JP2015508281A5 - - Google Patents
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- JP2015508281A5 JP2015508281A5 JP2014541420A JP2014541420A JP2015508281A5 JP 2015508281 A5 JP2015508281 A5 JP 2015508281A5 JP 2014541420 A JP2014541420 A JP 2014541420A JP 2014541420 A JP2014541420 A JP 2014541420A JP 2015508281 A5 JP2015508281 A5 JP 2015508281A5
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- Prior art keywords
- seq
- allele
- nucleic acid
- acid sequence
- snp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108700028369 Alleles Proteins 0.000 claims 56
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 48
- 150000007523 nucleic acids Chemical group 0.000 claims 47
- RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 claims 36
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 claims 24
- 229940113082 thymine Drugs 0.000 claims 18
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 16
- 235000004279 alanine Nutrition 0.000 claims 16
- 102100040999 Catechol O-methyltransferase Human genes 0.000 claims 12
- 108020002739 Catechol O-methyltransferase Proteins 0.000 claims 12
- 102100020756 D(2) dopamine receptor Human genes 0.000 claims 12
- 101000931901 Homo sapiens D(2) dopamine receptor Proteins 0.000 claims 12
- 102000002114 Reduced Folate Carrier Human genes 0.000 claims 12
- 108050009454 Reduced Folate Carrier Proteins 0.000 claims 12
- 238000003556 assay Methods 0.000 claims 12
- 108010030837 Methylenetetrahydrofolate Reductase (NADPH2) Proteins 0.000 claims 10
- 102100029684 Methylenetetrahydrofolate reductase Human genes 0.000 claims 10
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 9
- 102100027346 GTP cyclohydrolase 1 Human genes 0.000 claims 8
- 101710094136 GTP cyclohydrolase 1 Proteins 0.000 claims 8
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims 8
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims 8
- 102100031551 Methionine synthase Human genes 0.000 claims 6
- 230000001430 anti-depressive effect Effects 0.000 claims 6
- 239000000935 antidepressant agent Substances 0.000 claims 6
- 229940005513 antidepressants Drugs 0.000 claims 6
- 235000019152 folic acid Nutrition 0.000 claims 6
- 239000011724 folic acid Substances 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 238000011269 treatment regimen Methods 0.000 claims 6
- 208000008589 Obesity Diseases 0.000 claims 5
- 235000020824 obesity Nutrition 0.000 claims 5
- 102200124653 rs4680 Human genes 0.000 claims 5
- 102100024810 DNA (cytosine-5)-methyltransferase 3B Human genes 0.000 claims 4
- 102100025413 Formyltetrahydrofolate synthetase Human genes 0.000 claims 4
- 102100040287 GTP cyclohydrolase 1 feedback regulatory protein Human genes 0.000 claims 4
- 101710185324 GTP cyclohydrolase 1 feedback regulatory protein Proteins 0.000 claims 4
- 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 claims 4
- 101000909249 Homo sapiens DNA (cytosine-5)-methyltransferase 3B Proteins 0.000 claims 4
- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 claims 4
- 102100024614 Methionine synthase reductase Human genes 0.000 claims 4
- 229940104302 cytosine Drugs 0.000 claims 4
- 229940014144 folate Drugs 0.000 claims 4
- 102200088972 rs1801133 Human genes 0.000 claims 4
- JVJFIQYAHPMBBX-FNORWQNLSA-N (E)-4-hydroxynon-2-enal Chemical compound CCCCCC(O)\C=C\C=O JVJFIQYAHPMBBX-FNORWQNLSA-N 0.000 claims 3
- 108010075604 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase Proteins 0.000 claims 3
- 108010074051 C-Reactive Protein Proteins 0.000 claims 3
- JVJFIQYAHPMBBX-UHFFFAOYSA-N HNE Natural products CCCCCC(O)C=CC=O JVJFIQYAHPMBBX-UHFFFAOYSA-N 0.000 claims 3
- 101000867811 Homo sapiens Voltage-dependent L-type calcium channel subunit alpha-1C Proteins 0.000 claims 3
- 102100032574 Voltage-dependent L-type calcium channel subunit alpha-1C Human genes 0.000 claims 3
- 230000001419 dependent effect Effects 0.000 claims 3
- 102200141619 rs1051266 Human genes 0.000 claims 3
- 102200088640 rs2274976 Human genes 0.000 claims 3
- 102220113388 rs4633 Human genes 0.000 claims 3
- 102100029172 Choline-phosphate cytidylyltransferase A Human genes 0.000 claims 2
- 101710100763 Choline-phosphate cytidylyltransferase A Proteins 0.000 claims 2
- 108010044266 Dopamine Plasma Membrane Transport Proteins Proteins 0.000 claims 2
- 102100020765 Formimidoyltetrahydrofolate cyclodeaminase Human genes 0.000 claims 2
- 102000015436 Glutamate formimidoyltransferase Human genes 0.000 claims 2
- 108010064766 Glutamate formimidoyltransferase Proteins 0.000 claims 2
- 101001116314 Homo sapiens Methionine synthase reductase Proteins 0.000 claims 2
- 101000639972 Homo sapiens Sodium-dependent dopamine transporter Proteins 0.000 claims 2
- 108010010685 Methenyltetrahydrofolate cyclohydrolase Proteins 0.000 claims 2
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims 2
- XJLXINKUBYWONI-NNYOXOHSSA-O NADP(+) Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-NNYOXOHSSA-O 0.000 claims 2
- 102000005029 SLC6A3 Human genes 0.000 claims 2
- 102100033928 Sodium-dependent dopamine transporter Human genes 0.000 claims 2
- 108010042865 aquacobalamin reductase Proteins 0.000 claims 2
- 239000000090 biomarker Substances 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 229960000304 folic acid Drugs 0.000 claims 2
- 108010060923 formiminotetrahydrofolate cyclodeaminase Proteins 0.000 claims 2
- 238000003205 genotyping method Methods 0.000 claims 2
- 208000024714 major depressive disease Diseases 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 208000020401 Depressive disease Diseases 0.000 claims 1
- 230000003321 amplification Effects 0.000 claims 1
- 238000004458 analytical method Methods 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- -1 calcium nucleic acid Chemical class 0.000 claims 1
- 238000003199 nucleic acid amplification method Methods 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 210000003296 saliva Anatomy 0.000 claims 1
- 229940124834 selective serotonin reuptake inhibitor Drugs 0.000 claims 1
- 239000012896 selective serotonin reuptake inhibitor Substances 0.000 claims 1
- 238000011282 treatment Methods 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161559541P | 2011-11-14 | 2011-11-14 | |
| US61/559,541 | 2011-11-14 | ||
| PCT/US2012/065084 WO2013074676A2 (en) | 2011-11-14 | 2012-11-14 | Assays and methods for selecting a treatment regimen for a subject with depression |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015508281A JP2015508281A (ja) | 2015-03-19 |
| JP2015508281A5 true JP2015508281A5 (enExample) | 2016-01-14 |
| JP6285865B2 JP6285865B2 (ja) | 2018-02-28 |
Family
ID=47279072
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014541420A Expired - Fee Related JP6285865B2 (ja) | 2011-11-14 | 2012-11-14 | うつ病を有する対象のための処置レジメンを選択するためのアッセイ及び方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US9540691B2 (enExample) |
| EP (1) | EP2780467B1 (enExample) |
| JP (1) | JP6285865B2 (enExample) |
| KR (1) | KR102035877B1 (enExample) |
| CN (1) | CN104053785A (enExample) |
| AU (1) | AU2012340015B2 (enExample) |
| BR (1) | BR112014011491A2 (enExample) |
| CA (1) | CA2855640C (enExample) |
| IL (1) | IL232407B (enExample) |
| IN (1) | IN2014DN04226A (enExample) |
| MX (1) | MX354547B (enExample) |
| RU (1) | RU2622082C2 (enExample) |
| WO (1) | WO2013074676A2 (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6285865B2 (ja) | 2011-11-14 | 2018-02-28 | アルファシグマ ソシエタ ペル アチオニ | うつ病を有する対象のための処置レジメンを選択するためのアッセイ及び方法 |
| CN105518685A (zh) * | 2013-03-12 | 2016-04-20 | 雀巢产品技术援助有限公司 | 用于为罹患抑郁症的个体选择治疗方案的测定和方法 |
| EP3636251B1 (en) | 2013-03-15 | 2022-01-19 | Janssen Pharmaceutica NV | Pharmaceutical composition of s-ketamine hydrochloride |
| US9610302B2 (en) * | 2013-12-05 | 2017-04-04 | Buriva, LLC. | Composition containing phospholipid-DHA and B vitamins |
| US20150250813A1 (en) * | 2013-12-05 | 2015-09-10 | Buriva, LLC | Dietary supplement containing phospholipid-dha, folate, and n-acetyl-l-cysteine |
| US9549937B2 (en) * | 2013-12-05 | 2017-01-24 | Burvia, LLC. | Composition containing phospholipid-DHA and folate |
| CA2940683A1 (en) * | 2014-03-05 | 2015-09-11 | Takeda Pharmaceutical Company Limited | Method for treating depression and major depressive disorder |
| WO2015136446A1 (en) * | 2014-03-11 | 2015-09-17 | Nestec S.A. | Methods for selecting antidepressant drug therapy to treat depression |
| KR101588119B1 (ko) * | 2014-05-16 | 2016-01-25 | 동아대학교 산학협력단 | Ｓｌｃ6ａ3 유전자의 다형성 소위성과 이를 이용한 ｄｎａ 타이핑 키트 및 상기 유전자 관련 질병의 진단키트 |
| MX2017001908A (es) * | 2014-08-13 | 2017-08-08 | Janssen Pharmaceutica Nv | Metodo para el tratamiento de la depresion. |
| WO2016044150A1 (en) | 2014-09-15 | 2016-03-24 | Janssen Pharmaceutica Nv | VAL66MET (SNP rs6265) GENOTYPE SPECIFIC DOSING REGIMENS AND METHODS FOR THE TREATMENT OF DEPRESSION |
| CN105671130A (zh) * | 2014-11-18 | 2016-06-15 | 武汉白原科技有限公司 | 一种心理性格检测试剂盒和方法 |
| US20160203591A1 (en) * | 2015-01-09 | 2016-07-14 | Umm Al-Qura University | System and process for monitoring the quality of food in a refrigerator |
| CN104655705B (zh) * | 2015-02-12 | 2017-03-08 | 江苏省原子医学研究所 | 一种用毛细管电泳快速检测生物样本中儿茶酚氧甲基转移酶comt活性的方法 |
| CN104789668A (zh) * | 2015-04-10 | 2015-07-22 | 浙江博惠生物科技有限公司 | 一种叶酸代谢能力评估的检测位点rs1801394的检测PCR扩增引物和单碱基延伸引物 |
| US11122997B2 (en) | 2015-04-17 | 2021-09-21 | Mayo Foundation For Medical Education And Research | Modulating the aryl hydrocarbon receptor system to treat major depressive disorder |
| WO2016176458A1 (en) * | 2015-04-28 | 2016-11-03 | Proove Biosciences, Inc. | System and method for processing genotype information relating to opiod risk |
| US20160332962A1 (en) | 2015-05-13 | 2016-11-17 | Janssen Pharmaceutica Nv | (s)-csa salt of s-ketamine, (r)-csa salt of s-ketamine and processes for the preparation of s-ketamine |
| AU2016267091B2 (en) * | 2015-05-25 | 2020-01-16 | Xiujuan Hao | Use of fluorescence for the quick and easy determination of S-Adenosylmethionine, S-Adenosylhomocysteine and Homocysteine |
| US11313868B2 (en) | 2016-06-14 | 2022-04-26 | Board Of Regents, The University Of Texas System | Methods of detecting anti-folic acid antibodies and uses thereof |
| AU2017331814B2 (en) * | 2016-09-26 | 2024-01-25 | Precision Medicine Holdings Pty Ltd | Diagnosis, prognosis and treatment for schizophrenia and schizoaffective psychosis |
| CN107245527A (zh) * | 2017-07-25 | 2017-10-13 | 重庆京因生物科技有限责任公司 | Mtrr基因多态性快速检测的引物、分子信标、试剂盒及其检测方法 |
| WO2019027568A1 (en) * | 2017-08-02 | 2019-02-07 | Glaxosmithkline Consumer Healthcare Holdings (Us) Llc | PORTABLE DEVICE AND APPLICATION FOR BEHAVIORAL CARRIER |
| US20200009081A1 (en) | 2017-09-13 | 2020-01-09 | Janssen Pharmaceutica N.V. | Delivery Of Esketamine For The Treatment Of Depression |
| WO2019126108A1 (en) | 2017-12-22 | 2019-06-27 | Janssen Pharmaceutica Nv | Esketamine for the treatment of depression |
| CN108251522B (zh) * | 2018-04-09 | 2020-11-27 | 江苏硕世生物科技股份有限公司 | 人类mthfr和mtrr基因检测试剂盒及其用途 |
| CN108642138B (zh) * | 2018-05-02 | 2021-11-30 | 广东药科大学 | 一种检测叶酸代谢相关基因遗传信息的方法及试剂盒 |
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| CN108823299A (zh) * | 2018-06-11 | 2018-11-16 | 苏州艾达康医疗科技有限公司 | 一种抑郁症用药相关基因的检测方法及试剂盒 |
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| JP2022524008A (ja) | 2019-03-05 | 2022-04-27 | ヤンセン ファーマシューティカルズ，インコーポレーテッド | うつ病の治療のためのエスケタミン |
| EP3969621A4 (en) | 2019-05-14 | 2023-01-25 | Prometheus Biosciences, Inc. | TL1A PATIENT SELECTION METHODS, SYSTEMS AND DEVICES |
| CN110148461B (zh) * | 2019-06-26 | 2021-09-21 | 周建勋 | 用于多参数测量的模块切换系统 |
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| CN111351945B (zh) * | 2020-03-18 | 2021-04-23 | 东南大学 | 维生素d结合蛋白作为标志物在精神疾病抑郁症诊断中的应用 |
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| CN116103385B (zh) * | 2021-11-11 | 2024-11-15 | 深圳理工大学 | 一种预测抑郁障碍患者对治疗反应的基因诊断试剂盒和系统 |
| CN116298233A (zh) * | 2022-03-16 | 2023-06-23 | 昱言科技(北京)有限公司 | 用于诊断双相障碍的生物标记物 |
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