620209D0 (en) | 1996-09-27 | 1996-11-13 | Cemu Bioteknik Ab | Method of sequencing DNA |
| US6465611B1 (en) | 1997-02-25 | 2002-10-15 | Corixa Corporation | Compounds for immunotherapy of prostate cancer and methods for their use |
| NZ516848A (en) | 1997-06-20 | 2004-03-26 | Ciphergen Biosystems Inc | Retentate chromatography apparatus with applications in biology and medicine |
| CA2303206A1 (en) | 1997-09-10 | 1999-03-18 | University Of Maryland, Baltimore | Method of amplifying dna and rna mismatch cleavage products |
| RU2222329C2 (ru) * | 1998-04-24 | 2004-01-27 | Скариста Лимитед | Лечение депрессии и фармацевтические препараты для этой цели |
| US6406921B1 (en) | 1998-07-14 | 2002-06-18 | Zyomyx, Incorporated | Protein arrays for high-throughput screening |
| IL141762A0 (en) | 1998-10-01 | 2002-03-10 | Novartis Ag | New oral formulations |
| US6395481B1 (en) | 1999-02-16 | 2002-05-28 | Arch Development Corp. | Methods for detection of promoter polymorphism in a UGT gene promoter |
| US7429466B2 (en) | 2000-01-24 | 2008-09-30 | Hypromatrix, Inc | Methods and arrays for detecting biological molecules |
| WO2001055454A1 (en) | 2000-01-28 | 2001-08-02 | Althea Technologies, Inc. | Methods for analysis of gene expression |
| EP1231956A2 (en) | 2000-03-09 | 2002-08-21 | Gambro, Inc. | Extracorporeal blood processing method and apparatus |
| US20020016293A1 (en) | 2000-04-21 | 2002-02-07 | Ratain Mark J. | Flavopiridol drug combinations and methods with reduced side effects |
| DE10022510A1 (de) | 2000-05-10 | 2001-11-15 | Basf Ag | Zusammensetzungen enthaltend Folsäure und reduziertes Folat |
| US6355433B1 (en) | 2000-06-02 | 2002-03-12 | Dna Sciences, Inc. | Determination of nucleotide sequence variations through limited primer extension |
| WO2002006231A1 (en) | 2000-07-18 | 2002-01-24 | Sumitomo Pharmaceuticals Co., Ltd. | Serotonin reuptake inhibitors |
| US20030099960A1 (en) | 2001-01-26 | 2003-05-29 | The University Of Chicago | Compositions and methods for optimizing UGT2B7 substrate dosings and for predicting UGT2B7 substrate toxicity |
| US6720003B2 (en) | 2001-02-16 | 2004-04-13 | Andrx Corporation | Serotonin reuptake inhibitor formulations |
| EP1385998A1 (en) | 2001-04-19 | 2004-02-04 | Ciphergen Biosystems, Inc. | Biomolecule characterization using mass spectrometry and affinity tags |
| US20030100476A1 (en) | 2001-05-11 | 2003-05-29 | Weinberger Daniel R. | Effect of COMT genotype on frontal lobe function |
| AU2001286171B2 (en) | 2001-05-25 | 2008-01-10 | Serono Genetics Institute S.A. | Human CDNAs and proteins and uses thereof |
| US7112408B2 (en) | 2001-06-08 | 2006-09-26 | The Brigham And Women's Hospital, Inc. | Detection of ovarian cancer based upon alpha-haptoglobin levels |
| US20030013208A1 (en) | 2001-07-13 | 2003-01-16 | Milagen, Inc. | Information enhanced antibody arrays |
| EP1425695A2 (en) | 2001-08-13 | 2004-06-09 | Beyong Genomics, Inc. | Method and system for profiling biological systems |
| UA81749C2 (uk) | 2001-10-04 | 2008-02-11 | Х. Луннбек А/С | Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну |
| AU2003207989A1 (en) | 2002-02-21 | 2003-09-09 | Idgene Pharmaceuticals Ltd. | Association of snps in the comt locus and neighboring loci with schizophrenia, bipolar disorder, breast cancer and colorectal cancer |
| US20030215858A1 (en) | 2002-04-08 | 2003-11-20 | Baylor College Of Medicine | Enhanced gene expression system |
| US7241281B2 (en) | 2002-04-08 | 2007-07-10 | Thermogenesis Corporation | Blood component separation method and apparatus |
| US20030194711A1 (en) | 2002-04-10 | 2003-10-16 | Matthew Zapala | System and method for analyzing gene expression data |
| WO2003091735A1 (en) | 2002-04-23 | 2003-11-06 | Millipore Corporation | Sample preparation of biological fluids for proteomic applications |
| US20030205538A1 (en) | 2002-05-03 | 2003-11-06 | Randel Dorian | Methods and apparatus for isolating platelets from blood |
| CA2415154C (en) | 2002-12-24 | 2009-06-16 | Biovail Laboratories Inc. | Modified release formulations of selective serotonin re-uptake inhibitors |
| US20040203034A1 (en) | 2003-01-03 | 2004-10-14 | The University Of Chicago | Optimization of cancer treatment with irinotecan |
| PL1610791T3 (pl) | 2003-03-31 | 2011-07-29 | Titan Pharmaceuticals Inc | Wszczepialne urządzenie polimerowe do przedłużonego uwalniania agonisty dopaminy |
| US20050054688A1 (en) | 2003-08-08 | 2005-03-10 | Pfizer Inc | Selective serotonin reuptake inhibitors in the treatment of disease |
| US20050069936A1 (en) | 2003-09-26 | 2005-03-31 | Cornelius Diamond | Diagnostic markers of depression treatment and methods of use thereof |
| US7893261B2 (en) | 2004-03-26 | 2011-02-22 | Baylor University | Serotonin reuptake inhibitors |
| JP2005312435A (ja) | 2004-03-29 | 2005-11-10 | Kazuhito Rokutan | うつ病の評価方法 |
| WO2006099164A2 (en) | 2005-03-10 | 2006-09-21 | Applera Corporation | Methods for multiplex amplification |
| US7972770B2 (en) | 2005-08-16 | 2011-07-05 | Memorial Sloan-Kettering Cancer Center | Methods of detection of cancer using peptide profiles |
| US20070254288A1 (en) | 2005-12-06 | 2007-11-01 | The General Hospital Corporation | Diagnostic methods for pain sensitivity and chronicity and for tetrahydrobiopterin-related disorders |
| US20080064702A1 (en) | 2006-09-08 | 2008-03-13 | Charalambos Antoniades | Use of folates for the prevention and treatment of vascular diseases |
| US8268347B1 (en) | 2006-10-24 | 2012-09-18 | Aradigm Corporation | Dual action, inhaled formulations providing both an immediate and sustained release profile |
| WO2008066769A2 (en) | 2006-11-29 | 2008-06-05 | Lohocla Research Corporation | Genetic diagnosis of depression |
| US20090075827A1 (en) | 2007-01-19 | 2009-03-19 | Queensland University Of Technology | Diagnostic methods and agents |
| US7947662B2 (en) | 2008-02-20 | 2011-05-24 | Gnosis S.P.A. | Folates, compositions and uses thereof |
| EP2227780A4 (en) | 2008-03-19 | 2011-08-03 | Existence Genetics Llc | GENETIC ANALYSIS |
| US8344115B2 (en) | 2008-04-21 | 2013-01-01 | Chan-Sui Pang, legal representative | Immunoassay for specific determination of S-adenosylmethionine and analogs thereof in biological samples |
| JP2011528321A (ja) | 2008-06-21 | 2011-11-17 | ケンバー，エルエルシー | ニュートリゲノミクス方法および組成 |
| US20100112589A1 (en) | 2008-11-03 | 2010-05-06 | Xie Yagang | Allele-allele interactions of mthfr gene variants, and uses thereof in predicting disease risk |
| EP2435586A4 (en) | 2009-05-29 | 2012-12-26 | Genomind Llc | METHODS OF EVALUATION AND TREATMENT OF DEPRESSION VIA USE OF ANALYSIS OF SIMPLE NUCLEOTIDE POLYMORPHISMS |
| EP2482677A1 (en) | 2009-09-30 | 2012-08-08 | The Regents of The University of California | Cofactors and methods for use for individuals |
| US20140088035A1 (en) * | 2010-12-03 | 2014-03-27 | The General Hospital Corporation | Treating schizophrenia |
| KR20120092993A (ko) | 2011-02-14 | 2012-08-22 | 지엘팜텍 주식회사 | 티아넵틴 또는 이의 약제학적으로 허용되는 염을 포함하는 경구투여용 서방성 정제 |
| AU2012235634B2 (en) | 2011-03-28 | 2017-05-25 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Sustained-release injectable formulation |
| US20120329749A1 (en) | 2011-06-21 | 2012-12-27 | Stephen Albert Lonnie Smith | Methods Of Preventing Or Treating Disease States Related To Certain Metabolic Abnormalities |
| AU2012340015B2 (en) | 2011-11-14 | 2017-09-21 | Alfasigma S.P.A. | Assays for selecting a treatment regimen for a subject with depression and methods for treatment |
| US20160058766A1 (en) * | 2011-11-14 | 2016-03-03 | Nestec S.A. | Assays and methods for selecting a treatment regimen for a subject with depression |
-
2012
- 2012-11-14 AU AU2012340015A patent/AU2012340015B2/en not_active Ceased
- 2012-11-14 IN IN4226DEN2014 patent/IN2014DN04226A/en unknown
- 2012-11-14 KR KR1020147016192A patent/KR102035877B1/ko not_active Expired - Fee Related
- 2012-11-14 CN CN201280065415.6A patent/CN104053785A/zh active Pending
- 2012-11-14 EP EP12795214.1A patent/EP2780467B1/en active Active
- 2012-11-14 CA CA2855640A patent/CA2855640C/en active Active
- 2012-11-14 RU RU2014124121A patent/RU2622082C2/ru active
- 2012-11-14 WO PCT/US2012/065084 patent/WO2013074676A2/en not_active Ceased
- 2012-11-14 BR BR112014011491A patent/BR112014011491A2/pt active Search and Examination
- 2012-11-14 MX MX2014005786A patent/MX354547B/es active IP Right Grant
- 2012-11-14 JP JP2014541420A patent/JP6285865B2/ja not_active Expired - Fee Related
-
2013
- 2013-03-07 US US13/789,075 patent/US9540691B2/en active Active
- 2013-03-12 US US13/796,362 patent/US9546401B2/en active Active
-
2014
- 2014-05-01 IL IL232407A patent/IL232407B/en active IP Right Grant
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2015508281A5 (enExample) | ||
| RU2014124121A (ru) | Анализы и способы выбора режима лечения пациента с депрессией | |
| RU2015143177A (ru) | Анализы и способы выбора схемы лечения для субъекта с депрессией | |
| WO2007130519A3 (en) | Viral nucleic acid microarray and method of use | |
| JP2012503985A5 (enExample) | ||
| JP2009077712A5 (enExample) | ||
| IL294121B1 (en) | An RNA test to diagnose the type of infection | |
| JP2009528060A5 (enExample) | ||
| JP2013544536A5 (enExample) | ||
| JP2011528903A5 (enExample) | ||
| ElSharawy et al. | Accurate variant detection across non-amplified and whole genome amplified DNA using targeted next generation sequencing | |
| McIver et al. | Population-scale analysis of human microsatellites reveals novel sources of exonic variation | |
| JP2010035532A (ja) | アレル特異的ｐｃｒ法 | |
| Rybicka et al. | Current molecular methods for the detection of hepatitis B virus quasispecies | |
| CN103820440B (zh) | 结核分枝杆菌异烟肼耐药相关的新突变位点及其应用 | |
| CA2901120C (en) | Methods and kits for identifying and adjusting for bias in sequencing of polynucleotide samples | |
| WO2009011297A1 (ja) | Ｊａｋ２遺伝子の変異検出用プローブおよびその用途 | |
| Bojarojc-Nosowicz et al. | Polymorphism and expression of the tumour necrosis factor-alpha (TNF-alpha) gene in non-infected cows and in cows naturally infected with the bovine leukaemia virus (BLV). | |
| CN101979658A (zh) | 引物第3位引入突变的扩增阻滞法检测mdr1单核苷酸多态性 | |
| CA2608161A1 (en) | Methods for the assesssment of risk of developing lung cancer using analysis of genetic polymorphisms | |
| de Paula Careta et al. | Recent patents on high-throughput single nucleotide polymorphism (SNP) genotyping methods | |
| JP4853898B2 (ja) | Ｄｎａ標準物質 | |
| WO2006091757A3 (en) | Detection of very virulent infectious bursal disease virus | |
| JP2002330755A5 (enExample) | ||
| KR20160148807A (ko) | 장 베체트병 진단용 바이오마커 및 이의 용도 |